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Lahiri Konada

As seen in: Nature, Cell Press
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Articles

The effect of cohesin mutations on HLA-class II expression in the myeloid leukemia of Down syndrome

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By Austin Boucher, Wojciech Rosikiewicz, Anitria Cotton, Amber L. Broadhurst, Melanie Bremm, Lahiri Konada, Madeline Niederkorn, Josiah Murray, Yichao Li, Shilpa Narina, Sarah Inglott, Anindita Roy, Philip Ancliff, Jing Ma, Michael Walsh, Jeffery M. Klco, Paul Thomas, Yiwen Wang, Aristotelis Tsirigos, Yong Cheng, Beisi Xu, Xiaotu Ma, Soheil Meshinchi, Elvin Wagenblast, Shondra M. Pruett-Miller, Sridhar Rao, Gang Wu, Yunusa Olufadi, Guolian Kang, Zuzana Tothova, Jeffrey Taub, Yubin Ge, Paresh Vyas, Jan-Henning Klusmann, John Crispino, Rishika Vadlamudi, Anna-Lena Schmell, Ricky Tirtakusuma
| Nature Verified
Abstract Children with Down syndrome (DS) frequently develop transient abnormal myelopoiesis that can evolve to the myeloid leukemia of DS (ML-DS). TAM spontaneously resolves in most cases but progresses to ML-DS with additional mutations, most commonly in the cohesin complex. However, the mechanisms by which these alterations promote leukemia are unknown.
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The heat shock transcription factor, HSF1, stimulates the catalytic engagement of topoisomerase IIβ over topoisomerase IIα

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By Lahiri Konada, Thomas Catley, Lance Heady, Morgan Crewe, Ilse Delint-Ramirez, Laura Wiggins, Sandra Fajardo Briseno, Mohd Younus Bhat, Amir Segev, Alice Pyne, Ram Madabhushi
| Cell Press Verified
ArticleVolume 86, Issue 13p2474-2491.e6Open access Affiliations & Notes 1Departments of Psychiatry, Neuroscience, and Cell Biology, University of Texas Southwestern Medical Center, Dallas, TX, USA 2Peter O’ Donnell Brain Institute, University of Texas Southwestern Medical Center, Dallas, TX 75390, USA 3School of Chemical, Materials and Biological Engineering, University of Sheffield, Sheffield S1 3JD, UK Article Info Publication History: Received August 19, 2024; Revised August 20, 2025;...
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Calcineurin dephosphorylates topoisomerase IIβ and regulates the formation of neuronal-activity-induced DNA breaks

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By Ilse Delint-Ramirez, Lahiri Konada, Lance Heady, Richard Rueda
| Cell Press Verified
Neuronal activity induces topoisomerase IIβ (Top2B) to generate DNA double-strand breaks (DSBs) within the promoters of neuronal early response genes (ERGs) and facilitate their transcription, and yet, the mechanisms that control Top2B-mediated DSB formation are unknown.
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