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Articles by Lingshu Wang
Structural Definition of Neutralizing Epitopes within and around the HKU1 Receptor-binding Site Reveals Cell Context-Dependent Neutralization
Abstract Endemic human coronaviruses (HCoVs), such as HCoV-HKU1, account for ~30% of common colds each year and can cause serious upper and lower respiratory infections, yet no licensed vaccines or therapeutic antibodies target HCoVs. Despite being endemic to the human population, little is known about the antigenic landscape of HCoV-HKU1.
Potent type-specific de novo antibodies complement broadly reactive imprinted antibodies in immune responses to SARS-CoV-2 variants
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Abstract For rapidly mutating viruses such as influenza viruses and severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), immune memory recalled by antigenically drifted variants primarily comprises antibodies that cross-react to the priming strain rather than de novo elicited responses, a phenomenon termed original antigenic sin or immune imprinting. The composition and functionality of de novo responses elicited by variant exposures remain unclear.
By Timothy Johnston, Shuk Hang Li, Mark Painter, Divya Swaminathan, Reilly K. Atkinson, Bernadeta Dadonaite, Shuishu Wang, Naomi R. Douek, Lucas Kampman, Rachel Kazmierski, Bob Lin, Leonid Serebryannyy, Haijuan Du, Amy Henry, Sarah Smith, Farida Laboune, I-Ting Teng, Lingshu Wang, Nicole A. Doria-Rose, Chaim A. Schramm, Theodore C. Pierson, Tongqing Zhou, Jesse Bloom, E. John Wherry, Scott Hensley Verified, Daniel Douek, Robin Schlesinger
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Nature
Verified
Full-length premembrane protein is not required for mature Zika virus particle assembly
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Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Proteolytic cleavage of the structural premembrane (prM) protein of flaviviruses such as Zika virus is seen as a defining step in virus particle maturation. Dowd et al. now show that Zika virus particles can assemble without the pr domain of prM, challenging established models of flavivirus generation.
By Shreya Kashyap, Alan Chramiec, M. Silva, Kimberly A. Dowd, Egan Sanchez, Beniah Brumbaugh, Bryant M. Foreman, Katherine E. Burgomaster, Wei Shi, Lingshu Wang, Natalie Caputo, David Gordon, Cindi L. Schwartz, Bryan Hansen, Adam S. Olia, Mehin Suleiman, Jessica Guyette, Maya Aleshnick, Wing-Pui Kong, Kaitlyn M. Morabito, Yaroslav Tsybovsky, Heather D. Hickman, Barney S. Graham, Elizabeth Fischer
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Science Magazine
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SARS-CoV-2 variant booster vaccination and infection alter the breadth of the memory B cell repertoire
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Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary As SARS-CoV-2 continues to evolve in response to vaccine- and infection-induced immune pressure, vaccines will need to be updated to match currently circulating strains. Here, Malek et al. evaluated what impact a SARS-CoV-2 Omicron variant booster vaccine had on the overall memory B cell (MBC) response to SARS-CoV-2.
By Kyeongseok Jeon, Axel A Guzmán-Solís, Rory Malek, Flávio Lemos Matassoli, Kyle Gordon, Geoffrey D. Shimberg, Grace Mantus, Abby Spangler, Ankita J. Chopde, I-Ting Teng, Tongqing Zhou, Bob Lin, Robin Carroll, Rachel Kazmierski, Lingshu Wang, Christine M. Posavad, Nadine Rouphael, Angela R. Branche, Paul Roberts, Leonid Serebryannyy, Sarah Andrews
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Science Magazine
Verified
Frontiers | Genotype-phenotype correlations of fasting C-peptide and lipids in HNF1A-MODY: a single-center series and multi-center cross-sectional analysis in Chinese population
1 Introduction Maturity-onset diabetes of the young (MODY) is a monogenic form of diabetes characterized by autosomal dominant inheritance. To date, 14 distinct MODY subtypes have been identified, among which HNF1A-MODY, caused by HNF1A gene mutations, represents one of the most prevalent subtypes, accounting for 30-70% of all MODY cases (1). However, recent study indicates that within the Chinese MODY population, the proportion of HNF1A-MODY cases is 16.03% (2).
A multispecific antibody against SARS-CoV-2 prevents immune escape in vitro and confers prophylactic protection in vivo
Highlights ● LY-CoV1404 potently neutralizes SARS-CoV-2, Omicron, BA.2 Omicron, and Delta variants ● No loss of potency against currently circulating variants ● Binding epitope on RBD of SARS-CoV-2 is rarely mutated based on current GISAID data ● Breadth of neutralizing activity and potency supports clinical development Abstract SARS-CoV-2 neutralizing monoclonal antibodies (mAbs) can reduce the risk of hospitalization from COVID-19 when administered early.
Structural basis for potent antibody neutralization of SARS-CoV-2 variants including B.1.1.529
New Results Tongqing Zhou, Lingshu Wang, John Misasi, Amarendra Pegu, Yi Zhang, Darcy R. Harris, Adam S. Olia, Chloe Adrienna Talana, Eun Sung Yang, Man Chen, Misook Choe, Wei Shi, I-Ting Teng, Adrian Creanga, Claudia Jenkins, Kwanyee Leung, Tracy Liu, Erik-Stephane D. Stancofski, Tyler Stephens, Baoshan Zhang, Yaroslav Tsybovsky, View ORCID ProfileBarney S. Graham, John R. Mascola, Nancy J. Sullivan, Peter D.
Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants
Defenses against SARS-CoV-2 variants Our key defense against the COVID-19 pandemic is neutralizing antibodies against the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) virus elicited by natural infection or vaccination. Recent emerging viral variants have raised concern because of their potential to escape antibody neutralization. Wang et al.
Ultrapotent antibodies against diverse and highly transmissible SARS-CoV-2 variants
Abstract The emergence of highly transmissible SARS-CoV-2 variants of concern (VOC) that are resistant to therapeutic antibodies highlights the need for continuing discovery of broadly reactive antibodies.
Structural Definition of a Neutralization-Sensitive Epitope on the MERS-CoV S1-NTD
Highlights • The epitope for the neutralizing antibody G2 is confined to the apex of the MERS-CoV S1-NTD • G2 epitope is relatively well conserved • G2 IgG and Fab both neutralize pseudotyped and authentic MERS-CoV • G2 neutralizes by preventing the binding of DPP4 to trimeric S protein Summary Middle East respiratory syndrome coronavirus (MERS-CoV) emerged into the human population in 2012 and has caused substantial morbidity and mortality.
Mutations in the Spike Protein of Middle East Respiratory Syndrome Coronavirus Transmitted in Korea Increase Resistance to Antibody-Mediated Neutralization
Virus-Cell Interactions Hannah Kleine-Weber, Mahmoud Tarek Elzayat, Lingshu Wang, Barney S. Graham, Marcel A. Müller, Christian Drosten, Stefan Pöhlmann, Markus Hoffmann Tom Gallagher, Editor DOI: 10.1128/JVI.01381-18 ABSTRACT Middle East respiratory syndrome coronavirus (MERS-CoV) poses a threat to public health. The virus is endemic in the Middle East but can be transmitted to other countries by travel activity.
Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape
Importance of Neutralizing Monoclonal Antibodies Targeting Multiple Antigenic Sites on the Middle East Respiratory Syndrome Coronavirus Spike Glycoprotein To Avoid Neutralization Escape
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