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Articles by Tuo Li
Publisher Correction: Conceptual framework and expert guidance on intrapancreatic fat deposition: the Melbourne consensus
Correction to: Nature Reviews Gastroenterology & Hepatology https://doi.org/10.1038/s41575-026-01224-6, published online 16 July 2026. In the original version of this article, the line regarding ref. 192 provided a brief description of the characteristics of a separate consensus initiative.
Kaempferol attenuates secondary brain injury after traumatic brain injury in mice with reduced neuroinflammation
Abstract Traumatic brain injury (TBI) triggers a secondary injury cascade characterized by neuroinflammation, blood-brain barrier disruption, cerebral hypoperfusion, and progressive neuronal loss, yet effective therapies remain limited. Here, we investigated whether kaempferol attenuates secondary brain injury after TBI in mice by suppressing neuroinflammation.
Conceptual framework and expert guidance on intrapancreatic fat deposition: the Melbourne consensus
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Abstract Intrapancreatic fat deposition (IPFD) has garnered appreciable attention across diverse medical disciplines amid the rising global burden of pancreatitis, pancreatic cancer and type 2 diabetes mellitus. Despite growing interest in the field, there remains no conceptual framework for it. To address this gap, 25 experts from 6 continents were brought together to develop guidance.
By Maxim S. Petrov, Hajime Yamazaki, Guotao Lu, Ahmad Al-Mrabeh, Claudio Luchini, Xiaowu Dong, Tsuyoshi Hamada, Yutong Liu, Hiroki Oyama, Susanne Rospleszcz, Saurabh Chawla, Yan Shen, Ethem Turgay Cerit, Idoia Labayen, John Virostko, Tuo Li, Cristina Cadenas-Sanchez, Laure Alexandre-Heymann, Reda M Albadawy, Danijela Budimir Mršić, Giuseppe Della Pepa, Zhiyin Huang, Juyeon Ko, Xiaoyu Li, Sunitha Priya, Matheus Souza
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Metabolically and epigenetically reprogrammed splenic TRNP1 hi CD8 + T cells exacerbate liver fibrosis
Abstract Metabolic dysfunction-associated steatotic liver disease (MASLD), especially its severe form, metabolic dysfunction-associated steatohepatitis (MASH), progresses to liver fibrosis, leading to cirrhosis and liver cancer. The cross-talk between spleen and liver in MASLD/MASH progression remains poorly understood. Here we found enlarged spleens in patients with MASLD and identified induced TRNP1hiCD8+ T cells in spleens of MASLD/MASH mouse models and patients.
Publisher Correction: PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling - Nature
Correction to: Nature https://doi.org/10.1038/s41586-025-10084-0 Published online 4 February 2026 In the version of the article initially published, the genetic background labels at the top of Fig. 5f and g were mistakenly deleted during production and have now been reinstated; in the grey section of Fig.
Hidden O‐Deglycosylation Activity Triggers O → C Rearrangement for Aryl Di‐C‐Glucoside Formation by the C‐Glycosyltransferase From Fortunella crassifolia - Li - Biotechnology and Bioengineering - Wiley Online Library
CGT C-glycosyltransferase FcCGT CGT from kumquat (Fortunella crassifolia) GmSuSy sucrose synthase from soybean (Glycine max) UDP uridine-5′-diphosphate 1 Introduction Rearrangement reactions are highly valued in organic synthesis because they exhibit excellent atom economy (Clark 2025; Sheldon 2017; Trost 1991). The rearrangement product is a structural isomer of the substrate, retaining all atoms of the starting material while displaying altered atomic connectivity (Wang et al.
PtdIns(3,5)P2 is an endogenous ligand of STING in innate immune signalling - Nature
Abstract Exposure to cytosolic DNA triggers innate immune responses through cyclic GMP–AMP (cGAMP) synthase (cGAS)1,2,3. After binding to DNA, cGAS produces cGAMP as a second messenger that binds to stimulator of interferon genes (STING), a signalling adaptor protein anchored to the endoplasmic reticulum (ER)3,4,5.
Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans
Abbreviations DSF, differential scanning fluorimetry ECM, extracellular matrix GAG, glycosaminoglycan SDR, short-chain dehydrogenases/reductases UDP-GlcA, UDP-glucuronic acid UDP-Xyl, UDP-xylose UXS, UDP-xylose synthase (EC4.1.1.35) Proteoglycans are key components of the extracellular matrix (ECM) in connective tissues [[1, 2]]. They consist of a core protein covalently tethered with long glycosaminoglycan (GAG) chains [[3, 4]].
Comparative efficacy of cisternal drainage versus external ventricular drainage in severe aneurysmal subarachnoid hemorrhage
Loading metrics Open Access Peer-reviewed Research Article Citation: Mahamat MH, Li T, Liu J, Zhang S, Miao Y, Li Z, et al. (2026) Comparative efficacy of cisternal drainage versus external ventricular drainage in severe aneurysmal subarachnoid hemorrhage. PLoS One 21(1): e0340013.
Fusaric acid detoxification mediates interspecies interactions for sustainable Fusarium wilt disease management
Effects of Rolling Parameters on Stress-Strain Fields and Texture Evolution in Al-Cu-Sc Alloy Sheets
This version is not peer-reviewed. Guoge Zhang †,Lijie Liu †,Tuo Li,Shan Tang,Bo Gao * Guoge Zhang †,Lijie Liu †,Tuo Li,Shan Tang,Bo Gao * † These authors contributed equally to this work. Submitted: 27 October 2025 You are already at the latest version This work examines how rolling speed, feeding rate, and pass schedule—with a constant total reduction—affect the stress–strain fields, rolling force, and texture evolution of Al–Cu–Sc alloy sheets.
Archaeal Lipids: Extraction, Separation, and Identification via Natural Product Chemistry Perspective
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Transcriptomic Profiling Reveals Key Gene in Trichoderma guizhouense NJAU4742 Enhancing Tomato Tolerance Under Saline Conditions
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Turning antagonists into allies: Bacterial-fungal interactions enhance the efficacy of controlling Fusarium wilt disease
Abstract Intense microbial competition in soil has driven the evolution of resistance mechanisms, yet the implications of such evolution on plant health remain unclear. Our study explored the conversion from antagonism to coexistence between Bacillus velezensis (Bv) and Trichoderma guizhouense (Tg) and its effects on Fusarium wilt disease (FWD) control.
One‐Pot Hetero‐Di‐C‐Glycosylation of the Natural Polyphenol Phloretin by a Single C‐Glycosyltransferase With Broad Sugar Substrate Specificity
CGTs C-glycosyltransferases FcCGT C-glycosyltransferase from kumquat (Fortunella crassifolia) hUXS1 UDP-xylose synthase from Homo sapiens GmSuSy sucrose synthase from soybean (Glycine max) HPCD 2-hydroxypropyl-β-cyclodextrin UDP-Gal UDP-galactose UDP-Xyl UDP-xylose UDP-Glc UDP-glucose UDP-GlcA UDP-glucuronic acid UDP uridine-5'-diphosphate βGal-βGlc phloretin 3'-C-β-galactosyl-5'-C-β-glucosyl phloretin βGlc-βXyl phloretin 3'-C-β-glucosyl-5'-C-β-xylosyl phloretin Aryl di-C-glycosylation is a...
The Value of MRI and Radiomics for the Diagnostic Evaluation of Thyroid-Associated Ophthalmopathy
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Diagnostics
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Disorganized chromatin hierarchy and stem cell aging in a male patient of atypical laminopathy-based progeria mandibuloacral dysplasia type A - Nature Communications
Abstract Studies of laminopathy-based progeria offer insights into aging-associated diseases and highlight the role of LMNA in chromatin organization. Mandibuloacral dysplasia type A (MAD) is a largely unexplored form of atypical progeria that lacks lamin A post-translational processing defects. Using iPSCs derived from a male MAD patient carrying homozygous LMNA p.R527C, premature aging phenotypes are recapitulated in multiple mesenchymal lineages, including mesenchymal stem cells (MSCs).
Study on the Influence of Thickness on the Pre-Bending Process of the JCOE Forming Plate Edge of Nickel-Based Alloy N08810
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Correction: Open-flow microperfusion combined with mass spectrometry for in vivo liver lipidomic analysis
Correction: Open-flow microperfusion combined with mass spectrometry for in vivo liver lipidomic analysis Correction for ‘Open-flow microperfusion combined with mass spectrometry for in vivo liver lipidomic analysis’ by Tuo Li et al., Analyst, 2021, 146, 1915–1923, https://doi.org/10.1039/D0AN02189J. This article is Open Access This article has not yet been cited.
Treating a type 2 diabetic patient with impaired pancreatic islet function by personalized endoderm stem cell-derived islet tissue - Cell Discovery
Dear Editor, Type 2 diabetes (T2D) typically starts with insulin resistance in peripheral tissues and proceeds with gradual loss of islet function due to the reduction in β-cell mass or dedifferentiation of β cells1,2. More than 30% of T2D patients eventually rely on exogenous insulin treatment. Cadaveric islet transplantation is an effective treatment for insulin-dependent diabetes3,4.
Functional Study of Different Lignocellulases from Trichoderma guizhouence NJAU4742 in the Synergistic Degradation of Natural Straw
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Experimental Study on Coefficient of Restitution of Small-Sized Spherical Particles during Low-Speed Impact
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Two-Phase Fermentation Systems for Microbial Production of Plant-Derived Terpenes
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RIGP-Induced Surface Modification of Cellulose for the Preparation of Amidoxime-Modified Cellulose/Graphite Oxide Composites with Enhanced Uranium Adsorption
Download Hi-Res ImageDownload to MS-PowerPointCite This:Ind. Eng. Chem. Res. 2024, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
41.6 Gb/s High-Depth Pre-Interleaver for DFE Error Propagation in 65 nm CMOS Technology
1. Introduction As is known to all, “0” and “1” in a communication system, such as in 400 Gb/s Ethernet [1], Infiniband, and PCI-e 6.0 [2], can normally be transmitted in the forms of voltage and current through printed circuit board (PCB) wires. However, as the data rate increases sharply, the channel loss of PCB wires becomes larger and larger, as shown in Figure 1a.
The effects of Selenohomolanthionine supplementation on the rumen eukaryotic diversity of Shaanbei white cashmere wether goats - Scientific Reports
Abstract Selenium (Se) is an important microelement for animal health. However, the knowledge about the effects of Se supplementation on rumen eukaryotic community remains less explored.
Orthogonal Reversed-Phase C18 and Pentafluorophenyl HPLC Separation for Phytochemical Profiling of Serrulatanes in Eremophila denticulata
Download Hi-Res ImageDownload to MS-PowerPointCite This:J. Nat. Prod. 2023, XXXX, XXX Terms & Conditions Most electronic Supporting Information files are available without a subscription to ACS Web Editions. Such files may be downloaded by article for research use (if there is a public use license linked to the relevant article, that license may permit other uses).
The Fabrication of GaN Nanostructures Using Cost-Effective Methods for Application in Water Splitting
1. Introduction The use of clean energy is the primary goal for the sustainable development of human society [1,2,3]. Conventional fossil fuels release contaminated residue and greenhouse gases, which cause serious harm to the environment [4,5,6]. As the environmental crisis intensifies, researching clean, safe, and sustainable energy sources is indispensable for replacing traditional fossil fuels.
Vaccinia E5 is a major inhibitor of the DNA sensor cGAS - Nature Communications
Abstract The DNA sensor cyclic GMP-AMP synthase (cGAS) is critical in host antiviral immunity. Vaccinia virus (VACV) is a large cytoplasmic DNA virus that belongs to the poxvirus family. How vaccinia virus antagonizes the cGAS-mediated cytosolic DNA-sensing pathway is not well understood. In this study, we screened 80 vaccinia genes to identify potential viral inhibitors of the cGAS/Stimulator of interferon gene (STING) pathway.
Ubiquitin-like Conjugation by Bacterial cGAS Enhances Anti-phage Defence - Nature
Abstract cGAS is an evolutionarily conserved enzyme that plays a pivotal role in immune defense against infection1-3. In vertebrate animals, cGAS is activated by DNA to produce cyclic GMP-AMP (cGAMP)4,5, which leads to the expression of antimicrobial genes6,7. In bacteria, cyclic dinucleotide (CDN)-based anti-phage signaling systems (CBASS) have been discovered8-11.
Biosynthesis of Hybrid Neutral Lipids with Archaeal and Eukaryotic Characteristics in Engineered Saccharomyces cerevisiae
Graphical Abstract Reconstitution of archaeal lipid biosynthesis in eukaryotic Saccharomyces cerevisiae resulted in unexpected production of hybrid neutral lipids, which contain both archaeal isoprenoids and eukaryotic fatty acids. The responsible enzymes, diacylglycerol acyltransferases (DGATs), were found to be present in all domains of life.
Enlarged range of measurement method with strong noise resistance for dual-wavelength digital holography: erratum
Abstract We present an erratum to our Letter [Opt. Lett. 46, 4694 (2021) [CrossRef] ]. This erratum corrects an unintended error in the labels of Figs. 5(h)–5(j). The corrections have no influence on the results and conclusions of the original Letter. © 2022 Optica Publishing Group There was an unintended error in the labels of Figs. 5(h)–5(j) in the original Letter [1]. A version of the figure in question with the correct labels is shown in Fig. 1.
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis
Keeping cGAS silent Cells detect microbial and self-DNA in the cytosol as a danger signal that triggers immune and inflammatory responses. Paradoxically, a large fraction of a DNA-sensing enzyme called cGAS is tightly associated with the chromatin, especially during mitosis. Li et al. uncovered two mechanisms that prevent cGAS from being activated by the chromatin DNA (see the Perspective by Ablasser).
Phosphorylation and chromatin tethering prevent cGAS activation during mitosis
Abstract The cyclic GMP-AMP synthase (cGAS) detects microbial and self-DNA in the cytosol to activate immune and inflammatory programs. cGAS also associates with chromatin especially after nuclear envelope breakdown when cells enter mitosis. How cGAS is regulated during cell cycle transition is not clear. Here we found direct biochemical evidence that cGAS activity was selectively suppressed during mitosis, and uncovered two parallel mechanisms underlying this suppression.
Open-flow Microperfusion Combined with Mass Spectrometry for in vivo Liver Lipidomic Analysis
Open-flow Microperfusion Combined with Mass Spectrometry for in vivo Liver Lipidomic Analysis At present conventional microdialysis (MD) technique cannot efficiently sampling lipids in vivo, possibly due to the high mass transfer resistance and/or the serious adsorption of lipids on the semi-permeable membrane of MD probe. In vivo monitoring of lipids could be of great significance for the study of disease development and mechanism.
Mutation screening of 17 candidate genes in a cohort of 67 probands with early‐onset high myopia
Original Article Tuo Li Corresponding Author E-mail address: 13986840088@139.com https://orcid.org/0000-0002-4764-882X Department of Ophthalmology, The Central Hospital of Enshi Tujia And Miao Autonomous Prefecture, Enshi Clinical College of Wuhan University, Enshi, China Correspondence: Tuo Li E‐mail address: 13986840088@139.com Search for more papers by this author Author contributions: Fang Liu and Junwen Wang contributed equally to this work.
Co-Incorporated Mesoporous Carbon Material-Assisted Laser Desorption/Ionization Ion Source as an Online Interface of In Vivo Microdialysis Coupled with Mass Spectrometry
Download Hi-Res ImageDownload to MS-PowerPointCite This:Anal. Chem.
A trans-synaptic nanocolumn aligns neurotransmitter release to receptors
Abstract Synaptic transmission is maintained by a delicate, sub-synaptic molecular architecture, and even mild alterations in synapse structure drive functional changes during experience-dependent plasticity and pathological disorders1,2. Key to this architecture is how the distribution of presynaptic vesicle fusion sites corresponds to the position of receptors in the postsynaptic density.
A Cascade-Reaction Enabled Synergistic Cancer Starvation/ROS-mediated/chemo- Therapy with Enzyme Modified Fe-based MOF
A Cascade-Reaction Enabled Synergistic Cancer Starvation/ROS-mediated/chemo- Therapy with Enzyme Modified Fe-based MOF Zong-jun Liu, Tuo Li, Fang Han, Yang Gan, You Wang, Junhui Shi, Tianran Wang, Muhammad Luqman Akhtar and Yu Li Abstract Synergistic cancer starvation/ROS-mediated/chemo- therapy is developed through a cascade reaction with enzyme glucose oxidase (GOX) modified on the surface of Fe-based metal organic framework (MOF(Fe)) and drug camptothecin (CPT) loaded into the cavities of...
Autophagy induction via STING trafficking is a primordial function of the cGAS pathway
Abstract Cyclic GMP-AMP (cGAMP) synthase (cGAS) detects infections or tissue damage by binding to microbial or self DNA in the cytoplasm1. Upon binding DNA, cGAS produces cGAMP that binds to and activates the adaptor protein STING, which then activates the kinases IKK and TBK1 to induce interferons and other cytokines2,3,4,5,6. Here we report that STING also activates autophagy through a mechanism that is independent of TBK1 activation and interferon induction.
Metal-organic frameworks as affinity agents to enhance microdialysis sampling efficiency of fatty acids
Microdialysis (MD) has been extensively used for in vivo sampling of hydrophilic analytes such as neurotransmitters and drug metabolites. In contrast, there are few reports on sampling of lipophilic analytes by MD. Lipophilic analytes are easily adsorbed on the surfaces of the dialysis membrane and the inner wall of tubing, which leads to a very low relative recovery (RR).
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