Liyang Wang
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Articles by Liyang Wang
Structural basis of ammonium transport and coordinated regulation of AMT1;1 in Arabidopsis thaliana
Abstract Efficient ammonium uptake is essential for plant growth and nitrogen-use efficiency, yet the structural basis of ammonium transport and regulation in plant AMTs remains unclear. Here, we determined multiple cryo-electron microscopy structures of the Arabidopsis thaliana ammonium transporter AMT1;1 in apo, ammonium-bound, methylammonium-bound, low-pH and phosphomimetic states.
Spatial Coordination of Phosphorus and Water Enhances Maize Growth and Phosphorus Uptake by Modifying Root Distribution
1 Introduction Phosphorus (P) and water are essential for plant growth and play key roles in regulating soil fertility and plant productivity (Han et al. 2022; Marschner 2012; Shen et al. 2011). Phosphorus in the soil solution is the only form directly available to plants and is rapidly taken up by the roots (Lambers 2022; Marschner 2012).
Retinal Racemose Hemangioma With Vascular Occlusion
A 40-year-old woman presented with a 4-day history of painless, sudden vision loss in her right eye. Her best-corrected visual acuity (BCVA) was counting fingers at 30 cm. Ophthalmologic examination revealed vitreous hemorrhage. After pars plana vitrectomy, findings were consistent with retinal racemose hemangioma.
Epstein-Barr virus-associated tumors: commonalities in pathogenesis and the tumor immune microenvironment
Abstract Epstein-Barr virus (EBV) is associated with a wide spectrum of lymphoid and epithelial malignancies. This review provides a comprehensive pan-tumor perspective on the convergent oncogenic mechanisms, immune microenvironment characteristics, and shared therapeutic vulnerabilities across EBV-related cancers.
Strong electromagnetically induced transparency effect constructed by quasi-BIC and Brillouin zone folding GMR in composite dielectric metasurfaces
Traditional electromagnetically induced transparency (EIT) typically exhibits low quality (Q) factors and limited tunability. Bound states in the continuum (BIC) offer a promising solution for achieving high-Q EIT. In this work, we engineer a high-Q EIT resonance on a silicon-membrane metasurface by coupling a quasi-BIC with a Brillouin zone folding guided mode resonance (BZF-GMR).
A Novel CYP2E1 Inhibitor, 4‐Methyl‐5‐Acetylthiazole (Q11), Alleviates Obesity Via Modulating Adipose Inflammation and Mitochondrial Dysfunction
1 Introduction Obesity is a chronic metabolic disease characterized by adipose tissue dysfunction and systemic metabolic derangements [1, 2]. Mounting evidence indicates that chronic low-grade inflammation and impaired mitochondrial homeostasis within white adipose tissue (WAT) are central drivers of obesity-related complications, including type 2 diabetes mellitus (T2DM), nonalcoholic fatty liver disease (NAFLD), cardiovascular disorders, and several malignancies [3-7].
Wound state monitoring by multiplexed, electrochemical, real-time, localized, inflammation-tracking nitric oxide sensor (MERLIN)
Abstract Nitric oxide (NO) released endogenously by induced NO synthase (iNOS) in macrophages is a key regulatory biomarker for wound inflammation. Detecting NO directly on the wound bed is challenging due to its short half-life time (6 to 50 seconds), low physiological concentration (nanomolar to micromolar), and interferences in the complex wound environment.
Machine Learning-driven Prediction Models for Brodalumab Therapeutic E
Back to Journals » Psoriasis: Targets and Therapy » Volume 15 Authors Peng L , Wang L, Chen L, Shen Z Received 8 May 2025 Accepted for publication 12 August 2025 Published 21 August 2025 Volume 2025:15 Pages 429—442 DOI https://doi.org/10.2147/PTT.S531925 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Tina Bhutani Lu Peng,1 Liyang Wang,2 Ling Chen,3 Zhu Shen1 1Department of Dermatology, Guangdong Provincial...
FveTRM5 plays a critical role in regulating fruit shape in woodland strawberry
Abstract Cultivated strawberry is a globally important fruit crop with high economic value. Fruit shape contributes to fruit quality and diversity and is a target for breeding, but very few regulatory genes have been reported in strawberry. Here, we identified an ethyl methanesulfonate (EMS) round fruit (rf) mutant that produces round or flat fruits in woodland strawberry.
Design methodology for heavy-haul railway track foundations under 40-tonne axle loads
ABSTRACT Heavy haul railway, recognized for high capacity and efficiency, is gaining traction worldwide. However, heavier axle loads can accelerate track and foundation deterioration without robust structural design. This study proposes a practical design methodology for heavy-haul track foundations under 40-tonne axle loads. Short axle spacing was considered in analyzing train load distribution, revealing significant stress superposition on the subgrade.
Wound state monitoring by multiplexed, electrochemical, real-time, localized, inflammation-tracking nitric oxide sensor (MERLIN)
Abstract Nitric oxide (NO) released endogenously by induced nitric oxide synthase (iNOS) in macrophages is a key regulatory biomarker for wound inflammation. Detecting NO directly on the wound bed is challenging due to its short half-life time (6 – 50 s), low physiological concentration (nM – μM) and interferences in the complex wound environment. Existing NO sensors suffer from limitations such as rigid substrates, single point of detection and complex measurement setup.
Germplasm Resources and Genetic Breeding of Huang-Qi (Astragali Radix): A Systematic Review
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Dual‐Crosslinked Bioactive Hydrogel Scaffold for Accelerated Repair of Genital Tract Defect
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202405966-sup-0001-SuppMat.docx9 MB Supporting Information adfm202405966-sup-0002-VideoS1.mp432.1 MB Supplementary Video S1 References 1, , , , , Tissue Eng. Regen. Med. 2016, 13, 447. 2, , , , , Reprod. Sci. 2021, 28, 1573. 3, , , Orphanet J. Rare Dis. 2020, 15, 214. 4, , , , , Hum. Reprod. 2016, 31, 2384. 5, , , , , Int. Urogynecol. J. 2022, 33, 723. 6, , , , , , , Orphanet J. Rare Dis. 2020, 15, 121.
Dual‐Crosslinked Bioactive Hydrogel Scaffold for Accelerated Repair of Genital Tract Defect
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description adfm202405966-sup-0001-SuppMat.docx9 MB Supporting Information adfm202405966-sup-0002-VideoS1.mp432.1 MB Supplementary Video S1 References 1, , , , , Tissue Eng. Regen. Med. 2016, 13, 447. 2, , , , , Reprod. Sci. 2021, 28, 1573. 3, , , Orphanet J. Rare Dis. 2020, 15, 214. 4, , , , , Hum. Reprod. 2016, 31, 2384. 5, , , , , Int. Urogynecol. J. 2022, 33, 723. 6, , , , , , , Orphanet J. Rare Dis. 2020, 15, 121.
Revealing the Molecular Interaction between CTL Base Oil and Additives and Its Application in the Development of Gasoline Engine Oil
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Predicting the Potential Distribution of Hypericum perforatum under Climate Change Scenarios Using a Maximum Entropy Model
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Diversity of Parasitoid Wasps and Comparison of Sampling Strategies in Rice Fields Using Metabarcoding
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Diversity of Parasitoid Wasps and Comparison of Sampling Strategies in Rice Fields Using Metabarcoding
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 30 January 2024 / Approved: 30 January 2024 / Online: 30 January 2024 (14:24:54 CET) Wang, L.; Wu, H.; He, W.; Lai, G.; Li, J.; Liu, S.; Zhou, Q. Diversity of Parasitoid Wasps and Comparison of Sampling Strategies in Rice Fields Using Metabarcoding. Preprints 2024, 2024012105. https://doi.org/10.20944/preprints202401.2105.v1 Wang, L.; Wu, H.; He, W.; Lai, G.; Li, J.; Liu, S.; Zhou, Q.
Urethral Microenvironment Adapted Sodium Alginate/Gelatin/Reduced Graphene Oxide Biomimetic Patch Improves Scarless Urethral Regeneration (Adv. Sci. 2/2024)
Graphical Abstract Urethral Reconstruction The nasty urine microenvironment (UME) is an inherent obstacle that hinders urethral repair due to fibrosis and swelling of the hydrogel-based biomaterials. In article number 2302574, Wenyao Li, Qiang Fu, Kaile Zhang, and co-workers report using reduced graphene oxide (rGO) along with double-freezedrying to strengthen a 3D-printed patch for realizing scarless urethral repair.
Mutational signature and prognosis in adenocarcinoma of the bladder
Supporting Information Filename Description path6239-sup-0001-FiguresS1-S7,TablesS1,S2.docxWord 2007 document , 8.5 MB Figure S1. The mutation frequencies in bladder urothelial carcinoma and colorectal adenocarcinoma for the top 15 mutated genes of BAC/UAC Figure S2. Strand bias for T:A>A:T mutations in adenocarcinoma of the bladder Figure S3. Global CNV landscape in BAC/UAC Figure S4. Comparison of the gene expression profiles between BAC/UAC and colorectal adenocarcinoma Figure S5.
A 4-Channel Optogenetic Stimulation, 16-Channel Recording Neuromodulation System with Real-Time Micro-LED Detection Function
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Urethral Microenvironment Adapted Sodium Alginate/Gelatin/Reduced Graphene Oxide Biomimetic Patch Improves Scarless Urethral Regeneration
1 Introduction Urethral stricture, which is a narrowing process of urethra lumen caused by fibrosis of the urethra mucosa and the surrounding spongy corpus spongiosum, is often inevitable after urethral injury.[1-3] It has been reported that 229 to 627 out of 100 000 males suffer from urethral stricture, but the treatment is still limited in the field of urology.[4] Obviously, urethral stricture has a substantial impact on the quality of life in patients with high health costs.[4]...
BiLSTM for Predicting Post-Construction Subsoil Settlement under Embankment: Advancing Sustainable Infrastructure
1. Introduction Over the past few decades, extensive construction of highway and railway projects has occurred on compressible soil deposits within transportation infrastructure []. Accurate prediction of subsoil settlement is not only a significant challenge for project management in large-scale construction but also a cornerstone of sustainable development [,]. Despite the utilization of advanced geotechnologies and rational calculations [], achieving reliable predictions remains elusive.
Enhancing the Security: A Lightweight Authentication and Key Agreement Protocol for Smart Medical Services in the IoHT
1. Introduction The Internet of Things (IoT) [1,2,3] is a technology that enables the collection of real-time data and the connection of devices, thus serving as an infrastructure in people’s lives. With the advancements in the Internet, mobile communication, and wireless technology, the IoT can be applied to various environments, including smart home [4], smart grid [5], Internet of Vehicles [6,7], and artificial intelligence [8,9].
Androgen receptor and MYC transcriptomes are equilibrated in multilayer regulatory circuitries in prostate cancer
Corresponding Author Shaoyong S. Chen PhD Department of Urology, The First Affiliated Hospital of Nanchang University, Nanchang, P.R.China Department of Medicine, Hematology-Oncology Division, Beth Israel Deaconess Medical Center and Harvard Medical School, Boston, Massachussetts, USA Correspondence Keshan Wang, MD, Department of Urology, Union Hospital, Tongji Medical College, Huazhong University of Science and Technology, 1277 Jiefang Ave, Wuhan 430022, China.
Cancers | Free Full-Text | Data-Driven Assisted Decision Making for Surgical Procedure of Hepatocellular Carcinoma Resection and Prognostic Prediction: Development and Validation of Machine Learning Models
Open AccessArticle by Liyang Wang 1,2,†, Danjun Song 3,4,†, Wentao Wang 5, Chengquan Li 1, Yiming Zhou 6, Jiaping Zheng 3, Shengxiang Rao 5, Xiaoying Wang 4, Guoliang Shao 3,7, Jiabin Cai 4,*, Shizhong Yang 2,* and Jiahong Dong 1,2 1 School of Clinical Medicine, Tsinghua University, Beijing 100084, China 2 Hepato-Pancreato-Biliary Center, Beijing Tsinghua Changgung Hospital, School of Clinical Medicine, Tsinghua University, Beijing 102218, China 3 Department of Interventional Therapy, The...
Climate-aware decision-making: lessons for electric grid infrastructure planning and operations
Changing climate patterns have already begun to strain society’s infrastructure systems, and projected trends in ambient and extreme conditions portend significant stresses in the coming years. Billions of people worldwide rely on large-scale infrastructure systems, such as electric power, water, and transportation, for their daily needs.
Breast cancer local recurrence rate after breast conservation surgery
Introduction: There is variation in the guidelines for margin re-excision following breast conserving surgery (BCS) for breast cancer. The aim of this project was to assess our outcomes at 5 years post implementation of a new margins policy, aiming to decrease re-excision rates without an increase in ipsilateral breast tumour recurrence (IBTR).
Winners Announced for Airport of the Future Student Design
December 10, 2021 09:00 ET | Source: Fentress Architects Fentress Architects Denver, Colorado, UNITED STATES Denver, Colorado, Dec. 10, 2021 (GLOBE NEWSWIRE) -- Fentress Architects is excited to announce the winners of Fentress Global Challenge (FGC) 2021: Airport of the Future, which garnered over 80 entries from students around the globe. This year’s competition challenged students to envision airport mobility in the year 2100.
An autonomous excavator system for material loading tasks
Abstract Excavators are widely used for material handling applications in unstructured environments, including mining and construction. Operating excavators in a real-world environment can be challenging due to extreme conditions—such as rock sliding, ground collapse, or excessive dust—and can result in fatalities and injuries. Here, we present an autonomous excavator system (AES) for material loading tasks.
Cross-sectional observational study of epidemiology of COVID-19 and clinical outcomes of hospitalised patients in North West London during March and April 2020
Cross-sectional observational study of epidemiology of COVID-19 and clinical outcomes of hospitalised patients in North West London during March and April 2020 http://orcid.org/0000-0002-8108-4431Guduru Gopal Rao1, Alexander Allen2, Padmasayee Papineni1, Liyang Wang1, Charlotte Anderson2, Alastair McGregor1, Ashley Whittington1, Laurence John1, Miriam Harris1, Stephen Hiles1, Thomas Nicholas1, Katherine Adams1, Ayesha Akbar1, Paula Blomquist2, Valerie Decraene2, Bharat Patel2, Rohini Manuel2,...
Replacement reaction-based synthesis of supported palladium catalysts with atomic dispersion for catalytic removal of benzene
Increasing the dispersity of noble metals in transition metal oxides is an effective way to increase their activity and utilization for the catalytic removal of volatile organic compounds (VOCs). Herein, we report a strategy to combine the galvanic replacement reaction between copper (Cu) seeds and palladium (Pd) ions in an organic medium with a thermal treatment to produce supported Pd catalysts with atomic dispersion in CuO for the catalytic oxidation of benzene.
Epigenetic Component p66a Modulates Myeloid-Derived Suppressor Cells by Modifying STAT3
Epigenetic Component p66a Modulates Myeloid-Derived Suppressor Cells by Modifying STAT3 Jiaxuan Xin, Zhiqian Zhang, Xiaomin Su, Liyang Wang, Yuan Zhang, Rongcun Yang The Journal of Immunology April 1, 2017, 198 (7) 2712-2720; DOI: 10.4049/jimmunol.1601712
Epigenetic Component p66a Modulates Myeloid-Derived Suppressor Cells by Modifying STAT3
Epigenetic Component p66a Modulates Myeloid-Derived Suppressor Cells by Modifying STAT3 Jiaxuan Xin, Zhiqian Zhang, Xiaomin Su, Liyang Wang, Yuan Zhang, Rongcun Yang The Journal of Immunology February 13, 2017, 1601712; DOI: 10.4049/jimmunol.1601712
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