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Articles by Luise Fast
Incorporating brain-inspired mechanisms for multimodal learning in artificial intelligence
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Multimodal learning enhances the perceptual ability of intelligent systems by integrating information across sensory modalities.
Foveated light-field compound imager
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Artificial vision systems hold transformative potential for biomedical imaging, diagnostics, and translational research by emulating and extending the capabilities of biological eyes.
Observational constraints from global ice-phase fraction indicate moderate climate sensitivity
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Cloud feedback remains the largest source of uncertainty in estimates of climate sensitivity. Among its components, the cloud optical depth (τ) feedback acts as a negative feedback that suppresses climate warming, yet it remains poorly constrained by observations.
Differential DNA damage response to WRN inhibition identifies a targetable vulnerability in ARID1A -mutated cancers
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract ARID1A (AT-rich interaction domain 1A), a key subunit of the switch/sucrose non-fermentable (SWI/SNF) chromatin remodeling complex, is frequently mutated in cancers.
The ligand preference of LRP1 is regulated by O-glycans
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The family of low-density lipoprotein receptor (LDLR) and LDLR-related proteins (LRPs) are endocytic receptors serving as essential regulators of multiple physiological processes including cholesterol clearance, protein reabsorption, and neuronal protein trafficking.
By Youngmin Ko, John Hintze, Luise Fast, Asli B. Topaktas, Thomas D. Madsen, Shifa Jebari-Benslaiman, Silvia D’Andrea, Noortje de Haan, Lasse H Hansen, Noé Quittot, Cesar Martin, César A. Martin, César Martín, Zhang Yang, Sergey Y. Vakhrushev, Rebecca Miller, Dudley K. Strickland, Bradley T. Hyman, Elisa Fadda, Katrine T. Schjoldager, Bethany H. Claridge, Rob Baars
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Near-inertial internal waves funneled into Taylor caps shape seamount tops, with implications for biodiversity in the deep ocean
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Internal waves are energetic and ubiquitous in the ocean and their interactions with submarine topography could drive sediment resuspension and reshape seafloor substrate. However, the mechanisms governing these interactions are largely unknown.
Biofunctionalized polymer semiconductors toward soft and stretchable transistor-based biosensors
Abstract INTRODUCTION RESULTS DISCUSSION METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Organic materials with tunable chemical and mechanical properties are ideal for interfacing with skin and tissue in biomedical applications.
Mass-invariant universal optical conductivity from quantum geometry
Abstract INTRODUCTION RESULTS AND DISCUSSION METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Mass is a defining property of particles, shaping their fundamental nature and interactions. In condensed matter systems, the effective mass of electrons has long been regarded as a key factor influencing material properties, including their transport and optical responses.
The myokine irisin ameliorates the secretory dysfunction of pancreatic β cells in experimental and human type 2 diabetes
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Irisin is a myokine that enhances insulin secretion and β cell viability in both rodent and human β cells. Here, we investigated whether irisin preserves β cell functional mass in vivo in diabetic mice and ex vivo in human pancreatic islets from subjects with type 2 diabetes (T2D).
By Youngmin Ko, John Hintze, Luise Fast, Nicola Marrano, Anna Borrelli, Giuseppina Biondi, Martina Rella, Rossella D’Oria, Valentina Annamaria Genchi, Cristina Caccioppoli, Valerio Galasso, Giovanni Galluzzi, Luca Roberto, Anna Signorile, Leonardo Vincenti, Fabrizio Aquilino, Rita Nano, Federico Baruzzi, Antonio Moretti, Luigi Lupo, Piero Marchetti, Lorenzo Piemonti, Angelo Cignarelli, Sebastio Perrini, Luigi Laviola
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Genomic-to-space measurements reveal large-scale ocean nutrient stress
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Phytoplankton growth and ocean primary production depend on a nutrient supply that fluctuates across seasonal to millennial timescales. Because surface nutrients and phytoplankton biomass recycle rapidly, they obscure the large-scale pattern of nutrient stress.
Electrode-omics reveals epochs in silicon anode evolution underpinning electrochemomechanical resilience
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Here, we advance electrode-omics to identify evolutionary bursts by which ethereal locally superconcentrated electrolytes (LSCEs) mitigate silicon anode degradation through its epochs of electrochemical and chemical reactions.
Broadband and high-speed terahertz wireless sensing via vertical-transport Dirac-source detector
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract In the realm of wireless sensing, it is envisioned that sensing and communication functionalities will coexist and be fully integrated within a unified system.
Architecting three-dimensional reconfigurable matter from pop-up kirigami with programmable multistability
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Mechanical pop-up systems, which reconfigure from two-dimensional (2D) into complex three-dimensional (3D) shapes, are promising for advanced manufacturing and deployable devices.
Light-based 3D printing of mechanoluminescent living gels loaded with dinoflagellates
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Dinoflagellates, a group of marine unicellular algae, are known for the fascinating glowing effects in coastal waters.
Engagement of the TCR against an oncolytic virus generates a population of effector CAR T cells with potent antitumor activity
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Chimeric antigen receptor (CAR) T cell therapy faces many challenges against solid tumors including T cell exhaustion and poor CAR durability.
Regulation of NAT1 activity in modern humans by a novel phosphorylation site
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract N-acetyltransferase 1 (NAT1) is an enzyme that acetylates certain drugs and carcinogens and is involved in folate metabolism. Some NAT1 variants are associated with susceptibility to cancer and birth defects.
Enteric viral infections promote systemic accelerated aging in Drosophila
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Do viral infections accelerate aging, and does this acceleration scale with pathogenicity?
Bioinspired spatiotemporal control of microhelix formation and actuation
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Helical structures provide critical functions in structural stability, locomotion, and mechanical flexibility.
The impactful role of the HDACs in the regulation of gene expression and as targets for disease therapy
Abstract INTRODUCTION RESULTS AND DISCUSSION Acknowledgments REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Histone deacetylases (HDACs) are potent regulators of gene expression, yet incomplete understanding of individual HDAC function coupled with the lack of selective inhibitors has impeded successful targeting of these proteins for the improvement of human health.
Structural and functional mapping of protective human monoclonal antibodies against enterovirus A71
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract EV-A71 has been responsible for recent severe HFMD outbreaks. We report structures for 12 potently neutralizing human anti–EV-A71 monoclonal antibody Fabs, alone and complexed with virus.
A minimal transcription factor network is sufficient to drive paclitaxel biosynthesis
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The supply of the anticancer drug paclitaxel is limited by its low natural abundance and complex chemical structure. We previously reported the development of a cultured Taxus cambial meristematic cell (CMC) system, where methyl jasmonate enhances paclitaxel production.
A sustained living coating for infectious keratitis therapy via probiotic consumption and production effects
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Excessive inflammation and infection are critical factors leading to biomaterial failure and delayed wound healing. Surface modification of biomaterials with drug-loaded coatings can effectively address these issues.
A potato late blight pathogen effector interacts with ENTH-domain protein TOL9a and an activated helper NLR to suppress immunity
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Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Pathogens counteract central nodes of NLR immune receptor networks to suppress immunity. However, the mechanisms by which pathogens hijack helper NLR pathways are poorly understood.
By Youngmin Ko, John Hintze, Luise Fast, Jogi Madhuprakash, AmirAli Toghani, Hsuan Pai, Madia Harvey, Adam R. Bentham, Benjamin A Seager, Juan Carlos de la Concepcion, David Lawson, Clare E. M. Stevenson, Angel Vergara-Cruces, Lida Derevnina, Tolga Bozkurt, Mark Banfield, Sophien Kamoun, Mauricio P. Contreras
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Reactive reconstruction and embedded passivation of heterointerfaces for intrinsically stable perovskite photovoltaics
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Heterointerface degradation under operational stress represents a critical limitation to perovskite solar cell longevity.
A plant pathogen effector blocks stepwise assembly of a helper NLR resistosome
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Helper NLRs function as central nodes in plant immune networks. Upon activation, they oligomerize into inflammasome-like resistosomes to initiate immune signaling, yet the dynamics of resistosome assembly remain poorly understood.
Massively parallel bead-free force spectroscopy with fluorescence
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Single-molecule force spectroscopy (SMFS) has transformed our understanding of biomolecular mechanics.
Enhanced chiral discrimination in mass spectrometry with orbital angular momentum beams
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Chirality, the absence of mirror symmetry, is a fundamental property observed from subatomic particles to molecules and macroscopic systems. Distinguishing molecular mirror images (enantiomers) is essential in pharmaceuticals and molecular diagnostics.
Erratum for the Research Article “Highly efficient light-gated COF membrane for precise multistage molecular separation” by L. Zhai et al .
Information & Authors Metrics & Citations View Options References Figures Tables Media Share In the original version of the Research Article, “Highly efficient light-gated COF membrane for precise multistage molecular separation” by L. Zhai et al., an error occurred during figure plotting. In Fig. 2E, the authors inadvertently used the same XRD data curve twice for two different samples. Figure 2 has been updated with the correct version of panel (E) and the raw XRD data for Fig.
Electric field–guided random-access DNA data storage
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract DNA offers the promise of high-density, long-term storage, yet current systems face limitations due to polymerase chain reaction–based manual workflows that are inherently slow, error prone, and difficult to scale for practical applications.
Evolution of a ZW sex determination system in sticklebacks
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract The stickleback system offers a powerful model for investigating the evolutionary dynamics of sex chromosome differentiation. Although a ZW sex determination mechanism has previously been reported in sticklebacks, its origin and evolutionary history remain poorly resolved.
Genomic evidence for limited entomophagy in ancient Europeans
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract To meet the rising food demands of our growing population, the Food and Agriculture Organization proposed edible insects as sustainable sources of animal protein.
Uncovering functional variants using a high-efficiency PE3-based screening platform
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Prime editing (PE) enables precise nucleotide changes but has limited utility in high-throughput functional screening due to low editing efficiency.
Tropical impacts of the Southern Ocean underestimated by mean-state biases
Abstract INTRODUCTION RESULTS DISCUSSION MATERIALS AND METHODS Acknowledgments Supplementary Materials REFERENCES Information & Authors Metrics & Citations View Options References Figures Tables Media Share Abstract Observed sea-surface temperature (SST) trends over recent decades feature cooling in the tropical eastern Pacific and the Southern Ocean (SO). Growing evidence suggests that tropical cooling may partly stem from remote impacts of the SO.
Search-and-remove genome editing allows selection of cells by DNA sequence - Nature Communications
Abstract The selection of cells that have acquired a desired gene edit is often done by the introduction of additional genes that confer drug resistance or encode fluorophores. However, such marker genes can have unintended physiological effects and are not compatible with editing of single nucleotides. Here, we present SNIPE, a method that allows the marker-free selection of edited cells based on single nucleotide differences to unedited cells.
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