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Articles by Robert Graham
Intrinsic Cell-Class-Specific Modulation of Intracellular Chloride Levels and Inhibitory Function, in Cortical Networks, between Day and Night
Animals and housing conditions All animal handling and experimentations were performed according to the guidelines of the UK Home Office and Animals (Scientific Procedures) Act of 1986 and approved by the Newcastle University Animal Welfare and Ethical Review Body. Mice were housed on a 12/12 h light/dark cycle with ad libitum access to food and water.
Peri-Operative Care of Technology-Dependent Adolescents and Young Adults
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Influenza and COVID-19 Vaccination Rates Among Children Receiving Long-Term Ventilation
Introduction Children who receive tracheostomy and home ventilation (HV) are at high risk of acute respiratory infections (ARIs), the leading cause of hospitalization and death among these patients.1 The Centers for Disease Control and Prevention and the American Academy of Pediatrics recommend annual influenza and COVID-19 vaccinations for all children aged 6 months or older, unless medically contraindicated.2,3 Concern, however, exists that growing antivaccination sentiments, emerging...
Pediatric pulmonology year in review-Pediatric pulmonary critical care
Subcommittee on Diagnosis and Management of Bronchiolitis Clinical practice guideline: the diagnosis, management, and prevention of bronchiolitis High-flow oxygen and other noninvasive respiratory support therapies in bronchiolitis: systematic review and network meta-analyses Improving outcomes for bronchiolitis patients after implementing a High-Flow nasal cannula holiday and standardizing discharge criteria in a PICU Quality improvement to reduce high-flow nasal cannula overuse in children...
Delayed Burr Hole Evacuation Compared With Acute Craniotomy for Acute Subdural Hematoma in Older Patients With Low-Energy Trauma
Specialty Please choose I'm not a medical professional. Allergy and Immunology Anatomy Anesthesiology Biostatistics Cardiac/Thoracic/Vascular Surgery Cardiology Critical Care Dentistry Dermatology Diabetes and Endocrinology Emergency Medicine Epidemiology and Public Health Family Medicine Forensic Medicine Gastroenterology General Practice Genetics Geriatrics Health Policy Hematology HIV/AIDS Hospital-based Medicine I'm not a medical professional.
Genetic mapping across autoimmune diseases reveals shared associations and mechanisms - Nature Genetics
Abstract Autoimmune and inflammatory diseases are polygenic disorders of the immune system. Many genomic loci harbor risk alleles for several diseases, but the limited resolution of genetic mapping prevents determining whether the same allele is responsible, indicating a shared underlying mechanism. Here, using a collection of 129,058 cases and controls across 6 diseases, we show that ~40% of overlapping associations are due to the same allele.
Bringing Pediatric Chronic Critical Illness Into Acute Focus
Implicit in its name, pediatric critical care medicine focuses on acute stabilization and intensive management for children. Although this description is certainly accurate, clinicians and families are increasingly aware of the intersection with complex, chronic pediatric illness.1,2 The spectrum of chronic disease among children spans all ages; origins range from congenital to acquired conditions and encompass those with static, slowly resolving, and progressive decreasing trajectories.
Autism and neurodevelopmental disability risks in children with tracheostomies and ventilators
1 INTRODUCTION Infants who survive prematurity and other critical illnesses but continue to require invasive mechanical ventilation (IMV) assistance beyond hospital discharge are at high risk of developmental delays and disabilities. Studies of extremely preterm cohorts (<28 weeks' gestation) demonstrate rates of 25% for intellectual disability (ID)1 and 7% for autism spectrum disorder (ASD)2 at 10 years of age.
Opinion: Robert Graham: The biggest threat to Americans’ health is food. It’s also the cure.
By Robert Graham Over the last 50 years, food has become more accessible than ever. Yet, Americans are experiencing the worst health outcomes of any high-income nation. The pervasiveness of food deserts, the prevalence of junk food, and a lack of nutritional education have led to mass obesity, which spurs the chronic disease epidemic, claiming 1.7 million lives annually — or seven of every 10 U.S. deaths. That’s more than three and a half times the number of tobacco-related deaths yearly.
Commentary: Better health through eating right
Over the last 50 years, food has become more accessible than ever. Yet, Americans are experiencing the worst health outcomes of any high-income nation. The pervasiveness of food deserts, the prevalence of junk food, and a lack of nutritional education have led to mass obesity, which spurs the chronic disease epidemic, claiming 1.7 million lives annually — or seven of every 10 U.S. deaths. That’s more than three and a half times the number of tobacco-related deaths yearly.
Journal of Agricultural, Biological and Environmental Statistics
Journal of Agricultural, Biological and Environmental Statistics, Aug 2023 Group testing is an important element of biosecurity operations, designed to efficiently reduce the risk of introducing exotic pests and pathogens with imported agricultural products. Groups of units, such as seeds, are selected from a consignment and tested for contamination, with a positive or negative test returned for each group.
Transglutaminase 2 Facilitates Murine Wound Healing in a Strain-Dependent Manner
Font Type: Arial Georgia Verdana Line Spacing: Column Width: Open AccessArticle by 1, 1, 1, 1,2,* and 1,2,* 1 Victor Chang Cardiac Research Institute, Darlinghurst, NSW 2010, Australia 2 School of Clinical Medicine, UNSW Medicine and Health, University of New South Wales Sydney, Kensington, NSW 2052, Australia * Authors to whom correspondence should be addressed. Int. J. Mol. Sci.
A village in a dish model system for population-scale hiPSC studies - Nature Communications
Ethics The research carried out in this study was conducted in accordance with the Declaration of Helsinki and approved by the Human Research Ethics committees of the University of Melbourne (1545394), the Garvan Institute of Medical Research (ETH01307) and the University of Queensland (2015001434). All patients gave written informed consent to collect and use their biological data for this research.
Genome-wide association meta-analysis of spontaneous coronary artery dissection identifies risk variants and genes related to artery integrity and tissue-mediated coagulation | Nature Genetics
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Abstract Spontaneous coronary artery dissection (SCAD) is an understudied cause of myocardial infarction primarily affecting women. It is not known to what extent SCAD is genetically distinct from other cardiovascular diseases, including atherosclerotic coronary artery disease (CAD). Here we present a genome-wide association meta-analysis (1,917 cases and 9,292 controls) identifying 16 risk loci for SCAD.
By David Adlam, Takiy-Eddine Berrandou, Adrien Georges, Christopher Nelson, Chris Finan, Siiri E. Iismaa, Xiang Zhou, Stephen Hamby, Liam R. Brunham, Stéphanie Debette, Philippe Amouyel, Jeffrey W. Olin, Stephanie E. Hesselson, Stavroula Kanoni, Krishna G. Aragam, Adam S. Butterworth, Nicolas Combaret, Diane Fatkin, Aroon Hingorani, Jacqueline Saw, Tom Webb, Sharonne N. Hayes, Xia Yang, Timothy Olson, Jason C. Kovacic, Robert Graham, Peter S. Braund
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Nature
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Effects of Fluoride on In Vitro Hydroxyapatite Demineralisation Analysed by 19F MAS-NMR
Bajram Ferizoli1, Alexander J. Cresswell-Boyes1*, Paul Anderson1, Richard J. Lynch1 and Robert G. Hill1 1Dental Physical Sciences Unit, Centre for Oral Bioengineering, Institute of Dentistry, Barts and the London School of Medicine and Dentistry, Queen Mary University of London, United Kingdom The final, formatted version of the article will be published soon. Receive an email when it is updated Fluoride plays a major role in inhibiting enamel dissolution and promoting fluorapatite (FAP) formation.
Lessons from US-based company's trial of a four-day week
The concept of a four-day work week has gained traction in the UK, but how feasible is it in other markets? US-based company Poll Everywhere decided to trial a shorter working week, with some interesting results, writes Robert Graham. The four-day work week has been a trending topic, partly because of a six-month trial involving 72 companies.
Adverse events after spontaneous coronary artery dissection
http://orcid.org/0000-0002-1042-2587Robert M Graham1,2,3,4 1 Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia 2 Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia 3 University of New South Wales, Sydney, New South Wales, Australia 4 John Hunter Hospital, New Lambton Heights, New South Wales, Autralia Correspondence to Professor Robert M Graham, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia;...
Adverse events after spontaneous coronary artery dissection
http://orcid.org/0000-0002-1042-2587Robert M Graham1,2,3,4 1Victor Chang Cardiac Research Institute, Sydney, New South Wales, Australia 2Department of Cardiology, St Vincent's Hospital, Sydney, New South Wales, Australia 3University of New South Wales, Sydney, New South Wales, Australia 4John Hunter Hospital, New Lambton Heights, New South Wales, Autralia Correspondence to Professor Robert M Graham, Victor Chang Cardiac Research Institute, Sydney, NSW 2010, Australia;...
#BlogTour #BookReview See No Evil By David Fennell #SeeNoEvil
Hello, Book Dragons! Today I would like to welcome you all to my stop on the Blog Tour for See No Evil By David Fennell and I would like to share a review, with all of you. Thank you very much to Tracy from Compulsive Readers for the invitation. Please do show some love to all the wonderful book bloggers on this blog tour by following and sharing their work. 🙂 Thank You very much to the publisher – Zaffre for the review copy.
A Woman Who Abstains from Alcohol Has Worsening Abdominal Pain
close Please confirm that you would like to log out of Medscape. If you log out, you will be required to enter your username and password the next time you visit. Log out Cancel Editor's Note: The Case Challenge series includes difficult-to-diagnose conditions, some of which are not frequently encountered by most clinicians but are nonetheless important to accurately recognize. Test your diagnostic and treatment skills using the following patient scenario and corresponding questions.
#GuestPost The Former Boy Wonder By Robert Graham
Publisher: Valley Press ISBN13: 978-1912436934 Genre: Humorous Fiction Release date: 24 02 2022 Price*: Kindle £4.99 (GBP)/ Paperback £11.17 (GBP) Kindle $6.99 (USD)/ Paperback $19.93 (USD) Pages: ~ 352 You can get this book here: Amazon UK Bookshop.org Description of the book: The Former Boy Wonder is a bittersweet comedy that takes a sidelong look at first love, fathers and sons, and fidelity.
Risk analysis for DEF CON 2021
Risk analysis for DEF CON 2021 It's the second year of the pandemic and the DEF CON hacker conference wasn't canceled. However, the Delta variant is spreading. I thought I'd do a little bit of risk analysis. TL;DR: I'm not canceling my ticket, but changing my plans what I do in Vegas during the convention. First, a note about risk analysis. For many people, "risk" means something to avoid. They work in a binary world, labeling things as either "risky" (to be avoided) or "not risky".
Vision problems due to droopy eyelids
Vision problems due to droopy eyelids Image by Alberto Ramirez on Vecteezy By Robert Graham, M.D. Posted on May 14, 2021 Dear Mayo Clinic: My droopy eyelids have worsened significantly over the past few years, but I’m hesitant to have surgery to fix them. What are the risks of having an eyelid lift, and how long is the recovery? A: Blepharoplasty, also called an eyelid lift, typically includes removing extra skin, muscle and fat from the upper and lower eyelids.
Surgery Can Eliminate Vision Problems Related to Droopy Eyelids
DEAR MAYO CLINIC: My droopy eyelids have worsened significantly over the past few years, but I’m hesitant to have surgery to fix them. What are the risks of having an eyelid lift, and how long is the recovery? ANSWER: Blepharoplasty, also called an eyelid lift, typically includes removing extra skin, muscle, and fat from the upper and lower eyelids. The surgery can reduce vision problems caused by excess eyelid skin and make your eyes look younger and more alert.
The Economic Relationship between Quantity Supplied and Prices
Education Economics The Economic Relationship between Quantity Supplied and Prices By Robert J. Graham Supply describes the economic relationship between the good’s price and how much businesses are willing to provide. Supply is a schedule that shows the relationship between the good’s price and quantity supplied, holding everything else constant. Holding everything else constant seems a little ambitious, even for economists, but there is a reason for that qualification.
Fast Five Quiz: Cataracts
A cataract is an opacification of the lens. Congenital cataracts are usually diagnosed at birth. If a cataract goes undetected in an infant, permanent vision loss may ensue. In addition to congenital cataracts, several other forms are recognized, including senile cataract, traumatic cataract, and posterior pole cataract. Given the potential for serious vision loss in some cases, how much do you know about the different types of cataracts, as well as best treatment practices?
Security Boulevard
This week, Trump’s opponents misunderstood a Regeneron press release to conclude that the REG-COV2 treatment (which may have saved his life) was created from stem cells. When that was proven false, his opponents nonetheless deliberately misinterpreted events to conclude there was still an ethical paradox. I’ve read the scientific papers and it seems like this is an issue that can be understood with basic high-school science, so I thought I’d write up a detailed discussion.
What “Food is Medicine” Really Means
“Food is medicine.” It’s an idea that goes all the way back to Hippocrates, if not before him. In one form or another, this notion is found in many cultures all around the world. It is easy to say, and it has been getting a lot of lip service in recent years. But what does it really mean? How can we make it practical for the good of our patients? We know that diet-related disease is a leading cause of death and disability in the US, as the 2019 Global Burden of Disease study clearly points out.
Peckham Community Kitchen
We are a community kitchen based in Peckham, preparing over seventy hot meals each Tuesday. We've been running out of the Artusi kitchen whilst it's closed, working alongside a Mutual Aid group who distribute the food to people without addresses in Peckham Square. Due to Covid-19, the need for community based aid is higher than ever, and us being out of work, we decided to contribute in the best way we can.
Ethical decision-making for children with neuromuscular disorders in the COVID-19 crisis
June 01, 2020Contemporary Issues First published June 1, 2020, DOI: https://doi.org/10.1212/WNL.0000000000009936 Abstract The sudden appearance and proliferation of COVID-19 has forced societies and governmental authorities across the world to confront the possibility of resource constraints when critical care facilities are overwhelmed by the sheer numbers of grievously ill patients.
Task Force 1. Report of the Task Force on Patient Expectations, Core Values, Reintegration, and the New Model of Family Medicine
Task Force 1 Writing Group*, Larry A. Green, MD1, Robert Graham, MD2, Bruce Bagley, MD3, Charles M. Kilo, MD, MPH4, Stephen J. Spann, MD5, Stephen P.
Coronavirus Stimulus Leaves Out Financial Relief for Thousands of Small Businesses
The opinions expressed by columnists are their own and do not necessarily represent the views of Townhall.com. After many businesses closed their doors and unemployment claims surged amid the global coronavirus slowdown, Congress passed a massive $2 trillion stimulus known as the CARES Act in order to help Americans weather the economic storm until the number of new COVID-19 cases flatlines.
Footbridge in Thornley Woods (C) Robert Graham
NZ1760 : Footbridge in Thornley Woods taken 6 years ago, near to Barlow, Gateshead, Great Britain Footbridge in Thornley Woods A steep sided little burn runs through the woods. © Copyright Robert Graham and licensed for reuse under this Creative Commons Licence.
CrimethInc. - Surviving the COVID-19 Corona Virus Crisis
Here is another anarchist perspective on the COVID-19 Corona virus crisis from CrimethInc. Let’s be clear: totalitarianism is no longer a threat situated in the future. The measures being implemented around the world are totalitarian in every sense of the word. We are seeing unilateral government decrees imposing total travel bans, 24-hour-a-day curfews, veritable martial law, and other dictatorial measures.
Mortality and respiratory support in X-linked myotubular myopathy: a RECENSUS retrospective analysis
Mortality and respiratory support in X-linked myotubular myopathy: a RECENSUS retrospective analysis Robert J Graham1, Francesco Muntoni2, Imelda Hughes3, Sabrina W Yum4, Nancy L Kuntz5, Michele L Yang6, Barry J Byrne7, Suyash Prasad8, Rachel Alvarez9, Casie A Genetti10, Tmirah Haselkorn11, Emma S James8, Laurie B LaRusso12, Mojtaba Noursalehi8, Salvador Rico8, Alan H Beggs10 1 Department of Anesthesiology, Critical Care and Pain Medicine, Division of Critical Care Medicine, Boston Children's...
The Responsible Solution to the Student Debt Crisis
The opinions expressed by columnists are their own and do not necessarily represent the views of Townhall.com. “There is no doubt that it is around the family and the home that all the greatest virtues, the most dominating virtues of human, are created, strengthened and maintained,” Winston Churchill said in 1948 on the birth of Prince Charles.
Congress Takes Right Step to Curb Gun Related Veteran Suicide
The opinions expressed by columnists are their own and do not necessarily represent the views of Townhall.com. Recent news reports showed that veteran suicide rates are still high. “Firearms were also singled out by researchers” for being used in nearly 70 percent of veteran suicides, while they are used in less than half of non-veteran suicides. The disparity is obvious, but unexplainable.
Security Boulevard
I’m currently experiencing the toxic hell that is a misunderstood tweet going viral. It’s a property of the social media. The more they can deliberately misunderstand you, the more they can justify the toxicity of their response. Unfortunately, I had to delete it in order to stop all the toxic crud and threats of violence. The context is how politicians distort everything.
Pick Up This Sport Coat At Robert Graham For A Big Last Minute Gift
Men’s Journal aims to feature only the best products and services. We update when possible, but deals expire and prices can change. If you buy something via one of our links, we may earn a commission. Questions? Reach us at shop@mensjournal.com. The holiday season is about to come to a head in a week’s time. With online shopping, there is still plenty of time to shop with the right shipping option. But it is getting into crunch time. Last-minute shopping can really limit what you get as a gift.
The growing veteran suicide epidemic
ANALYSIS/OPINION: Sixty-thousand veterans have committed suicide over the past decade. Between 2008 and 2017, our nation lost more service members at home than in active war zones. Sadly, a majority of those veterans who took their own lives died in the same way their brothers and sisters did on the battlefield — by a firearm. Firearm-related veteran suicides is an epidemic that lies beneath the surface of the national discourse, but it affects us all.
Association of a Multidisciplinary Care Approach With the Quality of Care After Pediatric Tracheostomy
Original Investigation September 19, 2019 JAMA Otolaryngol Head Neck Surg. 2019;145(11):1035-1042. doi:10.1001/jamaoto.2019.2500 Key Points Question Is a multidisciplinary tracheostomy program associated with the quality of care after pediatric tracheostomy?
Grassley’s Drug Price Proposal - Good Policy & Better Politics
The opinions expressed by columnists are their own and do not represent the views of Townhall.com. Since the 2016 election cycle, barrels of ink of have been spilled over the issue of prescription drug prices and how, in today’s partisan atmosphere, it is the one issue that both parties agree is a problem and legislation will, therefore, be forthcoming. It is true that there is bipartisan agreement on the problem and even, it appears, on some of the solutions.
Prescription-drug price gouging must stop
ANALYSIS/OPINION: This week, senators and representatives have returned to Washington, D.C., after a five-week recess. Most congressional members used that time period to criss-cross their state or district, talking to their constituents and hearing directly from them about what needs to be done in Washington. They no doubt heard about immigration concerns, the impact of the trade war and overall frustrations with a lack of action in Washington.
Mortality and respiratory support in X-linked myotubular myopathy: a RECENSUS retrospective analysis
Mortality and respiratory support in X-linked myotubular myopathy: a RECENSUS retrospective analysis Robert J Graham1, Francesco Muntoni2, Imelda Hughes3, Sabrina W Yum4, Nancy L Kuntz5, Michele L Yang6, Barry J Byrne7, Suyash Prasad8, Rachel Alvarez9, Casie A Genetti10, Tmirah Haselkorn11, Emma S James8, Laurie B LaRusso12, Mojtaba Noursalehi8, Salvador Rico8, Alan H Beggs10 1Department of Anesthesiology, Critical Care and Pain Medicine, Division of Critical Care Medicine, Boston Children's...
Tackling surprise medical billing with arbitration
ANALYSIS/OPINION: Has this happened to you? You visit the hospital for a procedure or perhaps for an emergency. You have insurance and while your deductible is higher than you’d like, you think you’re going to be okay, financially speaking. Then later, when you’re recuperating at home, you get an enormous bill in the mail. Turns out one of the providers who attended to you was “out-of-network.” And you’re on the hook. If this has happened to you, you’re hardly alone.
Pipeline Battle Could Help Trump Win Minnesota in 2020
COMMENTARY Last week, President Trump tweeted that he expects to win the state of Minnesota in next year’s election. The president said Rep. Ilhan Omar’s anti-Semitism and Minnesota’s booming economy are two reasons he will turn the state red in 2020. He may be right. But there is another reason that President Trump should feel confident about winning Minnesota.
The Raise the Wage Act would kill over 1 million jobs
The battle over whether to increase the minimum wage is ramping up in Congress with the House passing the Raise the Wage Act. The bill gradually raises the federal minimum wage over the course of six years to $15.00 by 2025. Not surprisingly, it has big support among the Democratic base. But according to the Congressional Budget Office (CBO), while raising the minimum wage would increase wages for millions of people, it would also cause 1.3 million Americans to lose their job.
Divergent paths to seizure‐like events
Abstract Much debate exists about how the brain transitions into an epileptic seizure. One source of confusion is that there are likely to be critical differences between experimental seizure models. To address this, we have compared the evolving activity patterns in two widely used in vitro models of epileptic discharges. Brain slices from young adult mice were prepared in the same way and bathed either in 0 Mg2+ or 100 µmol/L 4AP artificial cerebrospinal fluid.
A state that spends too much, and foolishly
ANALYSIS/OPINION: It’s no secret that the U.S. national debt is out of control and getting worse. The Congressional Budget Office projects that our debt-per-year could reach $1 trillion by 2020. More frightening is the “debt is projected to grow faster than the economy — forever.” The debt problem isn’t only at the federal level. States are spending excessively and unwisely as well, and there’s no better example of where this is happening than California.
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