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ArticleOnline now102988Open access Affiliations & Notes 1Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, 10065, United States of America 2Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia 3Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland 4Bioinformatics Resource Center, The Rockefeller University, New York, NY, 10065, United States of America 5Weill Cornell Medical...
Keywords proximity labeling TurboID obesity inflammation ER proteomics plasma proteomics Research topic(s) CP: metabolism Introduction In multicellular organisms, the maintenance of energy homeostasis requires the orchestration of metabolic processes across and between numerous cell types and tissues.
Abstract Obesity emerges from a complex interplay of factors, including imbalanced interoception, genetic predisposition, and environmental cues, which ultimately disrupt body weight homeostasis1. While much research has concentrated on strategies to suppress appetite for sustained weight loss, insufficient attention has been given to counterregulatory mechanisms that promote energy expenditure.
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