Sambad Sharma on Muck Rack

Sambad Sharma

As seen in: Nature, The Journal of Biological Chemistry
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Articles

MyD88-mediated chimaeric antigen receptor macrophages suppress brain metastasis using target-specific phagocytosis - Nature Biomedical Engineering

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By Shih-Ying Wu, Abhishek Tyagi, Kerui Wu, Eleanor Smith, Qianqian Song, Sambad Sharma, Lance Miller, Wei Zhang, Bo-Syong Pan, Hui-Kuan Lin, Jung-Shun Lee, Ashok Pullikuth, Fei Xing, Dan Zhao, Yin Liu, Jee Won Kim, Michael Soike, Jimmy Ruiz, Michael Chan, Jeff Chou, Kounosuke Watabe, Ravindra Pramod Deshpande, Alexandra Parson
| Nature Verified
Abstract Metastatic brain disease occurs in up to 30% of patients with lung, melanoma and breast cancers, and the median survival time remains less than a year. Treating these patients is a challenge because surgical approaches are limited and most chemotherapeutic drugs and immunotherapies are ineffective at crossing the blood–brain barrier (BBB).
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Publisher Correction: Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes - Nature Communications

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By Dan Zhao, Sambad Sharma, Fei Xing, Abhishek Tyagi, Ravi Singh, Martin Wabitsch
| Nature Verified
Correction to: Nature Communications https://doi.org/10.1038/s41467-022-35305-2, published online 14 December 2022 The original version of this manuscript contained a link to the Peer Review file which the authors had opted-out of for publication. This Peer Review file has now been redacted.
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Exosomal miR-1304-3p promotes breast cancer progression in African Americans by activating cancer-associated adipocytes - Nature Communications

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By Dan Zhao, Sambad Sharma, Fei Xing, Abhishek Tyagi, Ravi Singh, Martin Wabitsch
| Nature Verified
Abstract Breast cancer displays disparities in mortality between African Americans and Caucasian Americans. However, the exact molecular mechanisms remain elusive. Here, we identify miR-1304-3p as the most upregulated microRNA in African American patients. Importantly, its expression significantly correlates with poor progression-free survival in African American patients. Ectopic expression of miR-1304 promotes tumor progression in vivo.
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