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Mbolle Ekane

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Articles

Non-enzymatic hepatic ABHD6 interacts with Akt-FoxO1 axis to regulate metabolic health

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By Guannan Li, Laurence T. Maeyens, Jiyuan Yin, Jan-Bernd Funcke, Chanmin Joung, Ruizhen Li, Ziying Xu, Ting Wu, Xin Li Verified, Nisi Jiang, Maria Lopez, María Lopez Verified, María López Verified, Pengju Cao, Sijia He, Adam Salmon, S. R. Murthy Madiraju, Marc Prentki, Juli Bai, James Nelson, Xianlin Han, Yi Zhu, Shangang Zhao, Mbolle Ekane
| Nature Verified
Abstract The enzymatic role of ABHD6 in insulin secretion and resistance is well documented. However, its non-enzymatic function, especially its effects on metabolic health, including selective hepatic insulin resistance and metabolic dysfunction-associated steatotic liver disease (MASLD), is poorly understood.
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