Wei Meng
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Articles by Wei Meng
TRIM21-dependent ubiquitination of MCCase induced by hsa_circ_0009061 drives H3K36 crotonylation to suppress epithelial ovarian cancer progression through regulating glycolysis
Abstract Histone lysine crotonylation plays a pivotal role in gene transcription in diseases. However, the relationship between its levels and epithelial ovarian cancer (EOC) peritoneal metastasis remains unclear. Here, we report that the circular RNA hsa_circ_0009061 is crucial for 3-Methylcrotonyl-CoA carboxylase (MCCase)-mediated lysine crotonylation and glycolysis. Hsa_circ_0009061 acts as a tumor suppressor and inhibits EOC metastasis as well as glycolysis.
Computer Science > Computer Vision and Pattern Recognition
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Habitat-Based Radiomics Model of Pretreatment CT to Predict Pathological Response of Esophageal Squamous Cell Carcinoma to Neoadjuvant Chemoimmunotherapy: A Multicenter Prospective Study
Abbreviations LA-ESCC (locally advanced esophageal squamous cell carcinoma) NCIT (neoadjuvant chemoimmunotherapy) ML (machine learning) TRG (tumor regression grades) SHAP (shapely additive explanations) AUC (area under the receiver operating characteristic curve) ROC (receiver operating characteristic) Keywords Esophageal squamous cell carcinoma CT Habitat radiomics Neoadjuvant chemoimmunotherapy Tumor regression grades Get full text access Log in, subscribe or purchase for full access.
Repeated restraint stress enhances visual plasticity through locus coeruleus (LC)-V1 projection in adult mice
Abstract Stress modulates a broad range of brain functions, including the visual system. However, the specific neural mechanisms by which stress regulates function and plasticity in the adult visual system remain unclear. This study demonstrates that repeated restraint stress selectively enhances ocular dominance plasticity (ODP) in the primary visual cortex (V1) of adult mice. This stress-induced reinstatement of ODP depends on noradrenergic (NE) signaling.
Electrodeposited self-assembled molecules for perovskite photovoltaics
Abstract Preventing the detachment of self-assembled molecules (SAMs) and enhancing their passivation effect on perovskites are critical challenges for improving the performance and stability of perovskite solar cells (PSCs)1–3. Electrodeposited SAMs provide a route to improve coverage uniformity and anchoring robustness on conductive substrates beyond the limitations of conventional solution processing.
Account–Governance Platform Drift in Digital Financial Assets: A Reliability-Sensitive Socio-Technical Systems Analysis of Golden Apple’s Russian Digital Debt Issuance
You are already at the latest version Regulated digital financial assets can become more than financing instruments when issued through platform account infrastructures, but public texts do not directly reveal customer behavior. This article examines Golden Apple’s Russian digital financial asset issuance as a mechanism-informative socio-technical case and asks how public texts make account–governance platform drift visible before customer-behavior evidence is publicly closed.
Charts of the Day: Chinese Airlines Cancel More Flights Ahead of Holiday
1. A wave of flight cancellations is affecting international routes ahead of China's Labor Day holiday (May 1-5), driven by surging jet fuel prices forcing airlines to reduce capacity [para. 1][para. 2]. 2. Travelers report abrupt cancellations of pre-booked flights to destinations like Vietnam and Bangkok, with refunds offered but skyrocketing prices and no rebooking options due to full route suspensions, leaving prepaid accommodations wasted [para. 3][para. 4]. 3.
Strain‒induced spin regulation of stepped Co(111) for boosting peracetic acid magnetocatalysis
Abstract Atomic site–specific reactivity induced by the lattice distortion has garnered increasing research interest for advancing the heterogeneous catalytic conversions, owing to strain–field–tunable electronic structure of the distorted active sites. Here, we prepare the catalysts with reactive center of ferromagnetically nanoparticulate cobalt that is fully exposed by the Co(111) lattice plane with increasing strain.
A Biomimetic Framework for Collective Sensing and Immune-Inspired Verification in Complex Risk Analysis
You are already at the latest version Generative AI, retrieval-augmented architectures, and multi-source automated analytical tools are now being deployed in increasingly exacting risk-analytic environments. Yet faster processing has not yielded commensurate reductions in false alarms, missed alarms, hallucinated outputs, or failures of responsibility attribution.
Thinner-than-paper and broad-temperature-adaptive zinc-iodine batteries enabled by nanophase separated deep-eutectic hydrogel electrolytes
Abstract Hydrogel electrolyte based secondary batteries are promising for wearable electronics, yet face challenges including limited mechanical resilience, and narrow temperature range. Herein, we report a robust deep-eutectic hydrogel electrolyte fabricated via synergistic interplay of dual nanophase separation, hydrated eutectic solvation, and hydrogen-bond networks.
Rare Cause of Mitral Prolapse: Myocardial Infarction With Nonobstructive Coronary Arteries
Get full access to this article View all available purchase options and get full access to this article. Supplemental Material File (circcvim-2025-019488-s01.mp4) Videos S1–S2 File (circcvim-2025-019488-s02.mp4) File (circcvim-2025-019488-s03.pdf) References 1. Delgado V, Ajmone Marsan N, Bonow RO, Hahn RT, Norris RA, Zühlke L, Borger MA. Degenerative mitral regurgitation. Nat Rev Dis Primers. 2025;9:70. doi: 10.1038/s41572-023-00478-7 2.
The ‘Weaponisation of Fireworks’ and ‘Hollowed-Out Command’: A Systematic Risk Analysis of Non-Combatant Military Forces-A Comparative Institutional Study Centred on Authentic Battlefield Pressure Screening and ‘Rank Credibility Capital’[v1] | Preprints.o
Submitted: 28 January 2026 You are already at the latest version Non-combat environments do not inherently diminish military capabilities, but they systematically alter an organisation's feedback structures and promotion signals, thereby inducing two highly correlated risk states: Firstly, the ‘weaponry becoming mere pyrotechnics’ phenomenon, wherein equipment development and training outputs progressively shift from adversarial validation towards demonstrative proof, with organisations...
Triple Critique: Formal Logical Audit, Generative Verification of Intellectual History, and Consistency Testing with Sinicised Marxism in the New Era--A Review of Liu Tongfang's Marx's Intellectual Measure[v1] | Preprints.org
Submitted: 16 January 2026 You are already at the latest version This study takes Liu Tongfang's article Marx's Intellectual Measure, published in Guangming Daily, as its sole subject of investigation. Its objective is to examine the theoretical validity and interpretative boundaries of the author's approach to synthesising Marx's thought through the concept of ‘measure’.
From the “Cost of Living Narrative” to “Class Perception Divide”: The Social Consequences of Public Figures' Discourse and Their Ethical Responsibilities in the Arts and Literature - Taking the Controversy Surrounding Yan Xuejing's Live-Streamed Remarks a
Submitted: 10 January 2026 You are already at the latest version Taking the recent widespread controversy surrounding Yan Xuejing's live-streamed remarks as a case study, this paper analyses how public figures' discourse within commercial communication spheres is amplified by algorithms through digital expression and metaphorical labelling, thereby triggering class perception fractures and group emotional polarisation.
Policy as an Acceleration System: The Doctrine of Speed, Institutional Engineering, and Auditable Execution Mechanisms in the US Department of War’s ‘War Mobilisation-Level Artificial Intelligence Strategy’
Submitted: 17 January 2026 You are already at the latest version This paper proposes and validates a computable interpretative framework for ‘policy as an acceleration system’, using as its sole material the policy directive text issued by the US War Department on 9 January 2026: the Memorandum from Senior Leadership at the Pentagon: Artificial Intelligence Strategy for the Department of War.
From Technological Disruption to Institutionalised Assimilation-A Computational Content Analysis, Semantic Embedding and Longitudinal Discourse Drift Study Based on the Proceedings of the 2025 Intelligence Research Summit at the US Intelligence University
Submitted: 04 January 2026 You are already at the latest version Against the backdrop of artificial intelligence (AI) and cyber intelligence (CyINT) becoming increasingly embedded within intelligence systems, the core challenge facing intelligence organisations is no longer ‘whether to adopt new technologies’, but rather ‘how to transform technological disruption into governable, measurable, and trainable institutional capabilities’.
Computable Structures of National Narratives: A Model for Generating Governance Legitimacy Based on Computational Content Analysis, Emotional Mediation, and Semantic Networks
Submitted: 31 December 2025 You are already at the latest version This paper proposes the Computable Structure of National Narrative (CSNN) framework, treating state-level political texts as engineering-oriented governance systems. Using President Xi Jinping's 2026 New Year Address as a case study, it constructs a multi-level variable and causal pathway model encompassing ‘governance input—transformation mechanism—governance output’.
From Procedural Completeness to Audit-Proof Security: The Public Disclosure Gap in Rules Governing the Disclosure of Foreign-Related Impacts and Agency Relationships by Legislative Proposal Submitters to the National People's Congress
This version is not peer-reviewed. Submitted: 28 December 2025 You are already at the latest version This paper employs the OSINT evidence auditing methodology for normative texts, using publicly available and verifiable normative documents as the evidentiary boundary. It examines the configuration of disclosure rules governing foreign influence and agency relationships of proposal entities during the legislative proposal stage of the National People's Congress and its Standing Committee.
Computable Gap Assessment of Artificial Intelligence Governance in Children's Centres: Evidence-Mechanism-Governance-Indicator Modelling of UNICEF's Guidance on AI and Children 3.0 Based on the Graph-GAP Framework
Submitted: 20 December 2025 You are already at the latest version This paper addresses the practical challenges in governing “child-centred artificial intelligence”: regulatory texts often outline principles and requirements yet lack reproducible evidence anchors, clear causal pathways, executable governance toolchains, and computable audit metrics.
High-Dependency Border Fractures and National ‘Cascading Vulnerability’: A Framework for Identifying Critical Vulnerabilities, Intelligence-Driven Simulation, and Early Warning in Cambodia Based on Structured Knowledge Graphs, with a Discussion on Thailan
Submitted: 15 December 2025 You are already at the latest version Against a backdrop of increasingly frequent external shocks and deepening cross-sectoral coupling, traditional national risk assessments centred on ‘industry/sector’ units often struggle to explain why seemingly localised disturbances rapidly evolve into systemic instability. This paper proposes an integrated ‘Dependency Network–Knowledge Graph (DN-KG)’ framework tailored for intelligence research and academic discourse.
The Discourse and Logic of the Concretisation Turn: A Critical Assessment of Professor Min Chao's Article 'Marx's Study of the French Revolution of 1848 and the Concretisation Turn in the Materialist Conception of History
This version is not peer-reviewed.
OSINT Analysis Briefing on the Central Committee of the Communist Party of China Economic Work Conference
Submitted: 13 December 2025 You are already at the latest version This paper examines the policy signals emanating from the Central Economic Work Conference held in Beijing on 10–11 December 2025. It aims to reveal the underlying logic of China's macro-governance transition from ‘passively responding to shocks’ to ‘proactively restructuring growth models within a high-uncertainty environment’.
The Prognostic Value of Insulin Resistance Indices for Major Adverse Cardiovascular Events in Young and Middle‐Aged Patients With Hypertension
AUC area under the curve BMI body mass index CI confidence interval CKD chronic kidney disease CVD cardiovascular disease DBP diastolic blood pressure FPG fasting plasma glucose HbA1c glycated hemoglobin A1c HDL-C high-density lipoprotein cholesterol HR hazard ratio IR insulin resistance LDL-C low-density lipoprotein cholesterol MACE major adverse cardiovascular event METS-IR metabolic score for insulin resistance RAS renin angiotensin system RCS restricted cubic spline ROC receiver operating...
A Critical Analysis of Several Legal Proposals by Zhu Zhengfu, Deputy to the National Peopleʹs Congress of China：Reflections Grounded in Marxist Jurisprudence and the Comprehensive National Security Outlook
Submitted: 09 December 2025 You are already at the latest version In recent years, Zhu Zhengfu, a deputy to the National People's Congress, has consistently advocated for issues such as ‘abolishing the crime of provoking trouble’, ‘sealing minor criminal records’, and ‘sealing public security violation records for drug use’. His proposals have generated significant influence in both public discourse and legislative debates.
Critiquing Tsinghua University Professor Lao Dongyan’s Support for Peking University Professor Zhao Hong on Drug Record Sealing: Based on Marxist Legal Principles and Xi Jinping Thought on the Rule of Law
Submitted: 08 December 2025 You are already at the latest version This paper conducts a systematic critical analysis of Professor Lao Dongyan of Tsinghua University's public discourse advocating for Zhao Hong of Peking University and supporting the ‘sealing system for public order offences such as drug use’. The analysis is grounded within the normative framework constituted by Marxist legal principles and Xi Jinping Thought on the Rule of Law.
A Comprehensive Analysis of the Legitimacy Boundaries of Professor Zhao Hong's Proposal for Sealing Public Order Violation Records at Peking University Based on Marxist Jurisprudence and Xi Jinping Thought on the Rule of Law
This version is not peer-reviewed. Submitted: 07 December 2025 You are already at the latest version The newly revised Law of the People's Republic of China on Penalties for Public Order Violations introduces a "system for sealing public order violation records," with the sealing of records for acts such as drug use sparking intense public debate.
The Concentric Pattern of the Western Pacific-Indo-Pacific Region: Structural Analysis of Global Security Nodes Based on Spatially Heterogeneous Knowledge Graphs[v1] | Preprints.org
This version is not peer-reviewed. Submitted: 21 November 2025 You are already at the latest version This study employs a spatially heterogeneous knowledge graph to depict the multi-ring concentric structure centred on the Western Pacific–Indo-Pacific within the contemporary global security landscape.
From Correlation to Causation: Identifying NATO-Indo-Pacific Cooperation Mechanisms Based on Lossless Knowledge Graphs
This version is not peer-reviewed. Submitted: 15 November 2025 You are already at the latest version This study aims to address how NATO can simultaneously advance cooperation and mitigate sensitivities within the Indo-Pacific.
System Modelling of Hybrid Warfare in Grey Zones: An Analysis of Synergistic Effects Between Disruptive Networks and Financial Market Manipulation
Submitted: 01 November 2025 You are already at the latest version This study examines an emerging yet systematically uncharacterised strategic attack pattern: adversaries, without declaring war, simultaneously orchestrate infrastructure disruption incidents within target nations using highly dispersed, deniable small-scale infiltration units.
Mapping Resilience: Modeling Supply Chain System Diagnosis and Policy Response in the UK Based on a Mixed Study
This version is not peer-reviewed. Submitted: 26 October 2025 You are already at the latest version Amidst the dual shocks of Brexit and the COVID-19 pandemic, this paper constructs a supply chain diagnostic framework integrating policy, labour, logistics, and ESG factors. Employing a mixed-methods approach: quantitatively, it synthesises six real-world cases via knowledge graphs, covering a primary observation window of 2021 with a ±12-month robustness interval.
AI-Enhanced OSINT Evidence Governance: Academic Integrity, Platform Disposition, and National Security Risk Assessment in the Case of Shanghai Maritime University’s “First-Class Undergraduate Major” Controversy
This version is not peer-reviewed. Submitted: 03 October 2025 You are already at the latest version This study anchors its analysis on the controversy surrounding Shanghai Maritime University's “First-Class Undergraduate Programs” initiative in China.
The Intelligent Evolution of Open-Source Intelligence: Focusing on International Legion of Defence Intelligence of Ukraine
This version is not peer-reviewed. Submitted: 04 October 2025 You are already at the latest version This study aims to deepen open-source intelligence (OSINT) analysis of Ukraine's Defense Intelligence International Corps through artificial intelligence methods, exploring AI's application potential and methodological value in complex warfare information environments.
2025 Southeast Asia Eleven Nations Influence Index Report
Submitted: 24 September 2025 Posted: 25 September 2025 You are already at the latest version This study aims to construct a fully data-driven and reproducible Southeast Asia Influence Index (SAII v3) to overcome biases from expert scoring and subjective weighting, while mapping the hierarchical power structure across the eleven ASEAN nations.
From Courtesy to Influence: Identifying the Role of China’s New Ambassador to Thailand through OSINT-Based Multilayered Networks and Inflection Point Early Warning
This version is not peer-reviewed. Submitted: 19 September 2025 Posted: 22 September 2025 You are already at the latest version This study aims to examine how China's newly appointed ambassador to Thailand employs event networks and temporal dynamics to demonstrate issue entry and structural embedding in early diplomatic practices, thereby revealing the priorities and potential trends in China's diplomacy toward Thailand.
Beyond Expert Judgment: An Explainable Framework for Truth Discovery, Weak Supervision, and Learning-Based Ranking in Open-Source Intelligence Risk Identification
Submitted: 12 September 2025 Posted: 15 September 2025 You are already at the latest version In open-source intelligence (OSINT) research, traditional risk identification methods reliant on expert scoring face growing challenges due to their high subjectivity, cost, and lack of scalability. This study aims to propose and validate an algorithmic framework that transcends expert judgment.
Weaponization of the Social Sciences and Strategic Reconstruction of the National Academic System: A Policy Proposal
This version is not peer-reviewed. Submitted: 07 September 2025 Posted: 08 September 2025 You are already at the latest version This study aims to explore the potential role and pathways for transforming social sciences within the national security and strategic competition landscape.
Structural Variable Relationship Modeling in Cutting-Edge AI: A Framework Based on Spectra, Topology, and Entropy
Submitted: 01 September 2025 Posted: 03 September 2025 You are already at the latest version This study aims to overcome the structural and interpretative limitations encountered in artificial intelligence causal modelling and explainable AI (XAI) when employing advanced topic modelling techniques (LDA/HDP) alongside traditional grounded theory (GT). It proposes a novel structural variable-relationship modelling framework tailored for complex systems.
Nuclear Deterrence in the Beibu Gulf in a Three-Dimensional Framework: Model Development, Strategic Logic, and Empirical Comparison
This version is not peer-reviewed. You are already at the latest version The South China Sea, as one of the most important maritime corridors in the world, has become a frontier zone for the games of great powers. Beibu Gulf, located at the northern edge of the South China Sea, is both a strategic gateway to China's southern depth and a vulnerable link for potential external forces to intervene.
Accelerating the Deployment of China's National Standard and Industrialisation of Quantum Resistant Cryptography (PQC) Proposal for Building National Security "Double Insurance" in Quantum Era
Under the threat window of ‘interception first, decryption later’ in quantum computing, national security and industrial sovereignty face new systemic challenges. This paper proposes a dual-track approach of ‘PQC baseline + QKD enhancement’ to comprehensively compare the standard systems, governance models, and engineering progress of China and the United States in post-quantum cryptography (PQC) and quantum key distribution (QKD).
Advances in Pathogen Detection: From Traditional Methods to Nanotechnology, Biosensing and AI Integration
• , , , et al. . “ Correction: Antimicrobial Peptide Based Magnetic Recognition Elements and au@ag-GO SERS Tags With Stable Internal Standards: A Three in One Biosensor for Isolation, Discrimination and Killing of Multiple bacteria in Whole Blood .” Chemical Science , no. : . https://doi.org/10.1039/C8SC90250J.
Neural-Symbolic Emotion-Pose Graph Reasoning in AI-Based Human Synthesis: A Multimodal Model Integrating Cognitive Priors-Digital Restoration of the Aesthetics of the Statue of Venus[v1] | Preprints.org
This version is not peer-reviewed. This version is not peer-reviewed. This study aims to break through the traditional sculpture restoration paradigm centred on "geometric fitting", and proposes an aesthetic restoration framework that integrates emotion-gesture-symbol.
Analytical validation and sequencing coverage studies suggest that performance of a liquid biopsy assay is tumor agnostic (DNA-is-DNA)
Loading metrics Open Access Peer-reviewed Research Article Citation: Meng W, Petry R, Galicia NP, van den Hout A, Yu J, Gong S, et al. (2025) Analytical validation and sequencing coverage studies suggest that performance of a liquid biopsy assay is tumor agnostic (DNA-is-DNA). PLoS One 20(8): e0329392.
Policy Recommendations on Optimizing China's Study Abroad Strategy to Serve Belt and Road Cooperation and Alleviate Domestic Structural Employment Pressure
This version is not peer-reviewed. This version is not peer-reviewed. Against the backdrop of intensifying global strategic competition, structural imbalances in youth employment, and deep-seated demographic transitions, China's current overseas study policies have exposed significant issues such as structural mismatches and misaligned policy directions.
A Tactical Behaviour Recognition Framework Based on Causal Multimodal Reasoning: A Study on Covert Audio-Video Analysis Combining GAN Structure Enhancement and Phonetic Accent Modelling
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On C-normal and S-semipermutable subgroups of finite groups under coprime action
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