Mark Hamilton
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Articles by Mark Hamilton
Clonal hematopoiesis and cytopenias following CAR19 therapy
Abstract CD19-directed chimeric antigen receptor T cell therapy (CAR19) improves survival in relapsed/refractory large B cell lymphoma compared with immunochemotherapy with intent for autologous hematopoietic cell transplantation (autoHCT). However, major toxicities include prolonged cytopenias, infection and secondary hematologic malignancies.
Long-term clinical outcomes from the smart start trial: rituximab, lenalidomide and ibrutinib in patients with newly diagnosed large B-cell lymphoma Original
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Diffuse large B-cell lymphoma (DLBCL) represents the most common non-Hodgkin lymphoma, in which ~60–85% of patients achieve a complete response (CR) with standard frontline chemoimmunotherapy approaches [1,2,3]. Despite these promising response rates, ~40% of patients can develop relapsed or refractory disease, and significant research efforts have been devoted to improving the durability and response with frontline therapies through the incorporation of novel agents [1, 2].
By Karan L. Chohan, Eduardo Edelman Saul, R. Eric Davis, Fredrick Hagemeister, Raphael Steiner, Luis Fayad, Sairah Ahmed, Alma Rodriguez, Swaminathan Iyer, Ranjit Nair, Francisco Vega, Dai Chihara, Preetesh Jain, Luis Castillo, Chijioke Nze, Fateeha Furqan, Ayushi F. Chauhan, Mark Hamilton, Jared Henderson, Anath C. Lionel, Christopher Flowers, Sattva Neelapu, Michael Green, Jason R Westin
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Nature
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Spectrum, pathobiology, mechanistic insights and diagnostic challenges of post-CAR T cell therapy lymphoproliferative disorders
Abstract Chimeric antigen receptor (CAR) T cell therapy is now widely used for the treatment of various haematological malignancies, with emerging applications in solid tumours and autoimmune diseases. Alongside its demonstrated clinical activity, this therapeutic modality has a toxicity profile that differs from those associated with traditional cytotoxic therapies, other immunotherapies, and even other cell therapy approaches such as allogeneic haematopoietic stem cell transplantation.
A single-cell atlas characterizes dysregulation of the bone marrow immune microenvironment associated with outcomes in multiple myeloma - Nature Cancer
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Abstract Multiple myeloma (MM) remains incurable despite advances in treatment options. Although tumor subtypes and specific DNA abnormalities are linked to worse prognosis, the impact of immune dysfunction on disease emergence and/or treatment sensitivity remains unclear. We developed an Immune Atlas of MM by generating profiles of 1,397,272 single cells from the bone marrow (BM) of 337 newly diagnosed participants and characterized immune and hematopoietic cell populations.
By William C. Pilcher, Edgar Gonzalez-Kozlova, Mark Hamilton, Shivani Nanda, Yizhe Song, Julia Wang, Denis J. Ohlstrom, Mark A. Fiala, Michael Slade, Michael Rettig, Zhihong Chen, John DiPersio, Seunghee Kim-schulze, Shaji Kumar Verified, Madhav V. Dhodapkar, David Avigan, George Mulligan, Sacha Gnjatic, Ioannis S. Vlachos
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Nature
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American Society of Hematology (ASH) | Conferences | CGTlive®
The associate staff member at the Cleveland Clinic discussed a study he presented at ASH’s 2025 Annual Meeting. AZD0120, a dual-targeted CAR T-cell therapy, shows high efficacy in treating relapsed multiple myeloma, achieving a 96% response rate. ByMark Hamilton, MD, PhD,Noah Stansfield Mark Hamilton, MD, PhD, a hematology-oncology and BMT cell therapy fellow at Stanford University, discussed implications of his institution’s findings on treatment-related secondary malignancies.
42944 Calle Reva, Temecula, CA 92592, US
Copied 42944 Calle Reva, Temecula, CA 92592, US $730,000 42944 Calle Reva, Temecula, CA 92592 Checked: 19 hours ago Updated: Sep 08, 2025 at 09:35PM Investment Summary Potential Missing Expenses We noticed that are missing—this is a standard expense and should be considered in your estimate. Net Operating Income (NOI) minus mortgage payments.
Large B cell lymphoma microenvironment archetype profiles
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Keywords: lymphoma microenvironment CAR T cell single cell RNA sequencing Introduction Large B cell lymphomas (LBCLs) are a heterogeneous group of malignancies that are pathologically classified into diffuse large B cell lymphoma (DLBCL), high grade B cell lymphomas not otherwise specified (HGBCL), high grade B cell lymphoma with MYC and BCL2 translocations (double hit lymphoma; DHL), or other less common variants.1,2 Transcriptional profiling can further separate DLBCLs into activated B cell...
By Xubin Li, Kartik Singhal, Qing Deng, Dai Chihara, David A. Russler-Germain, R. Andrew Harkins, Jared Henderson, Kotaro Arita, Atish Kizhakeyil, Ryan Sun, Priya Lakra, Usama Khamis Hussein, Jennifer A Foltz, ashley wilson, Evelyn F. Schmidt, Imran Nizamuddin, Tommy Dinh, Akhil Kesaraju, Mark Hamilton, Carl Allen, Maher Gandhi, Joshua Tobin, Aixiang Jiang, Laura Hilton, David Scott Verified, Francisco Vega, Christopher Flowers, Jason R Westin, Obi L. Griffith, Todd A. Fehniger, Malachi Griffith, Michael Green
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Cell Press
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Analyzing PostCAR Myeloid Neoplasms
The FDA began requiring black box warnings for commercially available autologous chimeric antigen receptor T-cell (CAR-T) therapy products in early 2024, with the move made in relation to the potential risk for the development of secondary T-cell malignancies after treatment.1 Notably, a study being conducted at Stanford University seeking to better understand this risk was recently presented at the 66th American Society of Hematology (ASH) Annual Meeting and Exposition, held December 7-10,...
Takashi Murakami, Exhibition, Mixed media, Gagosian Gallery, London, United-Kingdom
Exhibition Gagosian Gallery, London, United-Kingdom Gagosian is pleased to announce a presentation of paintings by Takashi Murakami at its space in London’s Burlington Arcade. The display includes four new flower paintings, installed in the upstairs gallery, while the shop houses an extensive selection of publications, prints, and merchandise.
ARCHITECTURAL EXPRESSIONS OF FAITH
Keywords religious architecture, architectural expression, faith, LDS, temple College Fine Arts and Communications Abstract The temple is a widely recognized symbol of the LDS faith; however, more accessible to members and non-members around the world, in humble or elaborate form, is the basis of our weekly worship, the chapel. This research, completed as my senior project in Interior Design, analyzes the architectural and interior design of our chapels in three-parts.
Marion Mahony Griffin: A Woman Apart
Keywords Marion Mahony Griffin, gender, female artists, female inferiority College Fine Arts and Communications Abstract “An artist’s limitations are his best friends.”1 For many artists, this statement is perhaps true, but throughout history, one limitation has proven fatal: gender.
World Mental Health Awareness Day
It is World Mental Health Day on 10 October 2024. This year’s theme is “It’s Time to Prioritise Mental Health in the Workplace”. The theme highlights the importance of addressing mental health and wellbeing at work, recognising that doing so benefits not just employees, but organisations and communities as a whole. Mental health issues, such as stress, anxiety and burn-out, not only significantly impact employees' general wellbeing, but in turn their performance and morale at work.
Considering the right to switch off
As we highlighted in our May 2024 post, at the start of the summer the European Commission concluded a consultation on the "right to disconnect". The results of that consultation are yet to be published, but the issue is now on the UK government's agenda following the Labour Party's commitment to introduce a new "right to switch off" as part of its Plan to Make Work Pay.
Amish Beef and Noodles
One of my earliest “foodie” memories from childhood has to do with people coming back from the Amish country in southern New York State, near the Pennsylvania border, with all sorts of amazing pies, breads, and other baked goods. It was always a treat to enjoy whatever freshly made goodness they were sharing, but had I known about these beef noodles, I would have made a special request for their next road trip.
Bendamustine is a safe and effective lymphodepletion agent for axicabtagene ciloleucel in patients with refractory or relapsed large B-cell lymphoma
Discussion LD chemotherapy plays a critical role in the expansion and persistence of infused CAR T-cells. While CAR T-cell therapy has revolutionized the treatment of non-Hodgkin’s lymphoma, the incidence of CAR T-cell therapy-related toxicity is high and contributes to morbidity and mortality. In addition to drug shortage situations, there is a need to study alternative LD regimens to improve safety while preserving efficacy.
Cleft lip sidedness and the association with additional congenital malformations
The authors have declared no competing interest. Professor Sarah Lewis is supported by a project grant from the Medical Research Council (MR/T002093/1) I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Affirmation and delay in constructive dismissal
The Employment Appeal Tribunal (EAT) recently provided clarifications on key aspects of constructive dismissal – in particular, acceptance of the employer's breach (affirmation) and delay. The EAT ruled in Leaney v. Loughborough University that, when considering affirmation and constructive dismissal, all relevant features of the case should be carefully considered and that too much focus should not be put on the length of any delay.
¿La crónica de una militarización anunciada? El rol militar y las relaciones cívico-militares en los tiempos de pandemia
Bartolomé, Mariano [1] ; Hamilton, Mark [1] ; Pereyra Bordón, Roberto [1] [1] Colegio Interamericano de Defensa (CID), Organización de Estados Americanos, Washington DC Localización: Perspectivas: revista de ciencias sociales, ISSN-e 2525-1112, Vol. 8, Nº.
Editorial. The glymphatic system imagined and now imaged: what is it, and why is it important?
Correspondence Mark G. Hamilton: mghamilton.hydro@gmail.com. INCLUDE WHEN CITING Published online September 8, 2023; DOI: 10.3171/2023.7.JNS231284.
Deputy PSNI chief Mark Hamilton to face Police Federation
Mark Hamilton is due at the extraordinary meeting after his boss Simon Byrne resigned. Image caption, Deputy Chief Constable Mark Hamilton is in command of the PSNI until a new chief constable is in post By Jayne McCormack BBC News NI political correspondent Deputy Chief Constable Mark Hamilton is expected to attend an extraordinary...
Mark Hamilton: Could the Pebble Mine project have been done better? Here's how
By MARK HAMILTON There is no question the Pebble Project mine could have had a better beginning, and maybe a different outcome. I can’t tell you I would have done it differently, but with 20-20 hindsight, there was a better way. There were some efforts to involve the Bristol Bay Native Corporation, but not enough efforts. The fact that the mine site was on state land was not a reason to fail to educate all the people in Bristol Bay.
Mark Hamilton: Don't let Alaska get 'Pebbled' again
By MARK HAMILTON Something happened. I’m not going to speculate exactly what happened. Representing Pebble mine for three years, I spent far too much time dealing with speculation by opponents with no basis in fact. I have no facts, no smoking gun. But something happened.
Pebbled: Climate change and predictions for the future that were wildly wrong
By MARK HAMILTON Climate change is an anti-developer’s dream. It’s a topic everyone is familiar with and it can assign dire warnings to virtually anything, because it is a prediction of the future. Remember I asked you to develop your own filter so you can pick your experts? Before you panic, check if the source has correctly predicted anything. Nonetheless, regulations have been established that account for that fear-based future. I’ll introduce one in a bit.
Mark Hamilton: You can go fishing in a modern tailings pond
By MARK HAMILTON / PEBBLED SERIES Hopefully, in reading this series, your understanding of the mining process will allow you to be aware of the predictable fear mongering of any mining project in the future. Nothing is portrayed to be more sinister than the failure of the tailings facility. This message of doom is usually accompanied by references to historic catastrophes that did, in fact, occur. As part of your awareness, check the dates and the location of these very real events.
Mark Hamilton: The Fraser Report shows the importance of 'policy perception'
Part 11 of a series on the Pebble Project. By MARK HAMILTON The Fraser Institute Annual Survey of mining companies looked at 2,700 exploration, development, and other mining related companies around the world. Their findings consider mineralization and policy perception. They compile an overall investment attractiveness index. The mineralization looks at what’s there, and the policy perception is a judgment on the “hospitality” of the regulations, taxes etc.
Explore Fall Foliage at Unique Historical Sites in New York State
Make the most of the beautiful fall season by taking a break from everyday life and immersing yourself in history across the state. Discover historical and cultural attractions that tell the story of New York’s unique people, places and heritage at these amazing historic sites that offer magnificent views for fall foliage. Remember to social distance and wear a mask as required by state guidelines. Call ahead and check websites and social media to make sure attractions are open and available.
Pebbled: Mining 101, how we get our metals
By MARK HAMILTON / PEBBLED SERIES Mining is actually a simple process made voluminous by the very low density of the sought-after minerals. A mine with one gram of gold in every ton of earth would be sufficiently rich to take a look at. Getting at that gram is the process I will describe. Mining engineers might well wince at my description, but it is a way to understand for people like me who are not mining engineers. First, you remove the overburden, the top layer of what we might call soil.
Mark Hamilton: Here we go again, with EPA doubling down on power grabbing
By MARK HAMILTON Part 10 of a series on the Pebble Project. Here we go again with another power grab by a corrupted federal agency. We learned a lot during Act I of this farce. That extraordinary fantasy was an introduction of a 404(c) section of the Clean Water Act to block the Pebble Project before it was allowed to enter the National Environmental Policy Actprocess. This wasn’t simply rare; it was unprecedented.
Pebbled: Prices of metals may mean mining projects have better luck moving ahead
By MARK HAMILTON (Editor’s note: This is the 10th in a series by Mark Hamilton about the history of the Pebble Project in Alaska.) With a significant move upward in the price of metals, Alaska will begin to see more mining projects begin the long journey to production. The permitting process is a long and rigorous one, but necessary to determine if a development project meets the stringent requirements needed to protect the environment.
Mark Hamilton: The history of hysteria
By MARK HAMILTON (Editor’s note: This is the ninth in a series by Mark Hamilton about the history of the Pebble Project in Alaska.) I could probably tell how old you are by asking you to remember which of the hysteria you best recall. Was it the killer bee invasion? (No, not the murder hornets). How about the coming ice age? (Careful, remembering that one makes you pretty old). A younger person might remember the ozone depletion, acid rain, and a flooding world.
Mark Hamilton: Build your media filter based on science, not narrative
By MARK HAMILTON (Editor’s note: This is the eighth in a series by Mark Hamilton about the history of the Pebble Project in Alaska.) We are engaged in a contest between facts and narratives. This observation has been discussed in several books and papers recently, but I believe it is important for all of us to be aware of the unequal battlefield to which we are subjected.
Pebbled: The environmentalist who cries 'Wolf!' is louder than the scientific process
By MARK HAMILTON (Editor’s note: This is the seventh in a series by Mark Hamilton about the history of the Pebble Project in Alaska.) As Alaskans, perhaps more than any other state citizenry, we face a difficult future if we do not proceed in the responsible extraction of our natural resources. Virtually every major development will be “controversial.” There is nothing wrong with that word; it simply means there are opinions on both sides (or all sides) of the issue at hand.
Pebbled: The narrative of fear
By MARK HAMILTON (Editor’s note: This is the sixth in a series by Mark Hamilton about the history of the Pebble Project in Alaska.) On May 11, 2017, EPA agreed to a settlement agreement with the Pebble Limited Partnership to resolve litigation from 2014 relating to EPA’s pre-emptive veto of a permit application.
Pebbled: EPA 'just didn't have time' to actually go to Bristol Bay
By MARK HAMILTON (Editor’s note: This is the fifth in a series by Mark Hamilton about the history of the Pebble Project in Alaska.) EPA had a problem. The agency wanted, desperately, to try a pre-emptive veto on Pebble Mine. But it had no science and it had no time. How do you proceed when you have no science and have no time?
Pebbled: When the government dictates 'advanced prohibition' of any project
By MARK HAMILTON (Editor’s note: This is the fourth in a series by Mark Hamilton about the history of the Pebble Project in Alaska.) Part of our collective awareness must be the recognition of the opponents to our responsible development. It is important that Alaskans understand the degree to which preservationists will go to stop development.
Pebbled: The secret history of ANWR and the human hand that shaped it
By MARK HAMILTON (Editor’s note: This is the second in a series by Mark Hamilton about the history of the Pebble Project in Alaska.) Very few Alaskans know about the establishment of the Arctic National Wildlife Refuge. During the debates prior to the vote on Statehood, President Dwight D. Eisenhower sent his Secretary of the Interior Fred Seaton to Alaska, requesting one more set-aside of land to appease opponents who didn’t want to see Alaska developed.
Coronavirus and higher education students
1. Main points Average life satisfaction scores among students improved, returning to the same levels seen in November 2020 (5.2 out of 10), having been significantly lower in both January (4.6) and February (4.9) 2021.
Coronavirus and higher education students
1. Main points Over a quarter (26%) of students reported feeling lonely often or always, compared with 8% of the adult population in Great Britain over a similar period. Almost two-thirds (63%) of students indicated that their well-being and mental health had worsened since the start of the autumn term 2020; this has remained stable since January 2021.
Preparing for new disclosure changes
The new Disclosure (Scotland) Act 202, which received royal assent on 14 July, and the Management of Offenders (Scotland) Act 2019 are set to change the criminal record checks regime and the Protecting Vulnerable Groups (PVG) scheme. Mark Hamilton summarises the key changes Mark Hamilton is an employment partner at Dentons. mark.hamilton@dentons.com by Mark Hamilton What is the PVG Scheme?
What did Biblical authors think about prayer and public life?
Mark Hamilton Published 5:00 p.m. CT June 6, 2020 Social media lit up recently over the remarks of the mayor of the Dallas suburb of Wylie, Texas who cited the New Testament in defense of his views that only men should pray at the city council meeting of his town. I leave to others the question of whether such prayers pass legal standards. My question is different: does the mayor understand the Bible correctly? The answer is unequivocally no.
Putnam Co. Fair could be scaled down
By Mark Hamilton - For The Lima News OTTAWA — Members of the Putnam County Fair board met Friday evening and decided to conduct a scaled-down version of the fair — maybe. The board conducted a two-hour meeting Friday night at the junior fair building which involved a great deal of discussion and some tempers displayed. But the message was a united one — they will need a lot of help and donations pulling the event off if it is held. The fair, which began in 1855, is scheduled for June 22-27.
NEW VIDEO: Grimes' track "Violence"
Breaking News Grimes came out of whatever weird cave she lives in to release a new music video for her single "Violence." The video features a healthy mix of Greek mythology and Chinese cultural expression (we think). "Violence" will appear on Grimes' new album, Miss_Anthropocene. No firm release date has been set.
Pension obligations for part-time staff
by Mark Hamilton In an industry where working hours often vary for staff on flexible employment arrangements, the advent of pension auto enrolment has left many retail businesses unsure as to who has to be included in the company scheme. Mark Hamilton of Dentons offers practical advice Mark Hamilton is a partner in Dentons’ Employment and Labour practice. mark.hamilton@dentons.com Are employers required to auto enrol all employees in a pension scheme?
A fine line between banter and bullying
by Mark Hamilton ‘It was only banter’ is an often-used excuse. Mark Hamilton, a partner at Dentons, looks at a recent employment tribunal case showing that, surprisingly, this defence can work. However, while staff may enjoy friendly jokes on shift, managers still have to know where to draw the line Staff are happy to call each other names – should I intervene? The recent case of Evans v Xactly Corporation Ltd shows that context really is key.
Make sure you let staff take a break
Make sure you let staff take a break With the Christmas period approaching, employers and staff in Scotland’s retail sector will be preparing for a busy few weeks of long hours, hard work and good money: just remember that everyone is entitled to a break. Mark Hamilton, a partner at Dentons, looks at the law regarding rest breaks. If a staff member’s working time is more then six hours, they are entitled to a 20 minute break. Mark Hamilton is a partner in Dentons’ Employment and Labour practice.
Make sure you let staff take a break
Make sure you let staff take a break With the Christmas period approaching, employers and staff in Scotland’s retail sector will be preparing for a busy few weeks of long hours, hard work and good money: just remember that everyone is entitled to a break. Mark Hamilton, a partner at Dentons, looks at the law regarding rest breaks. If a staff member’s working time is more then six hours, they are entitled to a 20 minute break.
Ultrasound Produces Extensive Brain Activation via a Cochlear Pathway
Ultrasound (US) can noninvasively activate intact brain circuits, making it a promising neuromodulation technique. However, little is known about the underlying mechanism. Here, we apply transcranial US and perform brain mapping studies in guinea pigs using extracellular electrophysiology. We find that US elicits extensive activation across cortical and subcortical brain regions.
Ultrasound Produces Extensive Brain Activation via a Cochlear Pathway
Ultrasound Produces Extensive Brain Activation via a Cochlear Pathway Hongsun Guo, Mark Hamilton II, Sarah J. Offutt, Cory D. Gloeckner, Tianqi Li, Yohan Kim, Wynn Legon, Jamu K. Alford, Hubert H. Lim bioRxiv 233189; doi: https://doi.org/10.1101/233189
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