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Articles by Jing Gu
Equalizing or Reinforcing? The Impact of Organized Sports Club Membership on Gender Role Attitudes
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are openly available at: (1) WVS wave 7 (2017–2020): https://www.worldvaluessurvey.org/WVSDocumentationWV7.jsp; (2) World Bank: Government Expenditure on Education: https://data.worldbank.org/indicator/SE.XPD.TOTL.GD.ZS; (3) Human Development Reports: Gender Inequality Index: https://hdr.undp.org/data-center/documentation-and-downloads.
α/β-Hydrolase domain-containing 6 (ABHD6) accelerates the desensitization and deactivation of TARP γ-2-containing AMPA receptors
eLife Assessment This fundamental work demonstrates that ABHD6 regulates AMPAR gating kinetics in a TARP γ-2-dependent manner. The evidence in this study is compelling. This study will be of interest to readers in the field of synaptic transmission.
Designing a learning ecosystem for intangible cultural heritage in short-term study abroad: an outcome-based education case study
Abstract In the context of globalization, short-term study abroad (STSA) programs offer opportunities for Intangible Cultural Heritage (ICH) transmission, yet they often risk devolving into superficial cultural exposure. Addressing this design challenge, this study proposes a learning ecosystem model grounded in Outcome-Based Education (OBE) principles to support coherent and meaningful ICH learning within compressed timeframes.
ABL kinase inactivation induces transcription-replication conflicts and impairs replication fork progression in metastatic small cell lung cancer
ArticleVolume 45, Issue 7117699Open access Affiliations & Notes 1Department of Pharmacology and Cancer Biology, Duke University School of Medicine, Durham, NC, United States of America 2Department of Molecular Genetics and Microbiology, Duke University School of Medicine, Durham, NC, United States of America 3Division of Laboratory Animal Resources, Duke University School of Medicine, Durham, NC, United States of America Article Info Publication History: Received June 2, 2025; Revised May 6,...
Simulation Model To Estimate Pretreatment (Baseline) Low-Density Lipoprotein Cholesterol Levels in People Living With Homozygous Familial Hypercholesterolemia
Publication Date 1-1-2025 Journal Journal of Clinical Lipidology DOI 10.1016/j.jacl.2025.08.011 Abstract Introduction: Pretreatment levels of low-density lipoprotein cholesterol (LDL-C) are a primary consideration for the clinical diagnosis of homozygous familial hypercholesterolemia (HoFH). However, determination of pretreatment LDL-C can be challenging in this population because many individuals begin lipid-lowering therapy (LLT) early in life before diagnosis of HoFH.
Associations of genetic variants with gene expression factors reveal biological pathways underlying complex traits
Keywords expression factors trans effects pathway analysis effect consistency Get full text access Log in, subscribe or purchase for full access. References 1. Altshuler, D. ∙ Daly, M.J. ∙ Lander, E.S. Genetic mapping in human disease Science. 2008; 322:881-888 2. Hardy, J. ∙ Singleton, A. Genomewide association studies and human disease N. Engl. J. Med. 2009; 360:1759-1768 3. Wang, K. ∙ Li, M. ∙ Hakonarson, H. Analysing biological pathways in genome-wide association studies Nat. Rev. Genet. 2010; 11:843-854 4.
Longer lifetimes through quantum effects - Nature Energy
The effectiveness of solar-driven water splitting is constrained by inefficient separation of photogenerated charge carriers and their rapid recombination. Researchers now show that multilayered structures that exhibit quantum effects by confining electrons in thin layers can optimize charge carrier dynamics, resulting in photocatalysts with remarkable efficiency.
Nucleation of Battery‐Grade Li2CO3 Driven by Nanobubbles for Spent Battery Recycling
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available in the supplementary material of this article.
Spatial heterogeneity in the temperature-hand, foot, and mouth disease association among children: A multicounty time-series study in western China
Loading metrics Open Access Peer-reviewed Research Article Citation: Sun J, Yao G, Gu J, Tang H, Wu Y, Chang Y, et al. (2026) Spatial heterogeneity in the temperature–hand, foot, and mouth disease association among children: A multicounty time-series study in western China. PLoS Negl Trop Dis 20(1): e0013801.
Ru‐Loaded Nanosheet ZSM‐5 for Bisphenol A Hydrodeoxygenation to Bicyclic Alkanes with Coke Resistance and Insights into the Ru‐RuO2 Hydrogenation Mechanism
Conflict of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description adfm72912-sup-0001-SuppMat.docx10.4 MB Supporting Information References 1, , , , , , , , Nat. Mater. 2024, 23, 1622. 2, , , , , , , , Chem. Eng. Sci. 2017, 173, 91. 3, , , , , , , , Green Chem. 2015, 17, 5131. 4, , , , , , , , , , , , , J. Energy Chem.
Roles of inflammatory cytokines in the pathogenesis of hepatitis B virus-related acute-on-chronic liver failure and CAR-T therapy - Virology Journal
References Lee DW, Barrett DM, Mackall C, Orentas R, Grupp SA. The future is now: chimeric antigen receptors as new targeted therapies for childhood cancer. Clin Cancer Res. 2012;18(10):2780–90. PubMed PubMed Central Google Scholar Johnson LA, June CH. Driving gene-engineered T cell immunotherapy of cancer. Cell Res. 2017;27(1):38–58. PubMed Google Scholar Rouce RH, Sharma S, Huynh M, Heslop HE. Recent advances in T-cell immunotherapy for haematological malignancies. Br J Haematol. 2017;176(5):688–704.
From “immune silence” to “immune dialogue”: modification strategies for bone substitutes based on bone immunomodulatory characteristics
1 Introduction Bone defects represent a complex clinical pathological condition that poses significant medical challenges in their repair and treatment. Epidemiological data indicate a continuous upward trend in the global incidence of large segmental bone defects, primarily caused by trauma, tumor resection, infection, and congenital developmental anomalies (Zhang and Wang, 2020; Ouyang and Di, 2024).
Struct2D: A Perception-Guided Framework for Spatial Reasoning in MLLMs
arXivLabs is a framework that allows collaborators to develop and share new arXiv features directly on our website. Both individuals and organizations that work with arXivLabs have embraced and accepted our values of openness, community, excellence, and user data privacy. arXiv is committed to these values and only works with partners that adhere to them. Have an idea for a project that will add value for arXiv's community? Learn more about arXivLabs.
Evolutionary Dynamics and Functional Differences in Clinically Relevant Pen β-Lactamases from Burkholderia spp.
Introduction Click to copy section linkSection link copied! Antimicrobial resistance (AMR) is a leading cause of death worldwide. (1) The World Health Organisation highlighted that AMR was the direct reason for 1.27 million global deaths in 2019 and contributed indirectly to 4.95 million deaths.
Evolutionary Dynamics and Functional Differences in Clinically Relevant Pen β-Lactamases from Burkholderia spp.
Introduction Click to copy section linkSection link copied! Antimicrobial resistance (AMR) is a leading cause of death worldwide. (1) The World Health Organisation highlighted that AMR was the direct reason for 1.27 million global deaths in 2019 and contributed indirectly to 4.95 million deaths.
High burden of disease in patients with homozygous familial hypercholesterolemia despite recent advances in therapies and updated guidelines: A real-world study
KEYWORDS Homozygous familial hypercholesterolemia Atherosclerotic cardiovascular disease Low-density lipoprotein cholesterol Lipid-lowering therapies Real-world data Introduction Homozygous familial hypercholesterolemia (HoFH) is an ultra-rare autosomal dominant genetic disorder of lipid metabolism, caused by mutations in genes that encode for proteins involved in the hepatocellular uptake and catabolism of low-density lipoprotein (LDL).1-3 Of genetically confirmed HoFH cases, approximately...
Subgraph Topology and Dynamic Graph Topology Enhanced Graph Learning and Pairwise Feature Context Relationship Integration for Predicting Disease-Related miRNAs
Introduction Click to copy section linkSection link copied! MicroRNAs (miRNAs) are endogenous noncoding RNAs, typically 22 to 24 nucleotides long, that can regulate the expression of messenger RNAs (mRNAs). (1−3) An increasing number of studies indicate a significant correlation between miRNAs and the onset and progression of many diseases. For example, the expression of miR-509 is markedly decreased in colorectal cancer tissues and cells compared to normal tissues.
Multifunctional magnesium alloy scaffolds for osteomyelitis therapy: Integrating corrosion resistance, osteogenic activity, and antibacterial effects
Bone defects are common and complex clinical conditions. Bone grafting is a crucial method for treating bone defects. There are more than 2 million bone grafting procedures performed annually worldwide. Although autologous bone grafting remains the gold standard, this procedure causes secondary trauma to patients and has a limited supply [1]. Allogeneic grafting, in contrast, may induce immune rejection and increase the risk of infectious disease transmission [2].
Dynamic Differences in Clinically relevant Pen β-Lactamases from Burkholderia spp.
Abstract Antimicrobial resistance (AMR) is a global threat, with Burkholderia species contributing significantly to difficult-to-treat infections. Ambler Class A Pen β-lactamases are produced by all Burkholderia spp., and their mutation or overproduction leads to the resistance of β-lactam antibiotics.
Deep Learning-Based Intelligent Detection Algorithm for Surface Disease in Concrete Buildings
1. Introduction Bridge construction is indispensable in today’s social development, but with the passage of time and the impact of natural disasters, most bridges are subject to different degrees of damage [1]. We can detect apparent bridge damage, speculate on the degree of damage, and thus repair the diseased bridge in time to ensure the structural safety of bridge construction [2] and service life.
Decoding the influence of servitization on green transformation in manufacturing firms: The moderating effect of artificial intelligence
As an urgent global matter, environmental sustainability requires a strategic interplay between economic progression and environmental preservation. Amid escalating environmental challenges, it is paramount that we transition from traditional developmental models to models that are more ecologically sensitive and that adhere to high-quality standards, thereby underpinning both environmental conservation and economic resilience. (Yang and Ni, 2022; Yang et al., 2022).
α/β-Hydrolase domain-containing 6 (ABHD6) accelerates the desensitization and deactivation of TARP γ-2-containing AMPA receptors
Abstract AMPA receptors (AMPARs) mediate most of the fast excitatory synaptic transmission in mammalian brain. Their efficacy in responding to presynaptic glutamate release depends on their kinetics, which are determined by AMPARs and their auxiliary subunit composition. α/β-Hydrolase domain-containing 6 (ABHD6) is an AMPAR auxiliary subunit that has been shown to negatively regulate the surface delivery of AMPARs and AMPAR-mediated currents.
The Olfactory Receptor Olfr25 Mediates Sperm Dysfunction Induced by Low-Dose Bisphenol A through the CatSper-Ca2+ Signaling Pathway
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Poisoning resistance: challenges for hydrogen storage alloys toward engineering applications
Poisoning resistance: challenges for hydrogen storage alloys toward engineering applications Due to the safety and stability of hydrogen storage alloys in the field of large-scale energy storage, it has now become a hot spot of attention for researchers. However, the surface poisoning phenomenon caused by the impurity gas (O2, H2O, CO, etc.) contained in hydrogen is an unavoidable problem in engineering applications.
Obsidian + git repo, a better note taking alternative than Notion
Notion has dominated my note-taking life for long, it is present in all my devices and I almost use it to write down everything, from personal journals to dev notes, with all sorts of templates created. When Obsidian first came out, I didn't think it as efficient enough to compare with Notion, as it is just a markdown editor in my mind.
A Microactuator Array Based on Ionic Electroactive Artificial Muscles for Cell Mechanical Stimulation
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Differences in neuromuscular junctions between intrinsic muscles of the forepaw and biceps muscles in rats
Jing Qiao [1] ; Jing-Yu Gu [2] ; Bo Li [3] [1] Huashan Hospital Affiliated to Fudan University, China [2] Hospital of Shanghai University of Traditional Chinese Medicine, China [3] Yangpu Hospital, School of Medicine, Tongji University, Shanghai, China Localización: Histology and histopathology: cellular and molecular biology, ISSN-e 1699-5848, ISSN 0213-3911, Vol. 39, Nº. 4, 2024, págs.
Virtual Screening
Back to Journals » Drug Design, Development and Therapy » Volume 18 Authors Wang C, Gu J, Li H, Zhao B, Yu T, Guo CL, Huang M, Jiang W, Ouyang Q Received 20 March 2024 Accepted for publication 13 June 2024 Published 16 July 2024 Volume 2024:18 Pages 3075—3088 DOI https://doi.org/10.2147/DDDT.S461609 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Tuo Deng Chenkun Wang,1,2,* Jing Gu,2,* Hongwei Li,2,* Bo...
Deciphering the Coevolutionary Dynamics of L2 β-Lactamases via Deep Learning
Antimicrobial resistance (AMR) has emerged as a significant public health crisis in the 21st century, threatening a return to the 'pre-antibiotic' era. (1) This phenomenon, a natural evolutionary response of microbes to antimicrobial agents, risks nullifying decades of medical advancement in treating infectious diseases.
Facile and sustainable recovery of spent LiFePO4 battery cathode materials in a Ca(ClO)2 system
Facile and sustainable recovery of spent LiFePO4 battery cathode materials in a Ca(ClO)2 system Spent LiFePO4 batteries are gradually increasing in popularity and interest, and their stable and insoluble olive-shaped structure poses a great challenge for the sustainable recycling of Li. In this study, a simple and sustainable Ca(ClO)2 system was proposed for the recovery of spent LiFePO4 battery cathode materials.
The Structural Role of N170 in Substrate‐Assisted Deacylation in KPC‐2 β‐Lactamase
Introduction β-lactams, including penicillins, cephalosporins, carbapenems, and monobactams, are the most commonly used antibiotics that irreversibly inhibit enzymes involved in bacterial cell wall synthesis.1 As a result of persistent exposure to β-lactams and the imposed survival pressure, bacteria continually evolve to evade therapeutic action, predominantly via the production of β-lactamases in Gram-negative bacteria.2-5 β-Lactamases, categorized into classes A, B, C, and D,6 can degrade...
Deciphering the co-evolutionary dynamics of L2 β-lactamases via Deep learning
Abstract L2 β-lactamases, a serine-based class A β-lactamases expressed by Stenotrophomonas maltophilia plays a pivotal role in antimicrobial resistance. However, limited studies have been conducted on these important enzymes.
Cerebrospinal fluid proteomics in meningitis patients with reactivated varicella zoster virus
1 INTRODUCTION Varicella zoster virus (VZV) is a herpesvirus belonging to the genus Varicellovirus that primarily attacks human neurons. After infection, VZV stays latent in trigeminal ganglia or dorsal root ganglia. When patient's immune system is compromised, the latent VZV can be reactivated and leads to regional rash and severe pain, known as herpes zoster (HZ), which can also affect peripheral nervous system.
CFD Simulation and Experimental Study on a Thermal Energy Storage-Updraft Solid Waste Gasification Device
Abstract : A thermal energy storage–updraft gasification device is a type of reactor that should be considered for use in solid waste gasification research that can save energy. However, the operating parameters and internal flow field during its operation remain unclear.
The role of lysosomal membrane proteins in autophagy and related diseases
Introduction Macroautophagy (hereafter called autophagy) is the main intracellular system for degrading cytoplasmic substances. As a dynamic circulatory system, the fundamental purpose of autophagy is not to simply eliminate substances, but to continuously generate new energy and components for cell renewal and homeostasis [[1]].
How to Create Zoom Virtual Backgrounds
Shutterstock Create is an online image editing tool that helps anyone create impressive designs in less time. Here’s how you can use this incredible tool to create the perfect virtual background for remote meetings in Zoom. Step 1: Pick Your Background Image You can select your favorite image from this free Zoom virtual backgrounds pack or start by searching for even more background options in the Shutterstock Create.
The UK needs a strategy for research with, and about, China
Use policy and funding changes to reboot approach to collaboration, say Lewis Husain and colleagues The recent refresh of the UK government’s Integrated Review of Security, Defence, Development and Foreign Policy frames China as an “epoch-defining and systemic challenge with implications for almost every area of government”. This reflects the UK’s increasingly tense relations with China and an emerging strategy towards it.
The feasibility of using a pyrite standard to calibrate the sulfur isotope ratio of marcasite during SIMS analysis
The feasibility of using a pyrite standard to calibrate the sulfur isotope ratio of marcasite during SIMS analysis† Rucao Li, ab Xiao-Lei Wang, *b Yue Guan,b Jing Guc and Lan-Lan Tianb Abstract Marcasite (FeS2, orthorhombic) is a dimorph of pyrite (FeS2, isometric), which has been reported in many kinds of ore deposits and sedimentary rocks. The sulfur isotopic composition of marcasite could be used to track ore-forming fluid source(s) and ocean acidification events in deep time.
Conversion of Polyethylene to High-Yield Fuel Oil at Low Temperatures and Atmospheric Initial Pressure
Abstract : The transformation of waste plastics into fuels via energy-efficient and low-cost pyrolysis could incentivize better waste plastic management. Here, we report pressure-induced phase transitions in polyethylene, which continue to heat up without additional heat sources, prompting the thermal cracking of plastics into premium fuel products. When the nitrogen initial pressure is increased from 2 to 21 bar, a monotonically increasing peak temperature is observed (from 428.1 °C to 476.7 °C).
The functions of SID1 transmembrane family, member 2 (Sidt2)
ARM arginine-rich motif dsRNA double-stranded ribonucleic acid ECD extracellular domain HDL-c high-density lipoprotein cholesterol ISG insulin secretory granule LMPs lysosomal membrane proteins MetS metabolic syndrome NAADP nicotinic acid adenine dinucleotide phosphate NAFLD nonalcoholic fatty liver disease RDA RNautophagy/DNautophagy SID-1 systemic RNA interference deficiency-1 Sidt2 the SID1 transmembrane family member 2 TG triacylglycerols Introduction Lysosomes are acidic organelles...
Unraveling the Controversies of Chinese Foreign Aid
Jing Gu East Asia Forum May 4, 2022 China’s growing role as a provider of development assistance, and the broader impact of its international economic engagement, has been the subject of considerable interest both within and outside China. The question of whether Chinese development policy is about cooperation or competition has fascinated the world. Whether their intentions are benevolent or power driven often dominates discussions.
Unraveling the Controversies of Chinese Foreign Aid
What you need to know China’s new aid and security pact with the Solomon Islands is the latest case to raise the question of whether Chinese aid is developmental or a political. By Jing Gu China’s growing role as a provider of development assistance, and the broader impact of its international economic engagement, has been the subject of considerable interest both within and outside China.
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