Ryan Jackson
Canada
Certified Management Consultant (CMC), Entrepreneur, Mentor and Businessman
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Articles by Ryan Jackson
Publisher Correction: Targeting cancer-specific mutations with RNA-triggered chromatin shredding
Correction to: Nature https://doi.org/10.1038/s41586-026-10738-7 Published online 8 June 2026 In the version of this article initially published, in Fig. 4c, the label currently reading “TP53R280K transcript” appeared originally as “TP53R248Q transcript.” The figure is amended in the HTML and PDF versions of the article. About this article Zeng, J., Cheng, Z., Chen, H. et al. Publisher Correction: Targeting cancer-specific mutations with RNA-triggered chromatin shredding. Nature (2026).
Spatial analysis of head and neck cancer identifies two ecosystems with distinct modes of epithelial-to-mesenchymal transition
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Abstract Head and neck squamous cell carcinoma (HNSCC) shows substantial intra- and inter-tumoral heterogeneity. We mapped tumor architecture across HPV-positive and HPV-negative HNSCC through spatial transcriptomics (n = 26). HPV-positive tumors display hypercellularity, higher lymphocyte presence, enriched hypoxia and reduced partial epithelial-to-mesenchymal transition (p-EMT) in malignant cells.
By Dor Simkin, Thomas Barrett, Lingling Zhang, Michael Moore, Alissa C. Greenwald, Michael Mints, Salma Ramadan, Victoria Yu, Riley Mullins, Jesse M. Zaretsky, Douglas Adkins, Wade L. Thorstad, Sana D. Karam, Jason T. Rich, Ryan Jackson, Patrik Pipkorn, Paul Zolkind, Guangyong Peng, R. Alex Harbison, Rebecca D. Chernock, Anuraag S. Parikh, Sidharth V. Puram, Itay Tirosh, Noam Galili, Porter Bischoff, Randall C. Paniello
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Nature
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RNA-triggered Cas12a3 cleaves tRNA tails to execute bacterial immunity - Nature
Abstract In all domains of life, tRNAs mediate the transfer of genetic information from mRNAs to proteins. As their depletion suppresses translation and, consequently, viral replication, tRNAs represent long-standing and increasingly recognized targets of innate immunity1,2,3,4,5. Here we report Cas12a3 effector nucleases from type V CRISPR–Cas adaptive immune systems in bacteria that preferentially cleave tRNAs after recognition of target RNA.
What we know about the Franklin shooting involving Indianapolis police Original
This article will update. Indiana State Police are investigating a shooting involving Indianapolis officers in Franklin. Early reports indicate that Indianapolis Metropolitan Police Department SWAT officers were in Franklin to serve a warrant. In the aftermath of the shooting, IMPD Chief Chris Bailey and other top-ranking department members were on scene. Was anyone injured in the Franklin officer-involved shooting? No officers were injured in the shooting, but one person was shot.
2024 Big East Roster Tracker
Having trouble keeping track of who’s graduated, who’s taking a COVID year, and who’s going pro within Marquette’s Big East brethern…not to mention staying up to date on transfer madness? Paint Touches has you covered. We’ll be tracking the comings and goings of every team in the Holyland of Hoops with updates every few days.
How to harness the coming leaps in bank innovation
AI or not, “data readiness” is the first step to putting bank data to work. By Ryan Jackson Every journey begins with a single step, and for bankers whose 2024 goals include exploring the transformative power of artificial intelligence, that first step is developing a data strategy.
Quick Observations from 2nd Annual Blue vs. Gold Scrimmage
It’s here. The season opener may still be almost a month away but there’s no doubt that college basketball season is upon us. Current students are preparing for mid-terms, Milwaukee has developed a noticeable chill in the air, and Jon Rothstein is tweeting out obvious statements and claiming they are the product of well embedded moles instead of them just being common sense.
Cas12a2 elicits abortive infection through RNA-triggered destruction of dsDNA - Nature
Identification of the putative Cas12a2 nucleases Several Cas12a2 sequences were initially identified and tentatively classified as encoding Cas12a nucleases16. These Cas12a2 protein sequences were used as seeds for BLASTp searches of protein data in NCBI and for tBLASTn searches of metagenomic data in NCBI (https://www.ncbi.nlm.nih.gov) and JGI (https://img.jgi.doe.gov) to identify additional putative Cas12a2 nucleases.
RNA targeting unleashes indiscriminate nuclease activity of CRISPR–Cas12a2 - Nature
Abstract Cas12a2 is a CRISPR-associated nuclease that performs RNA-guided, sequence-nonspecific degradation of single-stranded RNA, single-stranded DNA and double-stranded DNA following recognition of a complementary RNA target, culminating in abortive infection1. Here we report structures of Cas12a2 in binary, ternary and quaternary complexes to reveal a complete activation pathway.
Brand New Lions - Marcellus News
Ok, I know I said earlier that I wasn’t going to write about the Lions any longer because well, I had given up on being optimistic about them. I am not a fan so I really don’t have any skin in the game but with so many Lions fans around here I can’t help but pay attention. But it seems like this team doesn’t have the same feel. It doesn’t feel like the same ole Lions. I think something is brewing over in Detroit. Last we chatted about the Lions they were 1-6 and floundering.
Quick Observations from 1st Annual Blue vs. Gold Scrimmage
Marquette Madness is dead and birthed from its ashes is a new tradition that certainly has less flair but a lot more focus on basketball. The Blue vs. Gold scrimmage was short, sweet, and to the point which might disappoint some but basketball nerds (and face it if you are reading this you are one) will appreciate the more extended preview of the men’s squad. The event was decently attended though the crowd was at least 90% alumni and their families.
Who should be in the running as Marquette’s next head coach?
(Photo by Ryan Messier/Paint Touches) It’s done. Firing a coach is never pleasant, but Marquette needed to move past the Steve Wojciechowski era. The next week or two will be two of the most critical weeks in Marquette basketball history. The brand has been damaged but not destroyed. Despite the lack of results of the Wojo era, the program never disappeared into the abysses that some other once proud programs have stumbled into.
How We Built Self-Serve
Yesterday, we announced self-serve sign up, an easy and secure way to start moving money within minutes. Easy, scalable payment operations should be available to every business. We believe the best companies, products, and innovations come when basic things such as money movement are available and affordable for all to use.
Top 55 Players in the Big East: #15-1
(Photo by Ryan Messier/Paint Touches) For the past four years, Paint Touches has been counting down the top 50 players in the Big East. It started as my personal opinion and over time it grew to the point of having representatives from each of our Big East bloggin’ brethren contribute to the rankings for a truly neutral picture of the best of the BEast. This year was supposed to be the biggest yet with the Prodigal Dawgs returning home to the Big East, pushing our top 50 into a top 55.
Top 55 Players in the Big East: #30-16
(Photo by Ryan Messier/Paint Touches) For the past four years, Paint Touches has been counting down the top 50 players in the Big East. It started as my personal opinion and over time it grew to the point of having representatives from each of our Big East bloggin’ brethren contribute to the rankings for a truly neutral picture of the best of the BEast. This year was supposed to be the biggest yet with the Prodigal Dawgs returning home to the Big East, pushing our top 50 into a top 55.
Top 55 Players in the Big East: #55-31
(Photo by Ryan Messier/Paint Touches) For the past four years, Paint Touches has been counting down the top 50 players in the Big East. It started as my personal opinion and over time it grew to the point of having representatives from each of our Big East bloggin’ brethren contribute to the rankings for a truly neutral picture of the best of the BEast. This year was supposed to be the biggest yet with the Prodigal Dawgs returning home to the Big East, pushing our top 50 into a top 55.
WAY Too Early Bracketology - Fall 2020
Normally we here at Paint Touches release our WAY too early Bracketology some time during the dog days of summer. This project started as a dorky way for me to pass the time between the National Championship and Marquette Madness. I mean what would you rather do? Spend endless hours entering data into a homemade algorithm to develop a bracket predication that maybe two dozen people and my mom will see?
A Mid-Cap Multifactor ETF With Broad Reach
John Hancock Multifactor Mid Cap ETF (JHMM) pursues the size, value, and quality factors with discipline. Its tilts toward these well-vetted investment factors are fairly tame, but effective diversification and a competitive expense ratio make it an appealing option. It earns a Morningstar Analyst Rating of Silver. This strategy tracks the John Hancock Dimensional Mid Cap Index.
Shades of Growth
Introduction Growth investors target stocks with competitive advantages and promising outlooks, believing that these firms’ strong businesses will equate to strong long-term returns. These enviable attributes are embedded in stock prices, so these firms come at a hefty cost. However, investors willing to “buy high, sell higher” have seen their investments outperform value strategies over the past decade.
A Broadly Diversified Gold Medalist
In a category filled with strong performers, Vanguard Growth ETF (VUG) has emerged as one of the best funds available. Market-cap weighting leverages the collective expertise of a well-defined market, and robust index buffer rules mitigate turnover and the associated costs. This effective strategy comes at an extremely low price, as it carries an expense ratio of just 0.04%. While the strategy itself is cheap, the stocks it holds are not.
Value in Disguise
Value investing is simple in principle: Buy cheap stocks that are underpriced by the market. How to choose a portfolio that best deploys this straightforward logic is not as clear, as there are different, and often non-obvious, ways to channel value. Invesco FTSE RAFI US 1000 ETF (PRF), which weights its holdings by fundamental measures of size, is an unconventional value strategy.
Choosing the Right SEO Keywords to Improve Your Website Rankings
By Ryan Jackson Do you know what you need to do to improve your ranking on Google search engines? For just about every business owner, the goal is to hold the number one position for SEO keywords that generate your sessions and conversions. Who doesn’t want to be top? So, you have read the top articles displaying tips and tricks about Google rankings factors without any casualty. But it becomes hard, especially if you have limited budget and resources since you are just starting your new venture.
NCAA Free Agent Tracker: March 31st Edition
It’s back and better than ever! Welcome to the NCAA Free Agent Tracker. This is Paint Touches’ sixth year of covering the NCAA basketball graduate transfer market. Every player listed here is eligible for either the Graduate Transfer Exception or the Graduate Transfer Waiver, meaning they will be immediately eligible for their new teams in the 20-21 season. This year, Paint Touches is also tracking regular transfers on a separate list. We are in weird place with the transfer market.
Metro East Open | Prep Baseball Report
Register Event Info What you Get Location History Rosters Have you already registered a player in the past?
How to keep productivity high and stress low
By Ryan Jackson, founder and CEO of Gemini Parking Solutions Many have the idea of starting a business as they are seeking more freedom, and want to earn more money while doing so on their own terms. Unfortunately for most, when setting up in business after a short period of time this dream soon fades away in to the background and a harsher reality then begins to appear. Spare time becomes a thing of the past as you sacrifice evenings and weekends in order to keep money coming in.
Endurance and success advice for entrepreneurs in tough times
Although many people believe that being an entrepreneur is a glamorous vocation, the reality is often far different from the dream. Long days, heavy workloads and immense pressure often weigh you down. These factors can cloud your view of the very reason why you set up in business in the first place. And while starting up can be a steep learning curve that requires all your time and energy – even when your business is established, there is no time to rest, or cruise along.
Moz Founder and Former CEO Rand Fishkin Shares Startup Cheat Code
Rand Fishkin is the founder of SparkToro, founder and former CEO of Moz, host of Whiteboard Friday, co-author of a pair of books on SEO, and co-founder of Inbound.org. "Lost and Founder" is his first solo book.
Congress must reject Westlands settlement as unjust to Hoopa tribe
Congress must reject Westlands settlement as unjust to Hoopa tribe The Trinity River water that had sustained the Hupa people’s fishery and 10,000 year-old economy, culture and religion now supplies industrial agriculture with irrigation and hydropower. Westlands Water District uses the lion’s share of that water. Its demand for Trinity water is insatiable. Federal law and judicial decrees strictly limit Trinity River diversions.
A Brief History of the Modern College Basketball Rebuild
(Photo by Ryan Messier/Paint Touches) Here we sit in the fourth year of the Wojo era and we seem to be no closer to answering the question “Is Wojo the right man for the job?” In fact, all you can say about the state of the Marquette fanbase is that it is firmly split into two camps, one that is running out of patience and one that is holding out hope.
JT Luper is the Leading Man
J.T. Luper, 2, raises the ball in front of the home crowd after scoring one of four touchdowns of the game on Saturday, Sept. 30, 2017. (Hayden Barzditis/The Vista) Senior wide receiver J.T. Luper is off to a record breaking start in his final year at the University of Central Oklahoma. Coming into this season, he was already considered a playmaker for the Bronchos, but he said he also wanted to be considered a leader for his team.
Broncho Soccer Gallops Past Weekend
UCO forward Samantha Mickle, 23, dribbles the ball at the Sunday, Sept. 24, 2017 soccer game against Southwest Baptist. (Provided/ UCO Photo Services). The University of Central Oklahoma soccer team added two wins to their win column over the weekend, which now makes their overall record for the season 4-4. On Friday, UCO played against Missouri Southern in a competitive game in which the Bronchos won 3-1.
UCO Tennis Ready to Make a Racket
Alli Hodges, junior UCO tennis player, returns the ball during a Spring 2017 match in Edmond, Okla. (provided/ UCO Archives). The University of Central Oklahoma tennis team begins their season this Friday as they play in the Oral Roberts Invitational tournament and will face off against ORU, Northeastern State and Tarleton State. Second year Head Coach Jaron Maestas said that the level of competition will help him see where his team is at in the beginning of the year.
Into the asylum: A postmortem of Human Head Studios' Lost Within
Chris Rhinehart was lead game designer on Lost Within. Ryan Jackson crushed countless dreams as its executive producer. We at Human Head have wanted to create a game set in an abandoned asylum for a very long time. While this setting may initially seem clichéd, the rich history of asylums and the architecture of the buildings themselves both make for a very compelling world in which to build a game.
Is The NBA As Deep As We Think It Is?
Many people argue that this is the deepest the league has ever been. And the numbers back that up. But we explore why that’s really not the case Much has been made this season about the depth of the NBA. Some argue that this is the deepest the league’s ever been, while some say that inflated statistics negate that argument. But just how deep is the league currently, all things accounted for?
Minnesota Timberwolves: 2016-17 Should Not Be Considered A Failure
Despite their slow start to the season, this year should not be considered a failure for the Minnesota Timberwolves Ignore the fact that the Minnesota Timberwolves have a bottom barrel 19-29 record. It’s irrelevant. Only the most optimistic optimists predicted playoff contention from this year’s bunch anyway. Development trumps results in Minnesota at the moment. Which is why we can call this so-called “lost season” a success. Think of it this way.
How the 76ers Can Be a Playoff Team by Next Season
The Philadelphia 76ers have been impressive so far this season, but there’s still steps to be taken before they can become a playoff contender. We explore what’s next for Philly An unforeseen series of events now have the Philadelphia 76ers at the center of the basketball world, well sort of. Having not surpassed the 20-win plateau in four seasons, they’re poised for a quick turnaround. And so far this season, that’s exactly what they’ve been doing.
The (Not So) Wild, Wild West
The NBA’s Western Conference is the worst it’s been in years. And that’s not a good thing moving forward for the NBA as a whole Oh, what a difference a few years makes in the NBA. It was only three seasons ago that the Western Conference was a model of excellence. We all pitied the Phoenix Suns, who finished 14 games over .500 and missed out on the 8th seed, and watched in awe at the heavyweight battles that would take place on a nightly basis out West. But three seasons later, it’s a new ballgame.
Boston Celtics: The Rise Of Isaiah Thomas
Boston Celtics point guard Isaiah Thomas is playing at an absurd level, something that many didn’t quite expect from him when he was selected 60th overall For the duration of his basketball career, Boston Celtics point guard Isaiah Thomas has always played with a chip on his shoulder. Like he had something to prove. And that’s because throughout his life, Thomas has had something to prove. He does have a chip on his shoulder.
New York Knicks: The Unfortunate Fall Of Carmelo Anthony
Carmelo Anthony’s time with the New York Knicks has been disappointing, to say the least. We look back at the fall of Melo Carmelo Anthony has seen this story before. He’s lived it, in fact, for the past three years. But, as the New York Knicks dropped their 9th game in 10 tries Wednesday against the lowly Philadelphia 76ers, the story’s ending began to take shape, and it wasn’t a happy one.
Milwaukee Bucks: Jabari Parker Is The NBA's Most Underrated Player
Milwaukee Bucks forward Jabari Parker is having a career year, but seems to get overlooked. And that’s why he’s the NBA’s most underrated player Throughout most of his basketball career, Jabari Parker was the center of attention. As a high-schooler, Parker was the focal point of recruitment for all of the college basketball powerhouses.
Joel Embiid's Journey To One Of The NBA's Most Dominant Big Men
Joel Embiid has taken the NBA by storm this season, but how he got here is even more impressive. We look back at his journey to the Association The year was 2009, the location Yaoundè, Cameroon. 15-year old Joel Hans Embiid picked up a basketball for the first time, totally unaware of just how far it would take him. A volleyball player for the majority of his childhood, Embiid had never considered basketball until he discovered Hakeem Olajuwon.
Patrick Mahomes is More Than an Air Raid Quarterback -
Air raid systems have scarred the masses. The air raid is largely comprised of four verticals, quick hitch and slant routes, and various screens. Every team has their own spin on the offense, but the air raid offense is typically looked down upon as the simplest–or least “pro-like”–offensive system in college football. Evaluators, myself included, have a tougher time grading quarterbacks who play in this type of system. Patrick Mahomes is not your typical air raid quarterback.
NFL Throws: Deshaun Watson Edition -
Share the post "NFL Throws: Deshaun Watson Edition" Throughout every NFL Draft cycle, the phrase “NFL throws” will be muttered by every analyst from every corner of the country. Each analyst’s description of the phrase will vary, but generally, it is a way to pinpoint a type of throw that a given prospects makes and declare that said prospect could make that same throw in the NFL. Clemson’s Deshaun Watson makes an array of passes now that he will be able to make in the pros.
NBA DraftKings 12/26/16
It’s post-Christmas time in the NBA, and I expect that with many of you needing your fantasy fix without the NFL, the NBA will be something you look at going forward. With over a quarter of the regular season over, we have learned a decent amount each team this year, so let’s take a look at the plays at each position for today’s 11 game slate… 1. LeBron/Kyrie resting- Both have been hinted at resting tonight. If one or both rest, Love becomes a must play. 2.
Blogging Dirty's NFL Week 14 Picks and Predictions
With plenty of teams still searching for their playoff spot, NFL Week 14 is upon us. Only the Dallas Cowboys have clinched a playoff spot but the New England Patriots, Kansas City Chiefs, and Oakland Raiders aren’t close behind. Teams who definitely won’t be appearing in the playoffs are the New York Jets, San Francisco 49ers, and Cleveland Browns. Either way, this week feels primed for another slate of entertaining action.
Atlanta Falcons vs. Los Angeles Rams: 3 Fantasy Football Plays
After the 29-28 loss to Kansas City, the Atlanta Falcons are out for a bounce-back win against the Los Angeles Rams. The Rams also come off a terrible loss and seek a return to form. Actually, Jeff Fisher’s squad is seeking some kind of winning form as they play out an awful season. Los Angeles recently handed the offense to Jared Goff, but the No. 1 overall pick remains 0-3 through 3 starts. The Rams do boast a strong defense that is led by defensive lineman Aaron Donald.
Falcons vs. Chiefs: Three Under-the-Radar Fantasy Football Picks
While there was some uncertainty coming back from the bye week after a loss, the Atlanta Falcons were firing on all cylinders on Sunday, beating the suffering Arizona Cardinals with a strong 38-19 outing in Week 12. It was an exciting game, with the offense coming out strong with some beautiful execution, and the defense improving as usual. The Falcons played well, and they should be able to continue that play into Week 13 when they face the Kansas City Chiefs.
Falcons vs. Cardinals: Three Under-the-Radar Fantasy Football Picks
Coming off of a Week 11 bye, the Atlanta Falcons are back and ready to go. In Week 12 they will face the Arizona Cardinals, who are trying to figure things out after a loss to the Minnesota Vikings last week. The Falcons look to come back strong after losing to the Philadelphia Eagles before their bye, looking bad on all sides of the ball. It is a good game for them to recover, as they face an opponent that appears to be stuck in a rut.
2017 Falcons NFL Draft Preview: Safety
As we continue on through the NFL’s regular season, we see which teams have issues at certain positions, and try to decide what they can do to fix them. While some may prefer established talent in free agency, the NFL draft is one of the most exciting times for team to find some new, developmental talent that can become superstars for their new teams.
2017 Falcons NFL Draft Preview: Interior Defensive Linemen
As we continue on through the NFL’s regular season, we see which teams have issues at certain positions, and try to decide what they can do to fix them. While some may prefer established talent in free agency, the NFL draft is one of the most exciting times for team to find some new, developmental talent that can become superstars for their new teams.
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