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Articles by Simon Clare
Intestinal infections establish antigen-specific, long-lived memory CD4 + T cells in the brain and meninges
Abstract The meninges form the border between the brain and periphery and house a rich network of immune cells. Here we show that gastrointestinal challenges (intracellular or extracellular bacteria and parasites) reshape the nature of CD4+ T cells in the dura mater, the outer meningeal layer, changing the dominant polarization states to T helper (TH) 1, TH17 and TH2 cells, respectively, with differing cytokine profiles.
A disease model resource reveals core principles of tissue-specific cancer evolution
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Abstract Oncogenes such as KRAS display marked tissue specificity in their oncogenic potential, genetic interactions and phenotypic effects, but the underlying determinants remain largely unresolved1,2,3,4,5. Here, to address these questions, we developed the Mouse Cancer Cell line Atlas, a broad-utility resource of 590 comprehensively characterized models across a wide range of entities (www.mcca.tum.de).
By Sebastian P. Mueller, Markus Tschurtschenthaler, Miguel Silva, Riccardo Trozzo, Thorsten Kaltenbacher, Magdalena Zukowska, Daniele Lucarelli, Rupert Öllinger, Nina Lucia Groß, Tanja Groll, Jeroen M. Bugter, Stefanie Barthel, Chiara Falcomatà, Alexander Strong, Aristeidis Papargyriou, Roman Maresch, David Sailer, Christian Schneeweis, Lisa Frohlich, Christine Klement, Juan Montero Verified, Ute Jungwirth, Maximilian Reichert, Markus Moser, Jens Neumann, George S. Vassiliou, Juan Enrique Cadiñanos, Ignacio Varela Verified, Carsten Marr, Daniel F. Alonso, Pier-Luigi Lollini, Jean J. Zhao, Louis Chesler, Clare M. Isacke, Angela Riedel, Christian J. Braun, Martin L. Sos, Filippo Beleggia, Hans Reinhardt, Monica Musteanu, Mariano Barbacid, Michael Quante, Marc Schmidt-Supprian, Günter Schneider, Simon Clare, Trevor D. Lawley, Gordon Dougan, Katja Steiger, Nathalie Conte, Allan Bradley, Dieter Saur, Roland Rad, Niklas de Andrade Krätzig, Chiara Thordsen, Perrine Simon, Frederic Saab, Joscha Griger, Jessica Löprich, Antonio E. Zaurito, Linus R. Schömig, Cordelia Brandt, Mulham Najajreh, Katharina A. N. Collins, Sebastian Burger, Alexander Belka, Lena Rad
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Nature
Verified
Avian-origin influenza A viruses tolerate elevated pyrexic temperatures in mammals
Editor’s summary Birds operate at body temperatures several degrees higher than those of mammals, and, like mammals, birds are infected by influenza viruses. Influenza viruses can move between animal hosts, often reassorting their gene segments as they transition. Knowing that the body temperature of humans often elevates when sick, Turnbull et al. investigated whether virus gene segments originating from hot-blooded birds may give the virus an advantage in feverish mammals.
WATCH: Princess Yachts Launches First Fully Immersive 3D Configurator at 2025 Cannes Yachting Festival
The tool made its debut at the 2025 Cannes Yachting Festival and will also be shown at the 2025 Monaco Yacht Show before being introduced at the Plymouth shipyard and through its global distributor network. A Step Beyond Traditional Commissioning Commissioning a yacht has traditionally relied on lengthy conversations, 2D drawings, and a heavy dose of client imagination.
Supporting safe urinary catheter insertion by promoting ANTT® principles
History Received 1 April 2025 Accepted 1 May 2025 Published online 20 June 2025 Published in print 19 June 2025
Enterocloster clostridioformis induces host intestinal epithelial responses that protect against Salmonella infection
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A drug repurposing screen for whipworms informed by comparative genomics
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Author Correction: Establishment, optimisation and quantitation of a bioluminescent murine infection model of visceral leishmaniasis for systematic vaccine screening
Author Correction: Establishment, optimisation and quantitation of a bioluminescent murine infection model of visceral leishmaniasis for systematic vaccine screening Correction to: Scientific Reports https://doi.org/10.1038/s41598-020-61662-3, published online 13 March 2020 The original version of this Article contained a typographical error in the spelling of the author Mary Edythe Wilson, which was incorrectly given as Mary Elizabeth Wilson.
SLAMF9 is found on select subsets of antigen‐presenting cells and promotes resistance to Salmonella infection
ORIGINAL ARTICLE Timothy J. Wilson Corresponding Author E-mail address: tim.wilson@miamioh.edu Department of Microbiology, Miami University, Oxford, OH, 45056 USA Cambridge Institute for Medical Research, Department of Medicine, University of Cambridge, Cambridge, CB2 0QQ UK Correspondence E-mail address: tim.wilson@miamioh.edu Search for more papers by this author Paul A.
Why artificial intelligence won’t replace advisers anytime soon
The robots are coming and they are after our jobs, so we’ve been told. Huge advances in artificial intelligence mean machines are now capable of doing many of the tasks once carried out by humans. That’s good news for employers, who will benefit from greater efficiencies, but it could potentially mean bad news for less skilled workers. By the mid-2030s as many as one in three jobs – both skilled and unskilled roles – could be lost to automation, according to consultancy PwC.
Episode 39: April 3, 2019 - ANTT- an International Standard for Safe Aseptic Technique, Part 3
Discuss the increase in health literacy and patient involvement related to ANTT®, an International Standard for Safe Aseptic Technique with Stephen Rowley and Simon Clare. Stephen Rowley, MSc, BSc (Hons), RN, RSCN Association for Aseptic Technique (ANTT) Stephen Rowley, MSc, BSc (Hons), RN, RSCN, is clinical director for the Association for Safe Aseptic Practice (ASAP) and the originator of the ANTT Clinical Practice Framework.
Epsiode 38: March 20, 2019 - ANTT- an International Standard for Safe Aseptic Technique, Part 2
Learn about the global impact of standardizing clinical practice in a discussion with Stephen Rowley and Simon Clare. Stephen Rowley, MSc, BSc (Hons), RN, RSCN Association for Aseptic Technique (ANTT) Stephen Rowley, MSc, BSc (Hons), RN, RSCN, is clinical director for the Association for Safe Aseptic Practice (ASAP) and the originator of the ANTT Clinical Practice Framework. Mr. Rowley leads the ASAP, a not-for-profit, nongovernmental organization with a global purview.
ANTT- an International Standard for Safe Aseptic Technique Part 1
ANTT- an International Standard for Safe Aseptic Technique Part 1 Noticing variability in clinical aseptic technique practices? Learn about standardizing clinical practice in a discussion with Stephen Rowley and Simon Clare. Stephen Rowley, MSc, BSc (Hons), RN, RSCN Association for Aseptic Technique (ANTT) Stephen Rowley, MSc, BSc (Hons), RN, RSCN, is clinical director for the Association for Safe Aseptic Practice (ASAP) and the originator of the ANTT Clinical Practice Framework.
New Variant of Multidrug-Resistant Salmonella enterica Serovar Typhimurium Associated with Invasive Disease in Immunocompromised Patients in Vietnam
ABSTRACTNontyphoidal Salmonella (NTS), particularly Salmonella enterica serovar Typhimurium, is among the leading etiologic agents of bacterial enterocolitis globally and a well-characterized cause of invasive disease (iNTS) in sub-Saharan Africa. In contrast, S. Typhimurium is poorly defined in Southeast Asia, a known hot spot for zoonotic disease with a recently described burden of iNTS disease.
Pulmonary metastatic colonisation and granulomas in NOX2‐deficient mice
Metastasis is the leading cause of death in cancer patients and successful colonisation of a secondary organ by circulating tumour cells (CTCs) is the rate‐limiting step of this process. We used tail‐vein injection of B16‐F10 melanoma cells into mice to mimic the presence of CTCs and allow for assessment of host (microenvironmental) factors that regulate pulmonary metastatic colonisation.
Correction: NK Cells Influence Both Innate and Adaptive Immune Responses after Mucosal Immunization with Antigen and Mucosal Adjuvant
Correction: NK Cells Influence Both Innate and Adaptive Immune Responses after Mucosal Immunization with Antigen and Mucosal Adjuvant Lindsay J. Hall, Simon Clare, Gordon Dougan The Journal of Immunology July 1, 2018, 201 (1) 306; DOI: 10.4049/jimmunol.1800632
Correction: NK Cells Influence Both Innate and Adaptive Immune Responses after Mucosal Immunization with Antigen and Mucosal Adjuvant
Correction: NK Cells Influence Both Innate and Adaptive Immune Responses after Mucosal Immunization with Antigen and Mucosal Adjuvant Lindsay J. Hall, Simon Clare, Gordon Dougan The Journal of Immunology May 16, 2018, ji1800632; DOI: 10.4049/jimmunol.1800632
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