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Articles by Simon Draper
Addition of blood-stage antibody enhances anti-sporozoite antibody protection in a humanized mouse model of Plasmodium falciparum infection
Keywords Plasmodium falciparum monoclonal antibodies circumsporozoite protein CSP RH5 317 Research topic(s) CP: immunology CP: microbiology Introduction Malaria is a vector-borne disease caused by Plasmodium parasites that are transmitted by female Anopheles mosquitoes. As of 2023, malaria remains endemic in 80 countries, resulting in approximately 610,000 annual deaths.1 Most infections are caused by two parasite species, P. falciparum (Pf) and P. vivax (Pv).
Analysis of monoclonal antibodies against the malaria invasion complex protein RIPR reveals the structural basis for synergistic antibody protection
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Keywords malaria monoclonal antibodies RIPR vaccines Plasmodium falciparum mAb blood stage Introduction Malaria disease, caused by the parasite Plasmodium falciparum, is a global health problem with an estimated 282 million cases in 2024.1 The WHO currently recommends two malaria vaccines, RTS/S/AS01 and R21/Matrix-M2; however, both vaccines target the same pre-erythrocytic sporozoite stage of the parasite life cycle.
By Barnabas G Williams, Jordan R. Barrett, Josefin Bartholdson Scott, Cassandra A Rigby, Matteo Cagiada, Doris Quinkert, Kirsty McHugh, Anna Huhn, Sean A. Burnap, Camille Gourjault, Francesca Byrne, Ana Rodrigues, Laura Bergamaschi, Simon Watson, Noah W. Miller, Lloyd D.W. King, Francesca R Donnellan, Camilla A. Gladstone, Sarah Silk, Jo Salkeld, Angela M Minassian, Katherine Skinner, Weston Struwe, Charlotte M. Deane, Stephen T. Reece, Andrew Ward, Simon Draper, Beatrice Balzarotti, Jemima Paterson, Stefania Scalabrino
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Cell Press
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Wimbledons Tennisgötter
Die Amerikanerin Billie Jean King setzte sich in den 70er-Jahren für Gleichberechtigung im Tennissport ein. Arthur Ashe kämpfte für Rassengleichheit auf und neben dem Platz.
Development of clinical immunity to Plasmodium vivax following repeat controlled human malaria infection - Nature Communications
Abstract Clinical immunity to malaria can lead to asymptomatic infection, but the underlying mechanisms remain unclear. To examine the development of clinical immunity, we conducted a multi-cohort, repeat controlled human malaria infection (CHMI) study with Plasmodium vivax, and a heterologous rechallenge with P. falciparum (ClinicalTrials.gov NCT03797989). Malaria-naïve adults underwent CHMI up to three times, by administration of red blood cells infected with P. vivax PvW1 clone or P.
Vaccine-induced human monoclonal antibodies to PfRH5 show broadly neutralizing activity against P. falciparum clinical isolates - npj Vaccines
Abstract Vaccines to the Plasmodium falciparum reticulocyte binding-like protein homologue 5 (PfRH5) target the blood-stage of the parasite life cycle. PfRH5 has the potential to trigger the production of strain-transcendent antibodies and has proven its efficacy both in pre-clinical and early clinical studies. Vaccine-induced monoclonal antibodies (mAbs) to PfRH5 showed promising outcomes against cultured P. falciparum laboratory strains from distinct geographic areas.
PvDBPII elicits multiple antibody-mediated mechanisms that reduce growth in a Plasmodium vivax challenge trial - npj Vaccines
Abstract The receptor-binding domain, region II, of the Plasmodium vivax Duffy binding protein (PvDBPII) binds the Duffy antigen on the reticulocyte surface to mediate invasion. A heterologous vaccine challenge trial recently showed that a delayed dosing regimen with recombinant PvDBPII SalI variant formulated with adjuvant Matrix-MTM reduced the in vivo parasite multiplication rate (PMR) in immunized volunteers challenged with the Thai P. vivax isolate PvW1.
The PfRCR complex bridges malaria parasite and erythrocyte during invasion - Nature
Abstract The symptoms of malaria occur during the blood stage of infection, when parasites invade and replicate within human erythrocytes. The PfPCRCR complex1, containing PfRH5 (refs. 2,3), PfCyRPA, PfRIPR, PfCSS and PfPTRAMP, is essential for erythrocyte invasion by the deadliest human malaria parasite, Plasmodium falciparum. Invasion can be prevented by antibodies3,4,5,6 or nanobodies1 against each of these conserved proteins, making them the leading blood-stage malaria vaccine candidates.
Respiratory mucosal immune memory to SARS-CoV-2 after infection and vaccination - Nature Communications
Abstract Respiratory mucosal immunity induced by vaccination is vital for protection from coronavirus infection in animal models. In humans, the capacity of peripheral vaccination to generate sustained immunity in the lung mucosa, and how this is influenced by prior SARS-CoV-2 infection, is unknown.
Why New Zealand needs to increase its engagement with Asia
Simon Draper was the executive director of the Asia New Zealand Foundation Te Whītau Tūhono. OPINION: By the time this article is published I would have finished the best job I’ve ever had and be off on some new adventure, I hope. I came to the Asia New Zealand Foundation because when running New Zealand’s United Nations Security Council campaign, I was intrigued that most of New Zealand’s quality UN support came from Asia.
Why New Zealand needs to increase its engagement with Asia
Simon Draper was the executive director of the Asia New Zealand Foundation Te Whītau Tūhono. OPINION: By the time this article is published I would have finished the best job I’ve ever had and be off on some new adventure, I hope. I came to the Asia New Zealand Foundation because when running New Zealand’s United Nations Security Council campaign, I was intrigued that most of New Zealand’s quality UN support came from Asia.
3 ways to improve your small business cashflow
Cashflow. You can’t have a conversation about financial constraints in any small business without mentioning it. In fact, you can’t have a conversation about business without mentioning cashflow. The latest research indicates that 93 per cent of businesses say cashflow is one of their top three priorities and the issues surrounding it don’t start and end with simply not having money available. There are several knock-on effects that stunt small business growth.
Malaria Vaccines: Recent Advances and New Horizons
Data sources for this figure included the WHO Malaria Vaccine Rainbow Table and Clinicaltrials.gov . Vaccines for P. vivax are colored blue. The life cycle figure was adapted from Modern malaria vaccine development began with seminal studies in mice using irradiated sporozoites ().
Would flexible access to salaries help financial wellbeing?
Could giving employees access to their salaries as they earn, rather than making them wait until pay day, be the answer to reducing financial stress? Simon Draper of Hastee Pay explains how instant access to their pay could benefit both employers and employees.
A new site of attack for a malaria vaccine
A newly discovered antibody epitope on the liver-infective form of the parasite that causes malaria opens new doors for vaccine development.
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