John Lees
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Articles by John Lees
A call for sharing phenotypic antimicrobial susceptibility data alongside bacterial genome sequence data in public archives
Abstract Genomics is widely used in the surveillance and investigation of antimicrobial resistance (AMR), with standard practice to deposit bacterial whole-genome sequence data in public archives to support research and public health.
LacR and TrxB are key virulence factors involved in pneumococcal meningitis as identified by a genome-wide association study
Abstract Pneumococcal meningitis is the most common form of bacterial meningitis, with high case fatality rates. Bacterial genetics influence disease severity, but the underlying mechanisms remain poorly understood. Here, we evaluated top variants from a genome-wide association study (GWAS) linking Streptococcus pneumoniae genetic variation to disease outcome. Fifteen S.
Efficient sequence alignment against millions of prokaryotic genomes with LexicMap - Nature Biotechnology
Abstract The size of microbial sequence databases continues to grow beyond the abilities of existing alignment tools. We introduce LexicMap, a nucleotide sequence alignment tool for efficiently querying moderate-length sequences (>250 bp) such as a gene, plasmid or long read against up to millions of prokaryotic genomes.
Sex, Stress and the Heart: Long-term Cardiovascular Effects of Embryonic Metabolic Disruption
Abstract Adverse conditions within the embryonic environment can alter embryogenesis, programming systemic physiological changes that may manifest as disease states in adult life. The process of developmental programming represents an important factor underlying cardiometabolic diseases, many of which are leading causes of death globally.
Final Cut
Charles Burns. Pantheon, $34 (224p) ISBN 978-0-593-70170-6 The manias of art-making and adolescent lust are brilliantly rendered by Burns in his first standalone graphic novel since Black Hole. Fans will recognize Burns’s lovingly etched backdrops and pulp sensibility as he returns to the subject of confused hormonal youths lost in a netherworld caught between reality and nightmare.
Between Two Sounds: Arvo Pärt’s Journey to His Musical Language
Joonas Sildre, trans. from the Estonian by Adam Cullen. Plough, $26 (230p) ISBN 978-1-63608-134-2 Sildre (Messages from Ukraine) delivers a lyrical ode to composer Arvo Pärt that translates the minimalist beauty and power of Pärt’s music to the page. Born in Estonia in 1935, Pärt grows up in a nation occupied alternately by Nazi Germany and the Soviet Union.
A Pillbug Story
Conway’s wryly whimsical latest (after The Lab) peers into the weeds of a bug’s life. Millie, a sweet-faced pill bug, lives in a leafy city with friends, including an ant who’s eager to show off her colony’s work, a spider with a brood of children clinging to her thorax, and a ladybug who can’t stop chowing down on aphids. She attends a campout, drinks cocktails by the beach, gets a check-up (“It looks like you have a copper deficiency.
Stan Mack’s Real Life Funnies: The Collected Conceits, Delusions, and Hijinks of New Yorkers from 1974 to 1995
Stan Mack. Fantagraphics Underground, $50 (336p) ISBN 978-1-68396-916-7 This hefty and hilarious anthology collects more than 300 of Mack’s Village Voice strips depicting conversations overheard on the streets of New York (“All dialogue guaranteed verbatim,” he claimed.) Like a crowded apartment building, the volume’s chock-full of stubborn individuality, and the joy and pathos of urban life.
Insider Secrets in the Interview Game
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Proxy Mom: My Experience with Postpartum Depression
Sophie Adriansen and Mathou, trans. from the French by Montana Kane. NBM, $19.99 trade paper (152p) ISBN 978-1-68112-334-9 In this gentle and accessible portrayal of a mental health crisis, Adriansen (Nina Simone in Comics) and Mathou draw on their experiences as mothers to tell the fictionalized story of Marietta, who becomes clinically depressed during the final trimester of her pregnancy.
Deer Editor
Ryan K. Lindsay and Sami Kivelä. Mad Cave, $17.99 trade paper (108p) ISBN 978-1-960578-67-9 Lindsay and Kivelä (the Everfrost series) deliver a taut, gritty noir studded with tough guys, suspicious dames, and hard-boiled dialogue delivered by a humanoid deer. “Sometimes you break a story, and well... sometimes the story breaks you,” says Bucky, a world-weary journalist who’s not afraid to put his body and soul on the line in service of The Truth—aka the big-city newspaper that signs his paycheck.
Traces of Madness: A Graphic Memoir
Fernando Balius and Mario Pellejer, trans. from the Spanish by Richard Beevor and Mailén Sganga. Graphic Mundi, $19.95 trade paper (128p) ISBN 978-1-63779-070-0 Balius and Pellejer’s raw and revealing graphic memoir debut depicts Balius’s mental illness as a shaggy monster shadowing his day-to-day life.
The Last Delivery
Dahm (The Harrowing of Hell) spins a dark fable featuring a meek deliveryman toting an enormous box. When he shows up at the door of a looming mansion, the deliveryman finds a riotous party underway and becomes hopelessly lost while searching for “the resident,” who needs to sign for the package.
Evil Eyes Sea
Özge Samancı. Uncivilized, $29.95 trade paper (270p) ISBN 978-1-941250-60-0 In this rambunctious murder mystery set in 1990s Turkey, Samancı (Dare to Disappoint) contrasts a playful and vibrant visual style with deadly serious themes. For university students Ece and Meltem, the only escape from the cramped dorm room they share with six other women is diving into the nearby Bosphorus Strait.
Brittle Joints
Maria Sweeney. Street Noise, $20.99 trade paper (160p) ISBN 978-1-951491-26-0 Cartoonist Sweeney debuts with a candid portrait of life with a disability, drawn in delicate brushstrokes and natural colors. Born in Moldova in 1994, Sweeney showed early signs of Bruck syndrome, which causes fragile bones and joint contractures.
Her Frankenstein
Kawashima Norikazu, trans. from the Japanese by Ryan Holmberg. Smudge, $19.95 trade paper (320p) ISBN 978-1-961581-91-3 A businessman’s past comes back to haunt him in this stunning psycho-horror manga by Norikazu, which was originally published in 1986.
The Puerto Rican War: A Graphic History
John Vasquez Mejias. Union Square, $20 (112p) ISBN 978-1-4549-5246-6 Indie cartoonist Mejias’s energetic trade debut, an Angoulême award winner, depicts 20th-century Puerto Rican history in striking woodcut panels. The bulk of the account takes place in 1950, as members of the Puerto Rican Nationalist movement launch an uprising against U.S. control of the island.
Inter-species gene flow drives ongoing evolution of Streptococcus pyogenes and Streptococcus dysgalactiae subsp. equisimilis - Nature Communications
Abstract Streptococcus dysgalactiae subsp. equisimilis (SDSE) is an emerging cause of human infection with invasive disease incidence and clinical manifestations comparable to the closely related species, Streptococcus pyogenes. Through systematic genomic analyses of 501 disseminated SDSE strains, we demonstrate extensive overlap between the genomes of SDSE and S. pyogenes.
Circadian stress response provides an insight into metabolic communication via the mitochondrial epigenome
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Circadian stress response provides an insight into metabolic communication via the mitochondrial epigenome
Who needs science fiction when you have the mitochondria? Billions of years ago, early plant and animal cells were infected by protobacteria which sought refuge from the outside world. Over time, these bacteria formed a symbiosis with our ancestors, removing damaging oxygen from their cells while receiving nutrition and a home in return. Today, these early invaders occupy almost all eukaryotic cells, using oxygen to form the primary fuel for life, ATP.
Impact of vaccinations, boosters and lockdowns on COVID-19 waves in French Polynesia - Nature Communications
Abstract Estimating the impact of vaccination and non-pharmaceutical interventions on COVID-19 incidence is complicated by several factors, including successive emergence of SARS-CoV-2 variants of concern and changing population immunity from vaccination and infection. We develop an age-structured multi-strain COVID-19 transmission model and inference framework to estimate vaccination and non-pharmaceutical intervention impact accounting for these factors.
Accurate and fast graph-based pangenome annotation and clustering with ggCaller
1,2,4 1MRC Centre for Global Infectious Disease Analysis, Department of Infectious Disease Epidemiology, Imperial College London, London W12 0BZ, United Kingdom; 2European Molecular Biology Laboratory, European Bioinformatics Institute, Wellcome Genome Campus, Hinxton CB10 1SD, United Kingdom; 3Department of Biostatistics, University of Oslo, Blindern, 0372 Oslo, Norway ↵4 These authors contributed equally to this work.
fastlin: an ultra-fast program for Mycobacterium tuberculosis complex lineage typing
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Genealogical inference and more flexible sequence clustering using iterative PopPUNK
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The mitoepigenome responds to stress, suggesting novel mito-nuclear interactions in vertebrates
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The Evil Dead: Number One Nasty By John Lees
Of all the films on the DPP Video Nasties list of criminalized films, perhaps the most famous, and almost surely the one that has seen the most enduring success as a viable property and in the subsequent careers of those involved, is The Evil Dead.
Accurate and fast graph-based pangenome annotation and clustering with ggCaller
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バークレイ・ジェイムス・ハーヴェスト 1971年傑作２ndアルバム『Once Again』CD３枚組＋ブルーレイオーディオ拡大盤再発 ― オリジナルステレオミックスの最新リマスター、新規ステレオミックス、1972年SQクアドロフォニックミックスなどを収録
バークレイ・ジェイムス・ハーヴェスト 1971年傑作２ndアルバム『Once Again』CD３枚組＋ブルーレイオーディオ拡大盤再発 70年代英国を代表する叙情派プログレッシヴロックバンド、バークレイ・ジェイムス・ハーヴェスト。名曲「Galadriel」「Mocking Bird」などを収録した 1971年の２ndアルバム『Once Again』が、CD３枚組＋ブルーレイオーディオの拡大盤で登場。 ロバート・ジョン・ゴドフリーによるオーケストラアレンジが施された幻想的で荘厳なシンフォニックサウンドが、儚いメロトロンの響き、泣きのギターソロ、メランコリックなヴォーカリゼーション、そしてときに牧歌的なムードを織り交ぜつつ展開されるバンド初期の傑作。 本編オリジナルステレオミックスの最新リマスターおよび新規ステレオミックスに加え、1972年のSQクアドロフォニックミックスや71年のBBCセッション音源などのボーナストラックを収録。またブルーレイには、前述各種ミックスの 96 kHz/24-bit 新規５.１サラウンドミックスも収録。 収録曲 CD1 Once Again – The...
Genealogical inference and more flexible sequence clustering using iterative PopPUNK
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How do I find a flexible side hustle?
Your question makes me wonder what you would really like to change. If your day job is fulfilling and rewarding in every way (except financially), it’s understandable that you might want some extra income. If not, this might be time to think about a career change. Starting a side hustle is demanding, both in terms of exploration time and the commitment itself, so it’s good to look thoroughly before you leap. First, begin with your own context.
Mandrake: visualizing microbial population structure by embedding millions of genomes into a low-dimensional representation
1. Introduction Advances in DNA sequencing technology have recently made whole-genome sequencing both affordable and scalable enough for routine use in pathogen surveillance by research organizations and public health agencies around the world [1,2]. A striking example of this is genomic surveillance of the SARS-CoV-2 virus for which over one million genome sequences became available in just 15 months after its initial discovery [3].
Pyledriver targets Arc de Triomphe after King George stunner
The La Pyle Partnership’s Pyledriver (GB) upset the established order at Ascot to capture the 1 1/2-mile King George VI and Queen Elizabeth Stakes (G1), Britain’s all-aged middle distance championship race, and earned a guaranteed starting position in the $4 million Breeders’ Cup Turf.
The Crimson Cage #5: AWA Studios Review
With the finale issue upon us, The Crimson Cage has taken readers on a wild ride, wrapping up in epic fashion. John Lees’ retelling of Macbeth set to the world of wrestling has been nothing short of stellar. With each page, each panel, The Crimson Cage has been a viscous, well-paced story that has been impossible to put down.
Free e-book launched for older jobseekers
National Older Workers Week* was inaugurated at the end of last year as a way to highlight the issues facing older workers, particularly with regard to recruitment, and to encourage better practice by employers. Sponsored by QA Ltd, it included sessions for employers on managing multigenerational teams and combatting ageism in the recruitment process among others. There was also a session devoted to older workers themselves, with advice from experts on how to find a job you love.
Executive PAs, Secretaries, Administrators, Office Managers, Resources, Information: DeskDemon UK
Do you have a career plan? It seems like hard work, so we don't do it - even though we assume that everyone else has their career mapped out. We give more time in a year to home decoration decisions than our careers. The result? - our job changes are guided by chance and opportunity rather than a sense of direction. Here are three steps that can help career changers cope with the 21st Century workplace.
Devil's Reign, Dark Knights of Steel, Buffy: THe Last Vampire Slayer AND MORE: THE GWW PULL LIST
The long-awaited Daredevil event has begun at Marvel, one of Tom Taylor’s many titles at DC Comics rolls on and the next exciting chapter in Buffy Summers’ tale —Buffy: The Last Vampire Slayer — has begun! Here’s what GWW’s writers thought about Devils Reign, Dark Knights of Steel, Buffy: The Last Vampire Slayer and the other big books from this week: Devil’s Reign #1 Marvel Comics WRITTEN BY: CHIP ZDARSKY ART BY: MARCO CHECCHETTO COLORS BY: MARCIO MENYZ LETTERS BY: CLAYTON COWLES Zdarsky...
PREVIEW: The Crimson Cage #1
CBR presents a preview of AWA Studios' The Crimson Cage #1 by John Lees and Alex Cormack. Double double toil and rumble...Brace yourself for a No-Holds-Bard reimagining of William Shakespeare's Macbeth from the critically-acclaimed creators of Sink. New Orleans, 1984. Chuck Frenzy is the main event star of the local Louisiana pro wrestling territory, but yearns for something greater.
The Crimson Cage #1 (REVIEW)
The Crimson Cage #1 Are you ready to rumble? Well, I hope so, because John Lees and AWA/Upshot studios have once again delivered another can’t-miss comic. The Crimson Cage #1 is a wonderful retelling of Shakespeare’s classic Macbeth, but instead of castles and kings, you have turnbuckles and wrestlers. While the retelling may be a little on the nose, The Crimson Cage #1 is still a wildly fun and viscous story that leaves a lasting impression.
Local News: The website for Neston News, Features, Events, Information, Business & Comment (Neston)
Neston Players Raised the Roof for Their First Performance Together in 723 Days Author: John Lees Published: 6th December 2021 16:33 With ages ranging from 10 to 77 and after a long gap of 723 days since their last performance in Neston, last Friday & Saturday saw the return to the stage for Neston Players with not just one but two, one act productions. The first being 'A Twisted Carol' written and directed by Cheryl Barker, based on the theme of Charles Dickens 'A Christmas Carol'.
PREVIEW: Hotell Vol. 2 Original
CBR presents a preview of AWA Studios' Hotell Vol. 2 by John Lees and Dalibor Talajić. Share Tweet Email Five more interconnected stories chronicle another harrowing week at Pierrot Courts, the mysterious roadside motel where lost souls make their last stand with the demons that haunt them. A family, desperate and destitute after being evicted from their home. A struggling artist, yearning for inspiration. A lonely bachelor, tending to his beloved, ailing dog.
Key epidemiological drivers and impact of interventions in the 2020 SARS-CoV-2 epidemic in England
COVID in the community Understanding factors related to the initial spread and control of SARS-CoV-2 is important in light of emerging variants. Knock et al. retrospectively examined differences in SARS-CoV-2 transmission and related mortality in care homes, hospitals, and the community in England since the virus was first introduced in December 2020, stratified by age and geographical region over time.
Key epidemiological drivers and impact of interventions in the 2020 SARS-CoV-2 epidemic in England
COVID in the community Understanding factors related to the initial spread and control of SARS-CoV-2 is important in light of emerging variants. Knock et al. retrospectively examined differences in SARS-CoV-2 transmission and related mortality in care homes, hospitals, and the community in England since the virus was first introduced in December 2020, stratified by age and geographical region over time.
Key epidemiological drivers and impact of interventions in the 2020 SARS-CoV-2 epidemic in England
Abstract We fitted a model of SARS-CoV-2 transmission in care homes and the community to regional surveillance data for England. Compared with other approaches, our model provides a synthesis of multiple surveillance data streams into a single coherent modelling framework allowing transmission and severity to be disentangled from features of the surveillance system.
Symbio Energy is rated "Bad" with 1.7 / 5 on Trustpilot
Stuart Parker 1 review GB Appalling customer service Price is great, but don't expect any sensible communication back from them. Bill's are constantly wrong, they do not use supplied readings. Their estimates are so far out, I've no idea our they work them out. I will be swapping away from them as soon as possible.
YEAR ZERO, VOL. 1
Writer: Benjamin Percy Illustrator: Ramon Rosanas Publisher: AWA UPSHOT Year Zero, AWA/Upshot, Cover art by Ramon Rosanas Year Zero is a masterfully executed, pre-apocalyptic-slow-burn-unfolding-into-an-apocalyptic-zombie-world comic. The story of five unlucky human beings whose imperfect existences begin to spiral into zombie terror. This first issue, from the first volume of two, skillfully lays tracks for the oncoming disaster. Think Fear The Walking Dead with This Is Us connective tissues.
EXCLUSIVE PREVIEW: Hotell #4
CBR presents an exclusive preview of AWA Studios' Hotell #4, by John Lees, Dalibor Talajic, Lee Loughridge and Sal Cipriano.
バークレイ・ジェームズ・ハーヴェスト 初期名作『And Other Short Stories』最新リマスター2CD＋DVD拡大盤再発
バークレイ・ジェームズ・ハーヴェスト 初期名作『And Other Short Stories』2CD＋DVD拡大盤再発 キャメルと共に70年代英国叙情派プログレッシヴロックシーンを牽引したバークレイ・ジェームズ・ハーヴェスト 1971年の名作『And Other Short Stories (バークレイ・ジェームズ・ハーヴェストのお話)』が2CD＋DVDからなる拡大盤で登場。 CD1に本編のオリジナルマスターテープからの新規リマスタリング音源、CD2に本編新規ステレオミックス音源をそれぞれ収録。DVDには同じく本編オリジナルマスターからの新規リマスタリング音源と新規ステレオミックスを2ch 24Bit/96kHz ハイレゾ & 5.1ch サラウンドミックスで収録。 ボーナストラックとして、CD1に本作の2002年EMI盤CDにも収録された「Brave New World」の71年デモ音源と71〜72年BBCラジオ放送用「She Said」「Galadriel」「Ursula (The Swansea Song)」「Someone There You...
EXCLUSIVE PREVIEW: Hotell #3
CBR presents an exclusive preview of AWA Studios' Hotell #3, by John Lees, Dalibor Talajic, Lee Loughridge and Sal Cipriano.
Improved Prediction of Bacterial Genotype-Phenotype Associations Using Interpretable Pangenome-Spanning Regressions
Research Article | Molecular Biology and Physiology John A. Lees, T. Tien Mai, Marco Galardini, Nicole E. Wheeler, Samuel T. Horsfield, Julian Parkhill, Jukka Corander Jacques Ravel, Editor DOI: 10.1128/mBio.01344-20 ABSTRACT Discovery of genetic variants underlying bacterial phenotypes and the prediction of phenotypes such as antibiotic resistance are fundamental tasks in bacterial genomics.
How to Crack the Hidden Job Market
I often hear British graduates expressing something like a physical revulsion at the idea that they might have to network their way into a job. The UK had a minor scandal about the fact that young people with great social connections find themselves in the top internships. Workers used to an equal opportunities culture often express ethical objections to the idea that you might talk your way into a short-list of one simply through opportunity or connections.
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