Sunjae Lee
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Jazz Right Now
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Articles by Sunjae Lee
Identification of antimicrobial peptides from ancient gut microbiomes - Nature Communications
Abstract Fecal coprolites preserve ancient microbiomes and are a potential source of extinct but highly efficacious antimicrobial peptides (AMPs). Here, we develop AMPLiT (AMP Lightweight Identification Tool), an efficient tool deployable to portable hardware for AMP screening in metagenomic datasets. AMPLiT demonstrates AUPRC performances of 0.9486 ± 0.0003 and reasonable overall training time of 3200 ± 53 s.
Easy and interactive taxonomic profiling with Metabuli App
Abstract Accurate metagenomic taxonomic profiling is critical for understanding microbial communities. However, computational analysis often requires command-line proficiency and high-performance computing resources. To lower these barriers, we developed Metabuli App, an all-in-one, stand-alone desktop application for taxonomic analysis. It features user-friendly interfaces for custom database creation, taxonomic profiling, and interactive result visualization.
Enhanced Computational and Experimental Approaches for Comparative Analysis of the Human Mycobiome
Abstract The mycobiome is now recognized as a critical part of the human microbial ecosystem, playing a significant role in both health and disease. Mycobiome research is currently in its infancy and relies on fungal-specific primers with challenges in bioinformatics to accurately determine the structure of the mycobiota community. In addition, the majority of computational and experimental methods currently in use have been optimized for bacteria rather than for fungi.
Normalization of Single-cell RNA-seq Data Using Partial Least Squares with Adaptive Fuzzy Weight
Abstract Normalization of single-cell RNA-seq (scRNA-seq) is a crucial step in downstream analysis, where raw data are adjusted to correct unwanted factors that prevent the direct comparison of expression measures. scRNA-seq data exhibits a multivariate relationship between transcript-specific expression and sequencing depth that a single scale factor cannot address.
Untargeted Plasma Metabolomics Unveils Distinct Metabolite Profiles in Parkinson Disease Subtypes: A Focus on idiopathic REM Sleep Behavior Disorders
Abstract Background: Parkinson's disease (PD) is characterized by diverse clinical presentations and etiological complexities, with rapid eye movement (REM) sleep behavior disorder (RBD) serving as a prodromal marker. While extensive unbiased metabolic profiling of plasma samples from PD subjects has been conducted to identify novel PD metabolic biomarkers, comprehensive metabolic profiling of PD subtypes based on RBD status remains limited.
Lack of sex education in GOP states puts students at risk
Although it may be a cliche, there is some truth to the trope ‘it takes a village to raise a child’ — whether it be through teachers, pediatricians, athletic coaches or politicians who create laws directly affecting youth. But in some states across the U.S., the adults in charge of youth policies are not doing their part in ensuring quality education for all. According to an Associated Press article, GOP-led states are at risk of losing sex education curricula in their schools.
Normalization of RNA-Seq Data using Adaptive Trimmed Mean with Multi-reference
Abstract The normalization of RNA sequencing data is a primary step for downstream analysis. The most popular method used for the normalization is the trimmed mean of M values (TMM) and DESeq. The TMM tries to trim away extreme log fold changes of the data to normalize the raw read counts based on the remaining non-deferentially expressed genes. However, the major problem with the TMM is that the values of trimming factor M are heuristic.
Pathogenic entero- and salivatypes harbour changes in microbiome virulence and antimicrobial resistance genes with increasing chronic liver disease severity
Abstract Background & Aims: Life-threatening complications of cirrhosis are triggered by bacterial infections, with the ever-increasing threat of antimicrobial resistance (AMR). Alterations in the gut microbiome in decompensated cirrhosis (DC) and acute-on-chronic liver failure (ACLF) are recognised to influence clinical outcomes, whilst the role of the oral microbiome is still being explored.
Magnetic delivery and ultrasound-responsive release of chelating microcapsules for selective removal of urolithiasis
Magnetic delivery and ultrasound-responsive release of chelating microcapsules for selective removal of urolithiasis Byung Kwon Kaang, Sunjae Lee, JunJie Piao, Hyuk Jin Cho and Dong-Pyo Kim Abstract A novel urolithiasis treatment in which chelating solution encapsulated in poly(lactic-co-glycolic acid; PLGA)-based microcapsules was delivered magnetically to specific urolithiasis sites and then subjected to ultrasound (US) to release the chelating solution and dissolve the stones.
Sunjae Lee by NFP with DKleine
Sunjae Lee joins DKleine to talk about a number of ongoing projects including Fermata Wellness on OpenSea and The Project URS. The two discuss his plans for a dedicated Discord community and possibilities for the near future in his NFT career.
Systematic analysis of gut microbiome reveals the role of bacterial folate and homocysteine metabolism in Parkinson’s disease
Highlights • Microbiome functional analysis reveals changes in carbohydrate-active enzymes in PD • Higher number of bacterial mucin and host degradation enzymes link to PD • Metabolic modeling reveals the contribution of bacterial-specific metabolism in PD • Gut-community modeling reveals the role of bacterial folate and homocysteine in PD Summary Parkinson’s disease (PD) is the most common progressive neurological disorder compromising motor functions.
Review: Soojin Suh’s Colorist Trio - Colorist
January 29, 2021 Sunjae Lee Album Reviews No comments Colorist is the newest project from Korean drummer Soojin Suh, one of the most prominent faces on the jazz scene in Seoul, Korea. The album feels like an early zenith in the arc of Soojin’s career, until one realizes that this is only her third album with decades of music ahead of her.
Liquid-Liquid Equilibria for the Ternary and Quaternary Systems of Water + Trimethylolpropane + (2-Ethylhexan-1-ol/Octan-1-ol) + Formaldehyde at 298.15 K | Journal of Chemical & Engineering Data
Ternary and quaternary liquid–liquid equilibria of three solutions (water + trimethylolpropane (TMP) + 2-ethylhexanol, water + TMP + octan-1-ol, and water + TMP + 2-ethylhexanol + formaldehyde) were studied at 298.15 K under atmospheric pressure. The consistency of the measured tie-line data was evaluated using the Othmer–Tobias, Bachman, and Hand equations.
Mature Human White Adipocytes Cultured under Membranes Maintain Identity, Function, and Can Transdifferentiate into Brown-like Adipocytes
Highlights • Mature adipocytes cultured as MAAC preserve cellular identity and function • Subcutaneous and visceral adipocytes can be cultured as MAAC • Adipocytes from lean and obese donors can be cultured • Human mature white adipocytes can transdifferentiate into brown-like adipocytes Summary White adipose tissue (WAT) is a central factor in the development of type 2 diabetes, but there is a paucity of translational models to study mature adipocytes.
A pathology atlas of the human cancer transcriptome
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Integrated Network Analysis Reveals an Association between Plasma Mannose Levels and Insulin Resistance
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5 Reasons Why Art is Good for Your Health
Many people view art as a superfluous activity, a luxury to be had only after the tasks of daily living are complete. As a painter and musician of 20 years, I believe in the importance of art and stress this importance to all of my patients as well. Not to mention, numerous studies are beginning to identify a link between art and good health as well.
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