Jenny Smith

Ohio’s Triple Nickle is a highlight of this Ohio, Kentucky, and Indiana motorcycle ride. (Photos by the author) It was almost noon as I rolled into Zanesville, Ohio, and my stomach reminded me that all I had for breakfast was black coffee and a granola bar. I had a decision to make, but there’s only one decision that should be made on an empty stomach.

I’m lucky to live in adventure bike heaven, with five (soon to be six, when Montana is released next year) Backcountry Discovery Routes accessible within a day’s ride and innumerable gravel and dirt forest service roads crisscrossing the landscape for hundreds of miles in every direction. The Idaho BDR, for example, is more than 1,200 miles long, and when you factor in the pavement miles required to get there and back, it’s been known to easily chew through a rear big-block knobby tire.

Abstract Gene expression of Plasmodium falciparum (Pf) liver-stage (LS) parasites has remained poorly characterized, although they are major vaccine and drug targets. Using a human liver-chimaeric mouse model and a fluorescent parasite line (PfNF54CSPGFP), we isolated PfLS and performed transcriptomics on key LS developmental phases. We linked clustered gene expression to ApiAP2, a major family of transcription factors that regulate the parasite life cycle.