Tim Lenz
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Articles by Tim Lenz
On-premise medical AI agents for reliable clinical decision-making
Abstract Autonomous clinical artificial intelligence (AI) agents powered by large language models (LLMs), meaning systems that can complete a diagnostic workflow without continuous human input, are increasingly capable of supporting complex reasoning and decision-making. Clinical translation, however, remains limited by two unmet requirements: institutionally governed deployment and reliable decision-time uncertainty estimation.
Christian Siriano Puts His Exuberant Stamp On a Historic Paris Apartment
Christian Siriano has always been a fan of Paris. “It’s a fashion mecca of the world,” says the designer, who has made extended visits since 2009, mounting presentations for his eponymous clothing line. But that appreciation reached a fever pitch several years ago, when he – older and even more established, with a blossoming interiors practice – purchased a Right Bank pied-à-terre. The wish list was simple: Someplace central and classic, with four bedrooms, grand windows, and Juliet balconies.
Letter: Feeding my shredder
My shredder hasn’t been fed this well in years. The over-abundance of political mailers has supplied it with a robust, daily intake. I’m especially happy to let it ingest those that read as desperate efforts to garner last-minute support. Though enticing as some may be, their strategic play on words and showy layouts simply lack faithful substance. That’s why casting my vote this year remains the same as I’ve done in the past - - with common sense.
Letter: 'Not so fast, my friend'
“Not so fast, my friend.” The late college football analyst and coach, Lee Corso, was famous for this one-liner. He regularly inserted this recognizable phrase into his gameday analysis when disagreeing with co-hosts. It was catchy, a bit humorous, and timely. This simple catchphrase is applicable today as we close in on the primary elections. The flurry of last-minute sound bites, campaign promises, and endorsements can be overwhelming.
Ready for a getaway? 4 NC resorts rank among best places to stay in the South
Skyline Lodge is one of four North Carolina resorts on the best-of list. Courtesy Skyline Lodge Key Takeaways AI-generated summary reviewed by our newsroom. Read our AI Policy. Four North Carolina destinations rank on Travel + Leisure’s list of top Southern resorts. Half-Mile Farm in the mountain town of Highlands ranked highest at No. 4. To create the list, the magazine studied reader input on fan-favorite destinations. If you’re in need of an idyllic getaway close to home, you may be in luck.
A deep learning framework for efficient pathology image analysis
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Abstract Artificial intelligence has transformed digital pathology by enabling biomarker prediction from high-resolution whole-slide images. However, current methods are computationally inefficient, processing thousands of redundant tiles per slide and requiring complex aggregation models. We introduce EAGLE (Efficient Approach for Guided Local Examination), a deep learning framework that emulates pathologists by selectively analyzing informative regions.
By Peter Neidlinger, Tim Lenz, Sebastian Foersch, Jan Clusmann, Marco Gustav, Lawrence A Shaktah, Rupert Langer, Bastian Dislich, Lisa Boardman, Amy French, Ellen L. Goode, Andrea Gsur, Stefanie Brezina, Marc J. Gunter, Robert Steinfelder, Christoph Röcken, Tabitha A. Harrison, Ulrike Peters, Amanda I Phipps, Giuseppe Curigliano, Nicola Fusco, Antonio Marra, Michael Hoffmeister, Hermann Brenner, Jakob Nikolas Kather, Chiara M. L. Loeffler, Hans-Michael Behrens
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Nature
Verified
Dans le Minnesota, un chalet de vacances aux couleurs scandinaves et aux raretés vintage
Avant de faire appel à l’architecte d’intérieur Anne McDonald pour son chalet de vacances, sa cliente suivait déjà son travail depuis près d’un an. Toutes deux vivent dans les « Twin Cities » de Minneapolis–Saint Paul, et la propriétaire avait appris à apprécier sa vision du design et de la vie quotidienne à travers ses publications en ligne.
Spatial biomarker discovery via interpretable semantic learning in histopathology
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ArticleVolume 44, Issue 8p1605-1622.e7Open access Affiliations & Notes 1Else Kroener Fresenius Center for Digital Health, Faculty of Medicine, TUD Dresden University of Technology, Dresden, Germany 2State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing, 100084, China 3Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center,...
By Junhao Liang, Xiaofeng Jiang, Nic Gabriel Reitsam, Tim Lenz, Li Zhang, Marco Gustav, Zunamys Itzell Carrero, Hannah Sophie Muti, Peter Neidlinger, Jan Clusmann, Laura Žigutytė, Vidhya Sainath, Fabian Wolf, Lisa Boardman, Amy French, Ellen L. Goode, Andrea Gsur, Stefanie Brezina, Marc J. Gunter, Robert Steinfelder, Tabitha A. Harrison, Ulrike Peters, Amanda I Phipps, Philip Quirke, Nicholas West, Michael Hoffmeister, Hermann Brenner, Durgesh Wankhede, Jitendra Jonnagaddala, Nicholas Hawkins, Robyn Ward, Elena Fountzilas, Kyriaki Papadopoulou, George Fountzilas, Thierry Andre, Thierry André, Julien Taieb, Jean-François Emile, Magali Svrcek, Lingjie Kong, Jakob Nikolas Kather
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Cell Press
Verified
Spatial biomarker discovery via interpretable semantic learning in histopathology
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ArticleVolume 44, Issue 8p1605-1622.e7Open access Affiliations & Notes 1Else Kroener Fresenius Center for Digital Health, Faculty of Medicine, TUD Dresden University of Technology, Dresden, Germany 2State Key Laboratory of Precision Measurement Technology and Instruments, Department of Precision Instrument, Tsinghua University, Beijing, 100084, China 3Department of Thoracic Surgery, Sichuan Clinical Research Center for Cancer, Sichuan Cancer Hospital & Institute, Sichuan Cancer Center,...
By Junhao Liang, Xiaofeng Jiang, Nic Gabriel Reitsam, Tim Lenz, Li Zhang, Marco Gustav, Zunamys Itzell Carrero, Hannah Sophie Muti, Peter Neidlinger, Jan Clusmann, Laura Žigutytė, Vidhya Sainath, Fabian Wolf, Lisa Boardman, Amy French, Ellen L. Goode, Andrea Gsur, Stefanie Brezina, Marc J. Gunter, Robert Steinfelder, Tabitha A. Harrison, Ulrike Peters, Amanda I Phipps, Philip Quirke, Nicholas West, Michael Hoffmeister, Hermann Brenner, Durgesh Wankhede, Jitendra Jonnagaddala, Nicholas Hawkins, Robyn Ward, Elena Fountzilas, Kyriaki Papadopoulou, George Fountzilas, Thierry Andre, Thierry André, Julien Taieb, Jean-François Emile, Magali Svrcek, Lingjie Kong, Jakob Nikolas Kather
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Cell Press
Verified
Il duplex a Manhattan di questa dirigente di Loro Piana è chic e senza tempo, proprio come un maglione di cachemire
Questo duplex a Manhattan è morbido, chic e senza tempo. Katherine Schlosstein ha le idee chiare. Quando si è presentata all’incontro iniziale con l’architetto e la designer per la ristrutturazione del suo duplex a Manhattan, Schlosstein non si è limitata ad esprimere nozioni generiche, ma si è presentata con delle slide. “Avevo già pronto un Powerpoint”, dice ridendo. “So cosa mi piace e cosa non mi piace, ma non sono troppo esigente.
Cette dirigeante de Loro Piana a rénové son duplex à New York : « J’avais préparé un PowerPoint »
Katherine Schlosstein sait ce qu’elle veut. Lors de la première réunion consacrée à la rénovation de son duplex à Manhattan avec son architecte et son architecte d’intérieur, elle n’est pas arrivée avec de vagues idées, mais avec une véritable présentation. « J’avais préparé un PowerPoint, oui », dit-elle en riant. « Je sais ce que j’aime et ce que je n’aime pas, mais je ne suis pas excessivement pointilleuse. Et comme nous sommes tous amis, je voulais que le processus soit le plus fluide possible.
El PowerPoint más minucioso del Upper East Side lo preparó esta ejecutiva de Loro Piana para reformar su casa (y no falló en ni una sola decisión)
El gusto impecable de Katherine Schlosstein, directiva de Loro Piana, marcó esta reforma en Nueva York pensada hasta el último detalle Katherine Schlosstein, vicepresidenta de marketing y comunicación de Loro Piana, hizo lo que probablemente haría cualquier persona acostumbrada a trabajar rodeada de perfección visual, tejidos impecables y lujo silencioso: llegar a la primera reunión para la reforma de su nueva vivienda con un esquema perfectamente organizado.
Una paleta escandinava, muebles ‘vintage’ y mucho espacio para la familia: así se transformó una casa rural con el objetivo de convertirse en vivienda definitiva
De cabaña de madera sin gracia a encantadora casa rural para escapadas en familia Cuando la clienta de Anne McDonald se puso en contacto con ella para hablar de la casa rural que estaban reformando en Minesota, ya llevaba un año siguiendo su trabajo en sus redes sociales. Así que cuando quiso consejo sobre la distribución de uno de los cuartos de baño, sabía perfectamente a quién iba a recurrir.
Gentleman's Retreat
When the owner of this Alexandria townhouse contacted interior designer Paul Corrie for an update, he had one stipulation—that it not look like a typical Alexandria townhouse with white walls and a traditional vibe. The client was the entertainment director for a luxury cruise line and had something a little less conventional in mind. In addition, the 1977 brick abode “looked like it was last updated in the 1980s,” shares Corrie.
Gentleman's Retreat
A 1950s French plaster bust of Marianne from the personal collection of architect Thierry Despont, obtained through Thomas Preston, commands a corner of the room near a French convertible chair from Obsolete. Ann Sacks tile lends Deco style to the entry. An Iksel mural from Schumacher animates the dining room walls. The guest room houses a daybed upholstered in Cowtan & Tout fabric and a Nick Mele photograph. A mirror from Jean-Marc Fray Antiques shines above a console in the guest room.
Benchmarking large language model-based agent systems for clinical decision tasks - npj Digital Medicine
Abstract Agentic artificial intelligence (AI) systems, designed to autonomously reason, plan, and invoke tools, have shown promise in healthcare, yet systematic benchmarking of their real-world performance remains limited. In this study, we evaluate two such systems: the open-source OpenManus, built on Meta’s Llama-4 and extended with medically customized agents; and Manus, a proprietary agent system employing a multistep planner-executor-verifier architecture.
This Louisville Home Shows What Happens When You Don’t Rush Design
When it comes to making bourbon, patience is a virtue. Long before a refreshing mint julep can hit your lips, grain must be malted, milled, mashed, and fermented, the resulting wash then distilled to concentrate the alcohol. Maturation can take years in a barrel to achieve the desired color, flavor, and smoothness. Good taste takes time.
This Designer Kept a Sea Captain’s Historic Casement Windows-And Built the Room Around Them
“I feel like a lot of clients come to us asking for a secret room,” laughs Blair Moore of Moore House Design. The Rhode Island–based designer recently renovated an expansive 1834 landmark—the residence of noted sea captain Ward Buckley—infusing it with historical charm (and that cleverly concealed room) for a couple and their two young sons. The 6,000-plus square-foot home sits in the heart of downtown Southport, Connecticut—an idyllic harbor village anchored on the Long Island Sound.
Benchmarking foundation models as feature extractors for weakly supervised computational pathology
Abstract External IDs PubMed 41034516
Abnormality-Driven Representation Learning for Radiology Imaging
Abstract Title 28th International Conference on Medical Image Computing and Computer Assisted Intervention Abbreviated title MICCAI 2025 Conference number 28 Duration 23 - 27 September 2025 Website Location Daejeon Convention Center City Daejeon Country Korea, Republic of
Deep learning can predict cardiovascular events from liver imaging
Background & Aims: Cardiovascular mortality remains the leading cause of death and a significant source of morbidity, with metabolic alterations being key etiological factors. As the main metabolic organ, the liver could predict prodromal changes associated with increased cardiovascular risk. However, quantifying this risk remains challenging. This study explores the use of transformer neural networks on liver magnetic resonance imaging (MRI) data to enhance cardiovascular risk prediction.
En la casa minimalista de la ‘yogui’ más famosa de internet: “Quería un espacio que se sintiera como un hogar, pero también como un refugio creativo”
Esta casa minimalista con toques vintage es el particular homenaje que una estrella del yoga y su pareja le han hecho tanto a sus raíces mexicanas como a su familia Cuando Adriene Mishler y su pareja empezaron a buscar casa en Austin (Texas), no estaban buscando simplemente un proyecto nuevo en el que invertir. Querían un lugar donde asentarse, con luz natural y el suficiente potencial para convertirla en algo totalmente suyo.
Andiamo a casa di una star dello yoga a Austin, in Texas: accogliente e meravigliosamente sobria
Adriene Mishler, fondatrice del programma di successo su YouTube Yoga with Adriene apre le porte della sua casa di Austin. Quando Adriene Mishler e il suo compagno hanno iniziato a cercare casa ad Austin, in Texas, non stavano cercando un progetto. Volevano un posto dove stabilirsi, un posto con struttura, luce solare e con il potenziale per essere trasformato in qualcosa che sentissero davvero loro.
La maison sobre et chaleureuse d’une star du yoga à Austin
Lorsqu’Adriene Mishler et son partenaire ont commencé à chercher une maison à Austin, ils n’envisageaient pas de se lancer dans un projet de rénovation. Ils voulaient un endroit où s’installer ; un endroit structuré, ensoleillé et susceptible d’être transformé en quelque chose qui leur appartiendrait entièrement.
Inside Yoga Star Adriene Mishler’s Warm and Wonderfully Understated Austin Home
All products featured on Architectural Digest are independently selected by our editors. However, we may receive compensation from retailers and/or from purchases of products through these links. When Adriene Mishler and her partner started house hunting in Austin, they weren’t looking for a project. They wanted somewhere to settle—a place with structure, sunlight, and potential to be shaped into something that felt entirely their own.
Tour a Serene Brooklyn Brownstone Built Around a Family’s Favorite Places
The mandate: incorporate a young couple’s love of Ancient Rome, James Turrell skyspaces, and stormy beach days into a tip-to-tail renovation of an 1840s Greek Revival brownstone. Fortunately for these clients, a pair of tech executives with a now toddler daughter, the ensemble team they enlisted for the three-year undertaking arrived with a shared understanding of their dream and a surfeit of creative ideas to achieve it.
Tour a Family’s Traditional-Meets-Modern Massachusetts Home
Vijay and Lauren Manthripragada believe in silver linings, for there is, they insist, no better explanation for how their home in Concord, Massachusetts, came to be. “We fell in love with a house in the area but failed to snatch it up,” says Lauren, a retired commercial architect turned stay-at-home mom.
Deep Learning for Biomarker Discovery in Cancer Genomes
Abstract Background: Genomic data is essential for clinical decision-making in precision oncology. Bioinformatic algorithms are widely used to analyze next-generation sequencing (NGS) data, but they face two major challenges. First, these pipelines are highly complex, involving multiple steps and the integration of various tools. Second, they generate features that are human-interpretable but often result in information loss by focusing only on predefined genetic properties.
Deep Learning for Biomarker Discovery in Cancer Genomes
BACKGROUND: Genomic data is essential for clinical decision-making in precision oncology. Bioinformatic algorithms are widely used to analyze next-generation sequencing (NGS) data, but they face two major challenges. First, these pipelines are highly complex, involving multiple steps and the integration of various tools. Second, they generate features that are human-interpretable but often result in information loss by focusing only on predefined genetic properties.
Deep Learning for Biomarker Discovery in Cancer Genomes
Abstract Background: Genomic data is essential for clinical decision-making in precision oncology. Bioinformatic algorithms are widely used to analyze next-generation sequencing (NGS) data, but they face two major challenges. First, these pipelines are highly complex, involving multiple steps and the integration of various tools. Second, they generate features that are human-interpretable but often result in information loss by focusing only on predefined genetic properties.
Counterfactual Diffusion Models for Mechanistic Explainability of Artificial Intelligence Models in Pathology
Abstract Deep learning can extract predictive and prognostic biomarkers from histopathology whole slide images, but its interpretability remains elusive. We develop and validate MoPaDi (Morphing histoPathology Diffusion), which generates counterfactual mechanistic explanations. MoPaDi uses diffusion autoencoders to manipulate pathology image patches and flip their biomarker status by changing the morphology. Importantly, MoPaDi includes multiple instance learning for weakly supervised problems.
Tour a Dreamy Napa Valley Cottage Whose Garden Is Listed in the Smithsonian’s Archives Original
Suzanne Tucker’s clients wanted to update the kitchen of their weekend cottage in Napa Valley, which they’d owned for more than 30 years. It was a relatively small job for Tucker, an experienced designer who’s usually tasked with transforming entire residences. Yet the clients were longtime friends, and so the kitchen renovation began. It didn’t take very long for new ideas to arise.
Fashion Icon Christian Siriano Transforms a Dilapidated Richmond, Virginia, Mansion Into a Family Sanctuary
All products featured on Architectural Digest are independently selected by our editors. However, when you buy something through our retail links, we may earn an affiliate commission. True to his Project Runway roots, Christian Siriano, the celebrated fashion designer known for his use of bold hues and elegant silhouettes, loves “a reveal moment.” How lucky then that his most recent interior design project featured not one, but two such occasions.
Isotactic polypropylene produced by rac/meso mixtures of hafnocene complexes through selective rac activation
1 INTRODUCTION In 1985, Brintzinger and Kaminsky were the first to employ racemic (rac) ansa-zirconocene complexes for the homogenous polymerization of propylene.1 Compared to the heterogenous Ziegler/Natta process,2 the homogenous polymerization offered far more precise control over the polymer's molecular weight, dispersity, and stereoregularity.1, 3 The correlation between the symmetry of the metallocene catalyst and the tacticity of the resulting polymer was disclosed by John Ewen, who...
A Turn-of-the-Century Brownstone Gets a Modern Makeover
Designer Joan Enger authored a masterful mix of old and new to help a young family write the next chapter of this townhouse. Clean, but layered. Elegant, but approachable. Contemporary, but classic. Some designers might be daunted by such a paradoxical client wish list, but not Joan Enger of J. Patryce Design. The New Jersey–based decorator seems to subscribe to the philosophy that the bigger the challenge, the better—much to the benefit of her clients.
Aluminum Alkyl Induced Isomerization of Group IV meso Metallocene Complexes
Introduction The discovery of the coordinative polymerization of ethylene and propylene by Ziegler and Natta in the 1950s marked arguably the most crucial breakthrough in polymer research to this date.1 30 years later, Brintzinger and Kaminsky established well-defined single-site, homogeneous ansa-zirconocene complexes for the iso-selective polymerization of propylene.2 Using methylaluminoxane (MAO) as a co-catalyst, they were able to produce polypropylene with far higher molecular weights...
Aluminum Alkyl Induced Isomerization of Group IV meso Metallocene Complexes
Introduction The discovery of the coordinative polymerization of ethylene and propylene by Ziegler and Natta in the 1950s marked arguably the most crucial breakthrough in polymer research to this date.1 30 years later, Brintzinger and Kaminsky established well-defined single-site, homogeneous ansa-zirconocene complexes for the iso-selective polymerization of propylene.2 Using methylaluminoxane (MAO) as a co-catalyst, they were able to produce polypropylene with far higher molecular weights...
This Multigenerational Upstate New York Refuge Is a Study in Thoughtful Design
The Hudson Valley, with its many Frederic Church painting-worthy charms, was a longtime hideaway for Erin Appleton, her mother, Kathleen Casey, and their family. It’s where they would spend summers at Mohonk Mountain House, the Victorian-era resort nestled on the spellbinding Shawangunk Ridge. But after Appleton’s father passed away, the women felt it was time to put down new roots.
Nell’Upper East Side una casa da sogno con una spettacolare sala da pranzo tutta “vestita” di tende
I proprietari di questo appartamento nell’Upper East Side, una giovane coppia che “non sapeva nulla di design”, volevano trovare un professionista che li accompagnasse nella loro prima grande ristrutturazione come famiglia. Per una coincidenza, la moglie aveva conosciuto il designer Josh Greene, che aveva conosciuto in qualità di co-presidentessa del gala annuale della School of American Ballet.
Raptors offer exciting winter wildlife-watching opportunities
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Ambient Catalytic Spinning of Polyethylene Nanofibers
Introduction Fibers and fibrous materials are widely used, e.g. in the textile and apparel industry.1 Different spinning techniques (naturally or artificially) for fibers exist.2 For example, protein-based silk from spiders and other glanded animals exhibits remarkable mechanical performance, which can readily exceed the strength of steel and suggests that the spinning process is key.3, 4 Nowadays, synthetic fabric materials constitute the bulk volume of products made of polymers like...
Tour a Dreamy Upper East Side Family Home With a Tented Room
The owners of this Upper East Side apartment, a young couple who “knew nothing about design,” wanted to find a professional who made them feel comfortable as they embarked on their first big renovation as a family. Coincidentally, the wife had become friendly with AD PRO Directory designer Josh Greene, whom she met as co-chair of the School of American Ballet’s yearly gala. She had seen the AD100 talent in action and had a strong sense he would be the right person for the job.
Tour a 19th-Century Town House in Hoboken, New Jersey
Seth and Kristina Brookman had lived in Manhattan for more than 20 years, so it came as a surprise when they decided to go see a home for sale in Hoboken, New Jersey. When the parents of two young children first toured this property, they did so with the understanding that it could handle change too. “Town house living is exactly our style—intimate yet bustling,” Seth says.
Perfectly Isotactic Polypropylene upon In Situ Activation of Ultrarigid meso Hafnocenes
Abstract Using in situ activation, hafnocene meso-I yields isotactic polypropylene instead of atactic polypropylene of meso-I and rac-I. With our easy and convenient isomerization and polymerization protocol, productivities comparable to pure rac-I if applied to pure meso-I or a mixture of both isomers are accessible.
An Apartment With Outsize Style That Belies Its Cozy Footprint
From his childhood on a farm in Kansas to designing luxury homes in New York and London via L.A. and Mexico, designer Andrew Torrey has come a long way—especially since founding his eponymous firm, B.A. Torrey, in 2013. When he first moved to New York at 21, Torrey knew he was ready to take on the bright lights and big city. However, following a stint in the music industry and years of high-level real estate deals, he ultimately realized none of it was his passion.
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