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Articles by Nian Chen
METTL3-mediated m⁶A methylation of E2F2 targets MCU to promote the malignant phenotype of gastric cancer cells
Abstract Gastric cancer (GC) is a highly prevalent malignancy worldwide, and its progression is closely linked to aberrant epigenetic regulation. E2F transcription factor 2 (E2F2), a member of the E2F transcription factor family, has been identified as an oncogene in various cancers. However, the regulatory effects of epigenetic modifications on E2F2 in GC remain incompletely clarified.
Anti-inflammatory, analgesic, and anti-immune-mediated polyarthritis activities of topically applied polarity fractions of Clematis florida var. Plena and their underlying mechanisms
Abstract Background: Clematis florida var. Plena (C. florida) holds significant potential as a topical treatment for immune-mediated polyarthritis (IMPA); however, its active fractions and mechanisms of action remain poorly understood. Given the chemical complexity of herbal remedies, this study adopted a bioactivity- and mechanism-driven approach, focusing on the effects of polarity-based fractions rather than isolated compounds. Methods: C.
Uncovering Electron-Transfer Mechanisms of Sulfur Anion Photosensitizers with Intramolecular Charge Transfer Click to copy article link Article link copied!
Abstract Click to copy section linkSection link copied! Sulfur anions have emerged as promising photosensitizers for light-driven single-electron transfer (SET) chemistry. Established mechanistic pictures typically invoke substrate preassociation, either through electron donor–acceptor (EDA) complexation or via covalent adduct formation.
Bayesian Optimization and Kinetic Modeling for Continuous-Flow Synthesis of 4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane Directed by Computational Fluid Dynamics Click to copy article link Article link copied!
Cite Jump to ExpandCollapse ArticleMarch 19, 2026 Bayesian Optimization and Kinetic Modeling for Continuous-Flow Synthesis of 4-(Chloromethyl)-2,2-dimethyl-1,3-dioxolane Directed by Computational Fluid Dynamics Click to copy article linkArticle link copied! Nian Chen Nian Chen Department of Pharmaceutical Engineering, School of Engineering, China Pharmaceutical University, Nanjing 211198, China Junfeng Zhi Junfeng Zhi Department of Pharmaceutical Engineering, School of Engineering, China...
Depression Aggravates Immune‐Mediated Hepatitis Through NLRP3 Overactivation Induced by Intestinal Microbiota
1 Introduction Autoimmune hepatitis (AIH), characterized by the disruption of immune tolerance, is an immune-mediated hepatitis with an increasing incidence [1]. A major depressive syndrome is five times more frequent in patients with AIH than in the general population [2]. Moreover, patients with other autoimmune diseases (AIDs) exhibit a significantly higher prevalence of depression than healthy controls [3, 4].
Endocrine Resistance Score Based on Three Key Genes Predicts Prognosis and Reveals Potential Therapeutic Targets for ER+HER2− Breast Cancer
1 Background Currently, the most common subtype of breast cancer (BC) is oestrogen receptor-positive and human epidermal growth factor receptor 2-negative (ER+HER2−) BC, accounting for 70% of the total incidence [1, 2]. The growth of ER+HER2− BC cells mainly depends on the activation of the oestrogen-ER axis in the nucleus.
Evaluation of the Effect of Exosomes From Adipose Derived Stem Cells on Changes in GSH/ROS Levels During Skin Photoaging
Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request.
CD70-targeted iPSC-derived CAR-NK cells display potent function against tumors and alloreactive T cells
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Keywords CD70 induced pluripotent stem cell multiplex gene editing natural killer cell chimeric antigen receptor allogeneic rejection Introduction Adoptive cellular therapy has revolutionized the conventional concept of cancer therapy as a “living drug.”1 Notably, chimeric antigen receptor (CAR)-based modification has markedly enhanced the efficacy of immune therapy, offering a potentially curative approach for previously incurable hematological malignancies.2,3 However, despite the approval...
By Linqin Wang, Yiyun Wang, Xiangjun He, Zhuomao Mo, Mengyu Zhao, Xinghua Liang, Kejia Hu, Kexin Wang, Yanan Yue, Yixuan Zhou, Ruimin Hong, linghui Zhou, Nian Chen, Lihong Shen, Xiaobin Song, Xiaofeng Jia, Yuxuan Shao, Peng Zhang, Mengqi Xu, Dongrui Wang, Yongxian Hu, Luhan Yang, He Huang, Guolong Mo, Youqin Feng, Wenxiu Zeng
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Cell Reports Medicine
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Polymers | Free Full-Text | The Production of Porous Asphalt Mixtures with Damping Noise Reduction and Self-Healing Properties through the Addition of Rubber Granules and Steel Wool Fibers
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Constructing Cyclic Hydrogen Bonding to Suppress Side Reactions and Dendrite Formation on Zinc Anodes
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Effect of carbon nanoparticles on the growth and photosynthetic property of Ficus tikoua Bur. plant
Effect of carbon nanoparticles on the growth and photosynthetic property of Ficus tikoua Bur.
Ficus tikoua Bur. May Have Resistance to Invasive Plant Alternanthera philoxeroides
Preprint Article Version 1 This version is not peer-reviewed Version 1 : Received: 16 February 2024 / Approved: 16 February 2024 / Online: 16 February 2024 (11:33:22 CET) Wang, J.; Chen, N.; Tian, X.; Xu, J.; Shi, D.; Yang, W. Ficus tikoua Bur. May Have Resistance to Invasive Plant Alternanthera philoxeroides. Preprints 2024, 2024020908. https://doi.org/10.20944/preprints202402.0908.v1 Wang, J.; Chen, N.; Tian, X.; Xu, J.; Shi, D.; Yang, W. Ficus tikoua Bur.
Hong Kong Activists in Exile Remain Defiant in Face of Bounties
What you need to know Hong Kong pro-democracy activists abroad dismiss fresh bounties for their arrest under the National Security Law, calling them “absurd” and a “publicity stunt.” By Nian Chen WASHINGTON — Overseas Hong Kong pro-democracy activists tell VOA they will not be swayed by a fresh round of bounties issued by authorities for information leading to their arrest over alleged violations of the Chinese territory’s National Security Law.
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