Is this you? As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.
Claim your profile
Articles by John Manis
Analysing long-read CRISPR experiments with CRISPRLungo
Abstract Long-read sequencing can characterize complex genome editing-induced DNA sequence changes such as large deletions, insertions and inversions that are difficult to detect using short-read sequencing. However, PCR amplification and sequencing errors complicate accurate variant detection, and existing analysis tools are not optimized for gene editing specific allelic outcomes.
Non-genotoxic transplantation and in vivo selection through epitope editing
|
Abstract The short-term and long-term effects of genotoxic pre-transplant conditioning remain barriers to the broader application of haematopoietic stem/progenitor cell (HSPC) transplantation and gene therapies1,2,3,4.
By Gabriele Casirati, Andrea Cosentino, Jing ZENG, Adele Mucci, Sébastien Levesque, Nola R. Neri, Enrico Drago, Francesco Romano, Varun Katta, Azusa Matsubara, Yichao Li, Mohammed Mahmoud, Christian Brendel, John Manis, Shengdar Tsai, Danilo Pellin, Daniel Bauer, Pietro Genovese, Marta Freschi, Viola Carzaniga, Moisés Chávez-Navarro
|
Nature
Verified
Editorial Expression of Concern: DOCK8 functions as an adaptor that links TLR-MyD88 signaling to B cell activation
|
Addendum to: Nature Immunology https://doi.org/10.1038/ni.2305, published online 13 May 2012. The Editor-in-Chief would like to alert the readers that concerns have been raised about some of the blots presented in this article. Specifically: Fig. 5b, Syk and Fig. 6d, pPyk2 appear to partially overlap Fig. 5g, p-Syk (Myd88−/−) and Fig. 6c, p-Src appear to be highly similar Fig. 6e, Src and Fig.
By Haifa H. Jabara, Douglas McDonald, Erin Janssen, Michel J. Massaad, Narayanaswamy Ramesh, Arturo Borzutzky, Ingrid Rauter, Halli Benson, Lynda Schneider, Sachin Baxi, Mike Recher, Luigi D. Notarangelo, Ghassan Dbaibo, Majed Dasouki, Waleed Al-Herz, Safa Baris, Necil Kutukculer, Hans D Ochs, Alessandro Plebani, Maria Kanariou, Gerard Lefranc, Ismail Reisli, Katherine A. Fitzgerald, Douglas T. Golenbock, John Manis, Sevgi Keles, Talal Chatila, Raif S. Geha, Rima Wakim, Isil Barlan, Reuben Ceja
|
Nature
Verified
Base editing HbS to HbG-Makassar improves hemoglobin function supporting its use in sickle cell disease - Nature Communications
Abstract Adenine base editing can convert sickle hemoglobin (HbS, βΕ6V) to G-Makassar hemoglobin (HbG, βE6A), a naturally occurring variant that is clinically asymptomatic. However, the quality and functionality of purified HbG and of mature HbGG and HbGS red blood cells (RBC) has not been assessed. Here, we develop a mouse model to characterize HbG. Purified HbG appears normal and does not polymerize under hypoxia.
"Syriac Origins for the Armenian Commentary on Genesis Attributed to Ep" by John Manis, Dr. Kristian Heal et al.
Keywords Syriac, Armenian commentary, Ephrem, Genesis commentary College Religious Education Department Ancient Scripture Abstract My experience with the ORCA mentoring program has been a useful look into scholarship as well as a valuable experience which will aid me in future educational and academic endeavors. Our main project objectives were met with a few adjustments, and I was able to gain the experience of working with a supportive and experienced professor.
Age-associated clonal B cells drive B cell lymphoma in mice - Nature Aging
Abstract Although cancer is an age-related disease, how the processes of aging contribute to cancer progression is not well understood. In this study, we uncovered how mouse B cell lymphoma develops as a consequence of a naturally aged system. We show here that this malignancy is associated with an age-associated clonal B cell (ACBC) population that likely originates from age-associated B cells.
Form Follows Function for Freeze‐Dried Platelets
COMMENTARY Jonathan A. Stefely, Jonathan A. Stefely orcid.org/0000-0003-3235-1107 Joint Program in Transfusion Medicine, Department of Pathology, Harvard Medical School; Department of Pathology, Brigham and Women's Hospital, Division of Blood Bank, Department of Laboratory Medicine, Boston Children's Hospital, Boston, Massachusetts, USA Search for more papers by this author John P. Manis, Corresponding Author John P.
Show More
loading
Actions
Is this you?
As a journalist, you can create a free Muck Rack account to customize your profile, list your contact preferences, and upload a portfolio of your best work.Get in touch with John
Contact John, search articles and posts on X, monitor coverage, and track replies from one place.
Learn more about Muck Rack