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Articles by John Eisman
Long-Term Impact of Bariatric Surgery and Dietary Interventions on Weight Loss, Physical Activity, and Food Preferences
1 Introduction Bariatric surgery is the most effective long-term intervention for severe obesity, producing substantial and sustained reductions in body weight and cardiometabolic risk. Beyond weight loss, these procedures induce complex physiological and behavioral adaptations, including alterations in appetite regulation, dietary intake, and physical activity patterns.
Multiscale analysis and functional validation of the cellular and genetic determinants of skeletal disease
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Abstract Musculoskeletal diseases are a major health burden. Development of bone-active therapies has been hindered by limited understanding of the cells and genes that regulate the skeleton. We exploited the value of cross-species analysis and developed single-cell methodologies in skeletal tissues to define the critical endosteal compartment that regulates bone turnover.
By Ryan C. Chai, Mischa Lundberg, Bernard Freudenthal, Andrew Boughton, Kaitlyn Flynn, Monika Frysz, Weng Hua Khoo, Davide Komla-Ebri, Siobhan E. Guilfoyle, John Logan, Natalie C. Butterfield, Victoria Leitch, Andrea Pollard, Lorenzo Ramos-Mucci, Amaia Vilas-Zornoza, Yunshun Chen, Raymond Yip, Jeremy Er, Siew Zhuan Tan, Michelle McDonald, Scott E Youlten, C. Sergio, Ariel Castro-Martinez, Shelley Young, Elena Y. Skorokhodova, David Evans, Joseph Powell, Christiaan de Leeuw, Adam Ewing, John Eisman, Robert Blank, Tri Giang Phan, Anne K. Lagendijk, Edwin Hawkins, Rebecca McIntyre, Edith Hessel, Jake P. Taylor-King, Emma Duncan Verified, Graham Williams, Peter Croucher, John Kemp, Yuandan Zhang, Alexander P. Corr, Michael R. G. Dack, Riikka E. Mäkitie, Nathaniel Bradford, Horng Lii Oh, Paul A. Baldock, J. H. Duncan Bassett
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Nature
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Effects of bariatric surgery and dietary intervention on insulin resistance and appetite hormones over a 3 year period - Scientific Reports
Baseline characteristics of study subjects were analyzed according to intervention groups. Normally distributed variables were presented as mean (± SD) and non-normally distributed variables were presented as median (± interquartile range).
Timing of therapy in osteoporosis: does it matter?
Figures Abstract Osteoporosis is a common condition encountered in general practice and is significantly undertreated. Tailoring the type and timing of treatment to the individual patient is important to improve outcomes and minimise potential side effects. Many patients with osteoporosis will need indefinite treatment. Lower-risk patients who respond well to treatment may be considered for a break from treatment after five to 10 years of therapy.
Microsimulation model for the health economic evaluation of osteoporosis interventions: study protocol
Microsimulation model for the health economic evaluation of osteoporosis interventions: study protocol Lei Si1,2, John A Eisman3,4,5, Tania Winzenberg2, Kerrie M Sanders6, Jacqueline R Center3,5, Tuan V Nguyen3,5,7, Andrew J Palmer2,8 1 The George Institute for Global Health, UNSW Sydney, Sydney, New South Wales, Australia 2 Menzies Institute for Medical Research, University of Tasmania, Hobart, Tasmania, Australia 3 Bone Biology Division, Garvan Institute of Medical Research, Sydney, New...
Acute hypocalcaemia following denosumab in heart and lung transplant patients with osteoporosis
Osteoporosis is highly prevalent in the heart and lung transplant population. Given high rates of concurrent renal impairment, there is increasing use of denosumab in this population. However, denosumab may be associated with hypocalcaemia, particularly in patients with chronic kidney disease (CKD). To explore the risk of hypocalcaemia in a heart and lung transplant cohort prescribed denosumab for osteoporosis.
Acute Hypocalcaemia Following Denosumab in Heart and Lung Transplant Recipients With Osteoporosis
Osteoporosis is highly prevalent in the heart and lung transplant population. Given high rates of concurrent renal impairment, there is increasing use of denosumab in this population. However, denosumab may be associated hypocalcaemia, particularly in patients with chronic kidney disease (CKD). This study sought to explore the risk of hypocalcaemia in a heart and lung transplant cohort prescribed denosumab for osteoporosis.
Bone remodeling during pregnancy and post-partum assessed by metal lead levels and isotopic concentrations
Publication HistoryPublished Online: May 24, 2016Accepted: May 23, 2016; Received in revised form: May 21, 2016; Received: January 8, 2016;
Bone health in adults with non-ambulatory neuromuscular disorders: scoping review of risk factors, diagnosis and management
BMD Bone mineral density CP Cerebral palsy CT Computed tomography DMD Duchenne Muscular Dystrophy DXA Dual-energy X-ray absorptiometry GMFCS Gross Motor Function Classification System pQCT Peripheral Quantitative Computerised Tomography SCI Spinal cord injury Introduction Osteoporosis and fragility fractures are common complications of bone disease, leading to early mortality, functional disability, reduced quality of life and substantial economic burden.1 Although risk factors, diagnostics...
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