Lan Hu
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Articles by Lan Hu
Repurposing Cas12a2-mediated abortive infection for efficient and low-toxicity microbial genome editing
Abstract CRISPR-Cas systems have revolutionized microbial genome engineering, yet counter-selection strategies typically rely on targeted DNA cleavage, where the severe cytotoxicity of double-strand breaks restricts transformation efficiency and clonal recovery. Here, we present an innovative strategy, SuCas12a2-Universal Recombination Editing (SURE), that circumvents these limitations by repurposing the RNA-targeting CRISPR-Cas12a2 system.
Individual and joint associations of physical activity and sleep duration with cognitive function in a Chinese nationwide cohort
Abstract Despite growing evidence linking sleep duration and physical activity (PA) to cognitive performance, their interactive effects remain understudied. This study aimed to investigate the individual and joint associations of sleep duration and PA with cognitive function in a Chinese nationwide cohort of mid-to-older-aged population.
Multiscale organization of momentum-flux transport in the unstable atmospheric surface layer
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CPSF2-mediated 3’ UTR truncation of MTERF3 drives mitochondrial dysfunction and osteosarcoma progression
Abstract Alternative polyadenylation (APA), an important post-transcriptional regulatory mechanism, is aberrantly activated in cancer, but how APA functions in tumorigenesis remains elusive. We analyzed APA events in osteosarcoma (OS) tissues and identified 3′ UTR alterations associated with both OS patient prognosis and gene expression changes involving loss of tumor-suppressive miRNA binding sites.
Computer Science > Computation and Language
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Aún con la marea alta, cruzamos juntos cordilleras y océanos: la nueva coordenada del desarrollo de China
Hoy en día, la economía global atraviesa una recuperación compleja, marcada por la aparición continua de tensiones geopolíticas y el recrudecimiento del unilateralismo y el proteccionismo. Frente a esta realidad, los países unen voluntades y terminan «coincidiendo entre sí» en la necesidad de garantizar un crecimiento seguro y explorar nuevas vías de desarrollo.
CoDES: A Context-Efficient Framework for Enhancing Small Language Models via Domain-Specific Adaptation and Model Ensembling
You are already at the latest version Efficiently adapting large language models (LLMs) to specialized domains remains challenging due to substantial computational and memory requirements. In this work, we introduce CoDES (Context-efficient Domain Ensemble System), a framework designed to enhance small language models through context-efficient domain adaptation and weighted parameter ensembling.
Access to Axially Chiral Vinyl Sulfilimines via Copper‐Catalyzed Enantioselective Radical Relay Trifluoromethyl‐Sulfilimination of Terminal Alkynes
Conflict of Interests The authors declare no conflict of interest. Data Availability Statement All data supporting the findings of this study, including experimental procedures and compound characterization, NMR, HPLC, and X-ray analyses, are available in the Supporting Information. The crystallographic data used in this study are available in the Cambridge Crystallographic Database under accession codes CCDC 2495322 (4j) and CCDC 2508120 (6q).
Integrative analysis of pathogen detection, antimicrobial resistance, virulence, and host response in severe infections using metagenomic next-generation sequencing
Abstract Background: Metagenomic next-generation sequencing (mNGS) offers unbiased pathogen detection. However, its integrative value in simultaneously revealing resistance, virulence, and host-response interplay in Intensive Care Unit(ICU)-infected patients remains underexplored. Methods: In this retrospective cohort study of 156 ICU-infected patients, we compared the diagnostic performance of mNGS against conventional microbiological testing (CMT).
Del XIV Plan Quinquenal al XV: El Desarrollo de China Beneficia al Mundo
El término del “plan quinquenal” se originó en la década de 1920. Después de la Segunda Guerra Mundial, muchos países en desarrollo lo tomaron como una medida para impulsar la industrialización. Desde el I Plan Quinquenal iniciado en 1953, China ha formulado e implementado de manera continua 14 planes quinquenales, logrando un progreso integral en solo unas décadas.
Frontiers | Structural-functional connectivity decoupling reveals neural differences associated with subtypes of nonsuicidal self-injury among female depressive adolescents
Abstract Background: Nonsuicidal self-injury (NSSI) is a complex behavior prevalent among adolescents, particularly females and those with depression. The DSM-5 introduced recommended diagnostic criteria for NSSI, yet many adolescents engaging in NSSI do not meet these standards. The neurobiological distinctions between adolescents with NSSI who fulfill the DSM-5 criteria (NSSI+) and those who do not (NSSI-) remain unclear.
Recordando la historia, creando juntos un Futuro Mejor
LAN HU | EMBAJADOR DE CHINA EN VENEZUELA Este año es el 80º aniversario de la victoria en la Guerra de Resistencia del Pueblo Chino contra la Agresión Japonesa y la Guerra Antifascista Mundial. China organizará una serie de eventos para conmemorar solemnemente esta gran victoria. Ante el mundo cambiante y turbulento, China siempre ha mantenido el espíritu de recordar la historia, honrar a los héroes caídos, atesorar la paz y crear un futuro mejor.
Recordando la historia, creando juntos un Futuro Mejor
Este año es el 80º aniversario de la victoria en la Guerra de Resistencia del Pueblo Chino contra la Agresión Japonesa y la Guerra Antifascista Mundial. China organizará una serie de eventos para conmemorar solemnemente esta gran victoria. Ante el mundo cambiante y turbulento, China siempre ha mantenido el espíritu de recordar la historia, honrar a los héroes caídos, atesorar la paz y crear un futuro mejor.
Biomolecular phase separation in tumorigenesis: from aberrant condensates to therapeutic vulnerabilities - Molecular Cancer
Biomolecular phase separation regulates the stability and expression levels of proliferation-associated molecules, influencing tumor cell proliferation (Fig. 4). For example, in breast cancer cells, lncRNA CD2BP2-DT promotes YBX1 LLPS, forming protective condensates. These condensates enhance the stability of CDK1 mRNA, which encodes a cyclin-dependent kinase critical for cell cycle progression, promoting cell proliferation [173].
An ovary-targeted nucleic acid delivery system, OT-NADPS, efficiently mediates the generation of transgenic silkworms
Introduction Transgenic and gene editing technologies are essential in biological research. Evolving from gene microinjection to precise tools like clustered regularly interspaced short palindromic repeats (CRISPR) / CRISPR-associated protein 9 (Cas9), they enable targeted genome modifications for applications in medicine, agriculture, gene therapy, transgenic plants, and livestock (Shaukat, 2022; Wang & Doudna, 2023), as well as scalable design for cell-based therapies (Peterman et al., 2024).
An ovary‐targeted nucleic acid delivery system, OT‐NADPS, efficiently mediates the generation of transgenic silkworms
Supporting Information Filename Description ins70132-sup-0001-FigureS1.tif12.4 MB Fig. S1 Prokaryotic expression and purification of OT-NADP. ins70132-sup-0002-FigureS2.tif592.8 KB Fig. S2 The impact of various factors on the nucleic acid loading of OT-NADPS. ins70132-sup-0003-FigureS3.tif3.5 MB Fig. S3 OT-NADP demonstrates efficient nucleic acid loading capability. ins70132-sup-0004-FigureS4.tif6.9 MB Fig. S4 Analysis of P2C ovary-targeting and OT-NADPS dose-dependent delivery efficiency.
China y Venezuela: Cincuenta y un años de avances y logros, escribiendo capítulos nuevos
El 28 de junio de 1974, China y Venezuela establecieron relaciones diplomáticas. Durante 51 años, especialmente desde el siglo XXI, hemos compartido muchas vicisitudes, forjando una amistad inquebrantable en medio de los cambios internacionales. En 2023, el presidente Xi Jinping y el presidente Nicolás Maduro anunciaron conjuntamente la elevación de las relaciones a la Asociación Estratégica a Toda Prueba y Todo Tiempo, escribiendo un nuevo capítulo en las relaciones bilaterales.
Barriers to the prevention of insulin injection-associated lipohypertr
Saiyu Gao,1– 3 Pan Su,3,4 Hongxia Zhuo,5 Lan Hu,1– 3 Yun Peng,1– 3,* Liaofang Wu3,6,* 1Department of Geriatrics, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People’s Republic of China; 2National Clinical Research Center for Geriatric Disorders, Xiangya Hospital, Central South University, Changsha, Hunan, 410008, People’s Republic of China; 3Teaching and Research Section of Clinical Nursing, Xiangya Hospital of Central South University, Changsha, Hunan, 410008,...
Sobrepasando viento y lluvia, creciendo hacia el sol
En el año 2015, el Presidente Xi Jinping y los líderes de América Latina y el Caribe (ALC) declararon conjuntamente el lanzamiento del Foro China-CELAC (FCC), abogando por construir la comunidad de futuro compartido China-ALC. A lo largo de estos diez años, gracias a los esmerados esfuerzos de China y ALC, el FCC ha pasado de un plantón tierno a un árbol erguido.
Rapid Synthesis of Honeycomb-Structured FeP2@NHC for High-Rate and Durable Lithium Storage
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La coerción comercial unilateral de EEUU fracasará
La Administración estadounidense firmó el 1 de febrero una orden ejecutiva que establece un arancel del 10% sobre productos chinos, en respuesta a preocupaciones sobre el “aprovisionamiento y la distribución de fentanilo ilegal en EEUU”. Sin embargo, esta medida podría distorsionar el mercado, sin favorecer la prosperidad de las industrias locales. En última instancia, las empresas y consumidores estadounidenses podrían verse afectados negativamente por esta decisión, un tiro al pie.
US unilateral trade coercion will fail
The US administration signed an executive order on February 1 imposing a 10% tariff on Chinese products, in response to concerns about the “supply and distribution of illegal fentanyl in the US.” However, this measure could distort the market, without favoring the prosperity of local industries. Ultimately, American businesses and consumers could be negatively affected by this decision, a shot in the foot.
Activity dependent Clustering of Neuronal L-Type Calcium Channels by CaMKII
Abstract Neuronal excitation-transcription (E-T) coupling pathways can be initiated by local increases of Ca2+ concentrations within a nanodomain close to the L-type voltage-gated Ca2+ channel (LTCC). However, molecular mechanisms controlling LTCC organization within the plasma membrane that help creation these localized signaling domains remain poorly characterized. Here, we report that neuronal depolarization increases CaV1.3 LTCC clustering in cultured hippocampal neurons.
Evaluation of Nucleated Red Blood Cells in Peripheral Blood Increases the Predictive Value of Pediatric Critical Illness Score in Infants With Severe Pneumonia at 28 Days
References 1, , , et al., “National and Subnational All-Cause and Cause-Specific Child Mortality in China, 1996–2015: A Systematic Analysis With Implications for the Sustainable Development Goals,” Lancet Global Health 5, no. 2 (2017): e186–e197. 2, , , et al, “Tei Index and Its Relation to Outcome of Critically Ill Children on Continuous Renal Replacement Therapy,” Indian Journal of Pediatrics 11 (2023): 1127–1133.
HEXIM1 is correlated with Alzheimer's disease pathology and regulates immediate early gene dynamics in neurons
Abstract Impaired memory formation and recall is a distinguishing feature of Alzheimer's disease, and memory requires de novo gene transcription in neurons. Rapid and robust transcription of many genes is facilitated by their existence in a basal poised state, in which RNA polymerase II (RNAP2) has initiated transcription, but is paused just downstream of the gene promoter. Neuronal depolarization releases the paused RNAP2 to complete the synthesis of messenger RNA (mRNA) transcripts.
Metabolomic Analyses Reveal That IAA from Serratia marcescens Lkbn100 Promotes Plant Defense during Infection of Fusarium graminearum in Sorghum
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The Identification of Kabatiella zeae as a Causal Agent of Northern Anthracnose of Sorghum in China and Estimation of Host Resistance
1. Introduction Sorghum ranks as one of the world’s top five cereals and is a primary choice for agricultural production in arid regions. It plays a significant role in ensuring food and feed security in arid and semi-arid areas globally [1]. In China, sorghum boasts a long-standing history and extensive cultivation, serving as a crucial food and feed crop, as well as a key ingredient in brewing wine and vinegar [2].
Through the ages, China and Venezuela's unbreakable bond shines anew
Editor's note: Decision Makers is a global platform for decision makers to share their insights on events shaping today's world. Lan Hu is the ambassador of the People's Republic of China to the Bolivarian Republic of Venezuela. The article reflects the author's opinions and not necessarily the views of CGTN. June 28 this year marks a major milestone: the 50th anniversary of the establishment of diplomatic relations between China and Venezuela.
A novel method for sampling subgingival microbiome: a comparative metatranscriptomic study
The microorganisms in the oral cavity are important in maintaining an individual’s oral and systemic health [1,2]. The oral microbiome comprises viruses, phages, fungi, protozoa, archaea and bacteria; the bacterial communities alone consist of over 700 species [1,3]. These microorganisms are important for the body’s maintenance of health by maintaining oral homeostasis and protecting the oral cavity [4–6].
Protocol for a parallel assignment prospective, randomised, double-blinded, placebo-controlled trial to evaluate the efficacy of 0.01% atropine for near work-induced transient myopia and myopic progression in China
Paediatric ophthalmology Clinical Trial China This study is a parallel assignment prospective, randomised, double-blinded, placebo-controlled trial. One hundred fifty participants will be randomly assigned in a 1:1 ratio to receive 0.01% atropine or placebo eye drop once nightly bilaterally for 1 year. An evaluation of initial near work-induced transient myopia, cycloplegic refraction, axial length, best-corrected visual acuity, intraocular pressure and pupil diameter will be performed.
Bioengineering
Subarachnoid hemorrhage (SAH) denotes a serious type of hemorrhagic stroke that often leads to a poor prognosis and poses a significant socioeconomic burden. Timely assessment of the prognosis of SAH patients is of paramount clinical importance for medical decision making. Currently, clinical prognosis evaluation heavily relies on patients’ clinical information, which suffers from limited accuracy. Non-contrast computed tomography (NCCT) is the primary diagnostic tool for SAH.
Formation and Evolution Mechanism of Intermetallic Compounds of Friction Stir Lap Welded Steel/Aluminum Joints
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Functional Changes of White Matter Are Related to Human Pain Sensitivity during Sustained Nociception
2. Study Design The Strengthening Observational Studies in Epidemiology (STROBE) guideline was followed []. Moreover, the study was conducted in accordance with the Declaration of Helsinki, and the protocol was approved by the Ethics Committee of UESTC. To ensure the completeness and accuracy of observational data, a professional master performed experimental procedure. A professional magnetic resonance imaging (MRI) scanner performed data scanning.
Clustering of CaV1.3 L‐type calcium channels by Shank3
Filename Description jnc15880-sup-0001-DataS1.zipZip archive, 150.8 MB Data S1. Please note: The publisher is not responsible for the content or functionality of any supporting information supplied by the authors. Any queries (other than missing content) should be directed to the corresponding author for the article.
the US strategy is doomed to fail
Written by the Ambassador of the People’s Republic of China, Lan Hu. Since ancient times, Taiwan has been an inalienable part of China’s territory, which is solidly supported by numerous historical documents dating back to the 3rd century AD The Cairo Declaration issued in 1943 and the Potsdam Proclamation issued in 1945 make it clear that all Territories that Japan had stolen from China, including Taiwan, would be returned to China.
Investigation of Pre-Aged Hardening Single-Point Incremental Forming Process and Mechanical Properties of AA6061 Aluminum Alloy
Open AccessArticle by Yao Zhang 1, Zhichao Zhang 2, Yan Li 1, Lan Hu 2, Qiu Pang 3,* and Zhili Hu 1,4,5,* 1 Hubei Longzhong Laboratory, Wuhan University of Technology, Xiangyang 441000, China 2 Shanghai Aerospace Equipments Manufacturer Co., Ltd., Shanghai 200245, China 3 Department of Mechanical and Electrical Engineering, Wuhan Donghu University, Wuhan 430212, China 4 Hubei Key Laboratory of Advanced Technology for Automotive Components, Wuhan University of Technology, Wuhan 430070, China 5...
A novel method for sampling subgingival microbiome - a comparative metatranscriptomic study
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A clinically validated human saliva metatranscriptomic test for global systems biology studies
BioTechniquesVol. 74, No. 1 ReportsOpen Access Abstract The authors report here the development of a high-throughput, automated, inexpensive and clinically validated saliva metatranscriptome test that requires less than 100 μl of saliva. RNA is preserved at the time of sample collection, allowing for ambient-temperature transportation and storage for up to 28 days.
Participation in Household Physical Activity Lowers Mortality Risk in Chinese Women and Men
Abstract : The health benefits of sport and physical exercise (SPE) have been well documented, while the influence of household physical activity (HPA) on health has received much less research attention. This study aims to provide epidemiologic insight into the role HPA plays in the development of all-cause, cardiovascular disease (CVD), respiratory disease (RESP), and cancer mortality in a nationwide cohort of Chinese adults.
[Opinión] Un futuro ecológico, abierto y beneficioso para el pueblo
15 Nov 2022 - 11:23 p. m. China es, actualmente, el segundo principal socio comercial de Colombia y por lo mismo, las relaciones y cooperaciones bilaterales cuentan con amplias perspectivas. Lan Hu, embajador de la República Popular China en Colombia. Foto: Cortesía El otoño es la época más hermosa del año en la ciudad de Beijing.
La reunificación de China no será detenida por nadie
Ignorando la fuerte oposición y las serias gestiones de China, la presidenta de la Cámara de Representantes de Estados Unidos, Nancy Pelosi, visitó la región china de Taiwán. Esta es una seria violación del principio de Una Sola China y va en contra de lo estipulado en los tres comunicados conjuntos entre China y Estados Unidos.
Una búsqueda centenaria
04 de julio 2021 , 01:43 a. m. Este 2021 marca para China una fecha muy importante, el primer centenario de su Partido Comunista, años en los que hemos tenido tanto glorias como fracasos, pero en los cuales el objetivo del partido de erradicar la pobreza mundial no ha dejado de ser su prioridad. El partido, que se inició con tan solo 50 miembros, hoy suma más de 90 millones de militantes, convirtiéndose así en el más grande a nivel mundial y en el timonel del pueblo chino.
Una búsqueda centenaria
Este 2021 marca para China una fecha muy importante, el primer centenario de su Partido Comunista; años en los que hemos tenido tanto glorias como fracasos, pero en los cuales el objetivo del partido de erradicar la pobreza mundial no ha dejado de ser su prioridad. El partido que inició con tan solo 50 miembros, hoy suma más de 90 millones militantes, convirtiéndose así en el más grande a nivel mundial y el timonel del pueblo chino.
Propuesta común de China y Colombia
La semana pasada se celebró la 75.ª Asamblea General de las Naciones Unidas. En medio de un año crucial para las relaciones internacionales, líderes de todo el mundo aportaron ideas valiosas a la discusión sobre cómo superar la crisis global generada por el covid-19.
A Network-Based “Phenomics” Approach for Discovering Patient Subtypes From High-Throughput Cardiac Imaging Data
JACC: Cardiovascular Imaging Original Research Jung Sun Cho, Sirish Shrestha, Nobuyuki Kagiyama, Lan Hu, Yasir Abdul Ghaffar, Grace Casaclang-Verzosa, Irfan Zeb and Partho P. Sengupta This article requires a subscription or purchase to view the full text. If you are a subscriber or member, click the login link or the subscribe link in the top menu above to access this article. Author + information vol. 13 no.
China en acción: el libro blanco sobre la lucha contra el covid-19
El 7 de junio el Gobierno chino hizo público el libro blanco 'Luchando contra el covid-19: China en acción'. Expertos y académicos de distintos países aseguraron que el libro tiene un “valor científico mundial”, por lo que debería ser tomado como referencia para el manejo de la pandemia a nivel internacional. El libro blanco define con precisión que “el covid-19 es la pandemia más extensa y difícil que ha sufrido la humanidad en el último siglo”.
Solubilities of N-Nitrodiethanolamine Dinitrate in Pure and Mixed Organic Solvents at Temperatures between 283.15 and 313.15 K
The solubilities of energetic material N-nitrodiethanolamine dinitrate (DINA) were measured in ten commonly used pure organic solvents including methanol, ethanol, ethyl acetate, dichloromethane, acetone, dimethyl sulfoxide, 1,4-dioxane, toluene, 1,2-dichloroethane, and acetonitrile and three binary mixed solvents between 283.15 and 313.15 K by the gravimetric method. The solubility of DINA showed a temperature dependence for all test solvents.
Las cifras que deja el brote del covid-19 en China
La propagación reciente del covid-19 en varios países y, sobre todo, la confirmación del caso en Brasil el 26 de febrero, el primero en Latinoamérica, llamaron de nuevo la atención de todos hacia esa epidemia. China tiene toda la voluntad de compartir su experiencia con la comunidad internacional y los países afectados, así como de ofrecerles ayudas dentro del alcance de su capacidad. A continuación, una breve presentación de la experiencia china frente al coronavirus con datos y cifras.
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