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Articles by Jon Larson
Cell autonomous regional differences in oligodendrocyte lineage development and responses to oncohistone H3.3 K27M
Abstract Diffuse midline glioma, H3K27-altered (DMG), is a lethal midline brain tumor. Most DMG, unlike glioma arising in other regions, harbor histone H3.3 K27M (K27M) mutations. The basis for this anatomical selectivity remains unclear. Stem-like DMG cell transcriptomes most resemble oligodendrocyte precursor cells (OPCs).
Circular extrachromosomal DNA promotes tumor heterogeneity in high-risk medulloblastoma - Nature Genetics
Abstract Circular extrachromosomal DNA (ecDNA) in patient tumors is an important driver of oncogenic gene expression, evolution of drug resistance and poor patient outcomes. Applying computational methods for the detection and reconstruction of ecDNA across a retrospective cohort of 481 medulloblastoma tumors from 465 patients, we identify circular ecDNA in 82 patients (18%).
Factor analysis of the neurobehavioral symptom inventory in veterans with PTSD and no history of mild TBI
References Andrews, R. J., Fonda, J. R., Levin, L. K., McGlinchey, R. E., & Milberg, W. P. (2018). Comprehensive analysis of the predictors of neurobehavioral symptom reporting in veterans. Neurology, 91(8), e732–e745. https://doi.org/10.1212/WNL.0000000000006034 View [PubMed] [Web of Science ®], [Google Scholar] Bahraini, N. H., Hostetter, T. A., Forster, J. E., Schneider, A. L., & Brenner, L. A. (2018).
Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors
Genome and Epigenome Pauline J. Beckmann, Jon D. Larson, Alex T. Larsson, Jason P. Ostergaard, Sandra Wagner, Eric P. Rahrmann, Ghaidan A. Shamsan, George M. Otto, Rory L. Williams, Jun Wang, Catherine Lee, Barbara R. Tschida, Paramita Das, Adrian M. Dubuc, Branden S. Moriarity, Daniel Picard, Xiaochong Wu, Fausto J. Rodriguez, Quincy Rosemarie, Ryan D. Krebs, Amy M. Molan, Addison M. Demer, Michelle M. Frees, Anthony E. Rizzardi, Stephen C. Schmechel, Charles G. Eberhart, Robert B. Jenkins, Robert J.
Sleeping Beauty Insertional Mutagenesis Reveals Important Genetic Drivers of Central Nervous System Embryonal Tumors
Genome and Epigenome Pauline J. Beckmann, Jon D. Larson, Alex T. Larsson, Jason P. Ostergaard, Sandra Wagner, Eric P. Rahrmann, Ghaidan A. Shamsan, George M. Otto, Rory L. Williams, Jun Wang, Catherine Lee, Barbara R. Tschida, Paramita Das, Adrian M. Dubuc, Branden S. Moriarity, Daniel Picard, Xiaochong Wu, Fausto J. Rodriguez, Quincy Rosemarie, Ryan D. Krebs, Amy M. Molan, Addison M. Demer, Michelle M. Frees, Anthony E. Rizzardi, Stephen C. Schmechel, Charles G. Eberhart, Robert B. Jenkins, Robert J.
Sleeping Beauty insertional mutagenesis reveals important genetic drivers of central nervous system embryonal tumors
Research Article Pauline J Beckmann, Jon D. Larson, Alex T Larsson, Jason P Ostergaard, Sandra Wagner, Eric P Rahrmann, Ghaidan A Shamsan, George Maxwell Otto, Rory L Williams, Jun Wang, Catherine Lee, Barbara R Tschida, Paramita Das, Adrian M Dubuc, Branden S. Moriarity, Daniel Picard, Xiaochong Wu, Fausto J Rodriguez, Quincy Rosemarie, Ryan D Krebs, Amy M Molan, Addison M Demer, Michelle M. Frees, Anthony E Rizzardi, Stephen C Schmechel, Charles G. Eberhart, Robert B.
Histone H3.3 K27M Accelerates Spontaneous Brainstem Glioma and Drives Restricted Changes in Bivalent Gene Expression
Highlights • H3.3 K27M mutation enhances neural stem cell self-renewal • Neonatal PDGFRα activation and Trp53 loss induces supratentorial and brainstem glioma • H3.3 K27M preferentially accelerates hindbrain tumorigenesis • H3.3 K27M drives bivalent gene activation associated with neurodevelopment in DIPG Summary Diffuse intrinsic pontine gliomas (DIPGs) are incurable childhood brainstem tumors with frequent histone H3 K27M mutations and recurrent alterations in PDGFRA and TP53.
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