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Stefanie Barthel

As seen in: Nature, Cell Reports Medicine, Cancer Discovery
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Articles

A disease model resource reveals core principles of tissue-specific cancer evolution

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By Sebastian P. Mueller, Markus Tschurtschenthaler, Miguel Silva, Riccardo Trozzo, Thorsten Kaltenbacher, Magdalena Zukowska, Daniele Lucarelli, Rupert Öllinger, Nina Lucia Groß, Tanja Groll, Jeroen M. Bugter, Stefanie Barthel, Chiara Falcomatà, Alexander Strong, Aristeidis Papargyriou, Roman Maresch, David Sailer, Christian Schneeweis, Lisa Frohlich, Christine Klement, Juan Montero Verified, Ute Jungwirth, Maximilian Reichert, Markus Moser, Jens Neumann, George S. Vassiliou, Juan Enrique Cadiñanos, Ignacio Varela Verified, Carsten Marr, Daniel F. Alonso, Pier-Luigi Lollini, Jean J. Zhao, Louis Chesler, Clare M. Isacke, Angela Riedel, Christian J. Braun, Martin L. Sos, Filippo Beleggia, Hans Reinhardt, Monica Musteanu, Mariano Barbacid, Michael Quante, Marc Schmidt-Supprian, Günter Schneider, Simon Clare, Trevor D. Lawley, Gordon Dougan, Katja Steiger, Nathalie Conte, Allan Bradley, Dieter Saur, Roland Rad, Niklas de Andrade Krätzig, Chiara Thordsen, Perrine Simon, Frederic Saab, Joscha Griger, Jessica Löprich, Antonio E. Zaurito, Linus R. Schömig, Cordelia Brandt, Mulham Najajreh, Katharina A. N. Collins, Sebastian Burger, Alexander Belka, Lena Rad
| Nature Verified
Abstract Oncogenes such as KRAS display marked tissue specificity in their oncogenic potential, genetic interactions and phenotypic effects, but the underlying determinants remain largely unresolved1,2,3,4,5. Here, to address these questions, we developed the Mouse Cancer Cell line Atlas, a broad-utility resource of 590 comprehensively characterized models across a wide range of entities (www.mcca.tum.de).
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Multimodal profiling of pancreatic cancer reveals a TIMP-1-dominated secretory profile determining pro-tumor immunoinstruction in human cancers

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By Julian Frädrich, Carmen Reyes, Vanessa Brunner, Batu Toledo, Damjan Manevski, Alexander Sommer, Daniel Häußler, Dominik Beck, Lennard Halle, Raphael Kfuri-Rubens, Kaan Çifcibaşı, Anna Hirschberger, Rupert Öllinger, Percy A. Knolle, Katja Steiger, Roland Rad, Fabian J. Theis, Francisco X. Real, Stefanie Barthel, Jan P. Böttcher, Dieter Saur, Ihsan Ekin Demir, Achim Krüger, Michel Hendel, Daniele Lucarelli
| Cell Reports Medicine Verified
Keywords pancreatic cancer epithelial heterogeneity cancer heterogeneity pan-cancer cancer immunosuppression natural killer cells TIMP-1 Introduction In cancer, an immunosuppressive tumor microenvironment (TME) is central to malignant progression.1,2,3 Cancer cells can profoundly reprogram tumor-infiltrating immune cells, such as cytotoxic CD8+ T cells and natural killer (NK) cells, enabling evasion of tumor immune control,4 a well-known hallmark of cancer.5 Immunosuppression within the TME...
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Heterogeneity-driven phenotypic plasticity and treatment response in branched-organoid models of pancreatic ductal adenocarcinoma - Nature Biomedical Engineering

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By Stefanie Barthel, Hendrik A. Messal, Till Richter, Thomas Metzler, Sebastian Lange, Maximilian Schuster, Sebastian P. Mueller, Arlett Schäfer, Andreas Bausch, Günter Schneider, Katja Steiger, Georgios Kaissis, Jacco van Rheenen, Fabian J. Theis, Dieter Saur, Roland Rad, Aristeidis Papargyriou
| Nature Verified
Abstract In patients with pancreatic ductal adenocarcinoma (PDAC), intratumoural and intertumoural heterogeneity increases chemoresistance and mortality rates. However, such morphological and phenotypic diversities are not typically captured by organoid models of PDAC.
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