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Articles by Johan Ärnlöv
Tre läkare om en förbisedd folksjukdom: ”Kunskapen finns – att inte agera kostar liv”
Debatt DEBATT: Hundratusentals svenskar lever med kronisk njursjukdom eller högt blodtryck utan att veta om det. Båda är tysta folksjukdomar som i hög grad bidrar till hjärt-kärlsjukdom, demens, förtida död och omfattande vårdbehov. Sverige behöver agera nu, skriver tre läkare som varit med i en expertgrupp för ett nytt arbetsstöd om hjärt‑kärlsjukdom, kronisk njursjukdom och diabetes.
Multinational validation of the PREVENT and SCORE2 cardiovascular risk equations across 6.4 million individuals
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Abstract The American Heart Association’s PREVENT equations estimate risk of total cardiovascular disease (CVD), atherosclerotic CVD (ASCVD), and heart failure (HF) to guide lipid and blood pressure-lowering therapy in people ages 30 to 79 years in the United States. The SCORE2 risk algorithm is used to estimate CVD risk for similar purposes in people ages 40 and older in Europe. Neither set of equations has been comprehensively validated in global observational cohorts and randomized trials.
By Brendon L Neuen, Rupert W. Major, Morgan E. Grams, Yingying Sang, Josef Coresh, Shoshana H. Ballew, Aditya Surapaneni, Natalia Alencar de Pinho, Johan Ärnlöv, Clare Arnott, Samira Bell, Jarett Berry, Hermann Brenner, Elizabeth L Ciemins, Alexander Chang, Mary Cushman, James de Lemos, Juan Miguel Diaz-Tocados, Alfredo E. Farjat, Robert Fletcher, Ron T Gansevoort, Hiddo J. L. Heerspink, William G Herrington, Chuan Hong, Shih-Jen Hwang, Simerjot K Jassal, Philip A. Kalra, Ronit Katz, Sadiya Khan, Csaba P. Kovesdy, Florian Kronenberg, Jennifer Lees, Donald M. Lloyd-Jones, José Geraldo Mill, David Naimark, Chiadi E. Ndumele, Kevan R. Polkinghorne, Bruce M. Psaty, Patrick Schloemer, Michael G. Shlipak, Prabin Shrestha, Zean Song, Natalie Staplin, Dominik Steubl, Priya Vart, Frank L. J. Visseren, Mark Woodward, Kazumasa Yamagishi, Bessie A. Young, Charumathi Sabanayagam, José M. Valdivielso
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Nature
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Antibiotic use and gut microbiome composition links from individual-level prescription data of 14,979 individuals
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Abstract Disruptions in gut microbiome are implicated in cardiometabolic disorders and other health outcomes. Antibiotics are known gut microbiome disruptors, but their long-term consequences remain underexplored. Here we combined individual-level data from the Swedish Prescribed Drug Register with fecal metagenomes of 14,979 adults to examine the association between oral antibiotic use over 8 years and gut microbiome.
By Gabriel Baldanzi, Anna Larsson, Sergi Sayols-Baixeras, Koen F. Dekkers, Ulf Hammar, Diem Nguyen, Tiscar Graells, Shafqat Ahmad, Camila Gazolla Volpiano, Guillaume Meric, Josef D. Järhult, Thomas Tängdén, Jonas Ludvigsson, Lars Lind, Johan Sundström, Karl Michaëlsson, Johan Ärnlöv, Beatrice Kennedy, Marju Orho-Melander, Tove Fall
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Nature
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Genome-wide association analyses highlight the role of the intestinal molecular environment in human gut microbiota variation - Nature Genetics
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Abstract Despite the importance of the gut microbiome to health, the role of human genetic variation in shaping its composition remains poorly understood. Here we report genome-wide association analyses of harmonized metagenomic data from 16,017 adults in four Swedish population-based studies, with replication in 12,652 people from the Norwegian HUNT study. We identified variants in the OR51E1–OR51E2 locus, encoding sensors for microbiome-derived fatty acids, associated with microbial richness.
By Koen F. Dekkers, Kamalita Pertiwi, Gabriel Baldanzi, Per O Lundmark, Ulf Hammar, Marta Riise Moksnes, Eivind Coward, Maria Nethander, Ghassan Ali Salih, Mariam Miari, Diem Nguyen, Sergi Sayols-Baixeras, Aron C. Eklund, Jacob Bak Holm, H. Bjørn Nielsen, Camila Gazolla Volpiano, Guillaume Meric, Manonanthini Thangam, Liisa H. Hakaste, Tiinamaija Tuomi, Emma Ahlqvist, Christopher Smith, Marie Allen, Frank Reimann, Fiona M. Gribble, Claes Ohlsson, Kristian Hveem, Olle Melander, Peter M Nilsson, Gunnar Engström, J. Gustav Smith, Karl Michaëlsson, Johan Ärnlöv, Marju Orho-Melander, Tove Fall
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Nature
Verified
Predictive Value of Serum N‐Terminal pro‐B‐Type Natriuretic Peptide and Troponin T for Incident Heart Failure: A Meta‐Analysis of 9 International Cohorts | Journal of the American Heart Association
DISCUSSION In this meta‐analysis of >41 000 individuals enrolled in 9 international cohorts (including 2 cohorts with CKD), we found that NT‐proBNP significantly and consistently improved discrimination of risk of incident HF when added to a base model of traditional HF risk factors. NT‐proBNP was a stronger risk factor than other known risk factors for HF including eGFR and ASCVD.
The metabolic signature of salt intake: a cross-sectional analysis from the SCAPIS-study - Nutrition & Metabolism
Salt has been shown to affect metabolism in several ways. In vitro, a high salt load increased the expression of adipogenic/lipogenic genes, while downregulating genes involved in lipolysis, resulting in fat accumulation [38]. In a high salt fed rat model, chronic high salt intake stimulated the polyol pathway causing increased glucose-to-fructose conversion which led to the metabolic syndrome [8, 39]. In the same study, it was shown that this led to leptin resistance.
FEV1 and FVC as robust risk factors for cardiovascular disease and mortality: Insights from a large population study
Key message • What is already known on this topic: A graded association between lower FEV1 and FVC and their impact on mortality and cardiovascular outcomes have previously been shown. Are these differences present also in individuals with “normal” spirometry? Furthermore, how do impaired FEV1 and FVC compare to established cardiovascular risk factors in terms of their population attributable risk?
Heart failure outcomes by left ventricular ejection fraction in a contemporary region‐wide patient cohort
Introduction The global prevalence of heart failure is expected to increase beyond the 64 million people that it currently affects.1 Subsequently, its burden to healthcare systems is also expected to increase, exceeding the proportion (1–2%) of the annual healthcare budget that is currently allocated towards the condition.2, 3 The characteristics and prognosis of patients with heart failure change over time with the development of new treatments and updated guidelines.4-12 Therefore, there is...
Addition of cystatin C predicts cardiovascular death better than creatinine in intensive care
Cardiac risk factors and prevention Addition of cystatin C predicts cardiovascular death better than creatinine in intensive care http://orcid.org/0000-0002-6095-9163Johanna Helmersson-Karlqvist1, Miklos Lipcsey2, Johan Ärnlöv3,4, http://orcid.org/0000-0001-7464-0324Max Bell5,6, Bo Ravn5,6, Alain Dardashti7, Anders Larsson1 1 Department of Medical Sciences/Clinical Chemistry, Uppsala University, Uppsala, Sweden 2 Hedenstierna laboratory, CIRRUS, Department of Surgical Sciences/Anesthesiology...
Addition of cystatin C predicts cardiovascular death better than creatinine in intensive care
Cardiac risk factors and prevention Addition of cystatin C predicts cardiovascular death better than creatinine in intensive care http://orcid.org/0000-0002-6095-9163Johanna Helmersson-Karlqvist1, Miklos Lipcsey2, Johan Ärnlöv3,4, http://orcid.org/0000-0001-7464-0324Max Bell5,6, Bo Ravn5,6, Alain Dardashti7, Anders Larsson1 1Department of Medical Sciences/Clinical Chemistry, Uppsala University, Uppsala, Sweden 2Hedenstierna laboratory, CIRRUS, Department of Surgical Sciences/Anesthesiology...
Incidence and determinants of hyperkalemia and hypokalemia in a large healthcare system
Publication HistoryPublished online: July 14, 2017Accepted: July 12, 2017; Received in revised form: July 4, 2017; Received: May 1, 2017;
Association of Adipose Tissue Fatty Acids With Cardiovascular and All-Cause Mortality in Elderly Men
Figure 1. Correlations Between Fatty Acid Composition in Adipose Tissue in 853 Samples and Serum in 433 Samples, and Self-Reported Dietary Intake in 789 Samples A, Correlations between proportions of fatty acids in adipose tissue (weight percentage [wt%]) and dietary records (percentage of fat) in all men and in men not underreporting dietary intake according to the Goldberg cutoff as modified by Black15 (approximately 53%).
Risk of Recurrent Stroke and Death After First Stroke in Long‐Distance Ski Race Participants
Background Physical activity is of benefit for primary prevention of cardiovascular diseases, but it appears to increase the risk for atrial fibrillation. We aimed to study a cohort of patients following a first stroke in individuals with previous high physical activity, compare them to the general population with respect to recurrent stroke and death, and relate these to atrial fibrillation.
A Proinflammatory Diet Is Associated with Systemic Inflammation and Reduced Kidney Function in Elderly Adults
Background: Diet can affect kidney health through its effects on inflammation. Objective: We tested whether the Adapted Dietary Inflammatory Index (ADII) is associated with kidney function and whether effects of diet on chronic low-grade inflammation explain this association.
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