Shunnan Ge

Keywords cerebral edema microglial heterogeneity C5aR1+ microglia neurotoxic astrocytes neutrophils recruitment Get full text access Log in, subscribe or purchase for full access. References 1. Jiang, J.Y. ∙ Gao, G.Y. ∙ Feng, J.F. ... Traumatic brain injury in China Lancet Neurol. 2019; 18:286-295 2. Urday, S. ∙ Kimberly, W.T. ∙ Beslow, L.A. ... Targeting secondary injury in intracerebral haemorrhage--perihaematomal oedema Nat. Rev. Neurol. 2015; 11:111-122 3. McCrea, M.A. ∙ Giacino, J.T. ∙ Barber, J. ...

Abstract Although astrocytes undergo functional changes in response to brain injury and may be the driving force of subsequent neuronal death, the underlying mechanisms remain incompletely elucidated. Here, we showed that extracellular vesicle (EV)-shuttled miRNA-382-5p may serve as a biomarker for the severity of traumatic brain injury (TBI), as the circulating EV-miRNA-382-5p level was significantly increased in both human patients and TBI model mice.

Abstract Persistent neuroinflammation and progressive neuronal loss are defining features of acute brain injury including traumatic brain injury (TBI) and cerebral stroke. Microglia, the most abundant type of brain-resident immune cells, continuously surveil the environment and play a central role in shaping the inflammatory state of the central nervous system (CNS).