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Articles by Wei Chi
Association of multisystem vascular-related disease with incident parkinsonism: insights from a cohort study
Abstract Systemic vascular dysfunction has been implicated in parkinsonism, but prospective evidence on the cumulative burden of multisystem vascular-related disease (MVRD) and its relation to genetic susceptibility remains limited. We included 456,862 UK Biobank participants of White ethnicity with available genetic data who were free of diagnosed parkinsonism at baseline. MVRD comprised ischemic heart disease, stroke, chronic kidney disease, retinopathy, and neuropathy.
AS-OCT dataset with anatomical structure segmentation and scleral spur localization in cataract and glaucoma
Abstract Anterior Segment Optical Coherence Tomography (AS-OCT) provides high-resolution, non-invasive visualization of the anterior eye and is widely used for clinical diagnosis and surgical planning. However, automated analysis of AS-OCT images remains limited by the lack of publicly available datasets with comprehensive anatomical annotations and disease labels.
Uncertainty-inspired open-set model for identifying infantile fundus abnormalities
Abstract Accurate and safe identification of infantile fundus abnormalities is critical for large-scale screening, yet remains challenging because of heterogeneous disease presentations and overconfident predictions by conventional artificial intelligence (AI) models. In this study, we aim to develop an uncertainty-inspired open-set (UIOS) system to address these challenges.
Pan-retinal pathology detection in oct scans integrating natural language synthesis with diagnostic annotation
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Abstract While OCT is pivotal for macular disease diagnosis, its adoption in primary care is limited by AI systems that cannot simultaneously analyze multi-sectional scans across the full spectrum of maculopathies or generate diagnostically integrated reports. Here we present iOCT, an intelligent OCT analysis system that integrates a multi-level annotation framework with data distillation to enable automated multi-sectional scan analysis and comprehensive natural language report generation.
By Wangting Li, Weihao Gao, LU CHEN, Dong Fang, Lujia Feng, Canfeng Huang, Jia Liang, Yingying Diao, Bingyu Bai, Ting Xie, Pengfeng Li, Huiyan Zheng, Weihua Yang, Xue Yao, Fang Li, Zheng Gong, Zhuo Deng, Wenyong Huang, Bing Zhang, Zixia Zhou, Li Cai, Hongchang Yang, Xiaoshan Fang, Yunxia Leng, Danna Chen, Yingying Liang, Xiaoyan Dou, Haoying Li, Gang Du, Yunwei Hu, Lan Ma, Wei Chi, Shaochong Zhang, Yijing Zhuang, Pengxue Wei, Xiangqing Hei, Xianling Tang, Zengfen Wu, Donghui Pu, Guangbing Zhong, Linyi Luo
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Nature
Verified
Cryo-EM structures of biopsy-derived TTR fibrils in hereditary transthyretin amyloidosis
Abstract Hereditary transthyretin amyloidosis (ATTRv) is a fatal autosomal dominant disease characterized by systemic deposition of transthyretin (TTR) amyloid fibrils, leading to progressive neuropathy and cardiomyopathy. More than 130 pathogenic mutations in the TTR gene have been identified, but their roles in TTR fibril formation and disease pathogenesis remain unclear.
NAD+ modulates mitochondrial vulnerability in MERTK-associated models of retinitis pigmentosa
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Abstract Retinitis pigmentosa (RP) is the most common inherited retinal degenerative disease leading to blindness. RP is characterized by progressive loss of photoreceptors and retinal pigment epithelium (RPE), leading to retinal degeneration. The mechanisms that initiate RP and drive retinal vulnerability are poorly understood, and new strategies for preventing and treating RP are urgently needed.
By Lujia Feng, Ting Zhang, Xiaohua Zhuo, Yantao Wei, Lixian Liu, Zhaohao Huang, Guoming Zhang, LU CHEN, Yong Du, Dong Fang, Wangting Li, Linbin Zhou, Ling Zhao, Yingting Zhu, Jia Liang, Zhiquan Li, Xiaojing Song, Xingxing Mao, Xiaofeng Hou, Wenru Su, Wei Chi, Yehong Zhuo, Shaochong Zhang, Yuwen Wen, Caibin Deng
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Nature
Verified
Quality improvement strategies for preventing tracheostomy-related pressure injuries in children: a systematic review and meta-analysis
Abstract Background: Children with tracheostomies represent a high-risk population for medical device-related pressure injuries (MDRPI) due to prolonged cannulation, immature skin, limited mobility, and exposure to secretions, consistent with NPIAP/EPUAP definitions. The development of pressure injuries not only prolongs hospitalization and escalates healthcare costs but may also precipitate severe infectious complications.
Conserved DNA architect couples chloroplast development to cell cycle in developing cotyledons
Abstract Light orchestrates cotyledon greening and growth by coordinating chloroplast development with cell division and expansion, yet the molecular integrator of these processes remains unknown. Here we identify RDE (REGULATOR OF DG1 EXPRESSION), a conserved DNA architectural factor that synchronizes thylakoid protein complex biogenesis during chloroplast development with the G1–S transition of cell cycle progression in Arabidopsis thaliana.
Metformin attenuates TBHP-induced oxidative injury in human lens epithelial cells and is associated with SIRT1/FOXO1-related autophagy
Loading metrics Open Access Peer-reviewed Research Article Citation: Yan Z, Chi W, Yan Z, Wang H (2026) Metformin attenuates TBHP-induced oxidative injury in human lens epithelial cells and is associated with SIRT1/FOXO1-related autophagy. PLoS One 21(4): e0346822.
Construction of virtual whole eye model based on ultra-widefield optical coherence tomography in myopia - npj Digital Medicine
Abstract Recognizing the inconvenience of magnetic resonance imaging (MRI) in evaluating the ocular morphology, this study developed a three-dimensional virtual whole eye model (CET-1) using ultra-widefield swept-source optical coherence tomography. The CET-1 were validated with MRI models in 80 eyes from 40 individuals with different extent of myopia.
JMJD2 regulates enhancer–promoter interactions via biomolecular condensate formation - Nature Genetics
Abstract Enhancer–promoter (E-P) interactions regulate transcription during cell fate determination. However, the regulatory mechanisms underlying E-P interactions have remained elusive. Here we present a chromatin-interaction-based proteomic approach, LoopID, to profile proteins (termed the looposome) at certain E-P anchors.
High-throughput capture of actively transcribed region-interacting sequences reveals an intricate promoter-centered regulatory network
TechnologyVolume 85, Issue 23p4463-4479.e7Open access 1Shenzhen Eye Hospital, Shenzhen Eye Medical Center, Southern Medical University, 18 Zetian Road, Futian District, Shenzhen 518040, China 2School of Public Health and Emergency Management, Southern University of Science and Technology, Shenzhen 518055, China 3State Key Laboratory of Genetic Evolution & Animal Models, Yunnan Key Laboratory of Biodiversity Information, KIZ-CUHK Joint Laboratory of Bioresources and Molecular Research in...
Function of plastid translation in plant temperature acclimation: Retrograde signalling or extraribosomal ‘moonlighting’ functions?
DATA AVAILABILITY STATEMENT The data that support the findings of this study are available on request from the corresponding author. The data are not publicly available due to privacy or ethical restrictions.
The role of miR-6884-5p in epithelial-mesenchymal transition in non-small cell lung cancer
Introduction Non-small cell lung cancer (NSCLC) is one subtype of lung cancer, and takes up 85% of lung cancer cases, with an estimated 500,000 new cases and 300,000 deaths each year. NSCLC accounts for about 80% of all lung cancers. The incidence of NSCLC rises as the median age at diagnosis falls. However, approximately 75% of patients who are diagnosed with NSCLC are in the middle and late stages with an extremely low 5-year survival rate.
The role of miR-6884-5p in epithelial-mesenchymal transition in non-small cell lung cancer
Research Paper Volume 16, Issue 2 pp 1968—1979 1 Department of Pulmonary and Critical Care Medicine (PCCM) Ward II, Cangzhou Central Hospital, Cangzhou 061000, Hebei, China 2 Department of Geriatrics, Cangzhou Central Hospital, Cangzhou 061000, Hebei, China https://doi.org/10.18632/aging.205474 How to Cite Cite this Article Select the format you require from the list below Click to copy this citation from the text box above or download the citation: Citation | This is an open access article...
Deep learning for detecting visually impaired cataracts using fundus images
1 Introduction Worldwide, the incidence of visual impairment is increasing (GBD, 2019 Blindness and Vision Impairment Collaborators, 2021), which is an important public health problem, with cataracts being the leading cause of visual impairment (Flaxman et al., 2017).
Association of TIM-3 with anterior uveitis and associated systemic immune diseases: a Mendelian randomization analysis
Introduction T-cell immunoglobulin and mucin domain (TIM) protein family members have been identified as important regulators of the immune response. TIM-family proteins, which belong to the Type I group of transmembrane proteins, contain an N-terminal variable immunoglobulin (IgV)-like and mucin-like domain in the extracellular region, a single transmembrane domain, and an intracellular domain (1, 2). TIM-3 is a member of the TIM family and functions as an inhibitory costimulatory signal (3, 4).
Rh(III)‐Catalyzed Annulative Coupling of Sulfoxonium Ylides with Allyl Acetates: Generation of Bicyclo[4.1.0]heptan‐2‐ones
Abstract Highly efficient Rhodium(III)-catalyzed annulative coupling was developed for generating of bicyclo[4.1.0] heptan-2-ones from sulfoxonium ylides and allyl acetates under mild conditions. This cascade reaction is good in universality to construct cyclopropanes, and the starting materials are more stable and easily obtainable. Supporting Information As a service to our authors and readers, this journal provides supporting information supplied by the authors.
Rh(III)‐Catalyzed Annulative Coupling of Sulfoxonium Ylides with Allyl Acetates: Generation of Bicyclo[4.1.0]heptan‐2‐ones
As a service to our authors and readers, this journal provides supporting information supplied by the authors. Such materials are peer reviewed and may be re-organized for online delivery, but are not copy-edited or typeset. Technical support issues arising from supporting information (other than missing files) should be addressed to the authors.
Intraoperative choroidal detachment during small-gauge vitrectomy: analysis of causes, anatomic, and visual outcomes
Abstract Introduction To investigate the incidence and causes of intraoperative choroidal detachment (CD) during small-gauge vitrectomy, as well as the anatomic and visual outcomes. Methods We retrospectively reviewed the medical records of 1026 consecutive patients who underwent small-gauge vitrectomy from June 2017 to December 2018 at Zhongshan Ophthalmic Centre, Guangzhou, China.
Distinguishing Microvasculature Features of Vogt-Koyanagi-Harada in Patients in Acute and Convalescent Phases Using Optical Coherence Tomography Angiography
Purpose: To evaluate retinal and choroidal microvascular features of VKH patients in acute and convalescent phases after treatment using OCTA. Methods: A prospective, observational study was conducted in patients with initial VKH at the acute stage (n = 15) and healthy participants (n = 15) served as controls. After 3-month systemic corticosteroid treatment, patients’ vascular parameters were recorded by OCTA before and after treatment and compared with results observed in healthy participants.
Volatility spillover between the US, Chinese and Australian stock markets
Ali, A, Daly, K (2010) Macroeconomic determinants of credit risk: Recent evidence from a cross country study. International Review of Financial Analysis 19: 165–171. Google Scholar | Crossref Allen, DE, McAleer, M, Powell, RJ. (2017) Volatility spillovers from Australia’s major trading partners across the GFC. International Review of Economics & Finance 47: 159–175.
IL‐27 Signaling Deficiency Develops Th17‐enhanced Th2‐dominant Inflammation in Murine Allergic Conjunctivitis Model
Background While most studies focus on pro‐allergic cytokines, the protective role of immunosuppressive cytokines in allergic inflammation is not well elucidated. This study was to explore a novel anti‐inflammatory role and cellular/molecular mechanism of IL‐27 in allergic inflammation. Methods A murine model of experimental allergic conjunctivitis (EAC) was induced in BALB/c, C57BL/6 or IL‐27Rα deficient (WSX‐1‐/‐) mice by short ragweed pollen, with untreated or PBS‐treated mice as controls.
Purtscher-like retinopathy as a first manifestation of systemic lupus erythematosus
Dai Ye, Chi Wei. Purtscher-like retinopathy as a first manifestation of systemic lupus erythematosus BMJ 2018; 360 :j5551
Plastid-nucleus communication involves calcium-modulated MAPK signalling
The abi4, mpk3 (Salk_100651), mpk6 (Salk_127507), cas-1(Salk_070416) and MKK5DD transgenic plants were described previously24, 28, 35. Homozygous mutant lines were identified by PCR analysis using specific primers (Supplementary Table 2). All the mutants used in this study are in the Columbia background. Wild type and mutant seeds were sterilized with 10% sodium hypochlorite for 10 min, washed five times with sterile water, and sown onto MS medium.
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