John Crispino on Muck Rack

John Crispino

As seen in: Blood Cancer Journal, Patient Power, Nature, Wiley Online Library, Cell Press, CURE Magazine
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Articles

RPS19 and RPL5 haploinsufficient models reveal divergent ribosomal subunit controls of fetal hematopoiesis

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By Yuefeng Tang, Rashid Mehmood, Alexis Bertrand, Julien Papoin, Jianing Xu, Vincent P. Schulz, James Palis, Laurie A. Steiner, Betsy J. Barnes, Yong-Rui Zou, Philippe Marambaud, Robert A. J. Signer, Irene Roberts, Leonard I. Zon, Senthil Velan Bhoopalan, Mitchell Weiss, Jeffrey Lipton, PATRICK GALLAGHER, Narla Mohandas, Naomi Taylor Verified, Sébastien Durand, John Crispino, Lionel Blanc, Mushran Khan, Riaz Rao, Deena Iskander
| Nature Verified
Abstract Diamond Blackfan anemia syndrome (DBAS) is a congenital ribosomopathy caused by haploinsufficiency of ribosomal proteins (RPs), but how RP stoichiometry and activity regulates erythroid development remains enigmatic. Using in vivo models, we uncover divergent functions for the small and large ribosomal subunit proteins RPS19 and RPL5 in fetal hematopoiesis.
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Chromothripsis-associated chromosome 21 amplification orchestrates transformation to blast-phase MPN through targetable overexpression of DYRK1A - Nature Genetics

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By Charlotte K Brierley, Max Levine, G. Maria Jakobsdottir, Alex J. Cornish, Antonio Rodriguez-Romera, Matthew Bashton, Sally Clark, Madalina Giurgiu, Emily Hendrix, Shilpa Narina, Shondra M. Pruett-Miller, Amir Enshaei, Claire Harrison, Iléana Antony-Debré, James Davies Verified, Anton G. Henssen, David C. Wedge, Elli Papaemmanuil, Bethan Psaila, John Crispino, Aude Anais Olijnik
| Nature Verified
Abstract Chromothripsis, the chaotic shattering and repair of chromosomes, is common in cancer. Whether chromothripsis generates actionable therapeutic targets remains an open question. In a cohort of 64 patients in blast phase of a myeloproliferative neoplasm (BP-MPN), we describe recurrent amplification of a region of chromosome 21q (‘chr. 21amp’) in 25%, driven by chromothripsis in a third of these cases. We report that chr.
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Generating Off‐the‐Shelf Hematopoietic Stem Cells by “Stretching” Induced Pluripotent Stem Cells

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By John Crispino
| Wiley Online Library Verified
Use the link below to share a full-text version of this article with your friends and colleagues. Learn more. I have read and accept the Wiley Online Library Terms and Conditions of Use I have read and accept the Wiley Online Library Terms and Conditions of Use J.D.C. is an advisor to Alethiomics and receives research funding from Syndax. The other author declares no conflicts of interest. No abstract is available for this article.
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