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Articles by Xiaobo Du
Bispecific Antibody Ivonescimab Added to Chemotherapy in EGFR -Variant Non–Small Cell Lung Cancer : The HARMONi-A Randomized Clinical Trial
Key Points Question Does adding ivonescimab to chemotherapy improve overall survival in patients with epidermal growth factor receptor (EGFR) gene variant non–small cell lung cancer after disease progression with EGFR tyrosine kinase inhibitor (TKI) therapy? Findings In this phase 3, randomized, double-blind trial, ivonescimab plus chemotherapy significantly improved overall survival (median, 16.8 vs 14.1 months) and the 30-month survival rate (29.1% vs 18.4%) compared with chemotherapy alone.
FLASH radiotherapy using high-energy X-rays: validation of the Flash effect triggered by a compact device
Keywords FLASH radiotherapy Flash effect CHEXs Single gantry rotation short-interval pauses Introduction Cancer remains a leading cause of death worldwide, with an estimated 20 million new cases and approximately 9.7 million deaths reported in 2022 [1]. Radiotherapy, a commonly used treatment for cancer, is required by approximately 60–80% of affected patients throughout the course of the disease [2,3].
Neoadjuvant treatment of IBI310 plus sintilimab in locally advanced MSI-H/dMMR colon cancer: A randomized phase 1b study
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Keywords anti-CLTA-4 anti-PD-1 immunotherapy microsatellite instability-high mismatch repair-deficient colon cancer Introduction Colorectal cancer (CRC) is ranked as the third most common malignant tumor and the second leading cause of cancer-related death worldwide.1 In China, there is a heavy and increasing burden of CRC, which ranks second in incidence and fourth in mortality.1 Approximately 15% of patients with CRC were found to have microsatellite instability-high or mismatch...
By Feng Wang, Gong Chen, Meng Qiu, Jinfeng Ma, Xianwei Mo, Haiyi Liu, Yongqiang Li, Peirong Ding, Yingbin Hu, Xiwen Huang, Weiqin Jiang, Xiaojun Wu, Jia Luo, Yanbing Zhou, LePing Li, Quan Wang, Nanya Wang, Wu Jiang, Weitang Yuan, Liren Li, Linlin Liu, Xianglin Yuan, Guihua Wang, Zhangfa Song, Heli Liu, Jie Ge, Yaxu Wang, Peng Zhao, Taiyuan Li, Jun You, Jianqiang Tang, Xiaobo Du, Junzhong Lin, Rongxin Zhang, Zan Fu, Jianmin Xu, Haijun Zhong, Yanhong Deng, Xiaoxiao Lu, Qun Guo, Hui Zhou, Rui-hua Xu, Xiangbin Wan, Yanlai Sun
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Cell Press
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Multi-modal radiomics model based on four imaging modalities for predicting pathological complete response to neoadjuvant treatment in breast cancer - BMC Cancer
This single-center retrospective study was conducted in accordance with the Declaration of Helsinki and approved by the Ethics Committee of Mianyang Central Hospital. Informed consent was waived due to the retrospective design of the study. Surgically resected specimens served as the reference standard for assessing treatment response. The study aims to develop and validate a multi-modal radiomics model to predict pCR in BC following NAT.
Performance Evaluation of Porous Asphalt Mixture Reinforced with Waste Cellulose Acetate Fibers
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Laboratory Evaluation of Cold Patching Asphalt Mixture with Refined-Processed Recycled Asphalt Pavement
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Laboratory Evaluation of Asphalt Binder and Asphalt Mixture Modified Using Styrene-Butadiene-Styrene/Rock Asphalt
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Field Compaction Characteristics of Ultra-Thin Porous Friction Course Based on Laboratory Simulation
All articles published by MDPI are made immediately available worldwide under an open access license. No special permission is required to reuse all or part of the article published by MDPI, including figures and tables. For articles published under an open access Creative Common CC BY license, any part of the article may be reused without permission provided that the original article is clearly cited. For more information, please refer to https://www.mdpi.com/openaccess.
Performance Evaluation of Asphalt and Asphalt Mixtures Modified by Fuel-Resistant Admixture
1. Introduction Due to its high technological and service properties, asphalt concrete is a preferred material for road pavement construction [1]. As asphalt concrete contains asphalt as a binding material, and asphalt is a mixture of aromatic, aliphatic, and cycloalkane hydrocarbons generated during the refining of crude oil that are readily soluble in all oil-derived fuel [2].
An Improved Method for Optimizing the Timing of Preventive Maintenance of Pavement: Integrating LCA and LCCA
This is an early access version, the complete PDF, HTML, and XML versions will be available soon. Open AccessArticle by 1,*, 1, 2, 1 and 1 1 The Key Laboratory of Road and Traffic Engineering, Ministry of Education, Tongji University, 4800 Cao’an Road, Shanghai 201804, China 2 Postdoctoral Station of Mechanical Engineering, Tongji University, Shanghai 201804, China * Author to whom correspondence should be addressed. Appl. Sci.
Case Report: A rare case of recurrent ascites after anti-Claudin18.2 antibody therapy for metastatic gastric cancer while responding sustainingly
Introduction Gastric cancer is still one of the most incident and fatal malignant tumors of the digestive tract. Recently, the American Cancer Society released the latest cancer statistics: it is expected that 26,500 cases of stomach cancer will occur in the United States in 2023, with 11,130 deaths and a mortality rate of nearly 43% (1). Therefore, effective therapeutics are in urgent demand. Targeted therapy and immunotherapy have changed the treatment of advanced gastric cancer.
Applied Sciences | Free Full-Text | Optimization for Asphalt Pavement Maintenance Plans at Network Level: Integrating Maintenance Funds, Pavement Performance, Road Users, and Environment
1. Introduction Since its reform and opening up, China has made tremendous achievements in highway construction. According to the Statistical Bulletin on the Development of the Transportation Industry, the development process of high-speed highways in China in recent years is shown in Figure 1 .
Clinical progress of anti-angiogenic targeted therapy and combination therapy for gastric cancer
Donghan Xu1†, Yehao Luo2†, Peng Wang1, Jiaxin Li1, Linrui Ma1, Jie Huang1, Hao Zhang1, Xiaoman Yang1, Liqi Li1, Yuhong Zheng1, Gang Fang3* and Peiyu Yan1,4* 1Faculty of Chinese Medicine, Macau University of Science and Technology, Macao, Macao SAR, China 2School of Second Clinical Medicine, Guangzhou University of Chinese Medicine, Guangzhou, China 3Guangxi Key Laboratory of Applied Fundamental Research of Zhuang Medicine, Guangxi University of Chinese Medicine, Nanning, China 4State Key...
Exosomes: The Role in Tumor Tolerance and the Potential Strategy for Tumor Therapy
1. Introduction The global tumor burden has increased over the past few decades. In China, the national relative rate of cancer-related deaths increased from 10.1% in the 1970s to 24.2% in 2015 [1]. The tumors with the highest incidence are related to lung, stomach, liver, colorectum, and bladder cancers in men and breast, lung, colorectal, thyroid, cervical, and stomach cancers in women. More than 600,000 people in the U.S. will die from cancer by 2022 [2].
Development of a Runaway Vehicle Protective Barrier System Using Simulation and Full-Scale Crash Testing
Open AccessArticle by Xiuchen Xu 1, Hongchao Zhang 1, Xianpeng Zhao 2,*, Xiaobo Du 3, Desheng Lian 4 and Zhongmin Liu 5 1 The Key Laboratory of Road and Traffic Engineering, Ministry of Education, Tongji University, Shanghai 201804, China 2 School of Transportation Engineering, Tongji University, Shanghai 201804, China 3 Postdoctoral Station of Mechanical Engineering, Tongji University, Shanghai 201804, China 4 Shandong High Speed Zibo Development Co., Ltd., Zibo 255000, China 5 Shandong...
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