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Articles by Peter Wu
Wet purpura and petechiae in a 48-year-old man with immune thrombocytopenia
Article Figures & Tables Responses Metrics PDF A 48-year-old man presented to the emergency department reporting painful dark lesions inside his mouth and on his tongue. He was previously healthy.
Why Cooling Is Now a Strategic Imperative for AI Infrastructure
・ Blog ・ June 01, 2026 Artificial intelligence is changing the requirements of digital infrastructure faster than many organizations have expected. For years, most discussions around AI infrastructure focused on compute — more GPUs, faster interconnects, and larger clusters. Those things still matter. But as AI systems become more powerful and more widely deployed, another constraint is emerging: energy.
Fibroblast growth factor receptor inhibition for succinate dehydrogenase-deficient gastrointestinal stromal tumors: a phase 2 trial
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Abstract While most gastrointestinal stromal tumors are driven by oncogenic mutations in KIT or PDGFRA, 10–15% exhibit functional loss of the succinate dehydrogenase (SDH) complex and genome-wide DNA hypermethylation. Excess methylation in SDH-deficient gastrointestinal stromal tumors disrupts genomic insulators, inducing aberrant expression of oncogenic ligands FGF3, FGF4, and activating an autocrine signaling loop mediated through FGFR1.
By Priscilla Merriam, James Morrow Verified, Emanuele Mazzola, Nicole L. Solimini, Prafulla C. Gokhale, Ping Chi, Alice Chen, Mark Agulnik, Melissa Burgess, Scott M Schuetze, Neeta Somaiah, Brian Van Tine, Seth Pollack, Gabriel Tinoco, Jonathan C. Trent, Breelyn Wilky, Nicola Bothwick, Benjamin K. Eschle, Vivian Nguyen, Jan H. Beumer, Noushin Rastkari, Shahanawaz Jiwani, Peter Wu, Lorraine C. Pelosof, Matthew Hemming, Geoffrey I. Shapiro, George D. Demetri, Bradley E. Bernstein, Suzanne George
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Nature
Verified
How I Built a RAG System With a 7-Million-Node Knowledge Graph (And Why Vector Search Alone Isn't Enough)
How I built a conversational knowledge management system that processes medical textbooks, understands their concepts through a 7-million-node knowledge graph, and answers clinical questions with cited sources. Introduction Over the past several months, I've been building the Librarian — a conversational knowledge management system that processes PDF documents (medical textbooks, clinical guidelines, AI/ML references) and makes their content queryable through an intelligent chat interface.
Peter Wu, Cathay General Bancorp vice chairman, sells $1.15m in stock
Peter Wu, Cathay General Bancorp vice chairman, sells $1.15m in stock Peter Wu, Cathay General Bancorp vice chairman, sells $1.15m in stock Los Angeles – Peter Wu, Vice Chairman of , sold 20,000 shares of the company’s common stock on May 5, 2026. The transactions totaled $1,146,506. The shares were sold at a weighted-average price of $57.3253 per share. According to the filing, these shares were sold in multiple transactions at prices ranging from $57.25 to $57.38.
Mass Spectrometric Detected Cancer Proteins as Resources for Cancer Research Click to copy article link Article link copied!
Database Construction MSCP integrates data from diverse sources, including NCI-7 cell lines and tumor proteomes ( Figure 1 ). Different data acquisition modes, mass spectrometry, and quantification strategies from different cancer data sources contributed to various sample types and were collected for the database construction ( Table S1 ).
Mass Spectrometric Detected Cancer Proteins as Resources for Cancer Research Click to copy article link Article link copied!
Introduction Click to copy section linkSection link copied! The primary goal of proteomics is to characterize proteins and advance methodologies that enable protein detection from different biological resources. (1−3) Historically, the field of proteomics has evolved significantly with the advent of high-throughput mass spectrometry-based proteomics, antibody development, and protein microarrays, enabling the rapid and accurate identification of proteins.
Intoxication à l’isopropanol
L’intoxication à l’isopropanol est fréquente L’exposition à l’isopropanol, la deuxième cause principale des appels liés à l’alcool reçus aux centres antipoison1, se produit lorsque l’isopropanol est ingéré avec de l’éthanol ou comme substitut à celuici. L’isopropanol est absorbé rapidement et entraîne une intoxication plus marquée que l’éthanol en partie en raison de son poids moléculaire supérieur2. L’exposition par inhalation peut causer une irritation locale.
Court Watch: Judge Denies Public Defender Request, Sets Bail in Newport Beach Felony Case
NEWPORT BEACH, Calif. — A judge denied a request for a public defender and set bail during an arraignment Wednesday at the Harbor Justice Center, raising questions about financial eligibility and pretrial release for an accused facing multiple felony charges. During the hearing, Judge Maria D. Hernandez considered issues related to legal representation, bail and release conditions for an accused facing multiple felony charges.
Court Watch: Judge Acknowledges Accused’s Financial Hardship in Newport Beach Court
NEWPORT BEACH, Calif. — A judge in Orange County acknowledged financial hardship during a court hearing Friday after an accused person appeared before the court unable to make the full required monthly payment. During the hearing at the Harbor Justice Center in Newport Beach, Judge Richard E. Pacheco addressed the payment issue after the accused explained that financial difficulties had prevented the full monthly amount from being paid.
Sovereign AI for Cities: An End-to-End Architecture from Data Center to Street Level
Peter Wu, CEO, ASUS Cloud & Taiwan AI Cloud ・ Blog ・ March 16, 2026 Sovereign AI matters for cities because it helps strengthen and extend smart city efforts -enabling cities to achieve outcomes such as less congestion, faster response times, improved safety, and tangible savings in energy and operations.
Bail Reduced for Defendant in Newport Beach Financial Crimes Case
NEWPORT BEACH, Calif. — A judge reduced bail Friday for a person facing multiple financial-related felony charges, but questions remain about whether the accused can afford release despite the reduction. During a hearing Friday at the Harbor Justice Center in Newport Beach, Judge Derek G. Johnson considered arguments regarding bail and protective orders for a defendant facing multiple financial-related felony charges.
ACLU Report Warns Expansion of 287(g) Program Is Creating a National Deportation Policing Force
WASHINGTON, D.C. — The American Civil Liberties Union released a new research report this week titled Deputized for Disaster, warning that the Trump administration’s rapid expansion of the federal 287(g) program is transforming local police departments across the country into what the organization calls a “national deportation-policing force.” The report details the growing use of the 287(g) program, which allows U.S. Immigration and Customs Enforcement to delegate certain immigration...
Catholic Groups Urge Gov. Newsom to Commute California Death Sentences
LOS ANGELES — National and local Catholic organizations are calling on Gov. Gavin Newsom to commute the death sentences of those currently on California’s death row before his term expires and are organizing a Prayer Walk and Vigil to End the Death Penalty later this week, according to a press release from Catholic Mobilizing Network.
Vera Institute Launches Platform to Challenge Trump's Crime Fear Tactics
WASHINGTON — The Vera Institute of Justice, described as the largest and oldest criminal justice reform organization in the country, and Vera Action released a new platform this week aimed at countering what it called crime fearmongering, rebuilding trust with voters, and delivering safety people can feel in their daily lives.
COURT WATCH: Judge Keeps $200,000 Bail Despite Defense Citing Inability to Pay and Stabbing Victimization
ORANGE COUNTY, Calif. — A judge on Friday declined to reduce a $200,000 bail for an accused person facing multiple felony charges, rejecting defense arguments that nonfinancial alternatives should be explored and that the accused could not afford bail. After a lively debate Feb. 2 at the Newport Beach Harbor Justice Center over whether nonfinancial release options were appropriate, Judge Karen L. Robinson ruled that bail would remain unchanged for the accused, who is facing two felony charges.
Isopropanol toxicity
Isopropanol toxicity is common Isopropanol exposure, the second most common alcohol-related call to poison centres,1 occurs when isopropanol is ingested with or as a substitute to ethanol. Isopropanol is rapidly absorbed and is more intoxicating than ethanol in part because of its greater molecular weight.2 Inhalational exposure can cause local irritation.
Court Watch: Judge Denies Bail for Three Students in Home Invasion Case
ORANGE COUNTY, Calif. — After a contentious bail hearing Thursday at the Newport Beach Harbor Justice Center, John S. Adams ordered three students held without bail while granting supervised release to an alleged getaway driver in a planned home invasion case. During the Jan. 29 hearing, Judge Adams rejected defense proposals for bail and electronic monitoring for the three students, citing the seriousness of the remaining charges and public safety concerns.
Court Watch: Court Rejects $10,000 Bail for Pregnant Accused in Yolo County Case
WOODLAND, Calif. — In a pretrial conference held earlier today in Yolo County Superior Court, Judge Danette C. Brown ordered the release of the accused on supervised own-recognizance and rejected a proposed $10,000 bail, citing the accused’s pregnancy and financial circumstances.
How Nations are Forging Their Own Digital Futures with Sovereign AI
About ASUS ASUS is a global technology leader that provides the world’s most innovative and intuitive devices, components, and solutions to deliver incredible experiences that enhance the lives of people everywhere. With its team of 5,000 in-house R&D experts, the company is world-renowned for continuously reimagining today’s technologies. Consistently ranked as one of Fortune’s World’s Most Admired Companies, ASUS is also committed to sustaining an incredible future.
How nations can forge their digital futures with Sovereign AI
There has been a lot of discussion in recent months around sovereign AI and its implications for countries and corporations. Nvidia CEO Jensen Huang recently made a call for nations, world leaders and CEOs to look towards sovereign AI, emphasising the critical need for robust AI infrastructure to ensure digital sovereignty in light of the infrastructure gaps among many countries. But sovereign AI is not a new idea.
Resurrecting Vasek’s Spyder
To a passerby, the pile of steel tubing, aluminum panels, and fiberglass body parts baking in the desert sun probably looked more like the remnants of a 1970s kit car project than pieces of Porsche racing history. “A lot of people thought it was a dune buggy,” said Johnny Penner, who remembers the day his father, motorcycle racer and connoisseur of speed, John Penner, brought the car home.
Prescribing Patterns and Impact of Sedatives in Hospitalized Older Adults: A Secondary Analysis of the MedSafer Study
Key points ○ Sedatives, namely benzodiazepine receptor agonists and Z-drugs, are among the most frequently prescribed potentially inappropriate medications for older adults aged 65 years or older. ○ Among older adults, sedative use is associated with adverse events like falls that result in avoidable emergency department visits and hospitalizations, as well as a risk of permanent morbidity and mortality, despite not providing a clear long-term benefit for sleep quality.
Hypertensive Encephalopathy Triggered by Indomethacin Use
NSAIDs can trigger blood pressure decompensation, particularly in patients with underlying hypertension treated with RAS blocking agents. This case exemplifies the risk of treating symptoms without first understanding the diagnosis. Our patient's headaches were secondary to elevated blood pressure, and using NSAIDs exacerbated the underlying problem leading to hypertensive encephalopathy.
Intrathecal placement of percutaneous spinal cord stimulation leads: illustrative cases
Chronic pain syndromes such as persistent spinal pain syndrome that emanate from neuropathic pain processes and result in chronic low-back pain (LBP) can be effectively managed with spinal cord stimulation (SCS).1, 2 Stimulation of the thoracic cord can be achieved surgically by laminectomy and placement of paddle electrodes or procedurally through implantation of percutaneous SCS leads into the epidural space.3 SCS surgery has been extensively evaluated for safety and effectiveness, with...
Respirology Case Reports | APSR Respiratory Medicine Journal | Wiley Online Library
CLINICAL IMAGE A 28-year-old man required intubation after he was brought to the hospital following a high-speed motor vehicle accident. Examination revealed multiple injuries, including a fracture dislocation of the temporomandibular joint and multiple tooth avulsions. Computed tomography trauma series showed an aspirated tooth in the right lower lobe bronchus (Panel A, arrow).
Development and validation of an electronic version of Sydney Swallow Questionnaire
DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
Xylazine in the illicit opioid supply
Xylazine is a veterinary medicine sedative adulterating the illicit opioid supply Since 2019, it is increasingly identified in illicit drug samples tested across Canada,1 most commonly co-occurring with fentanyl,1–3 and patients using illicit opioids may be unaware of its presence. There are reports that it increases euphoria and may prolong the effects of fentanyl. 2,3 Xylazine should be considered when presentations are discordant with what would be expected from opioids only.
Post-quantum cryptography goes GA
Over the last twelve months, we have been talking about the new baseline of encryption on the Internet: post-quantum cryptography. During Birthday Week last year we announced that our beta of Kyber was available for testing, and that Cloudflare Tunnel could be enabled with post-quantum cryptography. Earlier this year, we made our stance clear that this foundational technology should be available to everyone for free, forever.
What Should I Know About Medication Deprescribing?
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What Should I Know About Medication Deprescribing?
It is common for people to be prescribed many medications and also to take over-the-counter treatments, vitamins, or supplements. Medications are often started for a good reason, but sometimes they are continued when they are no longer helpful and may cause adverse effects. Slowly and carefully cutting down on unnecessary medications with a health care professional is called deprescribing. Why Might My Medications Be Deprescribed?
Frequency spectra analysis of space- and time-averaged quantum stress tensor fluctuations
Abstract Observing physical effects of large quantum stress tensor fluctuations requires knowledge of the interactions between the probe and the particles of the underlying quantum fields. The quantum stress tensor operators must first be averaged in time alone or space and time to confer meaningful results, the details of which may correspond to the physical measurement process.
Melatonin for Insomnia in Medical Inpatients: A Narrative Review
Abstract : In this narrative review, we describe what is known about non-pharmacological and pharmacological treatments for insomnia in medical inpatients, with a focus on melatonin. Hospital-acquired insomnia is common, resulting in shortened total sleep time and more nighttime awakenings. Sleep disturbance has been shown to increase systemic inflammation, pain, and the likelihood of developing delirium in hospital.
Tecovirimat for monkeypox
Practice Open Access CMAJ 194 (46) E1573; DOI: https://doi.org/10.1503/cmaj.221210 Tecovirimat can be prescribed off label for treatment of monkeypox (MPXV) infection Tecovirimat is an antiviral drug with activity against orthopoxviruses.1 It was approved by Health Canada for the treatment of smallpox in November 2021 and approved in other jurisdictions for the treatment of cowpox, MPXV and smallpox.2 Studies involving animals infected with smallpox showed improved survival, clinical symptoms...
Experiment with post-quantum cryptography today
Practically all data sent over the Internet today is at risk in the future if a sufficiently large and stable quantum computer is created. Anyone who captures data now could decrypt it. Luckily, there is a solution: we can switch to so-called post-quantum (PQ) cryptography, which is designed to be secure against attacks of quantum computers. After a six-year worldwide selection process, in July 2022, NIST announced they will standardize Kyber, a post-quantum key agreement scheme.
Loperamide Cardiac Toxicity - Pathophysiology, Presentation and Management
Abstract Loperamide is a non-prescription medication commonly used to treat diarrhea. Although it is an opioid, it is very poorly absorbed and well tolerated, with no systemic toxicity at standard doses. In recent years, however, loperamide has been ingested in very large quantities, sometimes with concomitant medications intended to enhance absorption and/or passage across the blood-brain barrier.
Fluvoxamine for symptomatic outpatients with COVID-19
Practice Open Access Peter E.
Essential Technology Tools Will Outlive the Pandemic
By PETER WU, P.E., MBA, Stellar, Jacksonville FL While there are plenty of things we won't miss about pandemic life, there are tools and strategies that flourished over the past two years out of necessity. At Stellar, for example, several technologies helped us yield more efficient, predictable and accurate project results — and it's clear they're not going anywhere in a post-COVID world.
A 53-year-old woman with a suspected drug overdose
Practice Open Access Jane Kobylianskii, Emily Austin, Alexander Kumachev and Peter E. Wu CMAJ February 07, 2022 194 (5) E163-E166; DOI: https://doi.org/10.1503/cmaj.211620 A 53-year-old woman was brought to the emergency department after being found unresponsive at home, surrounded by empty pill bottles. Her partner had spoken to her on the phone 5 hours earlier, when she was reportedly well. Her medical history included bipolar I disorder and 2 previous suicide attempts.
Fluvoxamine for symptomatic outpatients with COVID-19
Original Articles Fluvoxamine for symptomatic outpatients with COVID-19 Peter E. Wu, Emily Austin and Derek Leong
The MedSafer Study-Electronic Decision Support for Deprescribing in Hospitalized Older Adults: A Cluster Randomized Clinical Trial
Key Points Question Does providing clinical decision support during an acute care hospitalization improve deprescribing of potentially inappropriate medications and 30-day postdischarge adverse drug events (ADEs) in older adults? Findings This cluster randomized multicenter trial of 5698 hospitalized participants found that providing electronically generated deprescribing reports did not have a significant impact on ADEs within 30 days despite increased deprescribing at discharge.
Learn how to create accessible content in PowerPoint and across Microsoft 365
Dec 17 2021 12:00 AM Do you have an important presentation coming up? Or do you need to write a report and share it with your team soon? You'll certainly put a lot of thought into how you craft your message so that you communicate it effectively to everyone you need to reach. But what if that includes people with disabilities? Will your presentations, documents, and other communications be accessible to people with disabilities?
The 2021 world plant-based award was announced, giving consideration to health and taste, making the industrial development more "sustainable"
“ 世界植物基大奖刚满2岁，却让我们看到全球植物基创新的异彩纷呈！ ” Text: Sabrina Li, HN Wang Source: foodaily daily food (ID: foodaily) In the early morning of December 10, the winners of the 2nd world plant based Awards (2021) were fresh. After careful consideration by the jury, 110 entries from 20 countries finally produced 15 single best winners, covering all aspects of plant-based industry products, technologies, brands, etc.
Increase worker safety in semiconductor fabs
Without the proper safety precautions in place, working in a semiconductor fabrication facility can be dangerous. On a day-to-day basis, semiconductor personnel face many different potential hazards. These range from the simple: body strains caused by ergonomic risk factors and slips and falls; to the extreme: exposure to pressurized sources like hazardous chemicals and gasses, and shocks from high electrical voltage. But this needn’t be the case.
17 common ammonia safety issues refrigeration personnel can control
It’s always a good time to check up on facility safety — but now the stakes are even higher when it comes to safety violations. Employers across the U.S. have been facing higher penalties from the Occupational Safety and Health Administration (OSHA) this year. In January 2021, the federal agency announced it was increasing the maximum penalty for serious and other than serious citations to $13,653 and the maximum for repeat and willful violations to $136,532.
A 54-year-old woman with chronic lithium toxicity
Practice Open Access Jane Kobylianskii, Emily Austin, Wayne L. Gold and Peter E. Wu CMAJ August 30, 2021 193 (34) E1345-E1348; DOI: https://doi.org/10.1503/cmaj.210725 KEY POINTS Lithium is a commonly used medication that has a narrow therapeutic index and may lead to important toxicity that can be acute, chronic, or acute on chronic.
Benign serous cystadenoma presenting with cough and back pain
Practice Open Access Madeleine Rudolph, Jessie Peng and Peter E. Wu CMAJ August 23, 2021 193 (33) E1304; DOI: https://doi.org/10.1503/cmaj.202850 A 27-year-old woman presented to the emergency department with a 1-week history of dry cough, preceded by 1 month of nontraumatic back pain. Her heart rate was 110 beats/min, and her other vital signs, cardiac examination and respiratory examination were normal.
Bird-like wings could help drones keep stable in gusts
Wings that can vary their shapes as freely as birds’ wings could have advantages for small aircraft in built environments, according to a study led by engineers at the University of Michigan. “These are just two uses that we identified, but another part that makes me really excited is that, as in birds, one 3D morphing wing can accomplish a wide variety of tasks.
Cummins integrates metal 3D printed production
By Mark T. Hoske July 9, 2021 Learning Objectives Cummins integrates metal 3D printed production into manufacturing. More than 20 parts are available via 3D printing, Cummins said. After-market customers benefit from cost and cycle times. By finalizing its first production part using a new, high-precision 3D metal printing technology called binder jet Cummins Inc.
New president at machine-builder automation and motion-control company
Steve Markham is the new president of Lenze Americas, an automation and motion control company, the company said in a July 7 announcement. Courtesy: Lenze Americas Learning Objectives Steve Markham is the new president of Lenze Americas, an automation and motion control company. Markham plans to invest in logistics and supply chain and expand its motion automation portfolio and engineering support.
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