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Abstract Alzheimer’s disease (AD) is the most common cause of dementia, with global case numbers projected to reach 153 million in 20501. AD is highly heritable, with twin-based heritability estimates of 60–80%2. Although 1,200 causal loci are predicted to exist for AD3, approximately 80 loci have been associated with AD in two recent studies4,5.
By Emil Uffelmann, Douglas P. Wightman, Shahram Bahrami, Alexey Shadrin, Vera Fominykh, Takafumi Ojima, Chenyang Jiang, Christian Benner, Elisa Moreno, Adrian Campos Verified, G. Bragi Walters, Richard Sherva, Tian Lin, Xuemin Wang, Julien Bryois, Kristi Krebs, Marijn Schipper, Akira Narita, Alessandro Serretti, Anne Corbett, Anne-Brita Knapskog, Annette Hartmann, Anouk den Braber, Argonde C. van Harten, Arvid Harder, Arvid Rongve, Betty M. Tijms, Bitten Aagaard, Bjørn Lichtwarck, Bjørn-Eivind Kirsebom, Byron Creese, Chandra A Reynolds, Sara Hägg, Ida Karlsson Verified, Christian Erikstrup, Christina Mikkelsen, Clive Ballard, Dag Aarsland, Daichi Shigemizu, Dan Rujescu, Daniel F. Gudbjartsson, Eivind Aakhus, Erik A. Sørensen, Eystein Stordal, Flora H. Duits, Frank J. Wolters, Frederic Blanc, Frédéric Blanc, Geert Jan Biessels, Geir Selbæk, Geir Bråthen, Gunhild Waldemar, Harro Seelaar, Henne Holstege, Henning Bundgaard, Henrik Zetterberg, Henrik Ullum, Ingmar Skoog, Ingvild Saltvedt, Irena Rektorová, J. Michael Gaziano, Jan Haavik, Jens Hjerling-Leffler, Jiao Luo, Jon Snaedal, Everard G. B. Vijverberg, Julia M. Sealock, Kaj Blennow, Kaja Nordengen, Karin Persson, Katja Scheffler, Koichi Matsuda, Kouichi Ozaki, Lasse Pihlstrøm, Lavinia Athanasiu, Lene Pålhaugen, Marc Hulsman, Margda Waern, Maria Averina, Marta R. Moksnes, Martijn Huisman, Masayuki Yamamoto, Mathias Toft, Matthew S. Panizzon, Mie Topholm Bruun, Mohsen Ghanbari, Nancy L Pedersen, Nathaniel Bell, Niccolò Tesi, Ole B. Pedersen, Oleksandr Frei, Olivier Bousiges, Per Svenningsson, Qingqin Li, Richard L Hauger, Rui Zhang, Shinichi Namba, Srdjan Djurovic, Tanya N. Phung, Thomas Truelsen, Thomas Werge, Thomas Hansen, Torgeir Engstad, Tormod Fladby, Victoria Merritt, Sverre Bergh, Wiesje van der Flier, Rujin Wang, Eli A Stahl, Basavaraj Hooli, Penn Medicine Biobank, Lea Davis, Mark W. Logue, Kelli Lehto, Anna Zettergren, Ben M Brumpton, Jian Zeng, Peter M. Visscher, Paul F. O’Reilly, Anubha Mahajan, Manuel Ferreira, Yukinori Okada, Sven J. van der Lee, Sisse R. Ostrowski, Ruth Frikke-Schmidt, Hreinn Stefánsson, Karl Heilbron, Ole A. Andreassen, Danielle Posthuma, Jesper Q. Thomassen, Emmanuel Minois-Genin, Anja H. Simonsen, Anna L. van Seumeren, Bengt O. Madsen, Helga Eyjolfsdottir, Ina Giegling, Ingrid T. Medbøen, Marianne Wettergreen, Monique Franc, Pieter J. Visser, Sigrid B. Sando, Steinunn Thordardottir, Tomoki Kyosaka
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Nature
Verified