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Articles by Pingping Li
Modelado basado en inteligencia artificial para la predicción y validación del riesgo de padecer la enfermedad de Alzheimer.
Background: Toinvestigatethemultimodalclinicalinfluencing factors of Alzheimer’s disease (AD)onset, andto establish and test a risk prediction tool derived from these determinants and additional clinical measures, thus facilitating early intervention and risk classification in individuals at high risk for AD. Methods: A retrospective cohort of 502 high-risk individuals for AD (exhibiting cognitive decline or family history) who visited our hospital was included.
When behavior outweighs infrastructure: disinfectant and latex exposure and preventive practice among operating room nurses in China
Abstract Background: Operating-room (OR) nurses encounter disinfectants, sterilizing agents, and latex products as embedded job tasks, yet their multi-domain symptom burden, safety awareness, and preventive practices have rarely been examined together, particularly in Chinese tertiary-care settings. Methods: We undertook a single-center cross-sectional investigation of operating-room nurses at a tertiary hospital in China.
Tungsten Oxide Sub-Nanowires as Inorganic Dental Collagen Crosslinker With Antibacterial Capacity
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement Research data are not shared. Supporting Information Filename Description smll75422-sup-0001-SuppMat.docx7.7 MB Supporting File: smll75422-sup-0001-SuppMat.docx. References 1 and , “Biomineralization of Enamel and Dentin Mediated by Matrix Proteins,” Journal of Dental Research 100 (2021): 1020–1029, https://doi.org/10.1177/00220345211018405.
Natural products targeting the Nrf2 signaling pathway: potential targets and intervention strategies for the prevention and treatment of colorectal cancer
Abstract Colorectal cancer (CRC) is a highly prevalent gastrointestinal malignancy worldwide, characterised by insidious onset, rapid progression, high tendency for recurrence and metastasis, and resistance to chemotherapy. It poses significant challenges for clinical management and has become a major public health issue threatening human health. Current clinical treatments for CRC remain significantly limited.
Association Between Cell-Free Fetal DNA and Placenta Accreta Spectrum: A Retrospective Cohort Study
Disclosure The findings of this study have not been previously presented in any form (e.g., as an abstract, poster, or oral presentation) at a scientific conference or public forum. Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data underlying this study consist of individual level clinical information derived from electronic medical records at a single tertiary perinatal center.
SmartSport: crowd counting meets large language models for smart facility management
Abstract Efficient management and optimal allocation of urban public sports facilities represents a critical challenge in modernizing public sports service governance. Current approaches to facility utilization assessment predominantly depend on manual counting and questionnaire surveys, which are constrained by low efficiency, limited coverage, and poor real-time responsiveness.
Discovery of F-18 labeled repurposed CNS drugs by computational strategy for effective tau imaging and alzheimer’s diagnosis
Loading metrics Open Access Peer-reviewed Research Article Citation: Tang P, Chen X, Li P, Zhang L, Tang B, Wen J, et al. (2025) Discovery of F-18 labeled repurposed CNS drugs by computational strategy for effective tau imaging and alzheimer’s diagnosis. PLoS One 20(12): e0338901. https://doi.org/10.1371/journal.pone.0338901 Editor: Gayathiri Ekambaram, Guru Nanak College, INDIA Received: July 16, 2025; Accepted: November 30, 2025; Published: December 22, 2025 Copyright: © 2025 Tang et al.
Progressive Knowledge Distillation and Numerical Reasoning Enhancement for Financial Report Question Answering
Submitted: 04 November 2025 You are already at the latest version Financial report question answering (FRQA) presents unique challenges due to the need for precise numerical reasoning, complex table structures, and multi-table associations. Existing approaches often overlook the domain-specific complexities of financial reports and struggle with accurate numerical computation, leading to suboptimal performance in real-world financial intelligence applications.
Wireless nonresonant stimulation of neurons on a magnetoelectric film surface
Abstract Wireless neural interfaces are emerging as a minimally invasive treatment option for neurological disorders. Among the wireless technologies, magnetically powered systems are effective for targeting deep brain sites. However, dependence on high-frequency electromagnetic fields in such systems limits their safe implementation.
Lyn restrains lupus via kinase-independent mechanisms that limit Toll-like receptor activation and type I interferon responsiveness
Abstract Lyn phosphorylates inhibitory immunoreceptors to terminate signaling; consequently, Lyn deficiency in mice causes hyperactive immune cells and lupus-like autoimmune disease. Lyn may also suppress autoimmunity independent of its kinase activity through inhibitory protein-protein binding interactions, although the importance of this mechanism is unclear.
Structures of rotary ATP synthase from Thermus thermophilus during proton powered ATP synthesis
Abstract ATP synthases are rotary molecular machines that use the proton motive force to rotate the central rotor complex relative to the surrounding stator apparatus, thereby coupling the ATP synthesis.
Nuclear 2′-O-methylation regulates RNA splicing through its binding protein FUBP1
Abstract 2′-O-methylation (Nm) is an abundant RNA modification exists on different mammalian RNA species. However, potential Nm recognition by proteins has not been extensively explored. Here, we used RNA affinity purification, followed by mass spectrometry to identify Nm-binding proteins. The Nm-binding protein candidates exhibit enriched binding at known Nm sites. Some candidates display nuclear localization and functions. We focused on the splicing factor FUBP1.
Enhanced FOS expression improves tumor clearance and resists exhaustion in NR4A3-deficient CAR T cells under chronic antigen exposure
Abstract The dysfunction of chimeric antigen receptor (CAR) T cells in the tumor microenvironment is a major obstacle to their therapeutic efficacy against solid tumors. Through single-cell RNA sequencing analysis of tumor-infiltrating T cells from patients with glioma, NR4A family genes were identified as closely associated with T cell exhaustion and were coexpressed with dysfunctional genes HAVCR2 and TIGIT.
Task-related activity in auditory cortex enhances sound representation
Abstract We describe here a mode of activity of neurons in auditory cortex of freely moving rats consisting of large, slow firing rate modulations, which were not driven by sounds, were larger than the sound evoked responses, and were locked to specific time points during the task, similar to responses of hippocampal time-sensitive neurons. This activity mode had important functional consequences to sound processing during task performance.
CysMP reveals metal ion-specific metalloproteomes and copper-regulated PGK1 activity in glycolysis
Abstract Metal ions are essential in regulating protein functions through interactions with residues such as cysteine, but comprehensive mapping of metal-specific metalloproteomes in mammals remains limited. Here, we introduce CysMP, a cysteine-centered metalloprotein profiling strategy to profile the metalloproteomes of 11 key metal ions.
A choline-sensing regulator coordinates metabolic adaptation and pathogenesis in Pseudomonas aeruginosa pulmonary infections
Abstract Pseudomonas aeruginosa exploits host-derived phosphatidylcholine (PC) to establish persistent lung infections, yet the mechanistic link between metabolic adaptation and pathogenesis remains unclear. Here, we demonstrate that choline (Cho)–induced regulator (CodR), a GcvA-type transcriptional regulator, serves as a master regulator integrating virulence, antibiotic resistance, and PC catabolism during pulmonary infection.
Genomic parallelism defines repeated evolution of an inducible offense
Abstract A common developmental response to resource competition is an inducible offense, the facultative predation of competitors. At its extreme, this response involves the development of alternative phenotypic morphs, or polyphenism. However, how polyphenism evolves to meet ecological challenges, such as competitor species, is unknown.
Targeting RRM2 with dual-modal theranostic smart nanoresponder overcomes osimertinib resistance and triggers immune remodeling in NSCLC
Abstract Osimertinib (Osi) resistance limits its efficacy in EGFR-mutant non–small cell lung cancer (NSCLC). Here, we developed a pH-responsive cationic nanovesicle (124I/Cy5.5-sO@FCLs), equipped with dual-modal positron emission tomography (PET) and fluorescence imaging capabilities, to enable dynamic monitoring of the role of ribonucleotide reductase M2 subunit (RRM2) disruption in overcoming Osi resistance and enhance targeted anticancer efficacy in NSCLC.
Beyond the limit: The estimated air pollution damages of overshooting the temperature target
Abstract Exposure to outdoor air pollution results in millions of premature deaths and illnesses that are associated with substantial economic loss. According to the Global Burden of Disease, outdoor air pollution was responsible for 4.7 million deaths in 2021. Climate change mitigation policies could provide cobenefits by reducing air pollution.
Kinesin-1 coordinates cross-talk between microtubule and actin cytoskeletons during dendritic cell migration
Abstract Dendritic cells (DCs) are professional antigen (Ag)–presenting cells that excel in initiating adaptive immune responses by continuously scanning peripheral tissues for Ags. To facilitate efficient DC migration, constant cross-talk between actin and microtubules is required to coordinate cytoskeletal networks and actomyosin contractility, but the related mechanisms have not been extensively characterized.
Lightweight and ultrastrong 3D nanoarchitected high-entropy ceramic metamaterials
Abstract Three-dimensional (3D) nanoarchitecture ceramics, such as ceramic nanolattices, have attracted intensive research interest due to good thermal stability, oxidation resistance, and damage tolerance. The high performance of lightweight ceramic nanolattices is still a goal to pursue. Herein, we report a high-entropy ceramic (HEC) 3D architecture with feature size down to 150 nanometers, exhibiting simultaneous high strength and energy absorption.
Palmitoyltransferase ZDHHC19 regulates histone-to-protamine exchange during spermiogenesis in mice
Abstract Spermiogenesis, the final phrase of spermatogenesis, involves replacing histones by protamines, a process known as histone-to-protamine exchange, which is crucial for chromatin condensation. While this exchange is essential, the precise mechanisms remain incompletely understood. In this study, we discovered that the palmitoyltransferase ZDHHC19 functions as a key regulator of mouse spermiogenesis. Loss of Zdhhc19 leads to male infertility and abnormal sperm morphology.
Femtosecond spectroscopy with paired single photons: Emulating a double-slit experiment in the time-frequency domain
Abstract Time-resolved spectroscopy has long served as a cornerstone technique for investigating the photophysics of materials. However, conventional methods based on intense optical pulses and ensemble measurements often fail to resolve quantum dynamics due to spectral overlap, coherent artifacts, and multiphoton effects.
Cooperative role of distinctive TP53 and PTEN combined loss in the peripheral T cell lymphoma-GATA3 molecular subgroup
Abstract Peripheral T cell lymphoma (PTCL) is a heterogeneous group of postthymic T cell neoplasms, with ~40% classified as PTCL–not otherwise specified (PTCL-NOS). PTCL-GATA3, a molecularly defined subtype, associated with T helper 2 (TH2)–like differentiation and poor prognosis, has frequent co-occurrence of TP53 loss/mutation and heterozygous PTEN loss.
Bacterial communities co-develop with respiratory immunity early in life, linking dysbiosis to systemic monocyte signature and wheezing
Abstract Early microbial colonization influences respiratory disease risk, yet mechanisms remain unclear. In a prospective birth cohort of 256 infants, we profiled bacterial, fungal, and viral communities in the upper airway and assessed local immune gene expression longitudinally and systemic gene expression at 1 year.
Dissociable cortical contributions to impulse control during waiting
Abstract Self-control requires regulating actions over time, particularly suppressing impulsive actions to obtain future rewards. Using a delayed-response task in mice, we identified distinct cortical contributions to impulse control during waiting. Optogenetic inhibition revealed that the dorsomedial frontal cortex (dmFC) promotes patience, the anterior insular cortex (AIC) drives impulsivity, and the posterior parietal cortex (PPC) regulates temporal precision in waiting.
Extrachromosomal circular DNA promotes inflammation and hepatocellular carcinoma development
Abstract Two decades after the initial report on increased micronuclei in human chronic liver disease (CLD) and hepatocellular carcinoma (HCC), their role in HCC development is still poorly understood. Here, we show that micronuclei in hepatocytes trigger a hepatic immune response and promote HCC development via an increased level of extrachromosomal circular DNA (eccDNA). Livers of a CLD model (Mcl1Δhep mice) show increased micronuclei and eccDNA levels.
Resistance to radiation enhances metastasis by altering RNA metabolism
Abstract The cellular programs that mediate therapy resistance are often important drivers of metastasis, a phenomenon that needs to be understood better to improve screening and treatment options for patients with cancer. Although this issue has been studied extensively for chemotherapy, less is known about a causal link between resistance to radiation therapy and metastasis.
Oxygen isotope composition of Mesoproterozoic (~1360 Ma) seawater constrained by clumped isotopes of North China limestones
Abstract The oxygen isotope composition (δ18O) of Phanerozoic seawater has been widely investigated, but the δ18O values of Precambrian seawater remain poorly constrained, with ongoing debate over whether they were substantially lower than those of Phanerozoic seawater. To address this question, we analyzed the clumped isotopes of limestones from the North China Craton to reconstruct Mesoproterozoic seawater temperature and δ18O values.
Short tandem repeats in populations of the Qinghai-Tibet Plateau and adjacent regions provide insights into high-altitude adaptation
Abstract Short tandem repeats (STRs) confer evolutionary advantages across various species, yet their roles in human high-altitude adaptation remain largely unexplored. In this study, we analyzed over 1.1 million STRs in 7876 whole-genome sequencing samples, including 3808 newly sequenced Tibeto-Burman (TB) speakers and Han Chinese individuals inhabiting the Qinghai-Tibet Plateau and neighboring regions.
Starspots as the origin of ultrafast drifting radio bursts from an active M dwarf
Abstract Detecting coherent radio bursts from nearby M dwarfs provides opportunities for exploring their magnetic activity and interaction with orbiting exoplanets. However, it remains uncertain whether the emission is related to flare-like activity similar to the Sun or magnetospheric process akin to magnetized planets.
Distributed direct air capture by carbon nanofiber air filters
Abstract The rising atmospheric CO2 concentration is one of the biggest challenges human civilization faces. Direct air capture (DAC) that removes CO2 from the atmosphere provides great potential in carbon neutralization. However, the massive land use and capital investment of centralized DAC plants and the energy-intensive process of adsorbent regeneration limit its wide employment.
CEP76 impairment at the centrosome-cilium interface contributes to a spectrum of ciliopathies
Abstract Dysfunction at the centrosome-cilium interface underlies a broad range of ciliopathies. Here, we identify biallelic variants in CEP76, encoding a centrosomal protein, in eight unrelated individuals presenting with neurodevelopmental, ocular, and variable additional multisystem features.
Efficacy and Safety of Ciprofol for Sedation in Critically Ill Patient
Back to Journals » Drug Design, Development and Therapy » Volume 20 Authors Guo L , Hong M, Li P, Du W, Li Y, Li J Received 20 September 2025 Accepted for publication 3 February 2026 Published 10 February 2026 Volume 2026:20 568956 DOI https://doi.org/10.2147/DDDT.S568956 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Prof.
A long-term ketogenic diet causes hyperlipidemia, liver dysfunction, and glucose intolerance from impaired insulin secretion in mice
Research Article PHYSIOLOGY INTRODUCTION A ketogenic diet (KD) is a very-high-fat, low-carbohydrate diet that has been used to manage refractory epilepsy for the past hundred years (1, 2).
Preparation and characterization of a iRGD-modified recombinant spider silk particles for antitumor polypeptide drug delivery into cancer cells - BMC Biotechnology
For NC construct, the primers used for NT were NT-F (5’- GGT CAG TCA CCA TGG CAA AAC-3’) and NT-R (5’- CAC GGC ATT TGC CTG AGC-3’), while primers for CT were CT-F (5’- CAG GCA AAT GCC GTG TCA GCA TCA TCT GCT GCT GCA G-3’) and CT-R (5’- TTA AGA AAG AGC TTG GTA AAC AG-3’). To generate NC, the NT and CT were used for overlap PCR, and the products were gel extracted, purified, ligated into pET-32a vector and transformed into Eecherichia coli strain DH5α.
Genome-wide analysis of pseudogenes reveals HBBP1’s human-specific essentiality in erythropoiesis and implication in β-thalassemia
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Main text (Developmental Cell 56, 478–493.e1–e11; February 22, 2021) In the originally published version of this paper, due to the similar electrophoretic patterns between the TAL1 and HBBP1 PCR products, the gel image of TAL1 PCR product in Figure 5A was erroneously replaced with that of HBBP1 PCR product from Figure 4F, resulting in duplicated images in Figures 5A and 4F. The authors sincerely apologize for the error, and the corrected version of the image can be found below.
By Yanni Ma, Siqi Liu, Jie Gao, Chunyan Chen, Xin Zhang, Hao Yuan, Zhongyang Chen, Xiaolin Yin, Chenguang Sun, Yanan Mao, Yi Shao, Qian Liu, Jiayue Xu, Daqi Yu, Pingping Li, Ping Yi, Jiahuan He, Guangfeng Geng, Qing Guo, Haipeng Li, Graham L. Banes, He Liu, Yukio Nakamura, Ryo Kurita, Yue Huang, Xiaoshuang Wang, Fang Wang, Gang Fang, James Douglas Engel, Lihong Shi, Yong Zhang, Jia Yu, Fanqi Zhou, Yanmin Si, Hualu Zhao
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Efficacy of Glucocorticoids in the Treatment of Retinal Detachment With Choroidal Detachment: Analysis by Proteomics
Data Availability Statement The MS data have been deposited to the ProteomeXchange Consortium via the iProX repository with the data set identifier PXD058498.
Study on the Improvement of Coastal Pumping Station Inlet Flow Regime and Evaluation of Transverse Flow Velocity Elimination
1. Introduction Coastal pumping stations effectively manage and allocate water resources, providing essential support for agriculture, industry, and urban development in coastal areas. They demonstrate considerable flexibility, adjusting to meet varying water resource management challenges. These advantages enable coastal pumping stations to play a pivotal role in water resource management, ecological protection, and economic development.
Tet3 Mediates O-GlcNAcylation-Induced Remyelination
Abstract The failure of oligodendrocyte precursor cells (OPCs) to generate mature oligodendrocytes represents a major hurdle impeding myelin repair. However, the cellular determinants for OPC differentiation and the pharmacological targets driving remyelination remain rudimentary. Here, we demonstrate that O-GlcNAcylation intrinsically drives remyelination, in which Tet3 is one downstream effector.
Characterization of Thirty Germplasms of Millet Pepper (Capsicum frutescens L.) in Terms of Fruit Morphology, Capsaicinoids, and Nutritional Components
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Effect of Exogenous Jasmonates on Plant Adaptation to Cold Stress: A Comprehensive Study Based on a Systematic Review with a Focus on Sustainability
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Defect Passivation of Mn2+‐Doped CsPbX3(X=Cl,Br) Perovskite Nanocrystals as Electrocatalyst for Overall Water Splitting
Conflict of Interests The authors declare no conflict of interest. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Unraveling the Role of Electron‐Withdrawing Molecules for Highly Efficient and Stable Perovskite Photovoltaics
Introduction Perovskite solar cells (PSCs) represent a groundbreaking innovation in optoelectronics, potentially rivalling existing crystalline silicon solar cells with the power conversion efficiency (PCE) of 26.1 %.1-6 Despite the rapid improvement in perovskite crystal quality, elevated non-radiative recombination rates and suboptimal contact at the interface between perovskite and hole transport layer (HTL) have emerged as significant impediments to the advancement of perovskite...
Unraveling the Role of Electron‐Withdrawing Molecules for Highly Efficient and Stable Perovskite Photovoltaics
Introduction Perovskite solar cells (PSCs) represent a groundbreaking innovation in optoelectronics, potentially rivalling existing crystalline silicon solar cells with the power conversion efficiency (PCE) of 26.1 %.1-6 Despite the rapid improvement in perovskite crystal quality, elevated non-radiative recombination rates and suboptimal contact at the interface between perovskite and hole transport layer (HTL) have emerged as significant impediments to the advancement of perovskite...
Regulating the Crystal Facet Differences of In2O3 via Different Precipitants to Affect Methanol Selectivity
Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Analysis of Hyperosmotic Tolerance Mechanisms in Gracilariopsis lemaneiformis Based on Weighted Co-Expression Network Analysis
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Vaccines | Free Full-Text | Knowledge and Attitudes about Contraindications and Precautions to Vaccination among Healthcare Professionals Working in Vaccination Clinics in Ningbo, China: A Cross-Sectional Survey
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Smart Energy Storage: W18O49 NW/Ti3C2Tx Composite‐Enabled All Solid State Flexible Electrochromic Supercapacitors
Conflict of Interest The authors declare no conflict of interest. Supporting Information Filename Description smll202400278-sup-0001-SuppMat.pdf1.4 MB Supporting Information smll202400278-sup-0002-MovieS1.mp46.7 MB Supplemental Movie 1 References 1, , , , , , Nat. Commun. 2020, 11, 2351. 2a) , , Science 2016, 352, 922; b) , Nat. Mater. 2006, 5, 89. 3, , , , Chem. Rev. 2022, 122, 14679. 4, , , , , , ACS Energy Lett. 2022, 8, 306. 5a) , , , , Energy Storage Mater.
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