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Articles by Mingxia Gu
Co-development of mesoderm and endoderm enables organotypic vascularization in lung and gut organoids
1Division of Pulmonary Biology, Perinatal Institute, Cincinnati Children’s Hospital Medical Center (CCHMC), Department of Pediatrics, University of Cincinnati College of Medicine, Cincinnati, OH 45229, USA 2Center for Stem Cell and Organoid Medicine (CuSTOM), CCHMC, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH 45229, USA 3Division of Developmental Biology, CCHMC, Department of Pediatrics, University of Cincinnati, College of Medicine, Cincinnati, OH...
Vascular motion in the dorsal root ganglion sensed by Piezo2 in sensory neurons triggers episodic neuropathic pain
Keywords dorsal root ganglion blood vessel calcium imaging Piezo2 neuropathic pain angiogenesis pericytes Get full text access Log in, subscribe or purchase for full access. References 1. Colloca, L. ∙ Ludman, T. ∙ Bouhassira, D. ... Neuropathic pain Nat. Rev. Dis. Primers. 2017; 3:17002 2. Murai, N. ∙ Sekizawa, T. ∙ Gotoh, T. ... Spontaneous and evoked pain-associated behaviors in a rat model of neuropathic pain respond differently to drugs with different mechanisms of action Pharmacol. Biochem. Behav.
Causal Associations Between the Gut Microbiota and Hypertension‐Related Traits Through Mendelian Randomization: A Cross‐Sectional Cohort Study
1 Introduction Hypertension, as an important global public health problem, is still the main risk factor leading to death [1]. Hypertension is a multifactorial disease with complex etiology. The largest genome-wide association study of blood pressure characteristics to date has identified 901 loci associated with blood pressure [2]. However, these loci can only explain 27% of the heritability of blood pressure [2].
Research Horizons
Healthy vs. defective heart valve formation Imagine being able to both detect and treat potentially fatal heart valve defects months before a baby is born. That day remains years away but has moved considerably closer to reality now that scientists have compiled an advanced “atlas” of human heart valve formation to guide future research. The new findings were published July 24, 2024, in Nature Cardiovascular Research.
Distributed optimization for discrete time‐varying linear multi‐agent systems with event‐triggered communication
REFERENCES 1, , . Event-triggered and self-triggered control for discrete-time average consensus problems. SICE J Control Measure Syst Integr. 2014; 7(5): 297-303. 2, , , . Prescribed-time consensus and containment control of networked multiagent systems. IEEE Trans Cybern. 2019; 49(4): 1138-1147. 3, , , . On necessary and sufficient conditions for exponential consensus in dynamic networks via uniform complete observability theory. IEEE Trans Automat Contr. 2021; 66(10): 4975-4981. 4, , , , , .
Researcher Recognition, January 2024
Chidiogo Anyigbo, MD, MPH Chidiogo Anyigbo, assistant professor, Division of General and Community Pediatrics, was named one of Emory University’s 40 Under 40 Notable Alumni. This program shines a light on a select number of notable alumni who are becoming pioneers in their fields.
iPSC-endothelial cell phenotypic drug screening and in silico analyses identify tyrphostin-AG1296 for pulmonary arterial hypertension
1Division of Pediatric Cardiology, Department of Pediatrics, Stanford School of Medicine, Stanford, CA 94305, USA. 2Vera Moulton Wall Center for Pulmonary Vascular Disease, Stanford School of Medicine, Stanford, CA 94305, USA. 3Stanford Cardiovascular Institute, Stanford School of Medicine, Stanford, CA 94305, USA. 4Division of Pulmonary Biology, Perinatal Institute, Cincinnati Children’s Hospital Medical Center, Cincinnati, OH 45229, USA.
Capillary cell-type specialization in the alveolus
Abstract In the mammalian lung, an apparently homogenous mesh of capillary vessels surrounds each alveolus, forming the vast respiratory surface across which oxygen transfers to the blood1. Here we use single-cell analysis to elucidate the cell types, development, renewal and evolution of the alveolar capillary endothelium.
Isolation of Endocardial and Coronary Endothelial Cells from the Ventricular Free Wall of the Rat Heart
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Remodeling of active endothelial enhancers is associated with aberrant gene-regulatory networks in pulmonary arterial hypertension
Abstract Environmental and epigenetic factors often play an important role in polygenic disorders. However, how such factors affect disease-specific tissues at the molecular level remains to be understood. Here, we address this in pulmonary arterial hypertension (PAH). We obtain pulmonary arterial endothelial cells (PAECs) from lungs of patients and controls (n = 19), and perform chromatin, transcriptomic and interaction profiling.
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