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Articles by Xiaolei Su
Shared Treg dysregulation underlies psoriasis vulgaris and atopic dermatitis through the PHF19-PRC2 epigenetic axis
Abstract Background: Psoriasis vulgaris (PV) and atopic dermatitis (AD) are chronic inflammatory skin diseases characterized by distinct dominant T cell subsets, yet emerging evidence suggests overlapping immune mechanisms. Whether a shared Treg abnormality underlies both diseases remains unclear. Methods: Single-cell RNA sequencing data from lesional T cells of 8 PV, 7 AD, and 7 healthy controls were analyzed.
Molecular characterization of hypoxia-inducible factor alpha isoforms reveals a pivotal role of HIF-3α in acute hypoxia adaptation of greenfin horse-faced filefish ( Thamnaconus septentrionalis )
Abstract Introduction: Hypoxia-inducible factor α (HIF-α) family members are key transcription factors mediating cellular responses to hypoxia. However, their specific roles in the greenfin horse-faced filefish, Thamnaconus septentrionalis, remain unclear. Methods: The hypoxia sensitivity of T. septentrionalis was determined by the critical O2 tension for loss of equilibrium (LOEcrit).
Mast cell extracellular granules are bioactive condensates assembled by heparin and polyamine - Nature Chemical Biology
Abstract Biomolecular condensates are membraneless bodies that organize biochemical reactions typically within cells. However, the roles of condensates in extracellular space—where conditions differ substantially from intracellular space—remain poorly understood. Here we report that mast cell extracellular granules (MCEGs), a stable membraneless entity, are condensates assembled through electrostatic interactions between glycosaminoglycans and polyamines.
Hyperbranched Aggregation-Induced Emission Luminogen-Based Sensor Array for Highly Sensitive Discrimination of Multiple Proteins
Abstract Click to copy section linkSection link copied! Simultaneous discrimination of multiple proteins with high sensitivity is of great importance for point-of-care prediction and diagnosis of diseases.
Regulation of Microstructure and Absorption Properties of MXene Materials: Theoretical and Experimental
1 Introduction The relentless progress of modern electronic technologies has spurred urgent demands for advanced microwave absorption materials, driven by dual imperatives: mitigating escalating electromagnetic interference (EMI) pollution and enhancing stealth technologies for defense applications.[1-4] In this context, 2D transition metal carbides/nitrides (MXenes) have emerged as transformative candidates, leveraging their unique layered architecture, tunable surface terminations (e.g.,...
Preparation and Hydrogen Resistance Property of CrCN Coating by Magnetron Sputtering Method Under Different C-Target Powers
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Broad‐Scale Meta‐Analysis of Drivers Mediating Adverse Impacts of Flow Regulation on Riparian Vegetation
Conflicts of Interest The authors declare no conflicts of interest. Supporting Information Filename Description gcb70042-sup-0001-Supinfo.docxWord 2007 document , 19.4 MB Data S1. References , and . 2023. “Socio-Ecological Challenges of Hydroelectric Dams Among Ethnic Minorities in Northern Laos.” Environmental Development 46: 100864. https://doi.org/10.1016/j.envdev.2023.100864. , , , et al. 2003.
G3BP1 ribonucleoprotein complexes regulate focal adhesion protein mobility and cell migration
Focal adhesion isolation Focal adhesions were isolated as previously described.26 Cells were seeded on tissue culture plastic coated with bovine plasma fibronectin (10 μg/mL in PBS overnight at 4°C).
236 Intrinsically disordered region (IDR) engineered CAR-T cells show increased signaling, tumor killing and high antigen sensitivity against solid and liquid tumors compared to 3rd generation CAR-T’s | Journal for ImmunoTherapy of Cancer
http://creativecommons.org/licenses/by-nc/4.0/ This is an open access article distributed in accordance with the Creative Commons Attribution Non Commercial (CC BY-NC 4.0) license, which permits others to distribute, remix, adapt, build upon this work non-commercially, and license their derivative works on different terms, provided the original work is properly cited, appropriate credit is given, any changes made indicated, and the use is non-commercial.
Pd/TiO2 decorated carbon fibers as an efficient anode catalyst for methanol electro‐oxidation
REFERENCES 1, , , , , , Inorg. Chim. Acta 2021, 520, 120293. 2, , , , , , , , , Mater. Chem. Phys. 2020, 252, 123234. 3, , , , , Electrochim. Acta 2020, 353, 136542. 4, , , Catal. Rev. Sci. Eng. 2022, 64, 126. 5, , , , , , , , , J. Electron. Mater. 2021, 50, 7222. 6, , , , , , Int. J. Hydrogen Energy 2021, 46, 14596. 7, , , Electrocatalysis 2019, 10, 9. 8, , , , , , , Chem. Eng. J. 2022, 427, 131937. 9, , , , Int. J. Energy Res. 2020, 44, 10071. 10, , , , , , Fuel Cells 2023, 23, 161. 11, , , , , J. Energy Chem. 2020, 49, 275.
Phase separation of signaling molecules promotes T cell receptor signal transduction
In T cell receptors, signaling molecules reorganize into tiny phase-separated droplets—like oil in water. Su et al. used an in vitro system with artificial membranes and 12 components of the T cell receptor signaling system to closely monitor the role of these molecular clusters (see the Perspective by Dustin and Muller). The clusters formed through phosphorylation-dependent association of the linker protein LAT (linker for activation of T cells) with other proteins.
Phase separation of signaling molecules promotes T cell receptor signal transduction
Activation of various cell surface receptors triggers the reorganization of downstream signaling molecules into micron- or submicron-sized clusters. However, the functional consequences of such clustering has been unclear. We biochemically reconstituted a 12-component signaling pathway on model membranes, beginning with T cell receptor (TCR) activation and ending with actin assembly.
Building Immunity: MBL Whitman Center team recreates a T-cell receptor signaling pathway
WOODS HOLE, Mass.-- The front line of the human immune system is made up of T-cells: white blood cells that circulate in the body and scan for foreign invaders and infections. If a T-cell surface receptor detects a threat during its surveillance, it relays a signal to the interior of the cell and activates it to attack.
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