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Articles by Wei Ma
ALKBH5 exerts an m6A-independent function to control the spindle assembly in oocytes through KIF22
Abstract ALKBH5 is a key determinant of oocyte quality by regulating N6-methyladenosine (m6A) to maintain maternal RNA stability in oocytes. However, the role of ALKBH5 in oocytes other than m6A has not been reported. Here, we document that ALKBH5 is expressed and localized to spindle during mouse oocyte meiotic maturation. The abnormal spindle in Alkbh5-/- oocytes can be both partially restored by the ectopic expression of exogenous wild-type Alkbh5 and enzymatically dead Alkbh5-H205A.
Water-oil interfacial kinetics control enables water-based organic solar cells with 12.59% certified efficiency
Abstract Organic solar cells (OSCs) are promising for clean-energy generation, but sustainable production remains constrained by hazardous organic solvents. Aqueous organic-semiconductor nanoparticle (NP) inks offer an environmentally friendly route to OSCs, yet low efficiency and limited stability hinder practical application. Here we report an interfacial-tension-mediated strategy that regulates NP structure and film formation.
Real-world safety and efficacy of blinatumomab for EBV viremia and EBV-related PTLD after allogeneic hematopoietic stem cell transplantation
To the Editor, Epstein–Barr virus (EBV) viremia and EBV-related post-transplant lymphoproliferative disorder (PTLD) remain major complications after allogeneic hematopoietic stem cell transplantation (allo-HSCT), occurring in approximately 30–60% and 1–10% of recipients, respectively, and reaching 70–80% and >15% in high-risk populations; PTLD mortality exceeds 50% [1,2,3,4].
Amplitude-controllable event-driven organic photosensors based on ionic-mediated inhibition
Abstract Next-generation artificial vision systems must integrate rapid temporal-contrast detection with dynamic sensory-gain modulation to prioritize task-relevant stimuli. Conventional semiconductor photosensors lack intrinsic mechanisms for spike generation with tunable amplitude, requiring complex multitransistor architectures and limiting efficiency.
Configuration optimization of underwater glider observation array for reconstruction of Mesoscale Eddy 3D structure
Abstract To address the issue that current underwater glider deployments for in situ observation of the 3D structure of mesoscale eddies are largely guided by empirical knowledge rather than a systematic quantitative evaluation framework, this paper, based on a synthesized anticyclonic eddy field in the northern South China Sea, systematically evaluates the reconstruction performance of three array topologies (parallel, grid, and radial) through numerical simulations, and proposes a...
Spontaneous Cyclic Levitation of Glycerol-Water Droplets at Low Pressures
1 Introduction Phase transitions of water are critical in fluid management, with applications ranging from biological preservation [1] and materials processing [2-4] to thermal management [5] and extraterrestrial resource utilization [6]. Unlike atmospheric phase changes, which are typically constrained by high saturation temperatures and heat transfer limits, low-pressure environments allow water's internal sensible heat to drive intense vaporization [7].
Unraveling the dual interaction patterns of land use intensity on carbon balance: spatial heterogeneity and drivers in a transitional region of China
Abstract Under China’s “Dual Carbon” goals, accurate assessment of regional carbon balance is of critical importance. Land use acts as a core factor governing carbon balance. However, the differentiated effects of land use intensity (LUI)—a comprehensive indicator quantifying human intervention on carbon storage, sequestration, and emissions, as well as their spa-tial driving factors, remain poorly understood.
Investigation on cross-scale coupled airflow-dust evolution and highly efficient integrated “source-suction and airflow-barrier” control technology for low-height rapid tunneling faces
Abstract Aiming at the respirable dust hazards caused by restricted space, dense equipment layout, and high dust generation intensity during rapid excavation in low-seam coal mines with a seam height below 2.85 m, this study investigated the cross-scale coupled evolution mechanism of airflow and dust in low-height excavation roadways. An onboard integrated dust control and removal technology combining “source suction purification” and “airflow diffusion control” was proposed.
Geometry-Aware Correspondence Learning for Sparse and Low-Overlap LiDAR Point Cloud Registration
Conflicts of Interest The authors declare no conflicts of interest. Data Availability Statement The data that support the findings of this study are available from the corresponding author upon reasonable request. References , , , , and . 2024. “PointTr: Low-Overlap Point Cloud Registration With Transformer.” IEEE Sensors Journal 24, no. 8: 12795–12805. https://doi.org/10.1109/JSEN.2024.3371021. , , , et al. 2023.
CDK2-mediated phosphorylation of TRF1 S11 facilitates DNA damage repair by remodeling telomeric chromatin
Abstract Telomeres, coated by the shelterin complex, prevent end-to-end fusions and aberrant DNA repair, yet how telomere-binding proteins coordinate chromatin remodeling during the DNA damage response remains unclear. Here we show that the telomeric protein TRF1 is phosphorylated at serine 11 (S11) in response to DNA double-strand breaks, a modification that enhances cellular resistance to DNA damage.
Zafirlukast ameliorates skin fibrosis through combined cellular inhibition effect on mast cells and fibroblasts
Abstract Mast cells and fibroblasts are essential regulators in the progress of skin fibrosis, while little is known for treatments of skin fibrosis in targeting both mast cells and fibroblasts. Zafirlukast, a leukotriene receptor antagonist, has shown positive effect on various inflammatory and fibrotic diseases. However, whether zafirlukast plays a role in skin fibrosis by targeting mast cells and fibroblasts was still unclear.
Deciphering the Formulation-Dependent Neurotoxicity of Irinotecan: An Integrated Pharmacovigilance and Mechanistic Study
1 Introduction Irinotecan, a topoisomerase I inhibitor, is a cornerstone of chemotherapy regimens for metastatic colorectal, gastric, and pancreatic cancers [1]. Despite its efficacy, treatment is often limited by adverse effects, with neurotoxicity emerging as a clinically significant concern [2]. Notably, clinical reports and trials suggest a disparity in neurotoxicity profiles between the conventional formulation (C-Irinotecan) and its liposomal counterpart (L-Irinotecan) [3, 4].
Effects of dietary N-carbamylglutamate supplementation on growth performance, meat quality, and cecal microbiota in Huoyan geese
Abstract This study evaluated dietary N-carbamylglutamate (NCG) effects on growth performance, body size indices, meat quality, and intestinal morphology in Huoyan geese, aiming to identify the optimal supplemental dose. Only the control and 0.06% NCG groups underwent 16S rRNA sequencing to explore associations between cecal microbiota and meat quality.
ZEB1 directly activates IL-6 to promote triple-negative breast cancer stemness in an epigenetically constrained context
Abstract ZEB1 is a key driver of breast cancer pathogenesis and therapy resistance, largely through its ability to promote cancer stem cells (CSCs). Although tumor-secreted cytokines such as IL-6 are known to support tumor progression, how their expression is regulated by upstream transcriptional factors such as ZEB1 remains incompletely understood. Here, we identify IL-6 as a direct transcriptional target of ZEB1 and reveal an epigenetic dimension associated with this regulation.
Systematic evaluation of long-read and short-read sequencing in neurological disorders diagnosis: a direct comparison study of 310 patients
Abstract Genetic neurological disorders are highly heterogeneous, and many are driven by complex variants that challenge short‑read genome sequencing (srGS). Long‑read genome sequencing (lrGS) has recently shown promise, but head‑to‑head evaluations are limited. A direct comparison study of srGS and lrGS was performed for 310 families with undiagnosed neurological disorders from the Hong Kong Genome Project to assess their diagnostic performance, technical capabilities and costing.
AI-CURA, an automated LLM workflow for high-accuracy genetic variant classification
Editor’s summary Abstract Supplementary Materials REFERENCES AND NOTES Information & Authors Metrics & Citations Check Access References Figures Tables Media Share Editor’s summary Genetic sequencing is essential for the medical care of many patients, but the need for extensive literature analysis and human data interpretation remain bottlenecks to its more widespread use. Ma et al.
Author Correction: UV and thermally stable hole-selective contacts with enhanced assembly density for inverted perovskite solar cells
Correction to: Nature Materials https://doi.org/10.1038/s41563-026-02619-1, published online 1 June 2026. In the version of the article initially published, the same image was used for both the “HOMO” and “LUMO” diagrams of “MeO-2PACz” in Fig. 1m. The “LUMO” diagram has now been corrected in the HTML and PDF versions of the article. About this article Zhan, L., Sun, Z., Zhang, S. et al.
UV and thermally stable hole-selective contacts with enhanced assembly density for inverted perovskite solar cells
Abstract The development of efficient inverted perovskite solar cells has been propelled by the adoption of self-assembled monolayers as hole-selective contacts. Nevertheless, the durability of such devices is still hampered by the vulnerability of conventional carbazole molecules to ultraviolet (UV) damage and thermal instability of phosphonic acid anchors.
Delayed cation dynamics enables dual-doped organic electrochemical transistors with high current sensitivity
Abstract The coupling between ionic and electronic species and their dynamic interplay lay the foundation for organic electrochemical transistors (OECTs) to transduce and amplify bio(chemical) signals through ion-modulated conductivity.
Early imaging differentiation of children with acute hematologic malignancies that present in pancytopenia: a retrospective study
Abstract Objectives: This retrospective cohort study aimed to identify potential differentiation indicators on thoracic and abdominal computed tomography (CT) among three hematologic malignancies characterized by acute pancytopenia in children. Methods: This study was conducted at the Children’s Hospital of Chongqing Medical University, Chongqing, China.
Population-scale genomic medicine with the Hong Kong Genome Project
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Abstract The Hong Kong Genome Project (HKGP) aims to build a foundational resource for precision medicine in the Chinese population through large-scale genome sequencing and integrated analyses. Here we report findings from over 20,000 HKGP participants across two cohorts: a rare disease cohort including 2,227 patients with suspected genetic diseases and a population cohort including 18,261 participants undergoing genomic screening for medically actionable findings.
By Dingge Ying, Ching-Lung Cheung, Chun-Kwan O, Chak Sing Lau, Ho Ming Luk, Christopher Brandon Preusch, Wei Ma, Wenshu Tang, Juliana Chan, Yap-Hang Chan, Shuk Ching Chong, Cheuk Fung, Stephanie Ho, Suhas Krishnamoorthy, Gabriel Matthew Leung, QING LI, Herbert Loong, Shan Luo, Becky Mingyao Ma, Rong Na, Sheila Suet-Na Wong, Su-Vui Lo
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Nature
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Nitrous oxide controls the DCN to VTA dopamine circuit by enhancing AMPA receptor functions during rewarding behavior
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Abstract Nitrous oxide (N2O) is a frequently used recreational drug with significant addictive potential. The ventral tegmental area (VTA) is a key brain region associated with the rewarding effects of drugs of abuse. However, how N2O influences VTA functions to mediate reward-related behavior remains poorly understood.
By Fukang Zhang, Shuyuan Fan, Shiqi Li, Yixin Xu, Yujing Wang, Xuan Liu, Wei Ma, Jianchen Zhang, Feng Hua Ding, Fangyuan Yin, Li Zhou Verified, Shanwu Feng, Jie Sun, Tengfei Ma, Yuxu Ren
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Nature
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Intra-mitochondrial glycolysis maintains mitochondrial function and underlies the pathogenesis of retinitis pigmentosa
Abstract Glycolysis is classically defined as a cytoplasmic process. Here, in our investigation of mitochondrial dysfunction in Retinitis Pigmentosa (RP), we report the unexpected discovery of a complete and functional glycolytic pathway operating inside mitochondria. Through CoIP-MS, polysome profiling, and [U-13C] glucose isotope tracing, we demonstrate that key glycolytic enzymes are locally translated and metabolically active within the organelle.
Correction to “Environmental Occurrence, Source Identification, and Health Hazards of Ultrashort-Chain PFAS in the Yangtze River Delta” Click to copy article link Article link copied!
The Supporting Information associated with the original manuscript contained typographical errors in the descriptions of the calibration procedure for trifluoroacetic acid (TFA) and the internal standard addition. The specific corrections to Text S1 and Text S3 are detailed in Table 1 (changes are highlighted in bold). The corrected Supporting Information is provided in full. Table 1. Corrections to the Supporting Texts (changes are highlighted in bold) originalcorrected Text S1.
Abstract The development of high-performance perovskite–organic tandem solar cells has been impeded by the scarcity of efficient narrow-bandgap small-molecule acceptors. Realizing such materials requires overcoming the energy gap law to minimize the energy loss and simultaneously optimizing the donor–acceptor phase separation.
Polyfluorophenyl quinoxaline derived acceptors with long exciton diffusion length for efficient thin-film/thick-film organic solar cells
Abstract Designing small-molecule acceptors (SMAs) with long exciton diffusion length (LD) and high electron mobility is vital for boosting power conversion efficiency (PCE) of organic solar cells (OSCs). However, the limited LD of most advanced SMAs hinders their practical applications in thick-film OSCs. Herein, we develop four SMAs (named Yq-0F, Yq-2F, Yq-4F, and Yq-6F) with fluorine-free/fluorinated phenyl-substituted quinoxaline cores by manipulating the number of fluorine atom.
Experimental Study of Freeze–Thaw Effects on the Dynamic Characteristics of Compacted Loess with Various Moisture Contents
Get full access to this article View all available purchase options and get full access to this article. Data Availability Statement Some or all data, models, or codes that support the findings of this study are available from the corresponding author upon reasonable request. Acknowledgments The authors express their gratitude to Prof. Lanmin Wang, Prof. Yongqi Su, Prof.
Concomitant Effect of Left-Wing Disaccharide, Chain Length, and Modification of C23-Aldehyde: An Effort to Develop Simple and Effective QS-21 Derivative Vaccine Adjuvants and Exploration of the Structural–Activity Relationship Click to copy article link A
On day 42 after the first immunization, the mice were euthanized and their spleens were collected. Single-cell suspensions were prepared by grinding and filtering. RBCs were lysed with lysis buffer for 5 min, followed by washing with PBS two times. The cells were suspended in a culture medium and stained with FITC antimouse CD3e (ABclonal), ABflo647 antimouse CD4 (ABclonal), ABflo594 antimouse CD8a (ABclonal), and PE antimouse NK1.1 (ABclonal) according to the manufacturer’s instructions.
Seasonal Variations of the Impacts of Low-Level Jets on Surface Ozone Photochemistry in Beijing Click to copy article link Article link copied!
Occurrence, Fate, and Transport of Aquatic and Terrestrial ContaminantsMarch 25, 2026 Yuzheng Wang Aerosol and Haze Laboratory, Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China Wei Ma Aerosol and Haze Laboratory, Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China Pengkun Ma Institute of Urban Meteorology, Chinese Meteorological...
A Stainless Steel Filter-Based Infrared Spectroscopy Method for Monitoring Hourly Evolution of Functional Groups in PM2.5
Cite Jump to ExpandCollapse ArticleMarch 4, 2026 A Stainless Steel Filter-Based Infrared Spectroscopy Method for Monitoring Hourly Evolution of Functional Groups in PM2.5 Click to copy article linkArticle link copied! Penghan Wang Penghan Wang Aerosol and Haze Laboratory, Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China Wei Ma* Wei Ma Aerosol and Haze Laboratory, Advanced Innovation Center for Soft Matter...
Ketogenic diet alleviates septic lung injury via microbial gut-lung axis
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Keywords sepsis ketogenic diet gut-lung axis Lactobacillus macrophages efferocytosis Get full text access Log in, subscribe or purchase for full access. References 1. Reyes, M. ∙ Filbin, M.R. ∙ Bhattacharyya, R.P. ... An immune-cell signature of bacterial sepsis Nat. Med. 2020; 26:333-340 2. Liu, V. ∙ Escobar, G.J. ∙ Greene, J.D. ... Hospital deaths in patients with sepsis from 2 independent cohorts JAMA. 2014; 312:90-92 3. Paoli, C.J. ∙ Reynolds, M.A. ∙ Sinha, M. ...
By Mingyuan Wei, Xinzhu Yi, Zhuandi Lin, Jingjing Cai, Shanze Chen, Fang Zhou, Hanqin Cai, Xinfeng Lu, Juan Tang, Yunfeng Shi, Liping Cui, Xinru Jing, Yunong Zeng, Rong Wu, Tingting Shu, Yuanyuan Li, Fangyuan Yang, Yi He, Zhibin Zhao, Yuqiong Yang, Wenjiao Zhu, Qiong Jiang, Weiwei Zhang, Xiang L. Tan, Zhuo Ma, Xiaoying Fan, Wei Ma, Wensheng Shu, Hong Wei, Zhiming Xiang, Jack Gilbert, Shenhai Gong, Zhang Wang
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Cell Metabolism
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Women’s Knowledge, Attitude, and Practice Regarding Oral Short-Acting Contraceptives After Induced Abortion: A Cross-Sectional Study in Beijing, China
Back to Journals » International Journal of Women's Health » Volume 18 Authors He S, Ma W, Gao J, Zhao J Received 3 March 2026 Accepted for publication 7 July 2026 Published 30 July 2026 Volume 2026:18 606368 DOI https://doi.org/10.2147/IJWH.S606368 Checked for plagiarism Yes Review by Single anonymous peer review Peer reviewer comments 2 Editor who approved publication: Dr Matteo Frigerio Shan He, Wei Ma, Jie Gao, Juan Zhao Department of Reproduction and Obstetrics, Beijing Luhe Hospital,...
From Functional Group and Metabolite Analysis to Rational Design: Discovery of BXY-14 as a Highly Potent TLR2 Agonist with Enhanced Vaccine Adjuvants and Cancer Immunotherapy
Abstract Click to copy section linkSection link copied! TLR2 bridges innate and adaptive immunity, with agonists showing promise in vaccines and cancer therapy. In this study, we found natural product CaLGL-1, which functions as a “quiescent agonist” of TLR2, with its immunostimulatory potential masked by a labile acetal group. In an oxidative environment, CaLGL-1 is converted into potent TLR2 agonist.
Gapless pangenome analyses reveal fast Brassica rapa subspeciation
Editor’s summary Pangenomes were developed to better encompass genetic variation across a species, but this concept is now being expanded to include variation across subspecies as well as genera. A pair of papers in this issue report pangenome creation for crops, which particularly benefit from this analysis approach given their high levels of diversification and ploidy (see the Perspective by Soltis and Soltis). Ma et al.
Retinoic acid inhibits the infection of porcine reproductive and respiratory syndrome virus
Abstract Introduction: Porcine reproductive and respiratory syndrome virus (PRRSV) is a major pathogen threatening the global swine industry, with existing vaccines failing to provide broad protection due to the high viral genetic variability and immune evasion capacity. Retinoic acid (RA), a vitamin A metabolite known for immunomodulatory functions, has been reported to enhance antiviral innate immunity and suppress excessive inflammation.
An uORF-encoded mobile peptide sparks systemic stomatal immunity
Keywords uORF mobile peptide systemic stomatal immunity receptor SIRK1 KIN7 MC4 Get full text access Log in, subscribe or purchase for full access. References 1. Melotto, M. ∙ Underwood, W. ∙ He, S.Y. Role of stomata in plant innate immunity and foliar bacterial diseases Annu. Rev. Phytopathol. 2008; 46:101-122 2. Hou, S. ∙ Rodrigues, O. ∙ Liu, Z. ... Small holes, big impact: stomata in plant-pathogen-climate epic trifecta Mol. Plant. 2024; 17:26-49 3. Melotto, M. ∙ Underwood, W. ∙ Koczan, J. ...
Early risk stratification of sepsis-related liver injury via machine learning: a multicohort study
Department of General Surgery, Nanjing Jinling Hospital, Affiliated Hospital of Medical School, Nanjing University, Nanjing, China Background: Sepsis-related liver injury (SRLI) is associated with poor prognosis and high morbidity in septic patients. Early mitigation of liver injury is crucial for improving outcomes in the critically ill. However, early detection and intervention remain challenging, due in part to the lack of effective diagnostic and screening strategies.
Arthroscopic internal drainage of popliteal cysts using the figure-of four position: a retrospective case series
Arthroscopic internal drainage of popliteal cysts using the figure-of four position: a retrospective case series Department of Orthopedics, Hangzhou Third People’s Hospital, Hangzhou, China DOI 10.7717/peerj.20658 Academic Editor Mehmet Burak Ateş Subject Areas Orthopedics, Sports Injury, Sports Medicine Keywords Popliteal cysts, Baker’s cysts, Arthroscopy, Internal drainage Copyright © Licence This is an open access article distributed under the terms of the Creative Commons Attribution...
R-NTN: a robust detection method for Ethereum phishing attacks based on multi-dimensional transaction features
Blockchain technology, proposed by Satoshi Nakamoto in 2008, has garnered widespread attention due to its characteristics of decentralization, immutability, transparency, anonymity, security, and programmability (Nakamoto, 2008). Blockchain does not rely on any central authority or third-party trust; instead, it maintains a reliable database through a distributed ledger system, with all participants jointly maintaining the integrity of the database (Iansiti & Lakhani, 2017).
High Aerosol Ionic Strength Possibly Affecting Nocturnal Chlorine Formation via Heterogeneous Reaction in Urban Beijing
Occurrence, Fate, and Transport of Contaminants in Indoor Air and AtmosphereDecember 31, 2025 Wei Ma Aerosol and Haze Laboratory, Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China High-Tech Research Institute, Beijing University of Chemical Technology, Beijing 100029, China Xin Chen Aerosol and Haze Laboratory, Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical...
High Aerosol Ionic Strength Possibly Affecting Nocturnal Chlorine Formation via Heterogeneous Reaction in Urban Beijing
Cite Jump to ExpandCollapse Occurrence, Fate, and Transport of Contaminants in Indoor Air and AtmosphereDecember 31, 2025 High Aerosol Ionic Strength Possibly Affecting Nocturnal Chlorine Formation via Heterogeneous Reaction in Urban Beijing Click to copy article linkArticle link copied! Wei Ma Wei Ma Aerosol and Haze Laboratory, Advanced Innovation Center for Soft Matter Science and Engineering, Beijing University of Chemical Technology, Beijing 100029, China High-Tech Research Institute,...
Impact of Digital Economy on Natural Resources Utilization Efficiency and Its Spillover Effect in the Belt and Road Initiative Countries
1 Introduction Natural resources are vital inputs for the development of agriculture, industry, and services, significantly contributing to trade growth, economic progress, and national competitiveness (Kerner et al. 2023; Singh et al. 2024). However, overexploitation and unsustainable practices have led to widespread environmental damage and rapid resource depletion, thereby threatening the global ecological balance (Jiao et al. 2023; Tahir et al. 2024).
Catalytic performance of ‘silica-rich core/catalytic shell' type HZSM-5 in the alkylation of 1,2,4-trimethylbenzene with methanol
ABSTRACT By selectively passivating acidic sites in the mid-section of the catalyst pores, an acidity-graded channel with the active regions at both ends and the inert region in the middle is constructed, where it can provide the most optimal catalytic micro-environment.
[2510.24460] Collaborating Unmanned Aerial Vehicle and Ground Sensors for Urban Signalized Network Traffic Monitoring
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Cell-type-specific defense priming and NHP-dependent systemic immunity against Pectobacterium in Chinese cabbage
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