Skip To Main Content
Josiah Murray on Muck Rack

Josiah Murray

As seen in: Nature

Get in touch with Josiah

Contact Josiah, search articles and posts on X, monitor coverage, and track replies from one place.

Learn more about Muck Rack

Actions

Share this page

Articles

The effect of cohesin mutations on HLA-class II expression in the myeloid leukemia of Down syndrome

|
By Austin Boucher, Wojciech Rosikiewicz, Anitria Cotton, Amber L. Broadhurst, Melanie Bremm, Lahiri Konada, Madeline Niederkorn, Josiah Murray, Yichao Li, Shilpa Narina, Sarah Inglott, Anindita Roy, Philip Ancliff, Jing Ma, Michael Walsh, Jeffery M. Klco, Paul Thomas, Yiwen Wang, Aristotelis Tsirigos, Yong Cheng, Beisi Xu, Xiaotu Ma, Soheil Meshinchi, Elvin Wagenblast, Shondra M. Pruett-Miller, Sridhar Rao, Gang Wu, Yunusa Olufadi, Guolian Kang, Zuzana Tothova, Jeffrey Taub, Yubin Ge, Paresh Vyas, Jan-Henning Klusmann, John Crispino, Rishika Vadlamudi, Anna-Lena Schmell, Ricky Tirtakusuma
| Nature Verified
Abstract Children with Down syndrome (DS) frequently develop transient abnormal myelopoiesis that can evolve to the myeloid leukemia of DS (ML-DS). TAM spontaneously resolves in most cases but progresses to ML-DS with additional mutations, most commonly in the cohesin complex. However, the mechanisms by which these alterations promote leukemia are unknown.
Open in Who Shared Issue with article?

Cohesin mutations in acute myeloid leukemia - Leukemia

|
By Josiah Murray, Sridhar Rao
| Nature Verified
Abstract The cohesin complex, encoded by SMC3, SMC1A, RAD21, and STAG2, is a critical regulator of DNA-looping and gene expression. Over a decade has passed since recurrent mutations affecting cohesin subunits were first identified in myeloid malignancies such as Acute Myeloid Leukemia (AML).
Open in Who Shared Issue with article?
See all 2 articles