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Modulating the immunodominance hierarchy of immunoglobulin germline-encoded structural motifs targeting the influenza hemagglutinin stem
Keywords influenza virus broadly neutralizing antibody bnAb hemagglutinin germline-targeting HA stem nanoparticle B cell IGHV1-69 IGHD3-9 Research topic(s) CP: Immunology Introduction Influenza A and B viruses cause seasonal epidemics and hundreds of thousands of hospitalizations and deaths every year.1 Influenza A viruses (IAVs) have also been responsible for four major global pandemics in the last 110 years.
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