Robert Peach
Berkeley
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Articles by Robert Peach
Multi-dimensional signal exploration on the effect of tremor interventions
Abstract Background: Machine learning in tremor time-series analysis has so far been applied to differentiate tremor disorders. Respective analytical approaches can similarly be geared to explore therapeutic interventions, which conventionally are assessed by their induced amplitude changes. This may overlook subtle signal alterations. Feature-based machine learning offers the potential to explore much more granular tremor signal changes induced by therapeutic interventions.
Vestibular nucleus stimulation for ameliorating locomotor dynamics in a Parkinsonian mouse model
Abstract Postural and locomotor dysfunction represent axial symptoms of Parkinson’s disease (PD), which remain poorly treated by medication and deep brain stimulation. Whilst non-invasive neuromodulation of the vestibular system via the vestibular nucleus complex (VNC) offers a novel therapeutic avenue, the underlying circuits are still poorly characterized.
Identifying maximal beta power from directional subthalamic local field potentials in Parkinson’s disease
Abstract Accurate subthalamic beta activity could guide deep brain stimulation programming in Parkinson’s disease, but bipolar recordings complicate contact selection. In 39 patients, we validated three methods to estimate pseudo-monopolar beta power. Distance-weighted methods (Euclidean, Strelow) agreed consistently with the externalized “ground-truth” beta distribution. Maximal beta power across 20s windows was more stable in ring than in directional channels.
StimVision: smartphone video kinematics to optimize DBS programming in Parkinson’s disease
Abstract Deep brain stimulation (DBS) improves motor function in Parkinson’s disease, yet programming remains labor-intensive and largely subjective. We evaluated a smartphone video-based kinematic framework (StimVision) for objective, within-session optimization of DBS settings and characterization of therapeutic motor signatures. Fifteen patients with subthalamic DBS performed repetitive hand opening–closing while multiple stimulation programs were tested in the medication-off state.
Unlocking motor reserve: behavioral and neuroimaging correlates of locomotor adaptability from youth to old age
ORIGINAL RESEARCH article Volume 19 - 2025 | https://doi.org/10.3389/fnsys.2025.1686509 This article is part of the Research TopicReserves in the CNS: Emerging Concepts and Future ProspectsView all articles Introduction Over the past century, rising life expectancy has led to a growing global population of older adults.
Book Review - June 2025
The Secret Barrister (author’s identity unknown, he seeks to teach the reader how absurdly broken the civil & criminal justice system is. He speaks of the French and the German justice system which reimburse at a rate of 7€ whereas in UK the fee is a whopping £38.00. Ridiculous ! I think many would agree. Watch this space for the development of this review. Robert Peach 4th June 2025
Kwarsi Kwarteng and why the Tories are in the Mire.
In quite possibly the most vacuous radio interview that I have ever heard, Kwarsi Kwarteng’s assertion of Conservative Party policy — In an interview with Alistair Campbell and Rory Stewart, was utterly pathetic. His back and forth tactics during the interview were absurd.
Trading 212 is YET another scam!
No employees, zero customer service an NO OPPORTUNITY to extract your own money. Scandalous.
Emma Raducanu
Robert Peach · Follow Just now -- Of mixed race, and exceedingly beautiful, her decision to take a short(ish) career break is probably the correct one👏, hopefully one that shall rehabilitate her stuttering career. As an eighteen year old prodigy and US open winner breathtaking success was achieved early and astoundingly quickly, her body still growing and tender was suffering- her joints and tendons especially- essentially aggravated growing pains.
Guinness
Robert Peach · Follow 1 min read · -- I’ll always remember something about Guinness and not the drink rather the charitable foundation that it funds. There once was a chap called Paul; CEO of the Guinness Trust, a UK registered charity based in UK. Clearly Paul was a man who just didn’t get a sales mentality and he told me so.
Long‐Term Stability of Spatial Distribution and Peak Dynamics of Subthalamic Beta Power in Parkinson's Disease Patients
Oscillatory beta band activity (13–35 Hz) in the subthalamic nucleus (STN) of Parkinson's disease (PD) patients is a well-characterized biomarker, with its intensity correlating with bradykinetic and rigid symptoms.1, 2 Both dopaminergic medication and neuromodulation have been observed to suppress beta activity, which aligns with motor improvement.3-5 Consequently, beta power has become a feedback signal in adaptive deep brain stimulation (aDBS) studies6, 7 and holds potential for optimizing...
The Banning of Social Media for the under 18s/14s?
Robert Peach · Follow 1 min read · -- This is a matter that we must pay attention to. As a teenager in the late 1970s I, still now, remember going to the park to play football or cricket with my brother and our friends. Indeed in the summer there were always similar cohorts playing games on the grass- green in winter and autumn and golden brown in summer. Spring is always – in this country a shameless mixture of severe showers or cloud covered dry periods! 😢.
Trump Take 2
Robert Peach · Follow 1 min read · -- He’s a nightmare for the world economy. Experts predict that he’ll crash it & I wouldn’t bet against this. His stance against Xi is worrying – he’s unerringly hostile. This concerns me- big time. The thing about China is that you MUST respect them, they are a global player- not to be taken lightly or slightly. The won is headed north and we simply have to take this seriously. There is serious concern about the global economy – where is it headed. & how fast?
The last rites.
What immediately strikes me is that this is an unholy alliance, the Pope is powerless and is aging fast, he looks a little older than he is! The Roman Catholic Church is struggling to know what to do and he is equally impotent. Robert Peach 17th February 2025
Good old Blighty!
Robert Peach · Follow Just now -- What happens when a whole colonial empire cedes to a massive Sun, moon & stars? Well, it’s like this folks it’s simply amazing! The stars give way to stalagmites and stalagmites and worlds become more diminutive! Like one of my two daughters, the elder Lexi Peach. She’s small herself and has, truth be known found herself a husband.
What on earth is happening out there?
What on earth is happening out there? There is Donald Trump, & there is a certain Joe Biden, albeit useless in ending the forever wars. Kamala Harris now leads the Democratic Party & … she is hapless & hopeless at this! There simply must be some alternative to this nuttiness. The world is in need of this. Robert Peach 16th February 2025
Right
Valentine’s Day Has passed us by thank the Lord, I find the whole thing a farce.
DAVID MILLIBAND
Yes, that Blairite waste of space. Currently IDLE ICRC (International Committee of the Red Cross) (cushty) role for a talentless waste of Square mileage. Ed, his brother- younger, is the Environmental minister, Ralph will be turning in his grave- he was a founding father of “new” Labour.
Bowling Alone
Robert Peach · Follow 1 min read · -- RD Putnam wrote this piece back in 2000. It is a milestone for American Academic literature . It, for (arguably) the first time links civic disengagement with the declining state of social capital. Having just read 12 academic analyses of this ground-breaking work – they all seem to recognize social capital as a «thing» now. There are but a couple of dissenting scholars but mainly the analyses are aligned with Putnam’s assertions.
Hail Elon! Or do we?
$100 million is a game-changing chunk of cash though!
The Reclamation of Land
Robert Peach · Follow Just now -- Michael Albertus of the University of Chicago has written, what I would call a highly prescient piece in today’s Financial Times on land «reshuffle». He claims things like Florida is doomed as are many, many land masses are at risk. As a seasoned risk professional I’d agree. Please read the article at @ft.com That’s all there is to say. In another article by Sarah O’Connor of the FT appraises the current status quo in the electric cars situation.
Trump Presidential success
Robert Peach · Follow 1 min read · -- Is this the complete echo of Dominic Cummings doings during the get Brexit Done campaign? Apparently Trump spent upwards of 1,000 hours talking to podcast-enabled influencers throughout the Republican campaign. For those of us who have viewed the film starring an impressive Benedict Cumberbatch this is both relevant as well as prescient with the new Labour government.
Reform UK
Robert Peach · Follow Just now -- Nigel Farage, at the 7th attempt (sic) has become an MP. He should believe in himself and crack on. As far as Mori is concerned the party has surpassed many of its rivals and is second place in a recent YouGov poll. Orators crack on too! The thing about Farage is he chimes with ‘the common man’ — he talks a lot of sense, he smokes, he drinks, he takes the p*** out of people and he loves a good laugh! Chatham will be good for the country, trust me!
FINTECH ‘24
Robert Peach · Follow Just now -- Please go to the Amazon website and search for: Rob Peach: The Handbook of FinTech, then PURCHASE my new book. approximately ($12.00) It may not change your life but it will help you to make your pension(s) safe. It’s a great read and I’d say a wise purchase for anyone who is looking to safeguard their future. As we come up to “Black Friday” & Christmas time it could be your perfect gift to you parents or friends. The price point is very good value methinks.
PLASTIC POLLUTION
Robert Peach · Follow Just now -- As I have repeatedly said – ‘that the earth – currently orbiting the sun for the time being, may well turn by c2035 into an invisible dark brown (or blue, during reflections) plastic «blob». Id Est. – it will not be biologically able to either move nor orbit any star, it may well be trapped in time. «you see that dark space up the the sky honey» that’s where your grandma was born. «when can we go over to see here» ?
CONSOLIDATION
Robert Peach · Follow Just now -- On the run into another (dreaded) Trump administration we’re — in the west dreading more phoney rhetoric and very real conflicts. In an almost global recession, we must hunker down, not, preferably “spend, spend spend” as government & central banks would have us do. Truth is, as rather typically human, as we are- are addicted to consumption, consumption, consumption; are we all doomed by this repetitive mistake.
Welby resigns at last. Thank the lord !!!!
Welby resigns at last. Thank the lord !!!! Having been in the presence of this scumbag (loud, obnoxious, arrogant) I concur with his decision. ROBERT PEACH 13th November 2024
World’s Living Religions
This Penguin Handbook, treats all the chapters and narrative with respect. Judaism with regard to the worship of God the Jahweh. It also tackles Hinduism, Zoroastrianism & the land of
POLITICS = FEBRILITY
Having just ploughed my way through FT journalist Sebastian Payne’s “The Fall of Boris Johnson” I am quite simply speechless. There seems to be an all too silent conspiracy between crooked politicians and febrile journalists to leak — almost at will. This, as US President Joe Biden has alluded to is decidedly unhealthy for global democracy. The critical question is what can WE do about it? It’s all febrile because MPs’ egos have no peak, they’re all so desperate for the limelight and the power.
Net Zero
Please think about your grandchildren rather than yourselves. Net Zero will cost hundreds of $billions if not trillions if done properly and relatively promptly. The state of global economic stability is parlous to say the least. I’ve concluded that politicians are out for only 2 things in their careers – their egos and themselves. We live in a selfish and morally flawed world – whilst USA can borrow trillions, Eastern Europe and many other countries cannot raise a bean. For love nor money.
Standardized wireless deep brain stimulation system for mice - npj Parkinson's Disease
Abstract Deep brain stimulation (DBS) has emerged as a revolutionary technique for accessing and modulating brain circuits. DBS is used to treat dysfunctional neuronal circuits in neurological and psychiatric disorders. Despite over two decades of clinical application, the fundamental mechanisms underlying DBS are still not well understood. One reason is the complexity of in vivo electrical manipulation of the central nervous system, particularly in rodent models.
There may be Trouble Ahead...
Trumpism is sadly, back with us. His "gag" about Kamala Harris being "black" rather than "Indian"was both racist and contained very distasteful overtones. Martin Wolf - economist & Janan Ganesh also a columnist for the Financial Times, both in timely fashion are warning of a) erratic, proposed Republican foreign policy and b) a Trump presidency per se. I definitely agreed with Wolf, the spectre of a DJT presidency haunts many a wise mind. On foreign policy please read Janan's excellent article.
Cyber Crime
By Robert Peach The recent outage was indeed alarming.Perhaps it is the future of criminality- let's hope not. The CrowdStrike CEO was rightly apologetic but it's not the company's fault it is exceptionally high levels of interdependency & globalization. There will have to be sanctions introduced against offenders that are either leaky or faulty in the IT security sector. Worrying. Robert Peach 07720 286651
Transformer-based deep learning model for the diagnosis of suspected lung cancer in primary care based on electronic health record data
The authors have declared no competing interest. This work was supported by a project grant from Cancer Research UK 37891/A25310 and the NIHR Imperial Biomedical Research Centre. I confirm all relevant ethical guidelines have been followed, and any necessary IRB and/or ethics committee approvals have been obtained.
Head movement dynamics in dystonia: a multi-centre retrospective study using visual perceptive deep learning - npj Digital Medicine
Abstract Dystonia is a neurological movement disorder characterised by abnormal involuntary movements and postures, particularly affecting the head and neck. However, current clinical assessment methods for dystonia rely on simplified rating scales which lack the ability to capture the intricate spatiotemporal features of dystonic phenomena, hindering clinical management and limiting understanding of the underlying neurobiology.
Why I was Wrong on Brexit.
Like many a voter, I was incorrect on Brexit - the queues at Dover & NI ports demonstrate why. Nigel Farage is, without a shadow of doubt the most articulate politician- Sunak is inept and both Cameron & May were a joke. BUT I was wrong on Brexit; it created more trade walls than it knocked down. I regret my ignorance with the benefit of hindsight. The key issue is and was the trade imperative.Anything that makes trade more difficult is to be condemned rather than praised.
it's All About Anniversaries
Q's. What have we all got access to? What are we clueless about ? A: the past & the future! The recurrent topics on Social Media are, and continue to be so - the past & the future! Every journalist now & before contends to be a "player" on both courts. Why not I hear you cry... The fabulous article in today's FT on Franz Kafka is a prime example of premier journalism.
The 12th Century & Moore's Law- how they changed the human race- aspirations & Achievement
In the 12th century a transformation in the City of London occurred- the Foundation of the first few Livery Companies & then in the 1990s the "technological outbreak" that was (still is) the World Wide Web. It was all about connectivity in C.12 and is still so in C21. The advent of networks in the 12th century and then the founding of the internet in 1991/2 were breakthrough moments for the human race. They simply leapt us forward decades, if not centuries on both occasions.
The neuron mixer and its impact on human brain dynamics
Highlights • A single neuron mixes exogenous and endogenous oscillations to produce new frequencies • Neural frequency mixing originates in the nonlinearity of voltage-gated ion channels • The human brain EEG displays local and inter-region frequency mixing interactions • Mixing of human posterior alpha and beta oscillations correlates with visual attention Summary A signal mixer facilitates rich computation, which has been the building block of modern telecommunication.
The Entire Planet/ human race...
By Robert Peach Is in a SEVERE tizzy over either the cost of living or climate change or...hellish high levels of corporate & governmental debt. I have 2 answers: A. Inspired by movie guru Baz Luhrmann- "wear sunscreen " B. Eliminate plastics from our lives permanently. That's it; simples!!! ROB PEACH 3rd May 2024 ( A.D.)!
Book Recommendation: 2nd.
Yesterday’s Spy (2023) By Tom Bradby (FT journalist & Author) I thoroughly recommend this book to all READERS! It is, as the capable testimonials testify, full of thrills & spills. U-Turns on theories (proffered by «politicos») are numerous. No change there then! The mind and emotions of the reader by the end of the book, will be saddened by the protagonist passing away.
Functionally annotated electrophysiological neuromarkers of healthy ageing and memory function
1 INTRODUCTION A major accomplishment of the 20th century was the remarkable gain in global life expectancy, particularly in industrialised countries, which saw a rise of approximately 30 years (Christensen et al., 2009). However, age is also the strongest risk factor for many chronic diseases, including cancer and cardiovascular and neurodegenerative diseases (Niccoli & Partridge, 2012).
More on Climate Change
We must be alarmed: so warn gurus on the subject – not least David Attenborough – a knight of the realm and somebody who has researched nature for 70 years or so. Impressed ? So you should be. The events in Dubai recently (one year’s rain fell across just 24 hours) and Iceland (the volcanic dust cloud) and the relentless flooding of UK cities and towns (at the very centre of the global time zones)- again, these all signal RED.
SPIRIT, CLIMATE CHANGE & SEWAGE 2024.
This year, I will, I can only hope turn 60 years old. Of course, like most of us: a) I deny being old!; b) I’m determined, pragmatic, and «never say die»; 3) I resent and am appalled at sewage being dumped into the seas & UK/ European & Asian rivers. Dreaded plastic (an OIL derivative) is getting into whales’, and fishes’ food chains. As is evidenced by – as early as Jacque Cousteau and then the inimitable David Attenborough more recently, we are killing (albeit slowly) our beloved planet.
There are only 2 things left to do on Our Planet…
Keep having sex, and keep spending cash! These are the only ways forward IF the Homo sapiens are to survive. On shows like the Hitch Hikers Guide to the Galaxy and (indeed) Star Trek/ Dr. Who we see a technology driven world of the future – dominated by «metal robots» or BOTS as they are now known. IF this is the future … we are, as Jodie Foster’s drama illustrates (True Detective) we ARE ALONE. Drama indeed.
Music
Is a wonderful thing. Throughout my 30s, 40s and 50s it continued to sustain me. It still does. Let me name a few inspirations: David Bowie Maisie Peters Sting Queen Beethoven Well done one & all. RP 1st March 2024
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