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Articles by John Allan
A minimal cellulosome-like system in Cellulosilyticum lentocellum
BIg-7 bacterial immunoglobulin-like domain type VII CAZyme carbohydrate-active enzyme CBM carbohydrate-binding module CDI calcium dilution and incubation CFE cell-free extract CMC carboxymethyl cellulose cpTM chain-pair predicted template modelling score DNS 3 DP degree of polymerisation GEBA Genomic Encyclopedia of Bacteria and Archaea GH glycoside hydrolase HPAEC-PAD high-performance anion-exchange chromatography with pulsed amperometric detection ipTM inter-chain predicted template...
Functional cooperation between the B-cell receptor and NOTCH1 in regulating metabolic reprogramming in chronic lymphocytic leukemia
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Abstract Mutations in NOTCH1, which occur in ~10% of Chronic Lymphocytic Leukemia (CLL) patients at diagnosis, are typically associated with unmutated (UM) B-cell receptor (BCR) subsets and define patients with earlier treatment need. Using primary CLL cells classified as NOTCH1 wild-type (CLL/NWT) or mutated (CLL/NM), both with UM-BCR, we show that BCR stimulation activates the NOTCH1 pathway, upregulating metabolic programs and mitochondrial biogenesis, selectively in CLL/NM.
By Francesco Vallone, Elodie Viry, Ilenia Sana, Alessia Morabito, Matteo Rovere, Nadia Bertola, Silvia Ravera, Samir Mouhssine, Marta Muzio, Paolo Ghia, Candida Vitale, Marta Coscia, Gianluca Gaidano, John Allan, Richard Furman, Tiziana Vaisitti, Silvia Deaglio, Amelia Fascì, Nahal Nabelsi, Silvia Seghezzi, Noemi Anna Pesce, Chloé Duculty, Etienne Moussay, Jerome Paggetti
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Nature
Verified
Outdoor adventure builds essential skills for youth employment - CYP Now
Outdoor adventure expert Dr John Allan assesses PGL Beyond’s outdoor residential programme designed to equip disadvantaged young people with resilience, wellbeing and employment skills. Being from a disadvantaged background significantly increases a young person’s chance of becoming Neet (not in education, employment or training). Moreover, without any early intervention, a cycle of cumulative disadvantage, unemployment and poor mental health will prevail.
Co-mapping clonal and transcriptional heterogeneity in somatic evolution via GoT-Multi
Keywords single-cell multi-omics cancer clonal evolution lymphoma single-cell genotyping single-cell RNA-seq therapy resistance Introduction Somatic evolution leads to cancer progression and therapy resistance. Underlying phenotypic progressions is the presence of marked clonal heterogeneity of most cancers.
Prognostic Implication of Karyotypic Evaluation in Patients With Richter Transformation in the Modern Era
To the Editor, Evaluation of karyotype is a standard prognostic test for patients with chronic lymphocytic leukemia (CLL) and Richter transformation (RT), defined herein as diffuse large B-cell lymphoma in the setting of CLL, as karyotype abnormalities in malignant cells have been repeatedly shown to correlate with worse outcomes.
Jouer en plein air comporte des risques - et c’est bon pour les enfants
[Un article de The Conversation écrit par Adele Doran - Maître de conférences / Responsable Recherche et Innovation, Université Sheffield Hallam - John Allan - Chercheur invité en éducation, Université Sheffield Hallam - Josephine Booth - Chercheuse principal en éducation, Université Sheffield Hallam] Nous traversons aujourd’hui une période de crise en ce qui concerne la santé mentale chez les jeunes.
Jouer en plein air comporte des risques - et c’est bon pour les enfants
Lorsqu’ils grimpent aux arbres, font du vélo à vive allure ou partent en exploration en forêt, les enfants s’initient à la prise de risque et apprennent à gérer les incertitudes. Nous traversons aujourd’hui une période de crise en ce qui concerne la santé mentale chez les jeunes. L’un des moyens d’améliorer le bien-être des enfants est de les laisser s’aventurer plus souvent hors de chez eux et participer à des jeux de plein air.
We can’t afford to stop talking about ‘boys in crisis’
Dr John Allan, head of impact and breakthrough learning at PGL Beyond, discusses how residential programmes deconstruct stereotypes and enable young men to be themselves.
Aviation Photo #7932659: CASA 1-131E Series 2000 Jungmann - Untitled
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Aviation Photo #7877327: CASA 1-131E Series 2000 Jungmann - Untitled
Distinct Views: 7 Photo Added: June 21, 2025 Photo Copyright © Javier Gonzalez - Iberian Spotters. All rights reserved. Airliners.net is not affiliated with any entity mentioned or pictured herein. All trademarks are the property of their respective owners.
Building essential life skills through outdoor experiences
Dr John Allan, head of impact and breakthrough learning at PGL Beyond, discusses how adventure and travel can grow vital soft skills in young people. A core of highly prized skills, known as 21st century skills, are recognised by governments, academics and employers as essential for generating solutions to some of society’s most critical problems.
Playing and exploring outdoors brings risk - and that’s good for children
We are currently in the midst of a youth mental health crisis. In 2023 in England, a fifth of children aged eight to 16 had a probable mental disorder. One way to address children’s wellbeing is through letting them take part in outdoor risky play. When climbing trees, building dens, riding a bike fast, constructing rafts to float on water, or exploring a woodland, children make their own decisions on which risks to take and which to avoid.
Cybernetic control of a natural microbial co-culture
Abstract A key obstacle in the widespread application of microbial co-cultures in bioprocesses is their compositional instability, as faster-growing species outcompete and dominate the culture. While several synthetic biology approaches have demonstrated control over co-culture composition, there has been an increased interest in computer-based cybernetic control approaches that can offload burdensome genetic control circuitry to computers and enable dynamic control and real-time noise rejection.
Making a Case for In-Season Potassium Applications
Nitrogen, phosphorus and potassium (NPK) are three major nutrient components of any fertility program and are developed to maximize crop uptake at a given growth stage. Most nitrogen is applied in-season via fertigation (in California) utilizing common materials such as urea, UAN, CAN17 and CN9. Phosphorus is applied early season or in-season based on crop need and timing.
Do not penalize short term rentals
Dear Select Board, After attending the Select Board meeting on April 2, where the theme for the night was discussing short term rentals (STRs) in Camden, I could not understand what the objective of the meeting was. It seemed as though STRs were being discussed to try to increase affordable housing in the town of Camden. While I applaud the planning board for making this effort to discuss affordable housing, ultimately connecting STRs to the process does not seem sincere or logical.
How To Build Resilience Through Outdoor Adventure
Create or add to an existing Knowledge Bank Select from an existing Knowledge Bank or create a new one using the dropdown Creative Teaching and Learning Resilience is widely recognised as key for optimising educational outcomes. Dr John Allan explains why outdoor adventure learning is an ideal pedagogical tool to help build resilience and adaptability in young people.
Lycopene Production in Dedicated Novel Chasses for Lignocellulosic Waste Material Utilisation Capable of Sustained Coculture
Abstract Municipal solid waste (MSW) represents tonnes of material that, for the most part, is relegated to landfill. Synthetic biology proposes solutions to many of the challenges faced by humanity today, but many approaches are confined to use in classical chassis organisms. In MSW there are a variety of potentially toxic materials such as glues, dyes, and preservatives that could pose a challenge to its capitalisation when using these commonplace chassis.
Empowering children through outdoor adventure
Although not a homogenous group, these youngsters are defined as average learners hidden within a typical class who fail to fulfil their potential due to low self-esteem, reduced confidence, and difficulties in maintaining friendships. Their behaviour generally reflects a ‘fixed mind set’ of achievement, where they believe their abilities cannot be changed.
Aviation Photo #7598203: Jodel DR-1050M Excellence - Untitled
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Resilience and the influence of outdoor learning
I don’t need convincing that outdoor learning impacts positively upon the education, health and well-being of young people. The wealth of researched evidence, citing a range of beneficial outcomes, is also difficult to ignore. For example, there is a strong correlation between the goals of outdoor adventure learning and experiences which generate resilience in young people. So, how can every child benefit from outdoor learning, and what makes this type of development not accessible to all?
How To Make Money Playing Video Games
In recent years, the video game industry has seen exponential growth and is now worth billions of dollars. With the rise of e-sports and the popularity of streaming platforms like Twitch and YouTube, playing video games has become a viable way to make money. In this article, we will explore how to make money by playing video games. E-sports is a growing industry that hosts competitive gaming tournaments with large prize pools.
Baile Meadhonach
<< Our Photo Pages >> Baile Meadhonach - Chambered Cairn in Scotland in Isle of Arran Submitted by Skryabin on Saturday, 04 January 2003 Page Views: 6064 Neolithic and Bronze AgeSite Name: Baile Meadhonach Country: Scotland County: Isle of Arran Type: Chambered Cairn Map Ref: NS018234 Landranger Map Number: 69 Latitude: 55.464174N Longitude: 5.13671W Condition: 5 Perfect 4 Almost Perfect 3 Reasonable but with some damage 2 Ruined but still recognisable as an ancient site 1 Pretty much...
Ten principles for effective outdoor education
Outdoor adventure education can provide many benefits for pupils, not least helping them to build skills and thrive. Expert Dr John Allan looks at 10 principles to make school-based outdoor and adventure activities effective Resilience or the ability to adapt our behaviours in uncertainty has been suggested as ranging from surviving to thriving (Calhoun & Tedeschi, 2004).
Angioimmunoblastic T‐cell lymphoma presenting with severe plasmacytosis mimicking plasma cell leukemia
This article has been accepted for publication and undergone full peer review but has not been through the copyediting, typesetting, pagination and proofreading process, which may lead to differences between this version and the Version of Record. Please cite this article as doi: 10.1002/ajh.26878.
IA launches Innovation Unit as Engine celebrates five-year anniversary
The IA has a long-standing commitment to innovation, and over the last few years we have been working at pace to drive forward our agenda in this space. In ‘Investing for the Future: Three potential paths for a tech-powered UK fund industry’, we outline the concept for Investment Fund 3.0, a vision of what funds could look like in the future, as our industry continues to prioritise keeping up with ever-changing investor and societal expectations.
A miniature cellulosome with novel interaction modes
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The JMA Mobile Recruiter is in Town
“Unemployment rates are going down, with 6.3 million unemployed and 10.6 million job openings. Where did everyone go?” says CFC Underwriting author. An unprecedented, unpredictable job market is here to say the least. Many trends are circulating now. We’ve seen an increase in early engagement with job candidates. Companies are actively building relationships with job seekers. A greater emphasis has been placed on diversity and inclusion in the workplace.
Making CLL Treatment Decisions
CLL Townhall: Weill Cornell Replay Along with so much treatment choice, comes treatment decision. In this replay of a recent CLL Townhall, Patient Power co-founder and host, Andrew Schorr is joined by Richard Furman, MD, John Allan, MD, and Susan Marchal, LCSW, OSW-C, experts from Weill Cornell Medicine, to discuss treatment choice, the anxiety that can accompany treatment decisions, and where all these new therapies fit in.
Contrasting the use of space in post-Roman Exeter: geoarchaeology of dark earth and medieval deposits below Exeter Cathedral
Hostname: page-component-6b67cbd877-vf4xx Total loading time: 0 Render date: 2023-02-18T09:45:08.110Z Has data issue: true Feature Flags: { "useRatesEcommerce": false } hasContentIssue true Published online by Cambridge University Press: 16 February 2022 Show author details Rights & Permissions[Opens in a new window] Abstract European urban dark earth investigations have aided our understanding of Late Roman and early medieval populations and their activities.
Personalized Medicine Improves Quality of Life in CLL
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Venetoclax in Previously Treated Waldenström Macroglobulinemia
Waldenström macroglobulinemia (WM) is characterized by the malignant accumulation of immunoglobulin M (IgM)-secreting lymphoplasmacytic cells in the bone marrow (BM) and other organs.1 Treatment options for WM include alkylating agents, anti-CD20 monoclonal antibodies, proteasome inhibitors, and Bruton tyrosine kinase inhibitors (BTKis).2 Highly recurring somatic mutations in MYD88 and CXCR4 are found in patients with WM, and can affect disease presentation, prognosis, and treatment response...
Venetoclax in Previously Treated Waldenström Macroglobulinemia
Jorge J. Castillo , MD1,2; John N. Allan, MD3; Tanya Siddiqi , MD4; Ranjana H. Advani , MD5; Kirsten Meid, MPH1; Carly Leventoff , BA1; Timothy P. White, BA1; Catherine A. Flynn, NP1; Shayna Sarosiek , MD1,2; Andrew R. Branagan , MD2,6; Maria G. Demos, BA1; Maria L. Guerrera, MD1; Amanda Kofides, BA1; Xia Liu, BA1; Manit Munshi, BA1; Nicholas Tsakmaklis, BA1; Lian Xu, BA1; Guang Yang , BA1; Christopher J. Patterson, BA1; Zachary R. Hunter , PhD1,2; Matthew S. Davids , MD2,7; Richard R.
Ibrutinib Plus Venetoclax for First-Line Treatment of Chronic Lymphocytic Leukemia: Primary Analysis Results From the Minimal Residual Disease Cohort of the Randomized Phase II CAPTIVATE Study | Journal of Clinical Oncology
Targeted therapies that antagonize B-cell receptor signaling by inhibiting the Bruton tyrosine kinase (BTK) pathway and restore apoptosis by inhibiting the antiapoptotic protein B-cell lymphoma 2 (BCL-2) have remarkably improved outcomes for patients with chronic lymphocytic leukemia (CLL).1 Ibrutinib, a once-daily BTK inhibitor, is the only targeted therapy to demonstrate both improved progression-free survival (PFS) and overall survival (OS) over standard chemotherapy and/or...
Want sky-high hair with drama? Go old school with a volumising hair foam
TextJohn AllanIllustrationCallum Abbott Never again underestimate the importance of prepping your hair before styling with L’Oréal Professionnel’s volumising foam Tecni.ART Full Volume Extra Mousse When it comes to hair, stylist and maverick John Allan likes to push the boundaries, reject the mundane, and embrace the 70s. Known for his adventurous cuts, from mullets to mohawks, and penchant for wig styling, Allan has worked with clients including Beabadoobee and Mowalola.
Breakthroughs in CLL Treatment and Research
Dr. Allan: Yeah, sure. So, it's a complicated scenario here, where there's a few serology tests that have been available, and it's kind of shifted over time as our understanding, time, and technology has rolled out, et cetera. Some of the early serology tests, so serology tests meaning looking for antibodies being produced against the virus, and or vaccine, looked at a nuclear capsid protein, essentially.
A smarter approach to food traceability
The dairy industry, along with the broad food industry, is on its way toward a more traceable supply chain. The FDA’s New Era of Smarter Food Safety Blueprint outlines a goal for the food industry to track and trace foods from farm to fork with the help of computer-based technology. The International Dairy Foods Association (IDFA) has supported the blueprint since its release in July 2020. However, not all progress is good progress.
Kensaleyre N Cairn
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Stone near Annishader
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District of Columbia Expands False Claims Act to Include Qui Tam Tax Fraud Actions | JD Supra
The enforcement of the District's tax laws had previously been left exclusively to government agencies; a newly enacted bill will make the District one of a few jurisdictions to allow relators to bring qui tam suits alleging tax law violations. Newly enacted Washington, D.C. Act A23-0564 amends the District's False Claims Act to allow qui tam actions for violations of District tax laws.
Choosing a CLL Treatment to Meet Your Lifestyle and Needs
View next Published on December 15, 2020 How to Select a CLL Treatment Path that Fits Your Needs Whether you are newly diagnosed with chronic lymphocytic leukemia (CLL), or are returning for further treatment, it can be overwhelming to research and choose a treatment path among the many treatment options. There are a variety of factors that may be a part of this decision, including other health factors, cost, side effects, accessibility and your current lifestyle and needs.
Let rugby referees use their heads!
Referees should be allowed to apply common sense when there’s a clash of heads between players, writes former Bok hooker JOHN ALLAN. I couldn’t believe it when Sharks centre Marius Louw was yellow-carded for a ‘dangerous tackle’ after clashing heads with Bulls flyhalf Morné Steyn at Kings Park last Saturday.
ASH 2020: CLL Treatment Overview and Addressing COVID Concerns
Published on December 14, 2020 Experts Share The Latest Developments in CLL Treatment and Patient Care What are the treatment options and newest developments in treatment research for chronic lymphocytic leukemia (CLL)? How do healthcare disparities affect access to CLL care? What should patients know about CLL and COVID-19?
John N. Allan, MD, on the Impact of First-Line Ibrutinib in Patients with CLL, TP53 Aberrations
This pooled analysis from 4 clinical trials suggested that though patients with TP53 aberrations remain at risk for progression, first-line treatment with ibrutinib has meaningfully improved the poor prognosis in this high-risk population. With 4-years of follow-up, researchers presented on the long-term efficacy of first-line ibrutinib (Imbruvica) treatment in patients with chronic lymphocytic leukemia and TP53 aberrations (del[17p] or TP53 mutation).
Do we forgive Pablo Matera?
Pablo Matera’s tweets were abhorrent but he can still be forgiven, writes former Bok hooker JOHN ALLAN. In May 2012, when Argentina’s current captain was 19 years old, he tweeted: ‘SOUTH AFRICA baby! I’m finally leaving this country full of blacks. OUCH!!’ Another tweet said: ‘Today is a good day to get in the car and drive over blacks.’ Those tweets (among others) are abhorrent and disgraceful. When they resurfaced after the Pumas’ second match against the All Blacks, Matera rightly apologised.
John N. Allan, MD, on Research Coming Out of ASH for CLL
The assistant professor of Medicine in the division of Hematology and Medical Oncology at Weill Cornell Medicine spoke about exciting research coming out of ASH for patients with chronic lymphocytic leukemia. In an interview with CancerNetwork®, John N.
Overpaid Executive Gross Receipts Tax Approved in San Francisco | JD Supra
The new tax takes effect on January 1, 2022, and will be imposed on businesses in which the highest-paid executive’s total compensation is more than 100 times the median San Francisco-based employee compensation. San Francisco’s Overpaid Executive Gross Receipts Tax ("OEGRT") will impose an additional gross receipts tax on entities engaged in business in San Francisco in which the highest-paid executive’s compensation exceeds 100 times the median compensation of its San Francisco-based employees.
Currie Cup needs fair Covid-19 rules
Former Springbok hooker JOHN ALLAN says a team not at fault for the cancellation of a Currie Cup match due to Covid-19 should be awarded a bonus-point win. On Saturday, the Bulls lifted the Super Rugby Unlocked trophy. While three Unlocked games were cancelled – Lions vs Cheetahs, Lions vs Pumas and Sharks vs Stormers – the Bulls would still have topped the log had the team not at fault for those cancellations been awarded the full five log points (the other team would have got none).
Pumas' preparation proved a point
Argentina’s incredible win against the All Blacks showed there’s more than one way to prepare for Test rugby, writes former Bok hooker JOHN ALLAN. What a phenomenal performance by the Pumas! What passion! Argentina’s first-ever victory against the All Blacks is all the more remarkable considering they hadn’t played a Test since last year’s World Cup and many of their players hadn’t played competitive rugby since March.
Piper's Stone (Dirleton)
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SA rugby needs another Danie Gerber
A midfield maestro like Danie Gerber would take the Springboks’ attacking game to the next level, writes former Bok hooker JOHN ALLAN. South African rugby has so many talented players in all positions. However, I still feel we’re missing something in the midfield. Damian de Allende and Lukhanyo Am both had a very good World Cup for the Springboks at 12 and 13, while Frans Steyn and Jesse Kriel provide quality back-up.
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