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Articles by Lu Yang
Sex-associated patterns of disease activity and physical function in ankylosing spondylitis: real-world cross-sectional evidence
Abstract Objective: To characterize sex-associated differences in disease activity and physical function in ankylosing spondylitis (AS) and to formally test whether the cross-sectional BASFI–ASDAS association differed by sex. Methods: We conducted a real-world cross-sectional analysis of 530 Chinese outpatients with rheumatologist-documented AS (387 men and 143 women).
Generation of spatiotemporal optical coil with controllable transverse intensity chirality Original
Abstract Chirality is a fundamental asymmetry in nature. In optics, control of chirality is evolving from spatial properties like polarization to the temporal chirality of local fields. Conventional approaches, however, encode chirality in abstract degrees of freedom such as phase or polarization, limiting direct and efficient coupling with matter on ultrafast timescales.
Life History Stage, Body Size and Morphology Dominate Fish Critical Swimming Speed: A Global Synthesis
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description faf70121-sup-0001-FigureS1-S4-TableS1-S14.docxWord 2007 document , 1.6 MB Figure S1: Flowchart of PRISMA for literature search and identification of relevant publications.
Association of Cognitive Function With Event-Related Potentials and Immune Inflammation in Adolescents With Major Depressive Disorder
1 Introduction Depressive disorder is a common and debilitating psychiatric condition characterized by persistent low mood, anhedonia, and reduced cognitive function. In adolescents, these symptoms not only hinder academic performance and social development but are also associated with functional impairment and cognitive difficulties that may persit across illness stages (Varghese et al. 2022; Schilling et al. 2021).
Ultrasound-Responsive Hydrogels Empowered by Two-Dimensional Sonosensitizers Enable Spatiotemporally Controlled Fracture Fixation and Bone Regeneration
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description smll76230-sup-0001-SuppMat.docx9.2 MB Supporting File: smll76230-sup-0001-SuppMat.docx. References 1, , , et al., “Biomaterials and Nanomedicine for Bone Regeneration: Progress and Future Prospects,” Exploration 1 (2021): 20210011.
Decoupling analysis of medical service provision and population health outcomes: a hybrid evaluation and machine learning approach
Abstract Introduction: Global healthcare faces a critical challenge where extensive medical resource expansion fails to translate into proportional population health outcomes due to diminishing marginal returns. The aim of this study was to explore the dynamic evolution, regional disparities, and non-linear associations between medical service provision (MSP) and population health outcomes (PHO) across Chinese provinces.
An open vision-language model for diverse medical applications
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Abstract Artificial intelligence has high potential for impact in healthcare applications, but its training and deployment are challenging due to diverse data, a complex spectrum of possible tasks and important privacy needs. High-performing foundation models that enable data-efficient fine-tuning for diverse downstream tasks can meaningfully accelerate development in this domain. We introduce MedGemma, a collection of medical vision-language foundation models based on Gemma 3.
By Sahar Kazemzadeh, Fereshteh Mahvar, Atilla P. Kiraly, Timo Kohlberger, Chufan Gao, Ronnachai Jaroensri, Shawn Xu, Cian O Hughes, Cían Hughes, Charles T. Lau, Justin Chen, Tiffany Chen, Jeremy Lai, Samuel Schmidgall, Lu Yang, Kejia Chen, Kenneth A Philbrick, Mercy Asaa Asiedu, Howard Hu, Howard Yang, Richa Tiwari, Sunny Jansen, Preeti Singh, Yubin Kim, Daniel McDuff, Catherine Kozlowski, Shreya pathak, Nino Vieillard, Sarah Perrin, Tatiana Matejovicova, Thomas Mesnard, Geoffrey Cideron, Michelle Casbon, Jean-Baptiste Alayrac, Vlad Feinberg, Sebastian Borgeaud, Cassidy Hardin, Robert Dadashi, Léonard Hussenot, Armand Joulin, Clement Farabet, Joelle Barral, Tris Warkentin, Jonathon Shlens, David Fleet Verified, Shekoofeh Azizi, Omar Sanseviero, Gus Martins, Phoebe Kirk, Anand Rao, Yossi Matias, Katherine Chou, Avinatan Hassidim, Dale Webster, Shravya Shetty, Yun Liu, David Steiner, Rory Pilgrim, Daniel Golden Verified, Lin Yang, Andrew Sellergren, Madeleine Traverse, Fayaz Jamil, Liron Yatziv, Bram Sterling, Stefanie Anna Baby, Susanna Maria Baby, Per Bjornsson, Shashir Reddy, Ryan Brush, Bashir Sadjad, Ines Mezerreg, Rachelle Sico, Aishwarya Kamath, Johan Ferret, Ramona Merhej, Alexandre Ramé, Morgane Riviere, Louis Rouillard, Jean-bastien Grill, Sabela Ramos, Edouard Yvinec, Elena Buchatskaya, Dmitry Lepikhin, Alek Andreev, Olivier Bachem, Victor Cotruta, Kavi Goel, Can Kirmizibayrak
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Nature
Verified
Nanoscale Thermocatalysis: Mechanisms, Regulation, and Biomedical Applications
1 Introduction Thermocatalysis, as a central branch of catalytic science, has long played a pivotal role in energy conversion and the chemical industry [1, 2]. In recent years, with the deep integration of nanotechnology and biomedical engineering, thermocatalysis has demonstrated emerging potential in biomedical applications [3].
Full power guarantee for World Cleanup Day global conference
The global main event of the 2026 World Cleanup Day Conference recently concluded in Shaoxing, Zhejiang province, marking the first time the conference's flagship global session has been held in China. State Grid Zhejiang Electric Power Company delivered all-round power support for the event in strict accordance with power guarantee standards applied for the Asian Games, successfully fulfilling its full-cycle power supply tasks.
Engineering Multifunctional Microneedle Devices: From Advanced Micro-Nano Manufacturing to Closed-Loop Theranostics
APCs antigen-presenting cells CAD computer-aided design CLIP continuous liquid interface production CMNs coated microneedles DDS drug delivery systems DLP digital light processing DMNs dissolving microneedles DRIE deep reactive ion etching ECG electrocardiogram EEG electroencephalogram FPBA fluorophenylboronic acid FRET förster resonance energy transfer GelMA gelatin methacryloyl GOx glucose oxidase HA hyaluronic acid SHMNs swellable hydrogel microneedles HMNs hollow microneedles ISF...
Sobre la base del respeto y la confianza mutuos, hacia un camino de desarrollo compartido
—Una nueva interpretación de la Asociación Estratégica Integral China-Ecuador en la nueva era Este año se cumple el décimo aniversario del establecimiento de la Asociación Estratégica Integral entre China y Ecuador.
Examining language practices on linguistic landscapes of tourism in Xi’an, China: A perspective of pride and profit
Aims and Objectives/Purpose/Research Questions: This paper draws on the framework of pride and profit to analyze language practices in the linguistic landscape of tourism in Xi’an, China. This study aims to answer (1) How are different languages used in the linguistic landscapes of tourism in Xi’an? and (2) How are the language practices on the tourism landscapes related to pride and profit? Design/Methodology/Approach: Visual ethnography is used for this interpretation.
Digital dividends across boundaries: inter-regional investment under enterprise digital transformation
ABSTRACT Inter-regional investment plays a critical role in enabling capital flows and fostering coordinated regional development. Drawing on the micro-level behaviour of establishing inter-regional subsidiaries, this study examines the impact of enterprise digital transformation on inter-regional investment using data on Chinese A-share listed companies from 2011 to 2023. Results show that enterprise digital transformation significantly facilitates inter-regional investment.
Integrative ferroptosis-related bioinformatics identifies PPARγ as a therapeutic target of ursolic acid against inflammation and pathological osteogenesis in ankylosing spondylitis
Abstract Background: Ankylosing spondylitis (AS) is an immune-mediated inflammatory disease characterized by persistent inflammation and aberrant new bone formation. Ferroptosis has increasingly been implicated in immune dysregulation and pathological bone remodeling; however, its molecular involvement in AS and its potential value for natural product discovery remain poorly understood.
Effects of Enhanced Recovery After Surgery-Based Nursing on Kinesiophobia and Anxiety-Depression in Elderly Patients After Hip Arthroplasty: A Retrospective Cohort Study
Background: Elderly patients undergoing hip arthroplasty frequently experience postoperative pain, limited mobility, and negative psychological states, which adversely affect rehabilitation outcomes. This study aimed to investigate the effect of Enhanced Recovery After Surgery (ERAS) on kinesiophobia, anxiety, and depression in elderly patients after hip arthroplasty. Methods: A single-centre retrospective cohort study of 132 elderly patients who underwent hip arthroplasty was conducted.
Machine Learning Reveals Role-Asymmetric Electronic Cooperation in Fe-Based Dual-Atom Catalysts
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description adma74833-sup-0001-SuppMat.pdf26.1 MB Supporting File: adma74833-sup-0001-SuppMat.pdf.
Defect Engineered Pyroelectric Ca 3 Co 4 O 9− x Nanostructure Enables Pyroptosis and Trained Immunotherapy
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description adma74768-sup-0001-SuppMat.docx29.8 MB Supporting File: adma74768-sup-0001-SuppMat.docx. References 1, , , and , “Biometallic Ions and Derivatives: A New Direction for Cancer Immunotherapy,” Molecular Cancer 24, no.
Alcohol reshapes liver zonal plasticity and immune-metabolic reprogramming in metabolic-syndrome associated hepatocellular carcinoma
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Abstract Hepatocellular carcinoma (HCC) commonly arises in metabolic dysfunction-associated steatohepatitis (MASH), alcohol-related liver disease (ALD), and metabolic dysfunction-associated ALD (MetALD), yet how zonal metabolic programs govern tumor lineage and immune responses remains unclear.
By Tian Tian, Yuhua Xue, Chunbao Sun, Lu Yang, Jinhui Wang, Brady Jin-Smith, Lin Jia, Huiping Zhou, Bilon Khambu, Xiao-Ming Yin, Daohong Zhou, Anastasia Chambers, Dongtao Ann Fu, Zhen Yuan Lin, Shengmin Yan, Lizi Wu, Chenglong Li, Li Zuo, Sergio Duarte, Sérgio Machado Duarte, Ali Zarrinpar, Hua Wang, Liya Pi, Joshua M. Barkin, Martin Nzegwu, Bryon Petersen
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Nature
Verified
The maize CMS-C fertility restore gene ZmRf4b encodes a SPL transcription factor that represses ZmMAP1D-mediated co-translational turnover of mitochondrial toxic ATP6C protein
Research articleOnline now Affiliations & Notes 1State Key Laboratory of High-Efficiency Production of Wheat-Maize Double Cropping, College of Agronomy, Henan Agricultural University, Zhengzhou, 450046, China 2The Shennong Laboratory, Zhengzhou, China 3Research Institute of Biology and Agriculture, University of Science and Technology Beijing, Beijing, 100083, China 4Shanghai Collaborative Innovation Center of Agri-Seeds, Joint Center for Single Cell Biology, School of Agriculture and...
Atomic-Level Strain-Engineered Piezoelectric Nanosheets for cGAS-STING Activation
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Research data are not shared. Supporting Information Filename Description anie74228-sup-0001-SuppMat.docx35.5 MB Supporting File 1: anie74228-sup-0001-SuppMat.docx. References 1, , , et al., “The cGAS‒STING Pathway in Cancer Immunity: Mechanisms, Challenges, and Therapeutic Implications,” Journal of Hematology & Oncology 18 (2025): 40, https://doi.org/10.1186/s13045-025-01691-5.
Photocuring-Induced Interfacial Dielectric Transition for Absorption-Dominated Electromagnetic Interference Shielding in Multi-Material 3D-Printed Composites
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Supporting Information Filename Description pc71523-sup-0001-TableS1-FigureS1-S2.docxWord 2007 document , 1.3 MB Table S1: Preparation parameters for materials of different concentrations.
PIGU expression is associated with poor prognosis and estimated immune cell infiltration in breast invasive carcinoma
Abstract Breast invasive carcinoma (BRCA) is a major cause of cancer-related mortality in women. PIGU, a subunit of the GPI-anchor biosynthesis complex, has been reported to be dysregulated in several cancers; however, its prognostic value and immune-related associations in BRCA remain unclear. We analyzed TCGA and GEO datasets to evaluate PIGU expression and its prognostic significance and association with immune infiltration patterns.
H2BK5ac is required for the establishment of inflammatory potential in mouse embryonic stem cells following differentiation
ReportVolume 45, Issue 8117850Open access Affiliations & Notes 1Laboratory of Molecular and Cellular Biology, Zhongzhou Laboratory for Integrative Biology, Institute of Metabolism and Health, School of Basic Medical Sciences, Henan University, Zhengzhou, Henan, 450046, China 2Kaifeng 155 Hospital, China RongTong Medical Healthcare Group Co. Ltd., Kaifeng, Henan, 475003, China 3Jining Key Laboratory of Forensic Medicine, School of Forensic Medicine and Neurobiology Institute, Jining Medical...
Epidemiological Characterizations and Diagnostic Strategies Variation in Parotid Gland Tumors (2010–2024): Observations Based on 2133 Cases
1 Introduction Salivary gland tumors (SGTs) are a rare type of tumor, accounting for 5% of all head and neck cancers. The World Health Organization's fifth-edition classification system for SGTs includes 20 types of primary malignant SGTs and 15 types of benign tumors [1]. Approximately 60%–80% of SGTs are located in the parotid gland [2]. Parotid gland tumors (PGTs) are highly heterogeneous, with significant differences in treatment strategies and prognosis between benign and malignant tumors.
MSC/MSC-EV therapy for chronic wounds: microenvironmental reprogramming, product design, and clinical translation
Abstract Chronic wounds are sustained not by a simple delay in the normal repair sequence, but by a hostile tissue microenvironment—persistent ischemia, non-resolving inflammation, proteolytic matrix degradation, oxidative stress, microbial burden, and senescence collectively form a self-reinforcing network that limits the effectiveness of conventional dressings and single-target interventions.
α-Satellite RNA maintains centromeric cohesion through R-loops
Keywords α-satellite RNA R-loops centromere centromeric cohesion chromosome segregation Get full text access Log in, subscribe or purchase for full access. References 1. Thakur, J. ∙ Packiaraj, J. ∙ Henikoff, S. Sequence, Chromatin and Evolution of Satellite DNA Int. J. Mol. Sci. 2021; 22, 4309 2. McNulty, S.M. ∙ Sullivan, B.A. Alpha satellite DNA biology: finding function in the recesses of the genome Chromosome Res. 2018; 26:115-138 3.
Concerted evolution reveals co-adapted amino acid substitutions in Na + K + -ATPase of frogs that prey on toxic toads
CorrectionOnline nowOpen access Article Info Publication History: Published online August 4, 2026 DOI: 10.1016/j.cub.2026.07.054 External LinkAlso available on ScienceDirect External Link Copyright: © 2026 Elsevier Inc. All rights are reserved, including those for text and data mining, AI training, and similar technologies.
Stepwise Anchoring of Atomically Dispersed Fe-Fe Diatomic Sites via a Prussian Blue Analogue Route for Advanced Oxygen Reduction in Zinc-Air Batteries
Conflicts of Interest The authors declare no conflict of interest. Data Availability Statement The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions. Supporting Information Filename Description smll74495-sup-0001-SuppMat.docx9.1 MB Supporting File: smll74495-sup-0001-SuppMat.docx.
Dietary Inflammatory Index, cardiovascular health, and long-term outcomes in hypertension: external validation in a Chinese percutaneous coronary intervention cohort
Abstract Background: Hypertension frequently coexists with poor cardiovascular health (CVH), yet whether the inflammatory potential of habitual diet, captured by the Dietary Inflammatory Index (DII), relates to CVH and to subsequent adverse cardiovascular events in this population remains unclear. Methods: A discovery analysis was performed in 12,376 hypertensive adults from NHANES (2005–2018), with suboptimal CVH defined as a Life’s Essential 8 (LE8) score < 80.
Ductile B2 Intermetallics-Driven Strength-Ductility Synergy in Heterolaminated Multi-Principal Element Alloys
1 Introduction Achieving the concurrent realization of high strength and large ductility remains a central challenge in structural alloy design [1, 2]. This well-known strength–ductility trade-off, rooted in the fundamentally antagonistic roles of mechanisms that promote strength versus those that accommodate plasticity, continues to limit the performance envelope of advanced metallic materials [3].
Breeding habitat characteristics of Saunders’s Gull ( Saundersilarus saundersi ) in the Liao River Estuary National Nature Reserve using MaxEnt
Abstract Conservation of breeding habitats is essential for sustaining populations of endangered waterbirds, yet quantitative links between breeding behavior and environmental drivers remain poorly understood. Saunders’s Gull (Saundersilarus saundersi), a globally endangered species, has its largest breeding population in the Liao River Estuary National Nature Reserve (LRENNR), China.
Pain, Sleep, and Affective Symptoms in Primary Dysmenorrhea: A Symptom Network and Insular Connectivity Study
Back to Journals » Journal of Pain Research » Volume 19 Original Research Pre-Clinical/Scientific Authors Yang L, Wei W, Hu K, Yang Q, Gong Y, Qian X , Tang Y , Si Y, Liu Q, Feng F, Yu S, Yang J Received 16 July 2026 Accepted for publication 20 October 2026 Published 3 November 2026 Volume 2026:19 641007 DOI https://doi.org/10.2147/JPR.S641007 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Ryan D'Souza Lu...
Covalently crosslinked chitosan–astaxanthin nanoparticles: a stable, bioavailable oral delivery system with potentiated relief efficacy against chronic colitis
CONFLICT OF INTEREST The authors declare that there is no conflict of interest. DATA AVAILABILITY STATEMENT Data supporting this work are included in this published article. Sequence data from this paper have been submitted to the NCBI databases under accession numberPRJNA1099755. REFERENCES 1, , , , , et al., Targeted delivery of fc-fused PD-L1 for effective management of acute and chronic colitis. Nat Commun 15: 1673 (2024).
The mediating effect of error management climate on the relationship between nursing informatics competency and information security attitude among clinical nurses: a cross-sectional study
Abstract Background: With the development of information technology, the issue of data leakage in hospitals has become increasingly prominent. As the primary personnel who handle sensitive data directly, the information security attitudes of nurses are a critical determinants of medical information safety. However, no studies have explored the relationships among nursing informatics competency, error management climate, and the information security attitudes of nurses.
Socioeconomic inequalities in self-reported vision impairment among middle-aged and older adults in China: a national longitudinal study from 2011 to 2018
Abstract To define temporal trends and socioeconomic inequalities in vision impairment in China. This analysis utilises data from the China Health and Retirement Longitudinal Study, a nationally representative cohort study, which enrolled 10,942, 11,026, 12,717 and 16,095 participants aged ≥45 years across four survey waves conducted in 2011, 2013, 2015 and 2018, respectively.
Modeling age-structured population density with time and spatial noises based on uncertain partial differential equation
Advanced search Mathematical Population Studies An International Journal of Mathematical Demography Latest Articles Submit an article Journal homepage Full Article Figures & data References Citations Metrics Reprints & Permissions Read this article /doi/full/10.1080/08898480.2026.2692419?needAccess=true ABSTRACT How to model migration population with age structure has always been one of the most concerned topics in demography.
Sulfur Vacancy-Enriched Cu 4 SnS 4−x Nanosheets Enable Synergistic Cuproptosis, Photothermoelectric Catalytic and Immunotherapy
1 Introduction Phototherapy is a non-invasive cancer treatment modality that encompasses photodynamic therapy (PDT), photocatalytic therapy (PCT), and photothermal therapy (PTT) [1-3]. These approaches utilize therapeutic reagents that generate reactive oxygen species (ROS) or photothermal effects under specific light irradiation for inducing cell apoptosis and death [4-6].
Advances of Peptide-Drug Conjugates in the Treatment of Digestive System Tumors
Introduction Digestive system tumors rank among the most prevalent malignancies globally and pose a significant threat to public health. Epidemiological studies consistently show that digestive cancers—including gastric, colorectal, hepatocellular, pancreatic, and esophageal carcinomas—are associated with high incidence and mortality rates worldwide.1,2 Current treatments for digestive system tumors include surgical resection, chemotherapy, radiotherapy, targeted therapy and immunotherapy.
Advances of Peptide-Drug Conjugates in the Treatment of Digestive System Tumors
Back to Journals » Drug Design, Development and Therapy » Volume 20 Authors Yang L, An M, Ma J, Li Y, Ma Y, Qin L, Han Z Received 25 June 2026 Accepted for publication 15 September 2026 Published 23 September 2026 Volume 2026:20 635765 DOI https://doi.org/10.2147/DDDT.S635765 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 4 Editor who approved publication: Prof.
Data mining and clinical observational study on the association between smoking and premature ovarian insufficiency
Abstract Objective: This exploratory study investigates the association between smoking and premature ovarian insufficiency (POI) to inform smoking cessation strategies and support women’s reproductive health. Methods: Using literature data mining and association rule analysis, we constructed a protein–protein interaction (PPI) network to identify potential core targets associated with POI.
Health Information-Seeking Behaviors Among Patients with Autoimmune Rheumatic Diseases: A Qualitative Study Guided by the S-O-R Theory
Introduction Autoimmune rheumatic diseases (ARDs) impose a substantial and growing global health burden.
The gut-heart axis: a review of the mechanisms and therapeutic prospects of gut microbiota and their metabolites in cardiovascular disease
Abstract The gut microbiota, a vital virtual organ, communicates bidirectionally with the host cardiovascular system via its intricate metabolic network, forming the gut-heart axis. This review systematically clarifies the causal relationship between gut dysbiosis and the pathogenesis of cardiovascular diseases CVD), moving beyond epidemiological associations to solid causal evidence from preclinical and clinical studies.
Correction: Case Report: Quantitative and qualitative evaluation for electroacupuncture combined with moxibustion in the treatment of recalcitrant low anterior resection syndrome
A Correction on Case Report: Quantitative and qualitative evaluation for electroacupuncture combined with moxibustion in the treatment of recalcitrant low anterior resection syndrome by Hu, C., Li, X., Yang, L., Fang, R., Huang, J., and Yang, M. (2026). Front. Med. 13:1815559. doi: 10.3389/fmed.2026.1815559 The correct corresponding authors are Jinchang Huang and Ming Yang.
ASPP2 inhibits hepatocellular carcinoma growth by regulating cuproptosis via mitochondrial protein lipoylation
Abstract Hepatocellular carcinoma (HCC) is a metabolically active malignancy. Cuproptosis, a copper-dependent programmed cell death pathway, has been found to be closely associated with tumor progression. Cells with strong oxidative phosphorylation (OXPHOS) capacity exhibit heightened susceptibility to cuproptosis. We demonstrate that the tumor suppressor ASPP2 regulates the key cuproptosis modulator FDX1 by promoting NR2F2 recruitment to the FDX1 promoter in HCC.
Photoactivatable CRISPR/Cas13d via upconversion nanoparticles for deep tissue RNA engineering and orthopedic therapy
Abstract Spatiotemporal control of RNA therapeutics remains a fundamental challenge limiting clinical translation. Here, we develop a photoactivatable CRISPR/Cas13d (paCas13d) system that enables non-invasive, light-controlled RNA manipulation in deep tissues. Through structure-guided engineering, we identify optimal split sites within RfxCas13d and create light-switchable fragments using CRY2PHR/CIBN optogenetic dimerization.
A degrader of HER2 and EGFR abolishes p95HER2 and shows robust antitumor efficacy in HER2-positive breast cancer
Abstract p95HER2 is commonly expressed in human epidermal growth factor receptor 2 (HER2)-positive breast cancer (BC) and is generated primarily from shedding of the extracellular domain of HER2. p95HER2 is oncogenic, driving aggressive tumor growth, and conferring drug resistance. Targeting p95HER2 is challenging. Clinically approved HER2 inhibitors either cannot bind to p95HER2 or show limited inhibitory effects.
Manganese-Doped Piezoelectric Layered Double Hydroxides Induce Catalytic Therapy and Ferroptosis
1 Introduction Sonopiezoelectric therapy (SPT) is a non-invasive therapeutic approach that employs ultrasound (US) at specific frequencies to activate sonosensitizers, generate reactive oxygen species (ROS), and induce tumor cell death [1-5]. This modality offers advantages that include safety, strong tissue penetration (∼10 cm), and high patient tolerance [6].
W-Mo 15 S 19 /Co 3 O 4 Composite Catalyst for Methanol Oxidation Reaction in Alkaline Media
Y.Wang, Y.Qin, L.Yang, Y.Hu, and H.Huang, “W-Mo15S19/Co3O4 Composite Catalyst for Methanol Oxidation Reaction in Alkaline Media.” Chemistry – A European Journal (2026): e70943. https://doi.org/10.1002/chem.70943 Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
CRISPR/Cas12a: A Comprehensive Review from Structural Foundations to Applications in Nucleic Acid Precision Detection Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! CRISPR/Cas12a technology, characterized by its distinctive trans-cleavage activity, has evolved beyond its gene-editing function to emerge as a powerful tool for molecular detection. This review systematically delineates its structural foundation and molecular mechanism, with a focus on how the technology converts specific nucleic acid recognition into cascade signal amplification.
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