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Articles by Jon M. Steichen
Vaccination elicits HIV broadly neutralizing antibodies in primates
Abstract The high antigenic diversity of HIV has been a major obstacle to development of a broadly protective vaccine. Nevertheless, protective HIV broadly neutralizing antibodies (bnAbs) exist and have been proposed as templates for vaccine development1-6.
Local antibody feedback enforces a checkpoint on affinity maturation in the germinal center and promotes epitope spreading
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Keywords B cell germinal center antibody feedback affinity maturation HIV vaccine sequential immunization plasma cells local antibody pool Introduction Affinity maturation is the fundamental process underpinning the humoral response to infection or vaccination.1,2 Exposure to antigen activates a polyclonal B cell response derived from those cells with B cell receptors (BCRs) meeting a minimum affinity threshold.3 Those with very high initial affinities will differentiate into extrafollicular...
By Yu Yan, Xuesong Wang, Zhenfei Xie, Daniel Bader, Ryan Lim, Krystal M. Ma, Christopher A. Cottrell, Jon M. Steichen, Liling Xu, Paula M. Villavicencio, Madhav Akauliya, Ja-Hyun Koo, Jacqueline Shen, Alexandra Vernich, Oleksandr Kalyuzhniy, Joel Allen, Ali Albowaidey, Anthony Alicea, Bingxian Chen, Erik Georgeson, Nushin Alavi, Abigail Esposito, Nicole Phelps Verified, Michael Kubitz, Quynh Anh Phan, Alessia Liguori, Thavaleak Prum, Ryan Tingle, Danny Lu, Saman Eskandarzadeh, John Warner, Stephanie R. Weldon, Sunny Himansu, Max Crispin, Usha B. Nair, Sophia Liu, William R. Schief, Facundo D. Batista, Jordan Renae Ellis-Pugh, Hannah Naili, Brendon Kelley, Xiaotie Liu
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Cell Press
Verified
Virus glycoprotein nanodisc platform for vaccine analytics - Nature Communications
Abstract Transmembrane glycoproteins of enveloped viruses are targets of neutralizing antibodies and essential vaccine antigens. mRNA-LNP technology allows in vivo expression of transmembrane glycoproteins, but in vitro biophysical characterization of transmembrane antigens and analysis of post-immunization antibody responses typically rely on soluble proteins. Here, we present a platform for assembling transmembrane glycoprotein vaccine candidates into lipid nanodiscs.
Simultaneous induction of multiple classes of broadly neutralizing antibody precursors by combination germline-targeting immunization in nonhuman primates
Editor’s summary The germline-targeting approach for HIV vaccines uses priming envelope (Env) immunogens that activate naïve B cells expressing potentially broadly neutralizing antibody (bnAb) precursors that can be shaped into mature bnAbs by subsequent immunization. A pair of papers from Xie et al. and Sutton et al. examines whether multiple immunogens could be given simultaneously without compromising efficacy.
Diverse priming outcomes under conditions of very rare precursor B cells
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Keywords naive B cells bnAb precursors germline-targeting adjuvants escalating dose HIV vaccines HIV bnAbs BG18 Introduction The aim of many vaccines against viruses is to induce neutralizing antibodies that protect against infection.1,2,3 B cell precursors that give rise to these types of neutralizing responses can be extremely rare in the naive B cell repertoire and infrequently participate in immune responses.4,5,6,7,8,9,10,11,12 Germline-targeting vaccine design is one approach to prime...
By Patrick Madden, Ester Marina-Zárate, Kristen A. Rodrigues, Jon M. Steichen, Monolina Shil, Kaiyuan Ni, Katarzyna Kaczmarek Michaels, Laura Maiorino, Swati Saha, Arpan Pradhan, Oleksandr Kalyuzhiny, Alessia Liguori, Paul Lopez, Ivy Phung, Claudia Flynn, Mariane B. Melo, Nicole Phelps Verified, Erik Georgeson, Michael Kubitz, Danny Lu, Amanda R. Metz, Oscar Rodriguez, Oscar Rodríguez, Óscar Rodríguez, Kaitlyn T Shields, Steven R. Schultze, Melissa Smith, Vanessa R. Lewis, Elana Ben-Akiva, William P. Pinney, Justin Gregory, Shuhao Xiao, Diane G. Carnathan, Sudhir Pai Kasturi, Corey T. Watson, Steven E. Bosinger, Guido Silvestri, William R. Schief, Darrell J. Irvine, Shane Crotty, Ashley Lemnios, Nushin Alavi, Saman Eskandarzadeh, Brandon S. Healy, Deuk Lim
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Cell Press
Verified
Diverse priming outcomes under conditions of very rare precursor B cells
Abstract Rare B cells can have special pathogen-recognition features giving them the potential to make outsized contributions to protective immunity. However, rare naive B cells infrequently participate in immune responses. We investigated how germline-targeting vaccine antigen delivery and adjuvant selection affect priming of exceptionally rare BG18-like HIV broadly neutralizing antibody-precursor B cells (~1 in 50 million) in non-human primates.
Ergotism and the Salem Village Witch Trials
Nicholas P. Spanos and Jack GottliebAuthors Info & Affiliations Get full access to this article View all available purchase options and get full access to this article. References Barber, T. X., Imagery: Current Cognitive Approaches: 102 (1971). Barger, G., Ergot and Ergotism (1931). Bove, F. J., The Story of Ergot (1970). Boyer, P.,Salem Possessed: The Social Origins of Witchcraft (1974). Boyer, P., Salem Village Witchcraft: A Documentary Record of Local Conflict in Colonial New England (1972).
AlphaFold2 structures guide prospective ligand discovery
Research Article Jiankun Lyu https://orcid.org/0000-0002-0461-5454 jiankunlyu@gmail.com, Nicholas Kapolka https://orcid.org/0000-0003-2223-8207, [...] , Ryan Gumpper, Assaf Alon https://orcid.org/0000-0001-8102-5290, [...] , Liang Wang https://orcid.org/0000-0002-8868-8449, Manish K.
Quantum interference in atom-exchange reactions
Research Article Yi-Xiang Liu https://orcid.org/0000-0001-7798-1028, Lingbang Zhu https://orcid.org/0009-0005-6836-2010, [...] , Jeshurun Luke https://orcid.org/0000-0002-4607-6583, J. J. Arfor Houwman https://orcid.org/0009-0003-3342-2322, [...] , Mark C.
Remote proton elimination: C-H activation enabled by distal acidification
Research Article ORGANIC CHEMISTRY Phillip S. Grant https://orcid.org/0000-0001-7077-8756, Miloš Vavrík https://orcid.org/0009-0003-2088-1108, [...] , Vincent Porte https://orcid.org/0000-0003-3156-2973, Ricardo Meyrelles https://orcid.org/0000-0002-0976-5494, and Nuno Maulide https://orcid.org/0000-0003-3643-0718 nuno.maulide@univie.ac.at+2 authors fewerAuthors Info & Affiliations Editor’s summary Dehydration of alcohols is a common reaction in organic chemistry.
Diamond-lattice photonic crystals assembled from DNA origami
Research Article PHOTONIC BANDGAPS Gregor Posnjak https://orcid.org/0000-0002-9863-4444 gregor.posnjak@lmu.de, Xin Yin https://orcid.org/0009-0000-4721-7520, [...] , Paul Butler https://orcid.org/0009-0004-0214-9834, Oliver Bienek https://orcid.org/0000-0001-9815-1082, [...] , Mihir Dass https://orcid.org/0000-0002-4654-4455, Seungwoo Lee https://orcid.org/0000-0002-6659-3457, Ian D.
Enantioselective remote methylene C−H (hetero)arylation of cycloalkane carboxylic acids
Research Article ORGANIC CHEMISTRY Tao Zhang https://orcid.org/0009-0002-1668-0453, Zi-Yu Zhang https://orcid.org/0009-0002-8542-8972, [...] , Guowei Kang https://orcid.org/0000-0002-8334-0339, Tao Sheng https://orcid.org/0000-0001-5339-9834, [...] , Jie-Lun Yan https://orcid.org/0000-0003-3340-2746, Yuan-Bin Yang https://orcid.org/0009-0000-6476-549X, Yuxin Ouyang https://orcid.org/0000-0001-5453-513X, and Jin-Quan Yu https://orcid.org/0000-0003-3560-5774 yu200@scripps.edu+5 authors +3...
DNA damage induces p53-independent apoptosis through ribosome stalling
Research Article CANCER Nicolaas J. Boon https://orcid.org/0009-0009-5328-2543, Rafaela A. Oliveira, [...] , Pierré-René Körner https://orcid.org/0000-0002-9964-234X, Adva Kochavi https://orcid.org/0000-0002-6274-1942, [...] , Sander Mertens, Yuval Malka https://orcid.org/0000-0002-1656-8480, Rhianne Voogd, Suzanne E. M. van der Horst https://orcid.org/0000-0001-6495-3482, Maarten A. Huismans https://orcid.org/0000-0003-1556-0820, [...] , Lidwien P.
News at a glance
Solar storm puts on stunning display Space Weather An aurora makes a rare appearance over the Bonneville Salt Flats in Utah. PHOTO: BLAKE BENARD/GETTY IMAGES Open in viewer On the night of 10 May, Earth’s magnetic field got walloped by the Sun, as the planet experienced its most extreme geomagnetic storm since 2003.
Tool use increases mechanical foraging success and tooth health in southern sea otters (Enhydra lutris nereis)
Research Article ADAPTIVE TOOL USE Chris J. Law https://orcid.org/0000-0003-1575-7746 cjlaw@uw.edu, M. Tim Tinker https://orcid.org/0000-0002-3314-839X, [...] , Jessica A. Fujii https://orcid.org/0000-0003-4794-479X, Teri Nicholson https://orcid.org/0000-0002-9895-1458, [...] , Michelle Staedler https://orcid.org/0000-0002-1101-6580, Joseph A. Tomoleoni https://orcid.org/0000-0001-6980-251X, Colleen Young https://orcid.org/0000-0001-9604-884X, and Rita S.
How power shapes behavior: Evidence from physicians
Research Article HEALTH ECONOMICS Stephen D. Schwab https://orcid.org/0000-0001-7268-0568 and Manasvini Singh https://orcid.org/0000-0002-0710-1117 msingh01@cmu.eduAuthors Info & Affiliations Editor’s summary The physician-patient relationship should be immune from bias, but growing evidence challenges physicians’ objectivity. Previous research has struggled to quantify variations in power differentials and the impact on diverse patients in real-world settings.
Taking climate-smart governance to the high seas
Policy Forum Ocean Comprehensive spatial planning in international waters is key to achieving ocean sustainability Catarina Frazão Santos cfsantos@ciencias.ulisboa.pt, Tundi Agardy, [...] , Cassandra Brooks, Kristina M. Gjerde, [...] , Cymie Payne, Lisa M. Wedding, José C. Xavier, and Larry B.
Progress on priming HIV-1 immunity
Perspective Medicine Four new studies inform on the multistep path to generate broadly active HIV-1 antibodies Rogier W. Sanders r.w.sanders@amsterdamumc.nl and John P. Moore r.w.sanders@amsterdamumc.nlAuthors Info & Affiliations Abstract A successful HIV-1 vaccine will have to induce broadly neutralizing antibodies (bnAbs), which can counter most circulating HIV-1 strains.
Lubert Stryer (1938-2024)
Perspective Retrospective Trailblazing biochemist and author Jeremy Berg jberg@pitt.eduAuthors Info & Affiliations Lubert Stryer, author of a revolutionary biochemistry textbook that contributed to the education of millions of students around the world, died on 8 April at the age of 86. As a researcher, Stryer pioneered fluorescence methods for measuring distances within macromolecules, elucidated the visual signal transduction cascade, and helped develop DNA microarrays.
Energy transition needs new materials
Chad A. Mirkin chadnano@northwestern.edu, Edward H. Sargent ted.sargent@northwestern.edu, and Daniel P. Schrag schrag@eps.harvard.eduAuthors Info & Affiliations The decreasing cost of electricity worldwide from wind and solar energy, as well as that of end-use technologies such as electric vehicles, reflect substantial progress made toward replacing fossil fuels with alternative energy sources. But a full transition to clean energy can only be realized if numerous challenges are overcome.
Tool use promotes dental health
Perspective Ecology Using tools increases foraging success in sea otters and protects their teeth from damage Barbara C. Klump barbara.klump@univie.ac.atAuthors Info & Affiliations Abstract Across the animal kingdom, different types of adaptation have evolved that allow animals to access otherwise inaccessible prey.
AI-driven robots discover record-setting laser compound
A network of automated labs discovered a compound that emits blue laser light with record efficiency. Who needs scientists anyway? A global consortium of six automated laboratories, overseen by artificial intelligence (AI), set out to produce new laser materials, dividing the labor from synthesis to testing. The effort yielded a compound that emits laser light with record-setting efficiency, researchers report on p. 756.
In Other Journals
Plant Science Protein degradation and cell expansion Ankit Walia As seedlings emerge through soil, an apical hook forms to protect delicate tissues. PHOTO: MATTHEW NOBLE HORTICULTURAL/ALAMY STOCK PHOTO The plant hormone auxin regulates differential cell expansion. As seedlings begin to navigate through soil after germination, an apical hook is formed by bending of the upper hypocotyl that protects the fragile shoot meristem.
The complexity of physician power
Perspective Medicine Inequitable variation in physician effort and resource use is revealed Laura Nimmon laura.nimmon@ubc.caAuthors Info & Affiliations Power is present in all human relationships. Thus, there is no interaction in which power and its potential to exert influence is not relevant in medicine (1). Although the role of power in medical interactions is important, few studies investigate how physicians allocate effort and execute their power when interacting with patients.
The inflamed brain
Thomas Müller displays his artwork, some of which was inspired by his experience with psychosis brought on by autoimmune encephalitis. Open in viewer THOMAS MÜLLER* ONCE ENJOYED a serene life as a psychiatrist with his wife and three children in Lahr, a German town near the French border. He was also a talented artist who loved painting with his kids, and a voracious reader fond of the speculative science fiction of Philip K. Dick and the eldritch tales of H. P. Lovecraft.
Plants in the human gaze
AAAS login provides access to Science for AAAS Members, and access to other journals in the Science family to users who have purchased individual subscriptions. Download and print this article for your personal scholarly, research, and educational use. Buy a single issue of Science for just $15 USD.
Undergraduate research data crucial to equity
Dustin B. Thoman dthoman@sdsu.edu, Jessi L. Smith, [...] , Ivan A. Hernandez, Christal D. Sohl, and Miguel T. Villodas+2 authors fewerAuthors Info & Affiliations Biochemist Christal Sohl (right) interacts with trainees Isaac Marquez (left) and Mowaffaq Adam (center) in her lab at San Diego State University.
Bandgap-universal passivation enables stable perovskite solar cells with low photovoltage loss
Research Article SOLAR CELLS Yen-Hung Lin https://orcid.org/0000-0001-6819-1235 yh.lin@ust.hk, Vikram, [...] , Fengning Yang https://orcid.org/0000-0002-0648-3619, Xue-Li Cao https://orcid.org/0009-0003-3636-1537, [...] , Akash Dasgupta https://orcid.org/0000-0002-7942-293X, Robert D. J. Oliver https://orcid.org/0000-0003-4980-7940, Aleksander M. Ulatowski, Melissa M.
Global band convergence design for high-performance thermoelectric power generation in Zintls
Research Article THERMOELECTRICS Xin Shi https://orcid.org/0009-0006-1068-2924, Shaowei Song https://orcid.org/0000-0002-4774-4889, [...] , Guanhui Gao https://orcid.org/0000-0002-4760-1378, and Zhifeng Ren https://orcid.org/0000-0001-8233-3332 zren@uh.edu+1 authors fewerAuthors Info & Affiliations Editor’s summary Zintl materials can be attractive for thermoelectric applications because of their wide range of compositions and tunable properties. Shi et al.
Inverse design of a pyrochlore lattice of DNA origami through model-driven experiments
Research Article PHOTONIC BANDGAPS Hao Liu https://orcid.org/0000-0002-0698-5766, Michael Matthies https://orcid.org/0000-0001-5979-1757, [...] , John Russo https://orcid.org/0000-0002-6234-6344, Lorenzo Rovigatti https://orcid.org/0000-0001-5017-2829, [...] , Raghu Pradeep Narayanan https://orcid.org/0000-0002-7036-9706, Thong Diep, Daniel McKeen https://orcid.org/0000-0001-5113-2247, Oleg Gang https://orcid.org/0000-0001-5534-3121, Nicholas Stephanopoulos...
Building on NIH’s data sharing policy
Information & Authors Information Published In Science Volume 384 | Issue 6697 17 May 2024 Copyright Copyright © 2024 The Authors, some rights reserved; exclusive licensee American Association for the Advancement of Science. No claim to original U.S. Government Works. Article versions Submission history Published in print: 17 May 2024 Permissions Request permissions for this article.
Vaccine priming of rare HIV broadly neutralizing antibody precursors in nonhuman primates
Research Article HIV VACCINES Jon M. Steichen https://orcid.org/0000-0002-4586-3251, Ivy Phung https://orcid.org/0000-0001-7283-4766, [...] , Eugenia Salcedo https://orcid.org/0000-0001-7352-118X, Gabriel Ozorowski https://orcid.org/0000-0002-9695-8138, [...] , Jordan R. Willis https://orcid.org/0000-0002-0135-5263, Sabyasachi Baboo https://orcid.org/0000-0002-4547-5160, Alessia Liguori https://orcid.org/0000-0002-8606-574X, Christopher A. Cottrell https://orcid.org/0000-0002-3364-3083, Jonathan L.
The whistleblowers
Books et al. Experimental Ethics A bioethicist probes the costs of exposing wrongdoing in medical research C. Fred Alford calford@umd.eduAuthors Info & Affiliations Get full access to this article View all available purchase options and get full access to this article. References and Notes 1 Z. Bauman et al., Modernity and the Holocaust (Cornell Univ. Press, 1989). Books 1 The Occasional Human Sacrifice: Medical Experimentation and the Price of Saying No Carl Elliott Norton, 2024. 368 pp.
Self-advocacy for young African scientists
Isildo de N. Nganhane isildonganhane@gmail.com and Harith FarooqAuthors Info & Affiliations Knowledge resources and financial capital are mainly concentrated in the Global North (1), whereas the Global South, particularly Africa, lacks both investment in research (2, 3) and researchers (4). As a result, less than 1% of the global research output is produced by African institutions (5).
In Science Journals
Reproductive Cost Care counts most Sacha Vignieri Because of their higher metabolic rate, mammals, such as this barbary ground squirrel mother and kit, generally incur large indirect reproductive costs. PHOTO: EDWIN GIESBERS/NATURE PICTURE LIBRARY/ALAMY STOCK PHOTO Reproduction is one of the biggest energy investments that an animal will make. It has also been well studied over many years, leading to much knowledge about how much energy is directly invested in the production of offspring.
mRNA-LNP HIV-1 trimer boosters elicit precursors to broad neutralizing antibodies
Research Article HIV VACCINES Zhenfei Xie https://orcid.org/0009-0006-9341-4721, Ying-Cing Lin https://orcid.org/0000-0002-3534-7974, [...] , Jon M. Steichen https://orcid.org/0000-0002-4586-3251, Gabriel Ozorowski https://orcid.org/0000-0002-9695-8138, [...] , Sven Kratochvil https://orcid.org/0000-0002-0446-2371, Rashmi Ray https://orcid.org/0000-0002-4794-3124, Jonathan L.
Delocalized, asynchronous, closed-loop discovery of organic laser emitters
Research Article ORGANIC CHEMISTRY Felix Strieth-Kalthoff https://orcid.org/0000-0003-1357-5500, Han Hao https://orcid.org/0000-0002-0176-3929, [...] , Vandana Rathore https://orcid.org/0000-0001-7815-6513, Joshua Derasp https://orcid.org/0009-0009-6016-4473, [...] , Théophile Gaudin https://orcid.org/0000-0003-3914-854X, Nicholas H.
Atomic physics on a 50-nm scale: Realization of a bilayer system of dipolar atoms
Research Article ATOMIC PHYSICS Li Du https://orcid.org/0000-0002-5940-0143 lidu@mit.edu, Pierre Barral https://orcid.org/0009-0004-9756-0959, [...] , Michael Cantara, Julius de Hond https://orcid.org/0000-0003-2217-934X, [...] , Yu-Kun Lu https://orcid.org/0000-0003-4840-0487, and Wolfgang Ketterle https://orcid.org/0000-0002-9528-3044+3 authors +1 authors fewerAuthors Info & Affiliations Editor’s summary Dipolar interactions between atoms with large dipole moments can be exploited for...
Structural disorder determines capacitance in nanoporous carbons
Research Article NANOMATERIALS Xinyu Liu https://orcid.org/0000-0002-6352-3517, Dongxun Lyu https://orcid.org/0009-0002-8588-1478, [...] , Céline Merlet https://orcid.org/0000-0003-3758-273X, Matthew J. A. Leesmith, [...] , Xiao Hua https://orcid.org/0000-0002-8673-5678, Zhen Xu https://orcid.org/0000-0001-9389-7993, Clare P. Grey https://orcid.org/0000-0001-5572-192X, and Alexander C.
Determination of single-molecule loading rate during mechanotransduction in cell adhesion
Research Article MECHANOBIOLOGY Myung Hyun Jo https://orcid.org/0000-0003-2745-2843, Paul Meneses https://orcid.org/0000-0001-9670-1271, [...] , Olivia Yang https://orcid.org/0000-0001-5328-6960, Claudia C.
Conflation of reforestation with restoration is widespread
Catherine L. Parr, et al. argue that “Conflation of reforestation with restoration is widespread” in their article of the same title (Science, 15 Feb 2024 Vol. 383 Issue 6684). The authors themselves then proceed to conflate reforestation and restoration throughout their analysis, including in their case study of the African Forest Restoration Initiative (AFR100) to restore degraded lands in Africa.
Teach Indigenous knowledge alongside science
Policy Forum Education Evidence supports the teaching of Indigenous knowledge alongside sciences in the classroom Amanda Black amanda.black@lincoln.ac.nz and Jason M. TylianakisAuthors Info & Affiliations Abstract Conflict has grown around Indigenous knowledge in education policy.
The new cell theory
AAAS login provides access to Science for AAAS Members, and access to other journals in the Science family to users who have purchased individual subscriptions. Download and print this article for your personal scholarly, research, and educational use. Buy a single issue of Science for just $15 USD.
Attenuated evolution of mammals through the Cenozoic
Research Article MAMMALIAN EVOLUTION Anjali Goswami https://orcid.org/0000-0001-9465-810X a.goswami@nhm.ac.uk, Eve Noirault, [...] , Ellen J. Coombs https://orcid.org/0000-0002-3760-8736, Julien Clavel https://orcid.org/0000-0002-2715-4988, [...] , Anne-Claire Fabre https://orcid.org/0000-0001-7310-1775, Thomas J. D. Halliday https://orcid.org/0000-0002-4077-732X, Morgan Churchill, Abigail Curtis, Akinobu Watanabe https://orcid.org/0000-0001-5057-4772, [...] , Nancy B.
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses
A highly effective HIV vaccine has been the goal of vaccinologists for nearly 35 years. A successful vaccine would need to induce broadly neutralizing antibodies (bnAbs) that are capable of neutralizing multiple HIV strains (see the Perspective by Agazio and Torres). Steichen et al. report a strategy in which the first vaccine shot can lead to immune responses that generate desired bnAbs.
A generalized HIV vaccine design strategy for priming of broadly neutralizing antibody responses
Download and print this article for your personal scholarly, research, and educational use. Buy a single issue of Science for just $15 USD.
Sequential Immunization Elicits Broadly Neutralizing Anti-HIV-1 Antibodies in Ig Knockin Mice
Antibodies hold great promise for HIV-1 prophylaxis because they can prevent infection in pre-clinical models even at low concentrations (Gautam et al., 2016xA single injection of anti-HIV-1 antibodies protects against repeated SHIV challenges. Gautam, R., Nishimura, Y., Pegu, A., Nason, M.C., Klein, F., Gazumyan, A., Golijanin, J., Buckler-White, A., Sadjadpour, R., Wang, K. et al. Nature.
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