Su Wu
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Articles by Su Wu
Thin-film lithium niobate waveguide-integrated p-i-n Tungsten selenide photodiodes with 10Gbit/s data reception
Abstract Thin-film lithium niobate (TFLN) is a promising photonic platform in next-generation integrated optoelectronics and on-chip/chip-chip interconnection due to its attractive optical property and versatility. However, integration of conventional-material-based photodetectors on TFLN platforms still faces multiple challenges. Herein, a high-bandwidth TFLN-based waveguide-integrated lateral WSe2 p-i-n photodetector is presented.
Optical design and field validation of a fiber spectrometer for solar-induced chlorophyll fluorescence observation
In this study, we designed a fiber spectrometer to address the need for long-term, high-precision, and low-cost field observations of solar-induced chlorophyll fluorescence (SIF). Optical simulations showed that the geometric encircled energy exceeded 99.92%. The full-spectrum modulation transfer function of the optical system exceeded 0.67 at 40 lp/mm, achieving a spectral full width at half-maximum below 0.3 nm across the operating band.
Curator Su Wu on Mesoamerican Modern
"When I began this project, I thought that we would be documenting a history, like the aura surrounding the artifacts in a museum," says Su Wu, author of Mesoamerican Modern: Ancient Ideas in Contemporary Mexican Homes. "Instead, what I found was the vibrant, living presence of Indigenous ideas in Mexico, in gestures that are at once traditional and radical, of the past in the future, and what is possible in a home." Casa Möbius, San Jerónimo, Mexico City.
How a Los Angeles local created a Monocle guide to a city with no centre
For a place that’s all about image, Los Angeles is surprisingly difficult to capture. The sprawling city comprises a patchwork of cultures and communities, and most visitors from major metropolises such as London, Tokyo and Paris spend their first day here trying to locate the centre before realising there isn’t one. But trying to make sense of it all – its complexities, hidden pockets and nuances – is what makes the place so compelling.
Research progress of short stature and advanced bone age, early-onset osteoarthritis and osteochondritis dissecans (SSOAOD) caused by acan gene mutation
Abstract Introduction: Heterozygous mutations in the ACAN gene are a key genetic cause of non-syndromic familial short stature. The associated disease spectrum includes short stature, advanced bone age, early-onset osteoarthritis, and osteochondritis dissecans (SSOAOD).
Low-cost chip-scale spectrometer enabled by equal-thickness interference spectral encoding
We present a low-cost, chip-scale spectrometer based on the principle of equal-thickness interference for spectral encoding. The design features a particularly simple structure, consisting of a plano-convex lens and a flat glass plate, both coated with silver on one side, while a charge-coupled device (CCD) captures the interferograms. The active chip is a square with a side length of 8.6 mm, and the overall spectrometer form factor is 7 cm.
High-flux, high-resolution compact Offner imaging spectrometer for hyperspectral applications
A high-flux, high-resolution Offner imaging spectrometer with a compact configuration is proposed and demonstrated. By introducing a custom-designed lens group between the entrance slit and the primary concave mirror, the effective slit is optically transformed into a virtual slit with extended divergence and path length.
MAISON CEO Chen Kan Unveils New Concept of Spatial Value Original
SHANGHAI--(BUSINESS WIRE)--MAISON Co-founder and CEO Chen Kan recently put forward this core viewpoint when sharing his concept of spatial value: "Top-tier residences in the future should be 'inhabitable collectibles'." In his opinion, the value of high-end residences has long gone beyond the location itself – the current demand of global elites for residences is shifting from the basic "functional satisfaction" to in-depth "spiritual resonance".
Harnessing AI to Combat DNS Abuse: Towards a Safer Digital World
Artificial intelligence (AI), once confined to the realm of science fiction, is increasingly becoming an integral component of our interconnected lives. As highlighted during iQ’s presentation at the DNS Abuse Workshop at Nordic Domain Days in April 2025, AI has the potential to revolutionize online safety, particularly in combating DNS Abuse. This article explores how AI can improve the handling of abuse reports, streamline processing, and transition from reactive to proactive measures.
Mechanistic Insights into the Plasmodium Phosphatase UIS2 in eIF2α Dephosphorylation via Integrated Structure-Based Modeling
Abstract The development of novel antimalarial drugs requires the identification of parasite-specific vulnerabilities. Translation control, regulated by eIF2α dephosphorylation, is essential for Plasmodium development during infection. The parasite phosphatase UIS2 regulates this modification. However, the structural basis for UIS2 substrate recognition remains unknown. Here, we show that UIS2 is crucial for parasite development in both liver and blood stages.
Coordinated Role of Autophagy and ERAD in Maintaining Neuroendocrine Function by Preventing Prohormone Aggregation
1 Introduction Accumulation of protein aggregates is one of the leading factors in neurodegeneration, raiding the brain and killing neurons.[1] Protein quality control (QC) systems are responsible for monitoring and triaging newly synthesized proteins to ensure proper folding, functioning, or timely degradation to prevent protein misfolding or aggregation.[2] As large amounts of newly synthesized proteins are misfolding-prone,[3] the protein QC process must function as housekeeping mechanism...
Author Correction: The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb - Cell Research
Correction to: Cell Research https://doi.org/10.1038/s41422-024-00938-z, published online 06 March 2024 It has come to our attention that in our paper published in Cell Research in 2024, the picture of Supplementary information, Fig. S8i (vector group, 0 h) was mistakenly reused from that of Supplementary information, Fig. S8d (shNC group, 0 h).
Direction-Finding Study of a 1.7 mm Diameter Towed Hydrophone Array Based on UWFBG
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Structural and mechanistic insights into Plasmodium eIF2alpha dephosphorylation by UIS2 during the erythrocytic stage
Abstract UIS2 is a promising therapeutic target for malaria due to its essential role in the transmission and infectivity of Plasmodium to the host hepatocytes. In Plasmodium, UIS2 acts as a phosphatase toward phosphorylated eIF2alpha at Ser59, regulating translation initiation. However, its role during the erythrocytic stage, which causes clinical symptoms, remains unclear, and its protein structure for elucidating the dephosphorylation mechanism is unavailable.
Determinants of taxonomic, functional, and phylogenetic beta diversity in breeding birds within urban remnant woodlots: Implications for conservation
1 INTRODUCTION Habitat fragmentation is the process where large, continuous habitats are divided into many smaller, isolated patches of varying sizes, often caused by natural changes or human activities such as urban construction and agricultural development (Fahrig, 2003).
Suitability and Trueness of the Removable Partial Denture Framework Fabricating by Polyether Ether Ketone with CAD-CAM Technology
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Diversity Analysis of Intestinal Bifidobacteria in the Hohhot Population
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
The rapid proximity labeling system PhastID identifies ATP6AP1 as an unconventional GEF for Rheb - Cell Research
Abstract Rheb is a small G protein that functions as the direct activator of the mechanistic target of rapamycin complex 1 (mTORC1) to coordinate signaling cascades in response to nutrients and growth factors. Despite extensive studies, the guanine nucleotide exchange factor (GEF) that directly activates Rheb remains unclear, at least in part due to the dynamic and transient nature of protein–protein interactions (PPIs) that are the hallmarks of signal transduction.
COMAC C919 & ARJ21 Land In Hong Kong For 1st Time
China's domestically developed aircraft, C919 and ARJ21, made their first visit to Hong Kong. The C919 aircraft is scheduled to perform a flight demonstration over Victoria Harbour on December 16th. Some commentators believe that the airworthiness standards of C919 are stringent, and the overall level of the aircraft can compete with products from Boeing and Airbus.
Gifts for Design Lovers: Charles & Ray Eames, Alexander Girard & More
There is no wrong season for good design, but the holidays give us a chance to show it off. From iconic designers Charles and Ray Eames, Alexander Girard, and Joe Colombo come their legendary creations; from Ige Design and Onora, there are modern takes on historic designs. The Eameses felt all of design was a gift, a message of hope.
China Is Working On An Upgrade To Its Y-20 Military Tanker
BY SU WU PUBLISHED Dec. 2 2023 China is transitioning the engine of its primary transport aircraft, the Y-20, from Russian-made to domestically produced. China is testing an updated variant of the Y-20U tanker with new high-bypass engines to enhance air-to-air refueling capabilities. The Y-20B, equipped with the China-produced WS-20 engine, has a maximum cargo capacity of 66 tons and lower operational costs.
China's Big 3 Airlines Post First Half Losses
China's three major central-government-owned airlines reported losses in the first half of 2023, but the losses have significantly narrowed compared to last year. Air China saw the most successful loss reduction, followed by China Southern Airlines. China Eastern Airlines experienced the heaviest losses among the three.
Russia Pulls Out Of The CR929 Widebody Program
The United Aircraft Corporation (UAC) has shifted from being a joint-venture partner to a key supplier in the CRAIC CR929 program, as stated by UAC CEO Yury Slyusar. Global technology pioneers collaborating with UAC and China have terminated their involvement due to sanctions imposed on Russia after the invasion of Ukraine.
The link between obesity and insulin resistance among children: Effects of key metabolites
1 INTRODUCTION Childhood obesity is one of the largest public health problems around the world. The World Health Organization reported that the number of obese children in the world had increased more than 10-fold in the last 40 years.1 Recently, China has become one of the countries that developed the fastest rising rate of childhood obesity.
Dubai Aerospace Enterprise Buys 64 Boeing 737 MAX Orders From A Chinese Lessor
Dubai Aerospace Enterprise (DAE) has procured 64 Boeing 737 MAX aircraft from China Aircraft Leasing Group. Deliveries are set to take place between 2023 and 2026. Various types of 737 MAX are included in the deal. This significant development was made public on August 14th, 2023. DAE revealed that one of its affiliated entities had finalized a binding arrangement to secure the rights, stakes, and responsibilities associated with a selection of 64 Boeing 737 MAX airplanes.
Computational inference of eIF4F complex function and structure in human cancers
Abstract The canonical eukaryotic initiation factor 4F (eIF4F) complex, composed of eIF4G1, eIF4A1, and the cap-binding protein eIF4E, plays a crucial role in cap-dependent translation initiation in eukaryotic cells (1). However, cap-independent initiation can occur through internal ribosomal entry sites (IRESs), involving only eIF4G1 and eIF4A1 present, which is considered to be a complementary process to cap-dependent initiation in tumors under stress conditions (2).
Antidiabetic activity of eupafolin through peroxisome proliferator‐activated receptor‐gamma and PI3K/Akt signaling in Type 2 diabetic rats
CONFLICT OF INTEREST STATEMENT The authors declare no conflict of interest. REFERENCES 1, Cell 1999, 97, 9. 2, , , Nutr. Metab. (Lond). 2005, 2, 5. 3, , , J. Transl. Med. 2015, 13, 62. https://doi.org/10.1186/s12967-015-0412-5 4, , , , , , , , BMC Complement. Altern. Med. 2014, 14, 198. https://doi.org/10.1186/1472-6882-14-198 5, , , , PLoS One 2012, 7(2), e31219. https://doi.org/10.1371/journal.pone.0031219 6, , , , , , , , , , Biochem. Biophys. Res. Commun. 1993, 195(2), 762.
Molecular subtypes of endometrial cancer: Implications for adjuvant treatment strategies
POLE The high mutational burden of “hypermutated” MMRd and “ultramutated” POLE mut endometrial cancers has several new antigens, including CD3-positive, CD8-positive and TILs, which induce PD-L1 expression on tumor cells, leading to more malignant features but a better prognosis.117 As a result, these tumors are highly immunogenic and infiltrated with TILs, leading to an upregulated T cell-mediated antitumor response.118 A study of 60 POLE mut tumors has shown that extreme TMB in POLE mut...
Air China Eyes Multiple International Route Resumptions From Chengdu
SU WU Courtesy Simple Flying As the summer travel peak approaches, Air China and other Chengdu-based airlines are increasing domestic and international flights to seize the market According to Air China, its Southwest Branch, which is based in Chengdu, a hub city in Southwestern China, will launch, resume, and put extra flights from Chengdu to multiple international destinations this July to cope with the upcoming summer travel peak.
Here's Who's Flying It Now
American air carrier United Airlines (NASDAQ:UAL) is strategizing ways to avoid the cancellations and delays in air travel witnessed last week at the Newark hub, especially for the 4th of July. As per a Wall Street Journal report, CEO Scott Kirby wrote to employees on July 1 that UAL is working with the respective authorities at the New York and New Jersey airports to open more gates for carriers to avoid long waiting hours on the taxiways as well as cancellations.
Intrusion Monitoring Based on High Dimensional Random Matrix by Using Ultra-Weak Fiber Bragg Grating Array
Open AccessCommunication by Hongcan Gu 1, Junbing Huang 1, Su Wu 2, Ciming Zhou 3, Zhiqiang Zhang 1, Cong Liu 4 and Yandong Pang 1,* 1 College of Weaponry Engineering, Naval University of Engineering, Wuhan 430000, China 2 College of Electronic Engineering, Naval University of Engineering, Wuhan 430000, China 3 National Engineering Laboratory for Fiber Optic Sensor Technology, Wuhan University of Technology, Wuhan 430070, China 4 College of Naval Architecture and Ocean Engineering, Naval...
China Will Open Its Westernmost Airport, Tashkurgan Khunjerab Airport At the Pamir Plateau On Friday
China Will Open Its Westernmost Airport, Tashkurgan Khunjerab Airport At the Pamir Plateau On Friday BY SU WU December 22 2022 Xinjiang welcomes its 25th airport into operation, making Xinjiang still rated No.1 among provinces regarding the number of airports within China.
The Mediator captures CDK7, an attractive transcriptional target in cancer
Cyclin-dependent kinase 7 (CDK7) is implicated in regulating the expression of cancer-dependent genes, and multiple CDK7-targeted therapies are currently under clinical investigation. Three recent studies elucidate the structure of human transcription machinery, offering vital mechanistic insights into CDK7 function and a potential pharmacodynamic marker of CDK7 activity in tumors.
A flow-injection system exploiting focused beam reflectance applied to the determination of high concentrations of sulfate
A flow-injection system exploiting focused beam reflectance applied to the determination of high concentrations of sulfate To evaluate the grain size and particle number formed in a non-equilibrium flow mixing state, flow-injection analysis (FIA) was combined with focused beam reflectance measurement (FBRM). The influence of BaCl2, PEG-4000, ethanol, flowrate, temperature and acidity on the dynamic formation of BaSO4 particles was evaluated.
A MicroRNA Linking Human Positive Selection and Metabolic Disorders
Highlights • The long haplotype at 2q21.3 is linked to positive selection and metabolic disorders • The miR-128-1 microRNA is located at the center of the 2q21.3 locus • miR-128-1 controls energy expenditure and contributes to metabolic disease • Ancient adaptation to famine and metabolic diseases may be linked through miR-128-1 Summary Positive selection in Europeans at the 2q21.3 locus harboring the lactase gene has been attributed to selection for the ability of adults to digest milk to...
Adaptive niche-genetic algorithm based on backpropagation neural network for atmospheric turbulence forecasting
Abstract Because systematic direct measurements of the refractive index structure constant ($C_n^2$) are not available for many climates and seasons, we developed an indirect method to forecast optical turbulence. The $C_n^2$ was estimated from a backpropagation neural network optimized by an adaptive niche-genetic algorithm. The estimated result was validated against the corresponding six-day $C_n^2$ data from a field campaign of the 30th Chinese National Antarctic Research Expedition.
Broadband astigmatism-free Offner imaging spectrometer with high resolution
Abstract An advanced optical design has been proposed for an astigmatism-free Offner imaging spectrometer with high resolution in the broadband spectrum. The anastigmatic theory is thoroughly analyzed. Astigmatism is corrected by two pairs of lens-mirror combinations. On the basis of the concentric structure, the lens is used to make the meridional image distance equal to sagittal image distance.
The Glass-Walled LA Loft of New Fashion Brand Everybody is Anything But Basic
05.04.17 As former creative leads at American Apparel, it’s no surprise that Iris Alonzo and Carolina Crespo have an idiosyncratic sense of what counts as basic. After all, these are the women who visually defined a generation by re-proportioning denim and T-shirts into high-waisted mom jeans and plunging V-necks.
A lipid-free and insulin-supplemented medium supports De Novo fatty acid synthesis gene activation in melanoma cells
Loading metrics Open Access Peer-reviewed Research Article Su Wu , Anders M. Näär Su Wu, Anders M. Näär Published: April 10, 2019 https://doi.org/10.1371/journal.pone.0215022 Figures Abstract While investigating the role played by de novo lipid (DNL) biosynthesis in cancer cells, we sought a medium condition that would support cell proliferation without providing any serum lipids.
Total Factor Productivity and Efficiency of Australian Airports
By using a Malmquist total factor productivity index and data envelopment analysis it is possible to investigate the efficiency and productivity of Australian airports during the 1990s. The results from this analysis indicate that these airports recorded strong growth in technological change and total factor productivity, but did not fare all that well in terms of growth in technical and scale efficiency during the 1990s.
Storyboard: Ill-Fated Expeditions - Etsy Journal
They say silence can be bought, and it’s the guilt that will cost you. But they must not know about this type of silence, the clear and solid sort, that stirs grand plans and something like resolve and finally lets you have your sadness.
The California Sunday Magazine
“Do not touch” is the refrain of most museum visits — but for art handlers, breaking that commandment is part of the job. At The Broad, the major contemporary-art museum opening September 20 in Los Angeles, the 18-member installation team for the inaugural exhibition wears nitrile gloves and avoids belt buckles, watches, and dangling jewelry.
Betye Saar’s Washboards Are an Artistic Act of Defiance
A half century ago, L.A.-based artist and Black Arts Movement icon Betye Saar created assemblages that challenged racist and sexist African American stereotypes. To paraphrase a popular sign from this year’s many women’s marches: It’s hard to believe she still has to protest this stuff. At 90, Saar has made a career of empowering the denigrated and vulnerable, most notably black women.
Tom Adler’s Home Sweet Surf Abode
Like any good hideout, the publisher Tom Adler’s redwood-frame house on Padaro Lane near Carpinteria, Calif., keeps a view of its own freedom.
Anti-oxidative Responses on Hepatic Tissue of Zebrafish (Danio rerio) in a Short Duration of Sub-lethal Concentrations of Cadmium Exposure
The aim of the present study was to identify whether the responses of oxidative stress in zebrafish liver are similar to those in mammalians upon low doses of Cd2+ exposure in short durations. Fish were exposed to 1.78 ?M Cd2+ (treatment) and 0.0 ?M Cd2+ (control) for 0, 1, 3, and 6 h. The reactive oxygen species (ROS) and lipid peroxidation (LPO) of hepatic tissues significantly increased after 3 and 6 h of Cd2+ exposure, respectively.
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