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Articles by Ting Yang
Zr-based oxyhalide superionic electrolyte with self-passivating interphase stabilisation for high-voltage and fast-charging all-solid-state lithium batteries
Abstract The pursuit of high-energy-density all-solid-state lithium batteries necessitates integration with next-generation high-voltage positive electrodes. However, a critical challenge lies in the intrinsic instability of most highly ionically conductive solid electrolytes, which decompose at potentials above 4.30 V vs Li+/Li, resulting in severe interfacial degradation and increased impedance.
Dynamic weighted federated contrastive learning for robust medical image classification under heterogeneous data
Abstract With the rapid advancement of artificial intelligence technologies, AI-driven medical image classification has attracted considerable attention in recent years. However, increasingly stringent data privacy regulations have significantly restricted data sharing among medical institutions, making it difficult for traditional centralized learning frameworks to effectively exploit distributed medical data resources.
Sacral Neural Crest-Derived Extracellular Vesicles Promote Pelvic Ganglion Repair Through Anti-Pyroptotic Effects Involving ANXA1–FPR2 Signaling
1 Introduction Pelvic autonomic nerve injury is a common and often unavoidable complication of pelvic surgery, particularly during radical procedures for rectal, prostate, and gynecologic cancers. Mechanical stretching, compression, thermal injury, and vascular disruption during pelvic dissection can damage the pelvic autonomic plexus, leading to persistent postoperative bowel dysfunction [1-4].
Prospective evaluation of a real-time AI assistant for outpatient documentation and quality control
Abstract Outpatient electronic medical record (EMR) quality is highly variable, yet few tools exist to support real-time documentation. Here we developed SMART-ASSISTANT, an end-to-end AI system that automates EMR writing for outpatients through integrated audio transcription, structured EMR generation, quality control, and assisted diagnosis.
Multi-omics profiling reveals homologous recombination repair hyperactivation as a therapeutic vulnerability in neuroendocrine cervical carcinoma
Abstracts Neuroendocrine cervical carcinoma (NECC) is an aggressive and rare malignancy comprising 0.9–1.5% of cervical cancers. Its molecular basis remains poorly understood, limiting treatment options. A national multicenter cohort survival analysis showed that NECC patients had a 5.17-fold higher death risk than non-NECC patients and demonstrated broad chemotherapy resistance, which was further validated in both NECC cell lines and patient-derived organoids.
Longitudinal associations between neighborhood built environment and self-rated health accounting for social capital
Abstract With the advancement of the “Healthy China 2030 Initiative”, increasing attention has been paid to health outcomes in China amid rapid urbanization and population ageing. Among various factors, Built Environment (BE) and Social Capital (SC) play important roles in shaping individuals’ Self-Rated Health (SRH). However, prior studies mainly relied on cross-sectional design, with limited attention to age and urban-rural differences in these associations.
Long-term multidimensional outcomes of China’s national cochlear implant assistance programme over twenty-one years
Abstract Long-term evidence on publicly funded cochlear implantation programmes remains limited, particularly regarding recipients’ sustained functional, rehabilitative, educational, social and quality-of-life outcomes in real-world settings. This study aimed to evaluate these multidimensional outcomes and identify implementation gaps among recipients of China’s national cochlear implant assistance programme.
Apparent pH-TAN operational breakpoint links duckweed-microbiome destabilization and nitrogen fate shift in ammonia-rich swine digestate
Abstract Ammonia-rich agricultural wastewaters challenge reliable biological treatment because treatment failure can leave reactive nitrogen in the dissolved phase. Duckweed-based systems offer a low-energy approach for polishing nutrient-rich wastewaters, but their stability under ammonia stress remains poorly resolved.
Unraveling the lexicon of complex mutational phenomena in human cancers
Abstract Although most mutations found in cancer genomes are randomly distributed, some form complex genomic patterns. Over the past 15 years, genomics studies have systematically uncovered multiple mutational phenomena, assigning several of them evocative Greek terms including kataegis, omikli, kyklonas, chromothripsis, chromoplexy, pyrgo, rigma and tyfonas.
Regulation of Intrinsic Defects on the Electronic Structure and Optical Properties of Sn 2 Nb 2 O 7
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. Supporting Information Filename Description pssr70258-sup-0001-SuppData-S1.pdf91.4 KB Supplementary Material References 1, “Transparent Conducting Oxide Semiconductors for Transparent Electrodes,” Semiconductor Science and Technology 20 (2005): S35.
What is new in delirium: A vascular etiology outlook
1 INTRODUCTION Delirium is characterized by acute and fluctuating disturbances in attention, awareness, and cognition. It is a common, costly, neurologic complication in patients, especially critically ill patients; patients with chronic metabolic disorders; or older adults.1, 2 In older adults, delirium is among the most consequential complications of hospitalization.
Therapy-educated fibroblast states link treatment pressure to residual disease and acquired resistance in gastric cancer
Abstract Chemotherapy, immune checkpoint blockade, HER2-targeted therapy, and anti-angiogenic therapy have widened treatment options for gastric cancer, yet residual disease and acquired resistance remain common. Cancer-associated fibroblasts (CAFs) are often classified as fixed subtypes, even though treatment exposes them to tissue injury, inflammatory cytokines, hypoxia, altered interstitial pressure, and matrix stress.
Anthracene-Based Tetraimidazolium Nanotube as Molecular Glue for DNA Hierarchically Chiral Assembly in Water
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that supports the findings of this study are available in the Supporting Information of this article. Supporting Information Filename Description anie74696-sup-0001-SuppMat.docx31.5 MB Synthetic and structural details, characteristic spectra, crystallographic data, NMR, ESI-MS, ITC, UV−vis, fluorescence, CD spectra, and Supporting figures and tables as described in the text.
Unveiling hidden seismicity: An AI-derived catalog of 380k earthquakes for Sichuan Province, China
Abstract Long-term, high-resolution seismic monitoring is a prerequisite for characterizing seismic structures, delineating fault geometry, and mitigating earthquake risks. Located on the eastern margin of the Qinghai-Xizang Plateau, Sichuan Province is among the most seismically active regions in China, with particularly intense activity concentrated in the shale gas extraction zones of the southern Sichuan Basin.
AGE-RAGE/NF-κB/SIRT3 signaling cascade is implicated in mitochondrial dysfunction in diabetic gastroparesis
Abstract Diabetic gastroparesis is a severe complication of diabetes mellitus, yet its underlying molecular mechanisms remain poorly understood. This study investigated how advanced glycation end products (AGEs) trigger mitochondrial dysfunction through NF-κB activation and SIRT3 suppression in diabetic gastroparesis. We analyzed clinical samples from diabetic gastroparesis patients and healthy controls. Primary gastric smooth muscle cells were treated with AGEs to examine cellular responses.
Successful treatment of inverse psoriasis with ustekinumab: a case report
Abstract Inverse psoriasis is a relatively rare and distinct subtype of psoriasis whose pathogenesis remains incompletely understood. The particular location of lesions presents significant therapeutic challenges, and no consensus guidelines are currently available. Immune mediated inflammation plays a key role in disease development. Lesions are susceptible to riction and moisture, which reduces treatment tolerance in affected areas.
Evolving frontiers in drinking water membrane technology: a 25-year bibliometric and antifouling perspective
Abstract Based on a comprehensive dataset of 5,925 publications retrieved from Scopus and the Web of Science Core Collection between 2000 and 2024, this study systematically maps the research landscape of membrane technology for drinking water production via integrated bibliometric analysis and visualization using VOSviewer, Origin 2023, and R statistical software.
Temporal Differentiation of Nonperipheral Washout Refines Prognostic Stratification in HCC
1 Introduction Hepatocellular carcinoma (HCC) is unique among solid malignancies in that it can be diagnosed noninvasively based solely on characteristic imaging features in high-risk populations, without the need for histopathological confirmation [1].
The “viral–metabolic” interaction mechanisms and management challenges in chronic hepatitis B combined with metabolic dysfunction-associated fatty liver disease: from clinical evidence to an integrated multidisciplinary framework
Abstract The comorbidity of chronic hepatitis B and metabolic dysfunction-associated fatty liver disease involves a bidirectional “virus–metabolism” interaction mechanism, presenting a clinical paradox characterized by improved virological markers alongside an increased risk of hepatocellular carcinoma.
A cooperative regulatory module between TAGL2 and JMJC1 activates specific defense genes against root-knot nematodes in tomato
Data availability All data generated or analyzed during this study are included in the main text and Supporting Information. Source data are provided with this paper (Notes ).
Adaptive spatiotemporal feature fusion attention-enhanced ConvLSTM for smart meter lifespan assessment
Abstract Accurate lifespan assessment of smart meters is essential for condition-based maintenance and efficient asset management in modern power grids. Existing approaches struggle to jointly exploit the heterogeneous, multi-source nature of meter operational data and the intertwined spatial and temporal degradation patterns that govern meter aging.
CCL7-CCR3 signaling mediates olfactory dysfunction in a mouse model of allergic rhinitis
Abstract Background: Allergic rhinitis (AR) is a prevalent chronic upper airway inflammatory disorder. Olfactory dysfunction (OD) in AR patients represents a frequent and burdensome complication that significantly compromises quality of life. While the pathogenesis of AR-associated OD remains incompletely characterized, emerging evidence points to olfactory bulb (OB) microglial neuroinflammation as a crucial contributor.
Anti-seizure medications and DRESS in paediatric patients: A FAERS disproportionality and time-to-onset analysis
CONFLICT OF INTEREST STATEMENT The authors have no relevant affiliations or financial involvement with any organization or entity with a financial interest in or financial conflict with the subject matter or materials discussed in the manuscript. This includes employment, consultancies, honoraria, stock ownership or options, expert testimony, grants or patents received or pending, or royalties.
Computer Science > Computer Vision and Pattern Recognition
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The long tail of nitrate pollution in groundwater challenges governance of global water quality
Abstract Groundwater nitrate pollution threatens drinking water safety. Legacy nitrogen (N) in the vadose zone creates a “long tail” of leaching that can persist for decades after policy actions. Here we model global nitrate dynamics in groundwater from 1961 to 2100. By 2020, shallow aquifers had accumulated 162 ± 6 Tg N as nitrate, exceeding the WHO drinking water limit across 10% of global land area.
Immunotherapy with B28, an antibody to Aβ oligomers, potently decreases amyloid plaques, microgliosis, and memory decline in APP knock-in mice
ArticleVolume 45, Issue 7117599Open access Affiliations & Notes 1Ann Romney Center for Neurologic Diseases, Department of Neurology, Brigham and Women’s Hospital, Harvard Medical School, 60 Fenwood Road, Boston, MA 02115, USA 2Abyssinia Biologics, Inc, 855 Boylston Street, #1000, Boston, MA 02116, USA 3Sanofi Neurodegenerative Research, Chilly Mazarin, France 4Sanofi US Large Molecule Research, 350 Water St, Cambridge, MA 02141, USA Article Info Publication History: Received December 11,...
Repurposing nitazoxanide as a novel ferroptosis inducer for triple-negative breast cancer via dual disruption of iron homeostasis and the β-catenin/GPX4 axis
ABSTRACT Background Ferroptosis induction is a promising triple-negative breast cancer (TNBC) therapy, but current inducers are suboptimal. Nitazoxanide (NTZ), an FDA-approved antiparasitic with anticancer and redox activity, may be repurposed as a ferroptosis inducer, yet its effects and mechanisms in TNBC are unclear. Methods Anti-TNBC effects of NTZ were assessed in MDA-MB-231 and Hs578T cells via viability, clonogenicity, migration/invasion, and zebrafish xenografts.
Correction: MAPRE2 is associated with macrophage-enriched innate immune dysregulation and malignant phenotypes in hepatocellular carcinoma
A Correction on MAPRE2 is associated with macrophage-enriched innate immune dysregulation and malignant phenotypes in hepatocellular carcinoma By An X, Gao Y, Zhao S, He W, Yang X, Wu Y, Li J, Yi R, Han Y, Li M, Li Q and Yang T (2026). Front. Immunol. 17:1849407. doi: 10.3389/fimmu.2026.1849407 There was a mistake in Figure 7A as published.
Preoperative Neutrophil-to-Lymphocyte Ratio, Platelet-to-Lymphocyte Ratio, and Other Predictors of Delayed Wound Healing After Anal Fistula Surgery: A Retrospective Study
Back to Journals » Journal of Multidisciplinary Healthcare » Volume 19 Authors Yang T, He T, Tan A, Pi M Received 5 June 2026 Accepted for publication 3 October 2026 Published 23 October 2026 Volume 2026:19 629310 DOI https://doi.org/10.2147/JMDH.S629310 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 3 Editor who approved publication: Professor Charles V Pollack Ting Yang, Tao He, Aiping Tan, Mao Pi Department of Anorectal, Xiangtan Hospital of...
Smart meter health state prediction based on residual-connected self-attention ConvLSTM network
Abstract Accurate health state prediction of smart meters is essential for ensuring metering reliability and enabling condition-based maintenance in advanced metering infrastructure. Existing approaches based on conventional machine learning or standard deep learning architectures struggle to simultaneously capture complex spatiotemporal degradation patterns, model long-range dependencies, and maintain stable training in deeper network configurations.
Study on the predictive value of NHR and UHR levels in early pregnancy for gestational diabetes mellitus: based on a retrospective analysis
Abstract Objective: This study aims to examine the relationship between the neutrophil to high-density lipoprotein cholesterol ratio (NHR) and the uric acid to high-density lipoprotein cholesterol ratio (UHR) in early pregnancy and the development of GDM, and to analyze the predictive value of these factors in combination, with a view to providing a basis for the early clinical prevention and treatment of GDM.
Establishment of an efficient Agrobacterium -mediated genetic transformation protocol for Saccharum officinarum using Black Cheribon as a model genotype
Abstract Efficient Agrobacterium-mediated transformation (AMT) is vital for the biotechnological improvement of sugarcane (Saccharum spp.). Saccharum officinarum is the main ancestor of all modern cultivars, yet little research has been conducted on its AMT system. In this work, an efficient AMT protocol for S. officinarum was developed, with Black Cheribon as the model genotype owing to its superior tissue culture performance and regeneration capacity.
Boron neutron capture therapy combined with immunotherapy: insights from radiotherapy, BNCT-specific evidence, and future directions
Abstract Boron neutron capture therapy (BNCT), a precision radiotherapy modality, has shown significant promise in targeted cancer treatment. Like conventional radiotherapy, the development of radioresistance hinders the efficacy of BNCT. Nevertheless, the physical parameters in BNCT induce the massive anti-tumor response compared to low-LET radiotherapy. Recent advancements have highlighted its synergistic potential with immunotherapy.
Functional brain abnormalities in patients with somatic symptom disorder presenting with chest pain: a resting-state fMRI study
Abstract Somatic symptom disorder (SSD) is characterized by persistent physical symptoms that cannot be fully explained by structural abnormalities or laboratory findings. However, the underlying neural mechanisms of SSD remain poorly understood. This study aimed to investigate functional brain abnormalities in SSD patients presenting predominantly with chest pain using resting-state functional magnetic resonance imaging (rs-fMRI).
Immunopeptidome profiling in pulmonary fibrosis provides a platform for identifying therapeutic targets
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Abstract Fibrosis is a severe pathological outcome of many chronic diseases, yet the therapeutic potential of targeting the altered major histocompatibility complex (MHC) class I immunopeptidome remains largely unexplored. Here we characterized the MHC class I immunopeptidomes from both fibrotic foci of human idiopathic pulmonary fibrosis lung explants and bleomycin-treated mice, identifying a diverse repertoire of fibrosis-associated peptides.
By Ziyi Bai, Tianxia Lan, Weiqi Hong, Haiying Que, Min Zhu, Xin Xiao, Jiayuan Ai, Shaoxiong Huang, Jiayu Wang, Qiaonan Hong, Yanyan Liu, Chengxin Xiao, Chengjian Zhao, Xin Wang, Xiaolong Zhang, Ting Yang, Heng Xu, Lunzhi Dai, Charles Powell, Luca Richeldi, Fengming Luo, Haohao Dong, Yong Yuan, Qiang Pu, Xiawei Wei, Dandan Wan
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Nutritional-inflammatory-metabolic indices associated with in-hospital mortality in acute kidney injury patients undergoing continuous renal replacement therapy: dose–response analysis and machine learning-based risk stratification
Abstract Background: Composite indices derived from routine laboratory parameters can reflect nutritional, inflammatory, and metabolic status, yet their prognostic value in acute kidney injury (AKI) patients receiving continuous renal replacement therapy (CRRT) has not been systematically compared. This study aimed to evaluate and compare the prognostic value of six such indices and to integrate them into machine learning-based prediction models.
Acacetin Alleviates Loperamide-Induced Functional Constipation by Inhibiting P53-Mediated Apoptosis in Colonic Epithelial Cells
1 Introduction Constipation is a highly prevalent gastrointestinal disorder characterized by difficult or infrequent bowel movements, often accompanied by symptoms such as abdominal discomfort, bloating, and straining during defecation [1, 2]. It is estimated that approximately 14% of the global population suffers from chronic constipation, with a higher prevalence among women and elderly individuals [3].
Cancer-associated SF3B1 mutation suppresses DNA repair by disrupting the organization of nuclear actin network
Abstract Nuclear actin filament is required for efficient repair of DNA double-strand breaks. While cancer-associated SF3B1 mutation leads to impaired DNA repair, the underlying mechanism remains elusive. Here, we found that SF3B1 mutation led to defective nuclear actin network during DNA repair. Mechanistically, SF3B1 mutation increased the expression of circATP9B, which interacted with and facilitated the degradation of MYH9.
A selective enrichment and specific probe terminal mediated strategy for highly sensitive detection of microRNAs
Abstract MicroRNAs are promising liquid biopsy biomarkers, but their clinical translation is hindered by detection challenges, including low abundance, high sequence similarity, and background interference. Here we present SE-SPTM-PCR, a detection platform integrating selective miRNA enrichment using locked nucleic acid probes with specific probe terminal mediated RT-qPCR.
Quercetin prevents age-related hearing loss in C57BL/6J mice by activating mitophagy and inhibiting the NLRP3 inflammasome
Loading metrics Open Access Peer-reviewed Research Article Citation: Feng M, Zhou X, Yang T, Chen Z, Yang G, Jiang X, et al. (2026) Quercetin prevents age-related hearing loss in C57BL/6J mice by activating mitophagy and inhibiting the NLRP3 inflammasome. PLoS One 21(3): e0342423. https://doi.org/10.1371/journal.pone.0342423 Editor: Kota V.
Pilot study of psilocybin in patients with post-treatment lyme disease - Scientific Reports
Abstract Lyme disease, caused by the bacterium Borrelia burgdorferi, is the most common vector-borne disease in the United States and Europe. Although antibiotics effectively treat most cases, an estimated 10–20% of patients develop post-treatment Lyme disease (PTLD), a chronic syndrome marked by fatigue, pain, cognitive difficulties, mood disturbance, and reduced quality of life. There are no established treatments for PTLD.
Journal of Environmental Sciences Study Reveals How Artificial Intelligence can Transform PM2.5 Monitoring
Journal of Environmental Sciences Study Reveals How Artificial Intelligence can Transform PM2.5 Monitoring A deep learning framework estimates hourly PM2.5 chemical components—sulfate, nitrate, ammonium, organic matter, and elemental matter—using routine air-quality and meteorological data, accurately capturing pollution patterns and outperforming existing methods.
Depression and anxiety in interstitial lung disease: a systematic review, meta-analysis and Mendelian randomization - Translational Psychiatry
Abstract To investigate the prevalence of depression and anxiety in interstitial lung disease (ILD) and reveal whether ILD is causally associated with depression and anxiety via Mendelian randomization (MR). Eligible studies were identified and selected from Web of Science, PubMed and Scopus. The pooled prevalence of depression and anxiety in ILD, as well as the clinical characteristics of ILD with depression or anxiety, were assessed.
Effects of Five‐Element Music Therapy on Depression Symptoms After Stroke: A Meta‐Analysis of Randomized Controlled Trials
1 Introduction Stroke is the leading cause of death and disability worldwide (GBD 2019 Diseases and Injuries Collaborators. 2020). Current estimates on the disease burden of stroke indicate that in 2019, there were roughly 7.09 million strokes in the US (Renedo et al. 2024) and 3.94 million new stroke cases in China (Ma et al. 2021). The survival rate of stroke has increased steadily in the past 20 years; however, longer survival is often accompanied by long-term effects of the sequelae (Patel et al.
Gut-Metabolome-Proteome Interactions in Age‐Related Hearing Loss: Insights from Fecal Microbiota Transplantation and Multi‐Omics Analyses
1 Introduction Age-related hearing loss (ARHL), or presbycusis, is a symmetrical, progressive, age-dependent decline in auditory sensitivity that predominantly affects high frequencies and arises from sensorineural pathology [1]. Demographic projections indicate that the global population aged 60 years and older will reach approximately 2.1 billion by 2050 [2].
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