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Articles by Lingli Chen
Pediatric spontaneous-reporting patterns for biologics approved or used for asthma: Analysis of the FDA adverse event reporting system
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. PEER REVIEW For transparency, the peer review documents associated with this article are available at https://doi.org/10.1111/pai.70495.
Biosynthesis of a nanoscale Vibrio cholerae conjugate vaccine elicits potent immunity through size and receptor effects
Abstract Cholera, caused by Vibrio cholerae, remains a significant global health threat, with the O1 serotype being the predominant cause of recent global outbreaks. Although conjugate vaccines against V. cholerae have been developed via chemical methods, the feasibility of applying novel biosynthetic approaches remains uncertain due to the special structure of its O-polysaccharide, which should be recognized by oligosaccharyltransferases.
AHNAK2 is a novel diagnostic biomarker for gallbladder adenocarcinoma
Objective. To investigate the pathological diagnostic value of AHNAK2 in gallbladder carcinoma (GBC), especially in adenocarcinoma (AC). Methods. Tissue microarrays (TMAs) were constructed from 296 gallbladder tumor cases, comprising 562 cores that included normal/atypical epithelium, low-grade intraepithelial neoplasia (LGIN), high-grade intraepithelial neoplasia/carcinoma in situ (HGIN/TIS), and GBC.
Molecular insights into early malignant transition of hepatocellular carcinoma
Keywords cancer hepatocellular carcinoma early carcinogenesis tumor heterogeneity malignant transition copy number alteration spatial transcriptomics Immune evasion evolutionary trajectories response to immune therapies Introduction The transition from premalignant lesions to early cancers represents a critical stage in carcinogenesis.
Effects of dietary Chaihu-Shugan-San on egg production performance, egg quality, and hepatic lipid metabolism of late-laying hens
Abstract This study aimed to evaluate the effects of Chaihu-Shugan-San (CSS) on egg production, egg quality, ovarian development, serum lipid levels, liver function, and hepatic lipid metabolism in laying hens. A total of 480 67-week-old laying hens (Jinghong No. 1) were randomly assigned to four groups. Each group comprised eight replicates of 15 hens.
Diagnostic value of AHNAK2 immunohistochemical expression in papillary thyroid carcinoma: an immunohistochemical study - Diagnostic Pathology
A total of 463 thyroid neoplasm patients, including 296 PTC patients, 36 FTC patients, 11 NIFTP patients, and 167 FA patients, were recruited from January 2018 to December 2022 in the Pathology Department of Zhongshan Hospital, Fudan University. All patients underwent total thyroidectomy or unilateral thyroidectomy with isthmic thyroidectomy, followed by histopathological diagnosis. Ethical approval was obtained from the ethics committee of Zhongshan Hospital, Fudan University (B2024-169).
The ESRP1 promoter reporter can function as an in vivo sensor of DNA methyltransferase inhibition - BMC Biotechnology
ESRP1 mRNA and protein expression levels in carcinoma and normal tissues were determined via the UALCAN database (http://ualcan.path.uab.edu/). Immunohistochemical (IHC) staining of ESRP1 in kidney renal clear cell carcinoma (KIRC) and normal tissues was performed via the Human Protein Atlas (HPA) database (https://www.proteinatlas.org/).
Highly Efficient Luminescent and Color-tunable White Emission from 0D Cs2InCl5·H2O Perovskites via Al3+ and Sb3+ Codoping
Highly Efficient Luminescent and Color-tunable White Emission from 0D Cs2InCl5·H2O Perovskites via Al3+ and Sb3+ Codoping All inorganic metal halide perovskites receive extensive attention due to their excellent photoelectric properties. However, addressing toxicity and instability through reasonable doping, as well as improving photoluminescence (PL) efficiency, remains a major challenge.
Effect of the Partial Substitution of NaCl with L-Arg on the Gel Properties and Aggregation Behavior of Beef Myosin
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Basic Amino Acids as Salt Substitutes in Low-Salt Gel-Based Meat Products: A Comprehensive Review of Mechanisms, Benefits, and Future Perspectives
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
DHGS: Decoupled Hybrid Gaussian Splatting for Driving Scene
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Genotypic and phenotypic features of 39 Chinese patients with glycogen storage diseases type I, VI, and IX
CONFLICT OF INTEREST STATEMENT Author X.L. and Y.R. were employed by the company Grandomics Biosciences. The remaining authors declare that they have no conflict of interests. Supporting Information Filename Description cge14530-sup-0001-supinfo.docxWord 2007 document , 61.5 KB Data S1: Supporting Information. REFERENCES 1, . Hepatic glycogen storage disorders: what have we learned in recent years? Curr Opin Clin Nutr Metab Care. 2015; 18(4): 415-421. doi:10.1097/mco.0000000000000181 2, , , et al.
Identifying Hub Genes and miRNA-mRNA Regulatory Networks in Mice Infected with H1N1 Influenza Virus
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Identifying Hub Genes and miRNA-mRNA Regulatory Networks in Mice Infected with H1N1 Influenza Virus
H1N1 influenza virus is a major factor in seasonal influenza outbreaks. After the body is infected with the influenza virus, the expression of certain mRNAs, including miRNAs, could be affected. However, the association between these mRNAs and miRNAs remains unclear. This study is aimed at identifying differentially expressed genes (DEGs) and miRNAs (DEmiRs) caused by H1N1 influenza virus infection and constructing a miRNA-mRNA regulatory network.
In Situ Synchrotron XRD Characterization of Piezoelectric Al1−xScxN Thin Films for MEMS Applications
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Postoperative recurrence of colorectal cancer diagnosis
Back to Journals » Cancer Management and Research » Volume 15 Authors Hong J, Chen X, Chen L, Wang Y , Huang B, Fang H Received 21 February 2023 Accepted for publication 28 June 2023 Published 3 July 2023 Volume 2023:15 Pages 563—572 DOI https://doi.org/10.2147/CMAR.S407930 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Professor Bilikere Dwarakanath Jianfeng Hong,1 Xindong Chen,2 Lingli Chen,2 Yigang Wang,2 Biao...
Gougunao tea polysaccharides ameliorate high-fat diet-induced hyperlipidemia and modulate gut microbiota†
Gougunao tea polysaccharides ameliorate high-fat diet-induced hyperlipidemia and modulate gut microbiota† Qihuan Deng, Wenjun Wang, Lieyuan Zhang, Lingli Chen, Qing-Feng Zhang, Ying Zhang, Sicheng He and Jing'en Li Abstract Many natural polysaccharides have been proved to have effects on ameliorating high-fat diet-induced hyperlipidemia with fewer side effects whereas there remains obscure about Gougunao tea polysaccharides.
Dual block HER2 assessment increased HER2 immunohistochemistry positive rate in resected specimens of gastric cancer: a prospective multicenter clinical trial from China | Diagnostic Pathology | Full Text
This is a prospective multi institutional study based on real world data. It is also a follow-up study of our previous single center studies. To our knowledge, this is the first multi-center study to explore the value of multiple-block HER2 assessment in GC. The results showed that HER2 positive rate and equivocal rate was increased by dual block assessment and meanwhile the HER2 negative rate was decreased. These findings were confirmed in total patients as well as in each hospital.
Association between frequency of spicy food consumption and hypertension: a cross-sectional study in Zhejiang Province, China
Hao Wang1, Lingli Chen2, Dun Shen2, Yuan Cao2, Xiaoyi Zhang2, Kaixu Xie2, Chunmei Wang2, Shuiqing Zhu2, Pei Pei3, Yu Guo3, Fiona Bragg4, Min Yu1, Zhengming Chen4 & Liming Li5,6 Nutrition & Metabolism volume 18, Article number: 70 (2021) Cite this article Abstract Background Hypertension is a known risk factor for multiple chronic diseases. Existing literature on the association between frequency of spicy food consumption and hypertension shows mixed findings.
Pancreatic lipase inhibitory activity of Bambusa multiplex cv. Fernleaf leaves extract in vitro and in vivo
Pancreatic lipase inhibitory activity of Bambusa multiplex cv. Fernleaf leaves extract in vitro and in vivo Bambusa multiplex cv Fernleaf (B. multiplex) is a species of bamboo. In present study, the B. multiplex leaves extract was prepared through resin absorption/desorption procedure and was analyzed by HPLC. C-glycosyl flavonoids were the main constituents of B. multiplex extract, and the content of isoorientin and vitexin were 51.8 and 23.1 mg/g, respectively.
Association of daytime napping in relation to risk of diabetes: evidence from a prospective study in Zhejiang, China
Hao Wang1, Lingli Chen2, Dun Shen2, Yuan Cao2, Xiaoyi Zhang2, Kaixu Xie2, Chunmei Wang2, Shuiqing Zhu2, Yu Guo3, Bragg Fiona4, Min Yu1, Zhengming Chen4 & Liming Li5 Nutrition & Metabolism volume 18, Article number: 18 (2021) Cite this article Abstract Background Diabetes was a major risk factor for numerous chronic diseases. However, the associations between daytime napping and diabetes in the existing literature is still inconsistent.
Smartphone-based colorimetric assay of antioxidants in red wine using oxidase-mimic MnO2 nanosheets
Smartphone-based colorimetric assay of antioxidants in red wine using oxidase-mimic MnO2 nanosheets In this work, we report a fast and colorimetric method for the detection of antioxidants based on the oxidase-like activity of two-dimensional MnO2 nanosheets. Specifically, MnO2 nanosheets can transform the colourless substrate, 3,3´,5,5´-tetramethylbenzidine (TMB), to a deep blue product (oxTMB) via catalytic oxidation, with arise a specific absorption peak at 652 nm.
Cell Press: Cell Press
Alteration of the colostrum whey proteome in mothers with gestational hypothyroidism
Proteomic technologies could be applied to improving our knowledge of the proteins present in breastmilk. Several studies have characterized the proteome of human breastmilk in different conditions, such as different gestational duration [ 16 ], lactation time [ 17 , 18 ], and health state during lactation [ 19 , 20 ]. Grapov et al.
Integrative analysis of DNA methylation and gene expression reveals hepatocellular carcinoma-specific diagnostic biomarkers
Hepatocellular carcinoma (HCC) is the sixth most common cancer and the third leading cause of cancer deaths in the world [1]. Most cases of HCC occur in developing countries, such as China, and the leading cause of HCC is chronic infection with hepatitis B virus (HBV); in contrast, the main cause in developed countries, such as the USA, is infection with hepatitis C virus (HCV) [2].
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