Kun Zhou
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Articles by Kun Zhou
Kirigami-Inspired Deployable Microneedle Robot With Enhanced Conformability for Targeted Oral Drug Delivery
1 Introduction Oral drug delivery offers a multitude of benefits including safety [1-4], non-invasiveness [5], convenience [6], cost-effectiveness [7], and accessibility [5, 8-10]. Of the various organs in the gastrointestinal (GI) tract, the small intestine is the principal site for drug absorption due to the higher permeability of its membrane [11, 12].
Professional competence development in the context of clinical uncertainty: a qualitative exploration of infection prevention and control nurses at a tertiary hospital in China
Abstract Background: Infection prevention and control nurses (IPCNs) are critical to preventing and controlling of healthcare-associated infections (HAIs), supporting patient safety, and responding to public health disasters.
Ionic gel-mediated synthesis of nanostructured chiral 2D halide perovskites with amplified chiroptical response
Abstract Chiroptical properties in metal halide perovskites typically arise from asymmetric crystal structures induced by chiral organic molecules during synthesis or chiral additives. However, the synthesis of two-dimensional chiral halide perovskites with sufficiently high dissymmetry factors for practical applications remains challenging.
Additive Manufacturing of Ordered Polymer Nanostructures (Adv. Mater. 47/2026)
How to cite Wu, D., Zhou, K., Lee, K., Xiu, Y., Yan, C.H.W., Lim, K.S. and Boyer, C. (2026), Additive Manufacturing of Ordered Polymer Nanostructures (Adv. Mater. 47/2026). Adv. Mater., 38: e74648. https://doi.org/10.1002/adma.74648 How to cite text copied to clipboard! COPY TEXT Download Citation If you have the appropriate software installed, you can download article citation data to the citation manager of your choice. Simply select your manager software from the list below and click on download.
Radiological and pathological integration predicts the efficacy of bevacizumab with chemotherapy in colorectal cancer liver metastases
Abstract The differential response of patients with unresectable colorectal cancer liver metastases to bevacizumab plus chemotherapy highlights the urgent need for high-specificity predictive biomarkers. Recent studies suggest that pretreatment contrast-enhanced abdominal CT can noninvasively predict subtypes of liver metastases resistant to bevacizumab-based combination therapy.
Shape-Complementary DNA Scaffold for Programmable Functionalization of Symmetric Protein Assemblies
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that supports the findings of this study are available in the Supporting Information of this article. Supporting Information Filename Description anie73989-sup-0001-SuppMat.pdf24.8 MB Supporting File: anie73989-sup-0001-SuppMat.pdf. References 1, , , and , “Assembly Reflects Evolution of Protein Complexes,” Nature 453 (2008): 1262–1265, https://doi.org/10.1038/nature06942.
Comparison of Point Spread Function Encoding EPI DWI and Turbo Gradient Spin Echo BLADE DWI for Imaging Intracranial Tumors
Abbreviations PSF (Point Spread Function) EPI (Echo Planar Imaging) TGSE (Turbo Gradient Spin Echo) PROPELLER (Periodically Rotated Overlapping ParallEL Lines with Enhanced Reconstruction) DWI (Diffusion-Weighted Imaging) ADC (Apparent Diffusion Coefficient) SNR (Signal-to-Noise Ratio) CNR (Contrast-to-Noise Ratio) ss-EPI (Single-Shot Echo-Planar Imaging) SENSE (SENSitivity Encoding) GRAPPA (Generalized Autocalibrating Partially Parallel Acquisitions) RESOLVE (Readout-Segmented Echo-Planar...
Publisher Correction: Multi-ancestry genome-wide association analyses of refractive error augment genetic discovery and polygenic prediction
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Correction to: Nature Genetics https://doi.org/10.1038/s41588-026-02576-0, published online 20 April 2026. In the version of the article initially published, the 23andMe Research Team was missing from the online author list. The HTML version of the article has now been amended.
By Fei-Fei Cheng, Xiaoxi Liu, Lizhong Wang, Ruilei Ma, Yazhou Guo, Julia Sidorenko, Chen Jiang, Tania Islam, Akira Meguro, Keiko Hikino, Yuki Ishikawa, Senwei Tang, Ruoyan Chen, Likun Wang, Reedik Mägi, Andres Metspalu, Masaki Takeuchi, Nobuhisa Mizuki, Hélène Choquet, Zi-Bing Jin, Gang Chen, Kun Zhou, Chikashi Terao, Jian Zeng, Jian Yang
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Nature
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Additive Manufacturing of Ordered Polymer Nanostructures
1 Introduction Natural materials exhibit extraordinary properties through hierarchical organization, where nanoscale order is seamlessly integrated into macroscopic architectures. This multilevel sophistication is exemplified by the periodic brick-and-mortar structure of nacre, which imparts exceptional fracture toughness, the vivid structural coloration of butterfly wings, and the extraordinary toughness of spider silk [1].
Multi-task deep learning assists detection and diagnosis of gliomas and brain metastases
Abstract Gliomas and brain metastases (BMs) on MRI pose significant diagnostic challenges for radiologists. This study aims to develop a multi-task model and a computer-aided diagnosis (CAD) system for the detection and diagnosis of gliomas and BMs. This study enrolled 3909 participants from seven centers, and developed a brain tumor segmentation and classification network (BTSC-Net) and BTSC-CAD with visualization of tumor masks.
Hairpin-Mediated TMSDR-CHA Signal Conversion for Highly Specific Single-Base Discrimination of EGFR L858R Mutation Click to copy article link Article link copied!
Cite Jump to ExpandCollapse ArticleMay 15, 2026 Hairpin-Mediated TMSDR-CHA Signal Conversion for Highly Specific Single-Base Discrimination of EGFR L858R Mutation Click to copy article linkArticle link copied! Qingfeng Gao Qingfeng Gao Key Laboratory of Clinical Laboratory Diagnostics (Chinese Ministry of Education), College of Laboratory Medicine, Chongqing Medical Laboratory Microfluidics and SPRi Engineering Research Center, Chongqing Medical University, Chongqing 400016, China Department...
Parous female donor confers superior relapse protection in Haplo-PBSCT: A multicenter study of ATG/PTCy combination-based GVHD prophylaxis in AML/MDS
Haploidentical donor (HID) has been increasingly considered due to the efficacy of graft-versus-host disease (GVHD) prevention with post-transplantation cyclophosphamide (PTCy) or anti-thymocyte globulin (ATG) alone-based regimen [1, 2]. Young male donor ( < 30 years) was preferably chosen due to superior survival and lower non-relapse mortality (NRM) [3], while parous female donor was considered suboptimal due to increasing GVHD risk [3, 4].
Multi-ancestry genome-wide association analyses of refractive error augment genetic discovery and polygenic prediction
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Abstract Refractive errors (REs) affect over half of the global population, with consequences ranging from blurred vision to blindness. Here we conducted ancestry-stratified and cross-ancestry meta-analyses of genome-wide association studies for RE in people of European (n = 1,495,159), East Asian (n = 121,172) and African (n = 144,737) ancestries.
By Fei-Fei Cheng, Xiaoxi Liu, Lizhong Wang, Ruilei Ma, Yazhou Guo, Julia Sidorenko, Chen Jiang, Tania Islam, Akira Meguro, Keiko Hikino, Yuki Ishikawa, Senwei Tang, Likun Wang, Reedik Mägi, Andres Metspalu, Masaki Takeuchi, Nobuhisa Mizuki, Hélène Choquet, Zi-Bing Jin, Gang Chen, Kun Zhou, Chikashi Terao, Jian Zeng, Jian Yang, Ruoyan Chen
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Nature
Verified
Deployable 3D-Printed Vascular Stent with Surface-Catalysed Endogenous Nitric Oxide Generation
1 Introduction Cardiovascular diseases are the leading cause of death worldwide, accounting for 19.8 million deaths—about 32% of all global deaths in 2022 [1]. Atherosclerosis, the underlying cause of many cardiovascular conditions, triggers heart attacks and strokes by obstructing blood vessels [2]. This blockage results from the progressive accumulation of lipids and platelets [3] on vessel walls [4], leading to thickening, narrowing, and restricted blood flow [5, 6].
Lymphocyte subset reconstitution and clinical outcomes following haploidentical hematopoietic stem cell transplantation - British Journal of Cancer
Abstract Immune reconstitution is critical for outcomes after allogeneic hematopoietic stem cell transplantation (allo-HSCT), but its prognostic role in haploidentical peripheral blood stem cell transplantation (haplo-PBSCT) remains unclear. We retrospectively analysed 577 patients who underwent T-cell replete haplo-PBSCT between 2016 and 2024.
Expanding DNA alphabet adds a previously unknown dimension to nanostructures
Abstract DNA nanotechnology has created nanostructures with astonishing complexity. However, with nanostructures becoming increasingly larger and more intricate, they have become more difficult to obtain in high yields and quality. Expanding the alphabet beyond the canonical base pairs can therefore be the key to push the technology to the next level.
Constructing and validating a prognostic prediction nomogram model for hepatocellular carcinoma patients following high-intensity focused ultrasound treatment
Abstract Objective: To develop and validate a nomogram model based on biological information and conventional imaging indicators for predicting overall survival (OS) in patients with hepatocellular carcinoma (HCC) following high-intensity focused ultrasound (HIFU) treatment. Methods: This retrospective study included 407 patients with HCC who received HIFU treatment at the Second Affiliated Hospital of Chongqing Medical University between January 1, 2013, and June 30, 2024.
DNA nanodevice for analysis of force-activated protein extension and interactions - Nature Nanotechnology
Abstract Force-induced changes in protein structure and function mediate cellular responses to mechanical stresses that are important in human development, physiology and diseases. However, existing methods to study proteins under mechanical force are generally single-molecule techniques unsuitable for biochemical and structural analysis.
SMF‐DETR: An Efficient Lightweight Detection Transformer for Real‐Time Bearing Surface Defect Detection
Conflicts of Interest The authors state no conflict of interest. Data Availability Statement The datasets generated during and/or analyzed during the current study are not publicly available but are available from the corresponding author upon reasonable request.
Surface Passivation of Cs2AgI3:Cu with AgI for High‐Performance X‐Ray Imaging Scintillators
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm71871-sup-0001-SuppMat.docx3.7 MB Supporting Information References 1, , , , ACS Energy Lett. 2021, 6, 739. 2, , , , , Adv. Sci. 2023, 10, 2205536. 3, , , , Nano-Micro Lett. 2023, 15, 128. 4, , , , , Angew. Chem., Int. Ed. 2023, 62, 202304638. 5, , , , , , , , , , IEEE Trans. Nucl. Sci. 2023, 70, 1244. 6, , , ACS Nano 2024, 18, 14029. 7, , , , , Nanoscale 2023, 15, 13628.
Formal C─H Functionalization of Quinolines at the C7 Position Through a Traceless Directing Strategy
Conflict of Interests The authors declare no conflict of interest. Supporting Information Filename Description anie202514319-sup-0001-SuppMat.docx22.5 MB Supporting Information References 1, , , , , , , Nat. Chem. 2018, 10, 383–394. 2, , , ACS Cent. Sci. 2021, 7, 245–261. 3, , , Angew. Chem., Int. Ed. 2021, 60, 15767–15790. 4, , , , , , , , , , , , , , , Nat. Rev. Methods Primers 2021, 1, 43. 5, , , , , , , , Chem. Soc. Rev. 2023, 52, 7461–7503. 6, , , Surf. Interfaces 2020, 21, 100634. 7, , , , Med. Chem.
Efficacy and safety of high-intensity focused ultrasound ablation under general anesthesia in older hepatocellular carcinoma patients
1 Introduction Primary liver cancer is one of the most common malignant tumors in the world and represents a significant public health challenge. Hepatocellular carcinoma (HCC), the most common subtype in primary liver cancer, accounts for 75%–85% (1). In recent years, the incidence of HCC has been steadily increasing among older patients (2).
Associations of maternal dietary iron intake during pregnancy with infant neurodevelopment: evidence from a prospective cohort study - Nutrition Journal
We conducted this study within the Jiangsu Birth Cohort (JBC) Study, which is a prospective and longitudinal study recruiting families who received assisted reproductive technology (ART) treatment and those with spontaneous pregnancies (SP). Detailed cohort design and data collection have been previously described [14].
Construction of a preoperative prehabilitation program for elderly esophageal cancer patients
ORIGINAL RESEARCH article Volume 15 - 2025 | https://doi.org/10.3389/fonc.2025.1694667 1 Introduction The Global Cancer Epidemiology Report (2024) indicates that in 2022, both the incidence and mortality rates of esophageal cancer in China ranked among the highest worldwide (1), with elderly patients accounting for over 70% of cases (2), imposing substantial medical and economic burdens on society and families.
C-H Functionalisation of [2.2]Paracyclophane under Copper catalysis
C-H Functionalisation of [2.2]Paracyclophane under Copper catalysis The direct C-H functionalisation of [2.2]paracyclophane (PCP) by forging diverse C-C bonds is appealing, yet has remained underexplored. Herein, we describe a copper-catalysed non-directed C–H arylation and alkenylation of PCP with various iodonium salts. This method features high selectivity, broad substrate scope, and mild conditions, constituting a practical platform for the modular access to PCP derivatives.
Piezoelectric Biomaterials for Bone Regeneration: Roadmap from Dipole to Osteogenesis
1 Introduction Bone is a remarkable tissue responsible for various bodily functions, including the production of red and white blood cells, the protection of internal organs, and enabling locomotion. The tissue undergoes different stages during its lifespan, including bone development, bone remodelling, and fracture-healing in response to non-critical injuries. Molecular and cellular events are crucial to facilitate normal tissue function.
Exploiting third-generation radiative cooling for energy applications
Keywords radiative cooling energy harvesting energy consumption Kirchhoff’s radiation law radiation reciprocity Introduction Radiative cooling is a ubiquitous process by which an object loses heat to cool itself by spontaneously emitting infrared thermal radiation.
4D printing of multiscale filler-reinforced thermoplastic polyurethane nanocomposites with electro-activated shape memory properties
?Mathematical formulae have been encoded as MathML and are displayed in this HTML version using MathJax in order to improve their display. Uncheck the box to turn MathJax off. This feature requires Javascript. Click on a formula to zoom. ABSTRACT Four-dimensional printing of shape memory materials has been developed to dynamically control the shapes of printed structures for applications such as self-deployable structures, actuators, and sensors.
Grain Boundary Guided Folding of Graphene for Twisted Bilayer Graphene
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Automated Fast Prediction of Bone Mineral Density From Low-dose Computed Tomography
Abbreviations BMD (Volumetric bone mineral density) OP (Osteoporosis) OA (Osteopenia) QCT (Quantitative Computed Tomography) LDCT (Low-dose CT) WHO (World Health Organization) CNN (Convolutional neural network) ROI (Regions of interest) PACS (Picture Archiving and Communication System) ACR (American College of Radiology) ISCD (International Society for Clinical Densitometry) DSC (Dice similarity coefficient) PPV (Positive predictive value) HD (Hausdorff distance) MSE (Mean squared error) R2...
Efficient Separation and Enrichment of Rubidium in Salt Lake Brine Using High-Performance PAN-KCuFC-PEG Adsorption Composite
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by Linhong Wu , Kun Zhou *, Yuchen Zheng , Ying Zeng , Guangyong Zeng , Ziyi Cheng and Yang Peng School of Materials and Chemistry & Chemical Engineering, Chengdu University of Technology, Chengdu 610059, China * Author to whom correspondence should be addressed.
Potential Therapeutic Targets of PANoptosis for Myocardial Infarction: A Summary-Data-Based Mendelian Randomization Study Integrating eQTL, mQTL, and Multi-GWAS Data
Acute myocardial infarction (MI), a critical and dangerous manifestation of coronary heart disease resulting from arterial or bypass graft thrombosis, rapidly induces myocardial ischemia and hypoxia, and culminates in cardiac failure [1]. PANoptosis, an inflammasome-dependent, inflammatory form of programmed cell death [2], involves a complex molecular network in which pyroptosis, apoptosis, and necroptosis mediate apoptotic programs in an interconnected manner.
Intratumoral and peritumoral PET/CT-based radiomics for non-invasively and dynamically predicting immunotherapy response in NSCLC - British Journal of Cancer
Abstract We aimed to develop a machine learning model based on intratumoral and peritumoral 18F-FDG PET/CT radiomics to non-invasively and dynamically predict the response to immunotherapy in non-small cell lung cancer (NSCLC). This retrospective study included 296 NSCLC patients, including a training cohort (N = 183), a testing cohort (N = 78), and a TCIA radiogenomic cohort (N = 35). The extreme gradient boosting algorithm was employed to develop the radiomic models.
Intratumoral and peritumoral PET/CT-based radiomics for non-invasively and dynamically predicting immunotherapy response in NSCLC
15 hours ago A mom was told she had a stomach bug — but a scary episode of vomiting a “cigarette tar”-like substance led to a cancer diagnosis, sepsis, and emergency surgery. Chloe Wakelin was 25 when she began experiencing stomach flu-like symptoms in 2023 — but as a daycare worker and the mom of a 6-year-old, …
Strength Analysis and Design of a Multi-Bridge V-Shaped Rotor for High-Speed Interior Permanent Magnet Synchronous Motors
1. Introduction In recent years, the rapid development of the new energy vehicle industry has made high-speed operation a key technical pathway for improving power density and achieving lightweight designs in electric drive systems. This trend has become a major focus in the advancement of drive motors [1,2]. Compared to surface-mounted permanent magnet synchronous motors, interior permanent magnet synchronous motors (IPMSMs) are gaining widespread attention in new energy vehicles.
[2501.15401] Splitting Property of quasitriangular Hopf algebras
arXiv:2501.15401 (math) View PDF HTML (experimental) Subjects: Quantum Algebra (math.QA); Representation Theory (math.RT) Cite as: arXiv:2501.15401 [math.QA] (or arXiv:2501.15401v1 [math.QA] for this version) https://doi.org/10.48550/arXiv.2501.15401 Submission history From: Kun Zhou [ view email] [v1] Sun, 26 Jan 2025 04:45:33 UTC (23 KB) Bibliographic Tools Bibliographic Explorer Toggle Bibliographic Explorer () Connected Papers Toggle Connected Papers (What is Connected Papers?) Litmaps...
Synergistic stabilization of perovskite quantum dots via in situ encapsulation in a thiomethyl-functionalized covalent organic framework
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Keywords halide perovskite stability covalent organic frame structure composite Introduction Methylammonium lead halide (MAPbX3, MA = CH3NH3+, X = Br, Cl, and I) quantum dots (QDs) are excellent optoelectronic materials that have attracted interest for use in high-efficiency solar cells,1,2,3,4,5,6 light-emitting diodes,7,8,9,10 lasers,11,12,13 photodetectors, X-imaging scintillators,14,15,16 and catalysis.17,18 However, MAPbX3 QDs suffer from extremely poor environmental stabilities, making...
By Yuting Xie, Hongyan Zhang, Partha Maity, Jinchen Qian, Gaopeng Xu, Hao Wang, Ting Chen, Kun Zhou, Hanlin Hu, Qingquan He, Jing Li, Yongwu Peng, Omar Mohammed Verified, Jun Pan
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Cell Reports Physical Science
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MOF‐derived Carbon‐Based Materials for Energy‐Related Applications
Conflict of Interest The authors declare no conflict of interest. References 1, , , Nat. Mater. 2017, 16, 16. 2, Science 2017, 355, 126. 3, , , , , , Science 2017, 355, eaad4998. 4, , , , , , Chem. Rev. 2016, 116, 9438. 5, , , , Chem. Eng. J. 2022, 440, 135459. 6, , Nano Energy 2024, 124, 109430. 7, , , , , , , Energy Storage Mater. 2024, 70, 103456. 8, , , , , , , , , , , , , , , Nat. Energy 2023, 8, 1199. 9, , , , , , , , , , , Energ. Environ. Sci. 2021, 14, 1854. 10, , , , Nat. Rev. Mater. 2022, 7, 870.
Effect of task interruption on the situation awareness of air traffic controllers
Loading metrics Open Access Peer-reviewed Research Article Citation: Zhou K, Wang C, Xie S, Zhou Y, Zhang X, Wang Y, et al. (2024) Effect of task interruption on the situation awareness of air traffic controllers. PLoS ONE 19(11): e0314183.
V- and VL-Scores Uncover Viral Signatures and Origins of Protein Families
Abstract Viruses are key drivers of microbial diversity, nutrient cycling, and co-evolution in ecosystems, yet their study is hindered due to challenges in culturing. Traditional gene-centric methods, which focus on a few hallmark genes like for capsids, miss much of the viral genome, leaving key viral proteins and functions undiscovered.
DNA nanodevice for analysis of force-activated protein extension and interactions
Abstract Force-induced changes in protein structure and function mediate cellular responses to mechanical stresses. Existing methods to study protein conformation under mechanical force are incompatible with biochemical and structural analysis. Taking advantage of DNA nanotechnology, including the well-defined geometry of DNA origami and programmable mechanics of DNA hairpins, we built a DNA nanodevice to apply controlled forces to proteins.
In Situ Self‐Assembly of Antibody‐Rhamnose Complex as a Pre‐Targeting Strategy for Enhanced Cancer Immunotherapy
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
The joint effect of cumulative metabolic parameters on the risk of type 2 diabetes: a population-based cohort study - Nutrition & Metabolism
The data of our study was extracted from basic public health services in Nanchang, which are provided by the government to all residents free of charge. This project was mainly targeted at children, pregnant and postpartum women, the elderly, and patients with chronic diseases. In our study, we extracted data from individuals aged 45 and older who underwent annual health examinations between 2021 and 2023.
Interface Fatigue Test of Hybrid-Bonded Fiber-Reinforced Plastic-Reinforced Concrete Specimen
1. Introduction FRP (fiber-reinforced plastic), with its lightweight, high-strength, corrosion-resistant properties, is widely used in the repair and reinforcement of railroad bridges. These structures that have been damaged require reinforcement to increase the capacity of the member beams and slabs. Additionally, these structures must be sufficiently durable to prevent fatigue failure of the members.
Ion Site Substitution in a Sulfonylcalix[4]arene-Supported Ln8 (Ln = Tb and Eu) Coordination Wheel with Tunable Luminescence
Crystal Growth & Design Cite this: Cryst. Growth Des. 2024, XXXX, XXX Click to copy citationCitation copied! Learn about these metrics Article Views are the COUNTER-compliant sum of full text article downloads since November 2008 (both PDF and HTML) across all institutions and individuals. These metrics are regularly updated to reflect usage leading up to the last few days. Citations are the number of other articles citing this article, calculated by Crossref and updated daily.
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