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ArticleOnline now102324Open access 1Department of Medicine, The University of Chicago, Chicago, IL 60637, USA 2Department of Obstetrics & Gynecology, The University of Chicago, Chicago, IL 60637, USA 3Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA 4Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA 5Health Science, DePaul University, Chicago, IL 60614, USA 6Department of Radiology and Imaging Sciences, Emory University...
Discussion Multiple NY-ESO-1 vaccination approaches have proven effective in their ability to induce integrated humoral and T cell responses, leading to improved survival for a subset of patients with NY-ESO-1-expressing tumors compared with their non-vaccinated counterparts.7 8 26–28 30–32 However, a major limitation of these and other vaccines is ineffective generation of memory T cells and eventual relapse of disease.
Anadon et al. demonstrate that human ovarian cancer-infiltrating T cells exhibiting hallmarks of sustained and active tumor antigen recognition are restricted to ∼13% of CD8+ T cells at tumor beds, corresponding to ∼3% of CD8+ clonotypes. These clonotypes represent TRM lymphocytes with a reservoir that retains features of stemness.
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