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Douglas Barrows

As seen in: Nature, PNAS, BioRxiv, Cell Stem Cell, Cell Press, Cell Reports Medicine, Texas Medical Center, The Journal of Biological Chemistry
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Articles

Exercise intensity modulates interorgan communication and is associated with cardiometabolic health outcomes in humans

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By Luke Olsen, Javier Botella, Douglas Barrows, Ethan Romero, Mutsumi Katayama, Ece Kilic, Christopher Peralta, Nadège Zanou, Henry Sanford, Laurie Ann Farrell, Christopher L. Axelrod, Kaja Plucinska, Jeanne M. Walker, Lu Yan, Katie Fredrickson, Olivier Pourquie, Jeremy Robbins, Ekaterina V. Vinogradova, Henrik Molina, Nicolas Place, John Kirwan Verified, Juleen R. Zierath, Anna Krook, Robert Gerszten, David Bishop, Paul Cohen, Kaitlyn Baird
| Cell Reports Medicine Verified
ArticleOnline now102988Open access Affiliations & Notes 1Laboratory of Molecular Metabolism, The Rockefeller University, New York, NY, 10065, United States of America 2Institute for Health and Sport, Victoria University, Melbourne, VIC, Australia 3Institute of Sport Sciences and Department of Biomedical Sciences, University of Lausanne, Lausanne, Switzerland 4Bioinformatics Resource Center, The Rockefeller University, New York, NY, 10065, United States of America 5Weill Cornell Medical...
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Molecular mechanisms of the MLL4 complex in H3K4 methylation and p53-dependent transcription activation

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By Jianfeng Sun, Zhiying Zhang, You Yu, Nicole Cruz, Sicong Zhang, Yufei Xiang, Keiichi Ito, Cole Lazarus, Zhanyun Tang, Buren Li, Douglas Barrows, Tom W. Muir, Yi Shi, Dina Schneidman-Duhovny, Shu-Ping Wang, Linas Urnavicius, Dinshaw J. Patel, Robert G. Roeder
| Cell Press Verified
Keywords MLL4 p53 H3K4 methylation transcriptional regulation nucleosome binding coactivator synergy epigenetic crosstalk Introduction Histone H3K4 methylation is a highly conserved post-translational modification intricately linked to transcription activation in eukaryotic cells.
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The conserved N-terminal SANT1-binding domain (SBD) of EZH2 Regulates PRC2 Activity

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By Yadira M Soto-Feliciano, Douglas Barrows, Laiba Khan, Agata Lemiesz Patriotis
| BioRxiv
Abstract Polycomb group proteins maintain gene expression patterns established during early development, with Polycomb Repressive Complex 2 (PRC2) methyltransferase a key regulator of cell differentiation, identity and plasticity. Consequently, extensive somatic mutations in PRC2, including gain- or loss- of function (GOF or LOF), are observed in human cancers.
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