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ArticleOnline now102988Open access Affiliations & Notes 1Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, 10065, United States of America 2Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia 3Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland 4Bioinformatics Resource Center, The Rockefeller University, New York, NY, 10065, United States of America 5Weill Cornell Medical...
Keywords proximity labeling TurboID obesity inflammation ER proteomics plasma proteomics Research topic(s) CP: metabolism Introduction In multicellular organisms, the maintenance of energy homeostasis requires the orchestration of metabolic processes across and between numerous cell types and tissues.
Abstract Uncovering the role of upstream open reading frames (uORFs) challenges conventional views of one protein per messenger RNA and reveals the capacity of some uORFs to encode microproteins that contribute to cellular biology and physiology. This study explores the functional role of a recently identified mitochondrial microprotein, SLC35A4-MP, in the brown adipose tissue of mice.
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