Rukang Zhang

Editor’s summary Structured Abstract Abstract Supplementary Materials References and Notes Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Milk is a vital nutrient source for young mammals, containing minerals, proteins, carbohydrates and fats. Fan et al. found that the fatty acid trans-vaccenic acid (TVA) could be augmented in the milk of female mice through diet, resulting in increased TVA levels in offspring.

ArticleOnline now102324Open access 1Department of Medicine, The University of Chicago, Chicago, IL 60637, USA 2Department of Obstetrics & Gynecology, The University of Chicago, Chicago, IL 60637, USA 3Department of Chemistry, The University of Chicago, Chicago, IL 60637, USA 4Pritzker School of Molecular Engineering, The University of Chicago, Chicago, IL 60637, USA 5Health Science, DePaul University, Chicago, IL 60614, USA 6Department of Radiology and Imaging Sciences, Emory University...

Highlights • Tyrosine phosphorylation of IDH1 is commonly required for reductive carboxylation • Reductive carboxylation attenuates SHP-2 to activate IDH1 • Reductive carboxylation elevates cytosolic ROS to inhibit SHP-2 • Diverse signals converge at the NOX2-SHP-2 axis to induce reductive carboxylation Summary Environmental stresses, including hypoxia or detachment for anchorage independence, or attenuation of mitochondrial respiration through inhibition of electron transport chain induce...